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Article ; Online: Adenosine induces IL-31 secretion by T-helper 2 cells: Implication for the effect of adenosine on atopic dermatitis and its therapeutic strategy.

Kawano, Masaaki / Takagi, Rie / Tokano, Mieko / Matsushita, Sho

Biochemical and biophysical research communications

2023 Volume 645, Page(s) 47–54

Abstract: Interleukin (IL)-31 is a recently-identified cytokine with a well-defined role in the pathogenesis of pruritus. Previously, we reported that adenosine upregulates IL-17A secretion by T-helper (Th)17 cells; however, the effect of adenosine on T cell ... ...

Abstract	Interleukin (IL)-31 is a recently-identified cytokine with a well-defined role in the pathogenesis of pruritus. Previously, we reported that adenosine upregulates IL-17A secretion by T-helper (Th)17 cells; however, the effect of adenosine on T cell subsets other than Th17 remains unclear. In this report, we show that adenosine upregulated production of IL-31 by cluster of differentiation (CD)4
MeSH term(s)	Animals ; Mice ; Adenosine/metabolism ; Dermatitis, Atopic/metabolism ; Dermatitis, Atopic/pathology ; Pruritus ; Th2 Cells ; Interleukins/metabolism
Chemical Substances	Adenosine (K72T3FS567) ; Interleukins
Language	English
Publishing date	2023-01-13
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2023.01.038
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Istradefylline, an adenosine A2a receptor antagonist, inhibits the CD4

Tokano, Mieko / Kawano, Masaaki / Takagi, Rie / Matsushita, Sho

Immunological medicine

2022 Volume 45, Issue 4, Page(s) 244–250

Abstract: Extracellular adenosine produced from ATP plays a role in energy processes, neurotransmission, and inflammatory responses. Istradefylline is a selective adenosine A2a receptor (A2aR) antagonist used for the treatment of Parkinson's disease. We previously ...

Abstract	Extracellular adenosine produced from ATP plays a role in energy processes, neurotransmission, and inflammatory responses. Istradefylline is a selective adenosine A2a receptor (A2aR) antagonist used for the treatment of Parkinson's disease. We previously showed using mouse models that adenosine primes hypersecretion of interleukin (IL)-17A
MeSH term(s)	Animals ; Humans ; Mice ; Receptor, Adenosine A2A ; Adenosine A2 Receptor Antagonists/pharmacology ; Interleukin-17 ; Interleukin-8/pharmacology ; Purinergic P1 Receptor Antagonists/pharmacology ; Leukocytes, Mononuclear ; T-Lymphocytes ; Adenosine/pharmacology ; CD4-Positive T-Lymphocytes ; Inflammation
Chemical Substances	Receptor, Adenosine A2A ; Adenosine A2 Receptor Antagonists ; istradefylline (2GZ0LIK7T4) ; Interleukin-17 ; Interleukin-8 ; Purinergic P1 Receptor Antagonists ; Adenosine (K72T3FS567)
Language	English
Publishing date	2022-07-05
Publishing country	England
Document type	Journal Article
ISSN	2578-5826
ISSN (online)	2578-5826
DOI	10.1080/25785826.2022.2094593
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Acute tenosynovitis following an accidental injection of Bacille Calmette-Guérin (BCG) in a health care worker

Mieko Tokano / Norihito Tarumoto / Kazuo Imai / Takuya Sekine / Yasuto Omura / Kosuke Uehara / Shigefumi Maesaki

Infection Prevention in Practice, Vol 6, Iss 1, Pp 100332- (2024)

A case report

2024

Abstract: Summary: Case: A 36-year-old female healthcare worker with no past medical history, accidentally injected her flexed right middle finger with live attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG). Swelling and erythema around the injured ... ...

Abstract	Summary: Case: A 36-year-old female healthcare worker with no past medical history, accidentally injected her flexed right middle finger with live attenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG). Swelling and erythema around the injured area appeared two days after the needlestick injury. She was referred to the hospital and presented approximately nine days after self-inoculation. Surgical debridement was immediately performed. After 38 days, colonies were observed on cultures of the removed tissue on Ogawa's medium. This isolate was identified as M. bovis BCG by polymerase chain reaction (PCR) based on RD1 gene deletion. She had a history of BCG vaccination and her skin lesion appeared immediately after the accidental injection of M. bovis BCG. Therefore, in the differential diagnosis, the possibility that the lesion was an allergic reaction to BCG was considered. The subsequent culture results came back positive for M. bovis BCG and acute tenosynovitis caused by M. bovis BCG was diagnosed. The skin lesion was treated with anti-mycobacterial drugs and resolved. Discussion: The allergic reactions to BCG should be considered in the differential diagnosis of skin lesions following BCG vaccination. It is important to promptly submit a specimen for culture as delayed initiation of appropriate treatment can lead to a poor prognosis. In patients with accidental injection of M. bovis BCG, it is important to consider timely surgical excision and appropriate antimycobacterial therapy.
Keywords	Tenosynovitis ; Mycobacterial infection ; Mycobacterium bovis bacillus Calmette-Guérin (BCG) ; Mycobacterium tuberculosis ; Accidental injection ; Infectious and parasitic diseases ; RC109-216 ; Public aspects of medicine ; RA1-1270
Subject code	630
Language	English
Publishing date	2024-03-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Acute tenosynovitis following an accidental injection of Bacille Calmette-Guérin (BCG) in a health care worker: A case report.

Tokano, Mieko / Tarumoto, Norihito / Imai, Kazuo / Sekine, Takuya / Omura, Yasuto / Uehara, Kosuke / Maesaki, Shigefumi

Infection prevention in practice

2023 Volume 6, Issue 1, Page(s) 100332

Abstract: Case: A 36-year-old female healthcare worker with no past medical history, accidentally injected her flexed right middle finger with live attenuated : Discussion: The allergic reactions to BCG should be considered in the differential diagnosis of ... ...

Abstract	Case: A 36-year-old female healthcare worker with no past medical history, accidentally injected her flexed right middle finger with live attenuated Discussion: The allergic reactions to BCG should be considered in the differential diagnosis of skin lesions following BCG vaccination. It is important to promptly submit a specimen for culture as delayed initiation of appropriate treatment can lead to a poor prognosis. In patients with accidental injection of
Language	English
Publishing date	2023-12-12
Publishing country	England
Document type	Case Reports
ISSN	2590-0889
ISSN (online)	2590-0889
DOI	10.1016/j.infpip.2023.100332
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Extracellular adenosine induces hypersecretion of IL-17A by T-helper 17 cells through the adenosine A2a receptor.

Tokano, Mieko / Matsushita, Sho / Takagi, Rie / Yamamoto, Toshimasa / Kawano, Masaaki

Brain, behavior, & immunity - health

2022 Volume 26, Page(s) 100544

Abstract: Extracellular adenosine, produced from ATP secreted by neuronal or immune cells, may play a role in endogenous regulation of inflammatory responses. Studies show that adenosine induces hypersecretion of IL-17A by ... ...

Abstract	Extracellular adenosine, produced from ATP secreted by neuronal or immune cells, may play a role in endogenous regulation of inflammatory responses. Studies show that adenosine induces hypersecretion of IL-17A by CD4
Language	English
Publishing date	2022-10-28
Publishing country	United States
Document type	Journal Article
ISSN	2666-3546
ISSN (online)	2666-3546
DOI	10.1016/j.bbih.2022.100544
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Malignant syphilis requiring differentiation from Kaposi's sarcoma.

Tokano, Mieko / Tarumoto, Norihito / Imai, Kazuo / Yamaguchi, Hiroshi / Takeji, Masaaki / Inayoshi, Fumito / Okamoto, Keita / Okumura, Nobuhito / Maesaki, Shigefumi

IDCases

2024 Volume 36, Page(s) e01943

Abstract: Malignant syphilis (MS) is a rare variant of secondary syphilis. Also known as rupioid syphilis, MS is characterized by the presence of multiple papules, papulopustules, black lamellate crust that may resemble an oyster shell, or nodules with ulceration ... ...

Abstract	Malignant syphilis (MS) is a rare variant of secondary syphilis. Also known as rupioid syphilis, MS is characterized by the presence of multiple papules, papulopustules, black lamellate crust that may resemble an oyster shell, or nodules with ulceration lacking central clearing. MS is often associated with immunodeficiency and frequently co-occurs with HIV infection. We here report a case of MS in a patient with HIV infection. HIV infection can cause atypical clinical symptoms of syphilis. In this case, unlike previous cases, cutaneous lesions of MS were limited to the face, making the diagnosis challenging based on clinical findings alone. However, his laboratory findings, appearance of the Jarisch-Herxheimer reaction, and a dramatic response to antibiotic therapy are characteristic of MS, making the diagnosis even more certain. Our case suggests the importance of physicians considering the possibility of MS when observing black-crusted lesions.
Language	English
Publishing date	2024-04-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2024.e01943
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A case of

Tokano, Mieko / Tarumoto, Norihito / Imai, Kazuo / Sakai, Jun / Kodana, Masahiro / Naito, Erika / Uchida, Yoshitaka / Nagata, Makoto / Maesaki, Shigefumi

IDCases

2022 Volume 31, Page(s) e01654

Abstract: We report a case ... ...

Abstract	We report a case of
Language	English
Publishing date	2022-12-01
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2745454-X
ISSN	2214-2509
ISSN	2214-2509
DOI	10.1016/j.idcr.2022.e01654
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Article ; Online: Vancomycin-resistant

Tokano, Mieko / Tarumoto, Norihito / Sakai, Jun / Imai, Kazuo / Kodana, Masahiro / Kawamura, Toru / Maeda, Takuya / Maesaki, Shigefumi

Microbiology spectrum

2023 Volume 12, Issue 1, Page(s) e0244423

Abstract: Importance: Our study emphasizes the efficacy of whole-genome sequencing (WGS) in addressing outbreaks of vancomycin-resistant enterococci. WGS enables the identification and tracking of resistant bacterial strains, early detection and management of ... ...

Abstract	Importance: Our study emphasizes the efficacy of whole-genome sequencing (WGS) in addressing outbreaks of vancomycin-resistant enterococci. WGS enables the identification and tracking of resistant bacterial strains, early detection and management of novel infectious disease outbreaks, and the appropriate selection and use of antibiotics. Furthermore, our approach deepens our understanding of how resistant bacteria transfer genes and adapt to their environments or hosts. For modern medicine, these insights have significant implications for controlling infections and effectively managing antibiotic use in the current era, where antibiotic resistance is progressing.
MeSH term(s)	Humans ; Vancomycin-Resistant Enterococci/genetics ; Molecular Epidemiology ; Vancomycin/pharmacology ; Vancomycin/therapeutic use ; Enterococcus faecium/genetics ; Japan/epidemiology ; Multilocus Sequence Typing ; Anti-Bacterial Agents/pharmacology ; Gram-Positive Bacterial Infections/epidemiology ; Gram-Positive Bacterial Infections/microbiology ; Bacterial Proteins/genetics
Chemical Substances	Vancomycin (6Q205EH1VU) ; Anti-Bacterial Agents ; Bacterial Proteins
Language	English
Publishing date	2023-12-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.02444-23
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Multicenter Study of the Effectiveness of Antifungal Stewardship Team Intervention for Candidemia in Japan in 2008-2021.

Tokano, Mieko / Tarumoto, Norihito / Sakai, Jun / Imai, Kazuo / Koizumi, Sakaru / Karaushi, Haruka / Hatanaka, Tamotsu / Kishi, Etsuko / Seki, Masafumi / Mitsutake, Koutaro / Maesaki, Shigefumi

Infectious disease reports

2024 Volume 16, Issue 2, Page(s) 356–366

Abstract: Candidemia, linked to high mortality rates, requires prompt antifungal therapy for better outcomes. Treatment is structured as an action bundle, which is beneficial when followed closely. However, the Japanese action bundle lacks detailed guidance on ... ...

Abstract	Candidemia, linked to high mortality rates, requires prompt antifungal therapy for better outcomes. Treatment is structured as an action bundle, which is beneficial when followed closely. However, the Japanese action bundle lacks detailed guidance on severe complications like endocarditis or ocular issues. To address this, we adjusted the action bundle and assessed outcomes with and without AFT intervention. We strengthened protocols for blood cultures and organ assessments, and the AFT contacted the primary physician when yeast-like fungi were detected in the patient's blood culture bottles. Analyzing 204 candidemia cases from 2008-2021, we observed increased adherence and reduced mortality post-AFT intervention. Ophthalmology consultations rose significantly, but many patients had only one visit, suggesting inadequate follow-up. If endophthalmitis is diagnosed, a change in the treatment approach may be necessary. There is a possibility that abnormal ocular findings will be detected during subsequent visits, which highlights the need for improvement in ophthalmology follow-up rates as a future challenge for our AFT activities.
Language	English
Publishing date	2024-04-15
Publishing country	Switzerland
Document type	Journal Article
ISSN	2036-7430
ISSN	2036-7430
DOI	10.3390/idr16020027
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Signaling via dopamine and adenosine receptors modulate viral peptide-specific and T-cell IL-8 response in COVID-19.

Tokano, Mieko / Takagi, Rie / Kawano, Masaaki / Maesaki, Shigefumi / Tarumoto, Norihito / Matsushita, Sho

Immunological medicine

2022 Volume 45, Issue 3, Page(s) 162–167

Abstract: B-cell but not T-cell responses have been extensively studied using peripheral blood mononuclear cells (PBMCs) obtained from patients with coronavirus disease 2019 (COVID-19). Our recent study showed that not only T-helper (Th) 17 but also Th1 cells ... ...

Abstract	B-cell but not T-cell responses have been extensively studied using peripheral blood mononuclear cells (PBMCs) obtained from patients with coronavirus disease 2019 (COVID-19). Our recent study showed that not only T-helper (Th) 17 but also Th1 cells directly produce interleukin (IL)-8, a major source of neutrophilic inflammation, which is also known to induce disseminated intravascular coagulation (DIC) in COVID-19 patients. Neutrophilic inflammation caused by IL-17A or IL-8 can be fatal; thus, therapeutic intervention is highly expected. The present study aimed to investigate the T-cell responses in the Japanese patients. We synthesized spike protein-derived 15-mer peptides that are expected to bind to HLA class II allelic products frequently observed in the Japanese population, and checked the T-cell responses in Japanese patients with COVID-19. We have found that (i) patients show marked IL-8 but not IL-17A responses; (ii) these responses are restricted by HLA-DR; and (iii) IL-8 responses are abrogated by a dopamine D2 like receptor (D2R) agonist, ropinirole, and an adenosine A2a receptor (A2aR) antagonist, istradefylline. Compounds used for the treatment of Parkinson's disease may ease DIC in COVID-19. (183 words).
MeSH term(s)	Dopamine ; Dopamine Agonists/pharmacology ; Humans ; Inflammation ; Interleukin-8 ; Leukocytes, Mononuclear/metabolism ; Purinergic P1 Receptor Antagonists ; Receptor, Adenosine A2A/metabolism ; T-Lymphocytes/immunology ; COVID-19 Drug Treatment
Chemical Substances	Dopamine Agonists ; Interleukin-8 ; Purinergic P1 Receptor Antagonists ; Receptor, Adenosine A2A ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2022-05-27
Publishing country	England
Document type	Journal Article
ISSN	2578-5826
ISSN (online)	2578-5826
DOI	10.1080/25785826.2022.2079369
Database	MEDical Literature Analysis and Retrieval System OnLINE

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