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Book ; Online ; E-Book: Understanding tourette syndrome

Dina, Carlotta Zanaboni / Porta, Mauro

a guide to symptoms, management and treatment

(Understanding atypical development)

2020

Author's details	Carlotta Zanaboni Dina and Mauro Porta ; foreword by James F. Leckman
Series title	Understanding atypical development
Language	English
Size	1 Online-Ressource (xv, 208 Seiten), Illustrationen
Publisher	Routledge
Publishing place	London
Publishing country	Great Britain
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
HBZ-ID	HT020154415
ISBN	978-0-429-94822-0 ; 978-0-429-48820-7 ; 9781138595590 ; 9781138595606 ; 0-429-94822-0 ; 0-429-48820-3 ; 1138595594 ; 1138595608
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Mapping Gilles de la Tourette syndrome through the distress and relief associated with tic-related behaviors: an fMRI study.

Zapparoli, Laura / Devoto, Francantonio / Mariano, Marika / Seghezzi, Silvia / Servello, Domenico / Porta, Mauro / Paulesu, Eraldo

Translational psychiatry

2024 Volume 14, Issue 1, Page(s) 7

Abstract: Personal distress associated with tic urges or inhibition and relief associated with tic production are defining features of the personal experience in Gilles de la Tourette syndrome (GTS). These affective phenomena have not been studied using fMRI, ... ...

Abstract	Personal distress associated with tic urges or inhibition and relief associated with tic production are defining features of the personal experience in Gilles de la Tourette syndrome (GTS). These affective phenomena have not been studied using fMRI, hindering our understanding of GTS pathophysiology and possible treatments. Here, we present a novel cross-sectional fMRI study designed to map tic-related phenomenology using distress and relief as predicting variables. We adopted a mental imagery approach and dissected the brain activity associated with different phases of tic behaviors, premonitory urges, and the ensuing tic execution or inhibition: these were compared with the mental simulation of "relaxed situations" and pre-determined stereotyped motor behaviors. We then explored whether the ensuing brain patterns correlated with the distress or relief perceived for the different phases of the tasks. Patients experienced a higher level of distress during the imagery of tic-triggering scenarios and no relief during tic inhibition. On the other hand, patients experienced significant relief during tic imagery. Distress during tic-triggering scenarios and relief during tic imagery were significantly correlated. The distress perceived during urges correlated with increased activation in cortical sensorimotor areas, suggesting a motor alarm. Conversely, relief during tic execution was positively associated with the activity of a subcortical network. The activity of the putamen was associated with both distress during urges and relief during tic execution. These findings highlight the importance of assessing the affective component of tic-related phenomenology. Subcortical structures may be causally involved in the affective component of tic pathophysiology, with the putamen playing a central role in both tic urge and generation. We believe that our results can be readily translated into clinical practice for the development of personalized treatment plans tailored to each patient's unique needs.
MeSH term(s)	Humans ; Cross-Sectional Studies ; Magnetic Resonance Imaging ; Tics/diagnostic imaging ; Tourette Syndrome/diagnostic imaging ; Inhibition, Psychological
Language	English
Publishing date	2024-01-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2609311-X
ISSN	2158-3188 ; 2158-3188
ISSN (online)	2158-3188
ISSN	2158-3188
DOI	10.1038/s41398-023-02711-z
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Article ; Online: Deep brain stimulation for Tourette syndrome: modulation of the limbic-motor interface network.

Avecillas-Chasin, Josue M / Galbiati, Tommaso / Porta, Mauro / Servello, Domenico

Journal of neurosurgery

2023 , Page(s) 1–10

Abstract: Objective: Deep brain stimulation (DBS) is an effective treatment for medically refractory Tourette syndrome (TS). Several effective targets have been reported, but there is still controversy about the networks involved in the efficacy of DBS for TS. ... ...

Abstract	Objective: Deep brain stimulation (DBS) is an effective treatment for medically refractory Tourette syndrome (TS). Several effective targets have been reported, but there is still controversy about the networks involved in the efficacy of DBS for TS. Here, the authors aimed to identify the basal ganglia-thalamo-cortical networks associated with tic and obsessive-compulsive behavior (OCB) improvement and the network link between the two main targets for TS. Methods: A retrospective analysis of 21 patients treated with pallidal and thalamic DBS was performed. Tics and OCB scores were recorded before and after DBS. The authors localized the electrodes in standard MNI (Montreal Neurological Institute) space and calculated the volume of tissue activated with the settings at the last follow-up to obtain areas of maximal improvement ("sweet spots") among all patients for the pallidal and thalamic targets. Tractography was used to show the white matter pathways associated with maximal tic and OCB improvement. Results: Ten patients treated with pallidal DBS and 11 patients treated with thalamic DBS were included. Responder rates were 80% in the pallidal and 64% in the thalamic target groups. Sweet spots for tics and OCB clustered in several areas across the basal ganglia and thalamus delineated two main networks. Tic reduction in the pallidal target mapped to a limbic pallidothalamic network and in the thalamic target to the premotor thalamocortical network. Putting these two networks together will form the main output of the so-called limbic-motor interface network. However, OCB reduction mapped a dorsomedial prefrontal cortex/dorsal anterior cingulate (dmPFC/dACC) network. Conclusions: The authors demonstrated the involvement of the limbic-motor interface network during effective DBS for tics in patients with TS. OCB redution was associated with the additional involvement of dmPFC/dACC connections passing dorsal to the head of the globus pallidus pars externa on its way to the thalamus and midbrain.
Language	English
Publishing date	2023-12-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2023.10.JNS231317
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Article ; Online: Assessment of bone turnover markers and DXA parameters to predict bone metastasis progression during zoledronate treatment: a single-center experience.

D'Oronzo, Stella / Cives, Mauro / Lauricella, Eleonora / Stucci, Stefania / Centonza, Antonella / Gentile, Marica / Ostuni, Carmela / Porta, Camillo

Clinical and experimental medicine

2024 Volume 24, Issue 1, Page(s) 7

Abstract: Bone metastases (BM) are a serious cancer complication, potentially causing substantial morbidity. Among the clinical issues related to BM, there is the lack of specific tools for early diagnosis and prognosis. We explored whether combining bone turnover ...

Abstract	Bone metastases (BM) are a serious cancer complication, potentially causing substantial morbidity. Among the clinical issues related to BM, there is the lack of specific tools for early diagnosis and prognosis. We explored whether combining bone turnover markers (BTM) with dual-energy X-ray absorptiometry (DXA) assessment could identify early BM progression and risk of skeletal-related events (SREs) during zoledronate treatment. Before the initiation of zoledronate (T0) and after six months of treatment (T1), serum levels of five BTM were measured, and patients (N = 47) underwent DXA evaluation. Standard radiological imaging was performed to assess bone tumor response to medical anti-cancer treatment. High tumor burden in bone correlated with higher serum CTX (p = 0.007) and NTX (p = 0.005) at baseline. Low concentrations of OPG at T0 predicted BM progression with a sensitivity and specificity of 63% and 77%, respectively, when a cutoff of 5.2 pmol/l was used; such a predictive meaning was stronger in patients with lytic BM (sensitivity: 88%, specificity: 80%; p = 0.0006). As for the risk of SREs, we observed an association between low baseline OC (p = 0.04) and OPG (p = 0.08) and the onset of any-time SREs, whereas an increase in OPG over time was associated with reduced risk of on-study events (p = 0.03). Moreover, a statistically significant correlation emerged between low baseline lumbar T-score and femur BMD and on-study SREs (p < 0.001 in both instances). These findings suggest that addition of DXA to BTM dosage could help stratifying the risk of SREs at the time of BM diagnosis but does not enhance our capability of detecting bone progression, during zoledronate treatment.
MeSH term(s)	Humans ; Zoledronic Acid/therapeutic use ; Absorptiometry, Photon ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/drug therapy ; Prognosis ; Bone Remodeling/physiology
Chemical Substances	Zoledronic Acid (6XC1PAD3KF)
Language	English
Publishing date	2024-01-19
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-023-01280-1
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Article ; Online: An update on Merkel cell carcinoma.

Sergi, Maria Chiara / Lauricella, Eleonora / Porta, Camillo / Tucci, Marco / Cives, Mauro

Biochimica et biophysica acta. Reviews on cancer

2023 Volume 1878, Issue 3, Page(s) 188880

Abstract: Merkel cell carcinoma (MCC) is a rare cancer of the skin characterized by a neuroendocrine phenotype and an aggressive clinical behavior. It frequently originates in sun-exposed body areas, and its incidence has steadily increased in the last three ... ...

Abstract	Merkel cell carcinoma (MCC) is a rare cancer of the skin characterized by a neuroendocrine phenotype and an aggressive clinical behavior. It frequently originates in sun-exposed body areas, and its incidence has steadily increased in the last three decades. Merkel cell polyomavirus (MCPyV) and ultraviolet (UV) radiation exposure are the main causative agents of MCC, and distinct molecular features have been documented in virus-positive and virus-negative malignancies. Surgery remains the cornerstone of treatment for localized tumors, but even when integrated with adjuvant radiotherapy is able to definitively cure only a fraction of MCC patients. While characterized by a high objective response rate, chemotherapy is associated with a short-lasting benefit of approximately 3 months. On the other hand, immune checkpoint inhibitors including avelumab and pembrolizumab have demonstrated durable antitumor activity in patients with stage IV MCC, and investigations on their use in the neoadjuvant or adjuvant setting are currently underway. Addressing the needs of those patients who do not persistently benefit from immunotherapy is currently one of the most compelling unmet needs in the field, and multiple clinical trials of new tyrosine kinase inhibitors (TKIs), peptide receptor radionuclide therapy (PRRT), therapeutic vaccines, immunocytokines as well as innovative forms of adoptive cellular immunotherapies are under clinical scrutiny at present.
MeSH term(s)	Humans ; Carcinoma, Merkel Cell/drug therapy ; Carcinoma, Merkel Cell/pathology ; Skin Neoplasms/drug therapy ; Immunotherapy/adverse effects ; Immunotherapy, Adoptive/adverse effects ; Combined Modality Therapy
Language	English
Publishing date	2023-03-11
Publishing country	Netherlands
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2918802-7
ISSN	1879-2561 ; 0304-419X
ISSN (online)	1879-2561
ISSN	0304-419X
DOI	10.1016/j.bbcan.2023.188880
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Article ; Online: Complications of deep brain stimulation in Parkinson's disease: a single-center experience of 517 consecutive cases.

Servello, Domenico / Galbiati, Tommaso Francesco / Iess, Guglielmo / Minafra, Brigida / Porta, Mauro / Pacchetti, Claudio

Acta neurochirurgica

2023 Volume 165, Issue 11, Page(s) 3385–3396

Abstract: Background: The number of deep brain stimulation (DBS) procedures is rapidly rising as well as the novel indications. Reporting adverse events related to surgery and to the hardware used is essential to define the risk-to-benefit ratio and develop novel ...

Abstract	Background: The number of deep brain stimulation (DBS) procedures is rapidly rising as well as the novel indications. Reporting adverse events related to surgery and to the hardware used is essential to define the risk-to-benefit ratio and develop novel strategies to improve it. Objective: To analyze DBS complications (both procedure-related and hardware-related) and further assess potential predictive factors. Methods: Five hundred seventeen cases of DBS for Parkinson's disease were performed between 2006 and 2021 in a single center (mean follow-up: 4.68 ± 2.86 years). Spearman's Rho coefficient was calculated to search for a correlation between the occurrence of intracerebral hemorrhage (ICH) and the number of recording tracks. Multiple logistic regression analyzed the probability of developing seizures and ICH given potential risk factors. Kaplan-Meier curves were performed to analyze the cumulative proportions of hardware-related complications. Results: Mortality rate was 0.2%, while permanent morbidity 0.6%. 2.5% of cases suffered from ICH which were not influenced by the number of tracks used for recordings. 3.3% reported seizures that were significantly affected by perielectrode brain edema and age. The rate of perielectrode brain edema was significantly higher for Medtronic's leads compared to Boston Scientific's (Χ Conclusion: Overall DBS has to be considered a safe procedure, but future research is needed to decrease the rate of hardware-related complications which may be related to both the surgical technique and to the specific hardware's design. The increased incidence of perielectrode brain edema associated with certain lead models may likewise deserve future investigation.
MeSH term(s)	Humans ; Parkinson Disease/therapy ; Deep Brain Stimulation/adverse effects ; Deep Brain Stimulation/methods ; Brain Edema/etiology ; Cerebral Hemorrhage/epidemiology ; Cerebral Hemorrhage/etiology ; Seizures/etiology ; Electrodes, Implanted/adverse effects ; Retrospective Studies
Language	English
Publishing date	2023-09-29
Publishing country	Austria
Document type	Journal Article
ZDB-ID	80010-7
ISSN	0942-0940 ; 0001-6268
ISSN (online)	0942-0940
ISSN	0001-6268
DOI	10.1007/s00701-023-05799-w
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Article: Adamantinoma-like Ewing sarcoma of the salivary glands: a case report and systematic literature review.

Lauricella, Eleonora / Manicone, Anna / Cavallo, Federica / Dagrada, Gian Paolo / Centonze, Giovanni / Bertulli, Rossella / Quattrone, Pasquale / Porta, Camillo / Cives, Mauro

Therapeutic advances in medical oncology

2023 Volume 15, Page(s) 17588359231165979

Abstract: Adamantinoma-like Ewing sarcoma (ALES) of the salivary glands is an exceedingly rare malignancy defined by the t(11,22) ...

Abstract	Adamantinoma-like Ewing sarcoma (ALES) of the salivary glands is an exceedingly rare malignancy defined by the t(11,22)
Language	English
Publishing date	2023-04-17
Publishing country	England
Document type	Case Reports
ZDB-ID	2503443-1
ISSN	1758-8359 ; 1758-8340
ISSN (online)	1758-8359
ISSN	1758-8340
DOI	10.1177/17588359231165979
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Article ; Online: Modeling neuronal avalanches and long-range temporal correlations at the emergence of collective oscillations: Continuously varying exponents mimic M/EEG results.

Dalla Porta, Leonardo / Copelli, Mauro

PLoS computational biology

2019 Volume 15, Issue 4, Page(s) e1006924

Abstract: We revisit the CROS ("CRitical OScillations") model which was recently proposed as an attempt to reproduce both scale-invariant neuronal avalanches and long-range temporal correlations. With excitatory and inhibitory stochastic neurons locally connected ... ...

Abstract	We revisit the CROS ("CRitical OScillations") model which was recently proposed as an attempt to reproduce both scale-invariant neuronal avalanches and long-range temporal correlations. With excitatory and inhibitory stochastic neurons locally connected in a two-dimensional disordered network, the model exhibits a transition where alpha-band oscillations emerge. Precisely at the transition, the fluctuations of the network activity have nontrivial detrended fluctuation analysis (DFA) exponents, and avalanches (defined as supra-threshold activity) have power law distributions of size and duration. We show that, differently from previous results, the exponents governing the distributions of avalanche size and duration are not necessarily those of the mean-field directed percolation universality class (3/2 and 2, respectively). Instead, in a narrow region of parameter space, avalanche exponents obtained via a maximum-likelihood estimator vary continuously and follow a linear relation, in good agreement with results obtained from M/EEG data. In that region, moreover, the values of avalanche and DFA exponents display a spread with positive correlations, reproducing human MEG results.
MeSH term(s)	Action Potentials/physiology ; Alpha Rhythm/physiology ; Brain/physiology ; Computational Biology ; Electroencephalography/statistics & numerical data ; Humans ; Likelihood Functions ; Magnetoencephalography/statistics & numerical data ; Models, Neurological ; Nerve Net/physiology ; Neurons/physiology ; Stochastic Processes ; Systems Biology
Language	English
Publishing date	2019-04-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2193340-6
ISSN	1553-7358 ; 1553-734X
ISSN (online)	1553-7358
ISSN	1553-734X
DOI	10.1371/journal.pcbi.1006924
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Article ; Online: Modeling neuronal avalanches and long-range temporal correlations at the emergence of collective oscillations

Leonardo Dalla Porta / Mauro Copelli

PLoS Computational Biology, Vol 15, Iss 4, p e

Continuously varying exponents mimic M/EEG results.

2019 Volume 1006924

Abstract	We revisit the CROS ("CRitical OScillations") model which was recently proposed as an attempt to reproduce both scale-invariant neuronal avalanches and long-range temporal correlations. With excitatory and inhibitory stochastic neurons locally connected in a two-dimensional disordered network, the model exhibits a transition where alpha-band oscillations emerge. Precisely at the transition, the fluctuations of the network activity have nontrivial detrended fluctuation analysis (DFA) exponents, and avalanches (defined as supra-threshold activity) have power law distributions of size and duration. We show that, differently from previous results, the exponents governing the distributions of avalanche size and duration are not necessarily those of the mean-field directed percolation universality class (3/2 and 2, respectively). Instead, in a narrow region of parameter space, avalanche exponents obtained via a maximum-likelihood estimator vary continuously and follow a linear relation, in good agreement with results obtained from M/EEG data. In that region, moreover, the values of avalanche and DFA exponents display a spread with positive correlations, reproducing human MEG results.
Keywords	Biology (General) ; QH301-705.5
Subject code	612
Language	English
Publishing date	2019-04-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: European Research Council: bottom-up principles of the Scientific Council and top-down proposal of the resigned President.

Porta, Raffaele

FEBS letters

2020 Volume 594, Issue 11, Page(s) 1647–1650

Abstract: The recent resignation of the President of the European Research Council (ERC) Mauro Ferrari has ...

Abstract	The recent resignation of the President of the European Research Council (ERC) Mauro Ferrari has opened a wide discussion both on the method of designation of the President of the ERC and on the validity of the different funding mechanisms for scientific research. From this point of view, Sars-CoV-2 was not only responsible for the pandemic, but also triggered a debate on an alleged primacy of applied research over the fundamental research.
MeSH term(s)	Europe ; Research/economics ; Societies, Scientific/economics ; Societies, Scientific/organization & administration
Keywords	covid19
Language	English
Publishing date	2020-06-08
Publishing country	England
Document type	Editorial
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.13846
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