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  1. Article ; Online: Isolation or De-isolation? Measuring the Infectivity of Severe Acute Respiratory Syndrome Coronavirus 2.

    Yang, Hung-Chih

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2020  Volume 73, Issue 9, Page(s) e2960–e2961

    MeSH term(s) COVID-19 ; Humans ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-10-28
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciaa1671
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  2. Article: Assessment of Ultrasonic Stress on Survival and β-Glucosidase Activity of Encapsulated

    Tseng, Hung-Chih / Yang, Chun-Yao

    Foods (Basel, Switzerland)

    2022  Volume 11, Issue 9

    Abstract: The enhanced β-glucosidase activity of ... ...

    Abstract The enhanced β-glucosidase activity of encapsulated
    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods11091234
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  4. Article ; Online: Isolation or De-isolation

    Yang, Hung-Chih

    Clinical Infectious Diseases ; ISSN 1058-4838 1537-6591

    Measuring the Infectivity of SARS-CoV-2?

    2020  

    Keywords Microbiology (medical) ; Infectious Diseases ; covid19
    Language English
    Publisher Oxford University Press (OUP)
    Publishing country uk
    Document type Article ; Online
    DOI 10.1093/cid/ciaa1671
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Recent Progress and Future Prospective in HBV Cure by CRISPR/Cas.

    Yang, Yu-Chan / Yang, Hung-Chih

    Viruses

    2021  Volume 14, Issue 1

    Abstract: Hepatitis B virus (HBV) infection remains an important issue of global public health. Although current antiviral therapy has dramatically reduced the mortality and morbidity of chronic hepatitis B (CHB), it fails to cure it. Rebound viremia often occurs ... ...

    Abstract Hepatitis B virus (HBV) infection remains an important issue of global public health. Although current antiviral therapy has dramatically reduced the mortality and morbidity of chronic hepatitis B (CHB), it fails to cure it. Rebound viremia often occurs after stopping antiviral therapy. Persistent HBV covalently closed circular DNA (cccDNA) and integrated DNA under antiviral therapy form the major barrier to eradication of HBV infection. CRISPR-mediated genome editing has emerged as a promising therapeutic approach to specifically destroy persistent HBV genomes, both cccDNA and integrated DNA, for HBV cure. However, the cleavage of integrated HBV DNA by CRISPR-Cas9 will cause double-strand break (DSB) of host genome, raising a serious safety concern about genome instability and carcinogenesis. The newly developed CRISPR-derived base editors (BEs), which fuse a catalytically disabled nuclease with a nucleobase deaminase enzyme, can be used to permanently inactivate HBV genome by introducing irreversible point mutations for generation of premature stop codons without DSBs of host genome. Although promising, CRISPR-mediated base editing still faces daunting challenges before its clinical application, including the base-editing efficacy, the off-target effect, the difficulty in finding conserved target HBV sequences, and in vivo delivery efficiency. Several strategies have been adopted to optimize the efficiency and specificity of CRISPR-BEs and to improve in vivo delivery efficacy through novel viral and non-viral delivery approaches. Particularly, the non-viral delivery of Cas9 mRNA and ribonucleoprotein by lipid nanoparticles exhibits attractive potential for liver-targeted delivery in clinical. Along with all progress above, the CRISPR-mediated gene therapy will ultimately achieve HBV cure.
    MeSH term(s) Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; CRISPR-Associated Protein 9/genetics ; CRISPR-Cas Systems ; DNA, Viral/genetics ; Gene Editing ; Genetic Therapy ; Genome, Viral ; Hepatitis B/therapy ; Hepatitis B/virology ; Hepatitis B virus/genetics ; Hepatitis B virus/physiology ; Hepatitis B, Chronic/therapy ; Hepatitis B, Chronic/virology ; Humans ; Protein Engineering
    Chemical Substances Antiviral Agents ; DNA, Viral ; CRISPR-Associated Protein 9 (EC 3.1.-)
    Language English
    Publishing date 2021-12-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14010004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Association Between

    Chen, Hung-Chih / Yang, Pei-Yu / Chen, Jung-Sheng / Bau, DA-Tian / Chao, Shih-Chun

    In vivo (Athens, Greece)

    2024  Volume 38, Issue 3, Page(s) 1229–1235

    Abstract: Background/aim: Given the characteristics of Serratia marcescens (S. marcescens), this study aimed at investigating its presence in the hands and contact lens cases of orthokeratology wearers, along with the status of bacterial contamination.: ... ...

    Abstract Background/aim: Given the characteristics of Serratia marcescens (S. marcescens), this study aimed at investigating its presence in the hands and contact lens cases of orthokeratology wearers, along with the status of bacterial contamination.
    Patients and methods: The 39 patients received the questionnaires about the background of orthokeratology and hygiene habits. A total of 39 contact lens cases and 39 hand samples from the patients were collected at Show Chwan Memorial Hospital from June to August in 2020 and sent to National Chung Cheng University for DNA extraction and PCR identification.
    Results: The results indicated a detection rate of 5.13% for S. marcescens in the contact lens cases and 12.82% in the hand samples. Additionally, 66.67% of contact lens case samples and 30.77% of hand samples found positive for 16s bacterial amplicons. The relationship between hand contamination and the duration of contact lens usage were revealed for both S. marcescens (p=0.021) and 16s bacterial amplicons (p=0.048).
    Conclusion: The results indicated that hand hygiene is more critical than focusing on contact lens hygiene when it comes to preventing S. marcescens infections. Nevertheless, both proper hand and contact lens hygiene practices can reduce the detection of bacterial eye pathogens, especially a common intestinal bacterium.
    MeSH term(s) Humans ; Serratia marcescens/isolation & purification ; Serratia marcescens/genetics ; Male ; Female ; Serratia Infections/microbiology ; Serratia Infections/epidemiology ; Serratia Infections/diagnosis ; Orthokeratologic Procedures/methods ; Contact Lenses/microbiology ; Contact Lenses/adverse effects ; Child ; Adolescent ; Hygiene ; Hand Hygiene ; Adult ; Hand/microbiology
    Language English
    Publishing date 2024-04-30
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 807031-3
    ISSN 1791-7549 ; 0258-851X
    ISSN (online) 1791-7549
    ISSN 0258-851X
    DOI 10.21873/invivo.13559
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    Zs.A 2288: Show issues Location:
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  7. Article: Climbing strategies of Taiwan climbers.

    Chen, Po-Hao / Chung, An-Ching / Lin, Hung-Chih / Yang, Sheng-Zehn

    Botanical studies

    2023  Volume 64, Issue 1, Page(s) 26

    Abstract: Background: The climbing strategies of lianas and herbaceous vines influence climber competition abilities and survival. The aim of this study was to investigate the climbing strategies of each plant species and observe their organs of origin.: ... ...

    Abstract Background: The climbing strategies of lianas and herbaceous vines influence climber competition abilities and survival. The aim of this study was to investigate the climbing strategies of each plant species and observe their organs of origin.
    Results: The results showed that all Taiwan climbers were approximately 555 species, accounting for 11% of the native flora. Among the 555 climbers, the twining stem type was the most common, with a total of 255 species (46%), the remaining climbing methods accounted for 300 species. Approximately twenty one climbing methods, including nine combination types, were exhibited, of which the most common type was the twining stem, followed by simple scrambling and twining tendrils. Most species of Fabaceae and Apocynaceae were twining stems in dextrorse, excluding Wisteriopsis reticulata and Alyxia taiwanensis, which were in sinistrorse. The prehensile branch of Fissistigma genus, Ventilago genus, and Dalbergia benthamii, originated from second-order or modified stems. In the simple scrambling type, some climbers were covered spines and prickles to attach the host, and the others were clinging to the supports or creeping on the ground without speculation. The hooks or grapnels of the genus Uncaria are derived from the branches, and a pair of curved hooks or a spine of Artabotrys hexapetalus are originated from the inflorescence to tightly attach to a host. The Piper genus use adhesive roots to climb their hosts. Among the genus Trichosanthes, only Trichosanthes homophylla exhibits a combination of twining modified shoots and adhesive roots. Gentianales includes four families with seven climbing mechanisms, while Fabales includes only Fabaceae, which presents six climbing methods.
    Conclusions: The twining tendrils had nine organs of origin in Taiwan climber, that these opinions of originated organs might be available to the studies of convergent evolution. The data presented herein provide crucial basic information of the climber habits types and origin structures, which are available for terms standardization to improve field investigation. The terminologies would aid in the establishment of climber habits as commonly taxon-specific and the combination of two climber habits could be a characteristic of taxonomic value.
    Language English
    Publishing date 2023-09-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2432110-2
    ISSN 1999-3110 ; 1817-406X
    ISSN (online) 1999-3110
    ISSN 1817-406X
    DOI 10.1186/s40529-023-00399-4
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  8. Article: Towards elimination of viral hepatitis in Taiwan by 2025: In memory of Professor Ding-Shinn Chen (1943-2020).

    Yang, Hung-Chih / Kao, Jia-Horng

    Journal of the Formosan Medical Association = Taiwan yi zhi

    2020  Volume 119, Issue 8, Page(s) 1247–1248

    MeSH term(s) Disease Eradication/history ; Hepatitis B/prevention & control ; Hepatitis C/prevention & control ; History, 20th Century ; History, 21st Century ; Humans ; Male ; Taiwan ; Viral Hepatitis Vaccines/administration & dosage
    Chemical Substances Viral Hepatitis Vaccines
    Language English
    Publishing date 2020-07-10
    Publishing country Singapore
    Document type Autobiography ; Historical Article ; Journal Article
    ZDB-ID 2096659-3
    ISSN 1876-0821 ; 0929-6646
    ISSN (online) 1876-0821
    ISSN 0929-6646
    DOI 10.1016/j.jfma.2020.07.007
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    Zs.B 1041: Show issues Location:
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  9. Article ; Online: Current practice and recommendations for management of hepatitis B virus in people living with HIV in Asia.

    Lui, Grace Chung-Yan / Wong, Grace Lai-Hung / Yang, Hung-Chih / Sheng, Wang-Huei / Lee, Sun Hee

    HIV medicine

    2023  Volume 24, Issue 10, Page(s) 1035–1044

    Abstract: Background: The prevalence of HIV and hepatitis B virus (HBV) co-infection is higher in Asia than in Europe and North America and varies significantly between different regions within Asia. Important routes of transmission of both these infections ... ...

    Abstract Background: The prevalence of HIV and hepatitis B virus (HBV) co-infection is higher in Asia than in Europe and North America and varies significantly between different regions within Asia. Important routes of transmission of both these infections include high-risk unprotected sexual contact, intravenous drug use, and transmission of maternal infection perinatally or in early childhood. While life expectancy among people living with HIV has been extended with effective antiretroviral therapy (ART), HBV-induced liver injury and complications have emerged as a leading cause of morbidity and mortality in people living with HIV.
    Objectives: This article describes the prevalence of co-infection, current clinical practice, and recommendations for the management of people living with HIV-HBV co-infection in Asia.
    Results and conclusions: Screening for HBV should occur at the time of HIV diagnosis; however, HBV screening rates in people living with HIV in Asia vary widely by region. Similarly, people with HBV should be screened for HIV before initiation of HBV antiviral therapy. People with HIV-HBV co-infection should be assessed for liver damage and risk factors for liver disease and be monitored regularly for liver complications and HBV DNA. Medical treatment with ART is lifelong and includes tenofovir and lamivudine or emtricitabine, unless intolerant or contraindicated, as these are active against both HIV and HBV. HBV vaccination programmes are effective in reducing co-infection rates. Mother-to-child transmission can be prevented through measures such as vaccination, antenatal screening, and treatment of pregnant women who are infected.
    Language English
    Publishing date 2023-09-21
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2001932-4
    ISSN 1468-1293 ; 1464-2662
    ISSN (online) 1468-1293
    ISSN 1464-2662
    DOI 10.1111/hiv.13545
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    Zs.A 5441: Show issues Location:
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  10. Article ; Online: Zinc supplementation is associated with improvement in hand-foot skin reaction in patients on vascular endothelial growth factor receptor-tyrosine kinase inhibitors: A cohort study.

    Lu, Chun-Wei / Yeh, Chun-Nan / Hsu, Hung-Chih / Chen, Chun-Bing / Yang, Tsai-Sheng / Pan, Yi-Ru / Chung, Wen-Hung / Hung, Shuen-Iu

    Journal of the American Academy of Dermatology

    2023  Volume 90, Issue 4, Page(s) 814–815

    MeSH term(s) Humans ; Vascular Endothelial Growth Factor A ; Tyrosine Kinase Inhibitors ; Cohort Studies ; Zinc/adverse effects ; Protein Kinase Inhibitors/adverse effects ; Receptors, Vascular Endothelial Growth Factor ; Dietary Supplements
    Chemical Substances Vascular Endothelial Growth Factor A ; Tyrosine Kinase Inhibitors ; Zinc (J41CSQ7QDS) ; Protein Kinase Inhibitors ; Receptors, Vascular Endothelial Growth Factor (EC 2.7.10.1)
    Language English
    Publishing date 2023-12-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2023.11.054
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