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  1. Article ; Online: Who commits the unnaturalistic fallacy?

    Ferguson, Kyle

    Journal of medical ethics

    2022  Volume 48, Issue 6, Page(s) 382–383

    Language English
    Publishing date 2022-05-11
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 194927-5
    ISSN 1473-4257 ; 0306-6800
    ISSN (online) 1473-4257
    ISSN 0306-6800
    DOI 10.1136/medethics-2022-108363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1163: Show issues Location:
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  2. Article ; Online: The Health Reframing of Climate Change and the Poverty of Narrow Bioethics.

    Ferguson, Kyle

    The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics

    2021  Volume 48, Issue 4, Page(s) 705–717

    Abstract: We must resist thoroughly reframing climate change as a health issue. For human health-centric ethical frameworks omit dimensions of value that we must duly consider. We need a new, an environmental, research ethic, one that we can use to more completely ...

    Abstract We must resist thoroughly reframing climate change as a health issue. For human health-centric ethical frameworks omit dimensions of value that we must duly consider. We need a new, an environmental, research ethic, one that we can use to more completely and impartially evaluate proposed research on mitigation and adaptation strategies.
    MeSH term(s) Bioethics ; Climate Change ; Ecosystem ; Environmental Health/ethics ; Ethical Analysis ; Ethics, Research ; Humans
    Language English
    Publishing date 2021-01-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1168812-9
    ISSN 1748-720X ; 1073-1105 ; 0277-8459
    ISSN (online) 1748-720X
    ISSN 1073-1105 ; 0277-8459
    DOI 10.1177/1073110520979381
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2075: Show issues Location:
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  3. Article ; Online: Ethical Challenges of Advances in Vaccine Delivery Technologies.

    Caplan, Arthur L / Ferguson, Kyle / Williamson, Anne

    The Hastings Center report

    2024  Volume 54, Issue 1, Page(s) 13–15

    Abstract: Strategies to address misinformation and hesitancy about vaccines, including the fear of needles, and to overcome obstacles to access, such as the refrigeration that some vaccines demand, strongly suggest the need to develop new vaccine delivery ... ...

    Abstract Strategies to address misinformation and hesitancy about vaccines, including the fear of needles, and to overcome obstacles to access, such as the refrigeration that some vaccines demand, strongly suggest the need to develop new vaccine delivery technologies. But, given widespread distrust surrounding vaccination, these new technologies must be introduced to the public with the utmost transparency, care, and community involvement. Two emerging technologies, one a skin-patch vaccine and the other a companion dye and detector, provide excellent examples of greatly improved delivery technologies for which such a careful approach should be developed in order to increase vaccine uptake. Defusing fears and conspiracy mongering must be a key part of their rollout.
    MeSH term(s) Humans ; Community Participation ; Vaccination ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2024-02-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194940-8
    ISSN 1552-146X ; 0093-0334
    ISSN (online) 1552-146X
    ISSN 0093-0334
    DOI 10.1002/hast.1563
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1672: Show issues Location:
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  4. Article ; Online: Phantom premise and a shape-shifting ism: reply to Hassoun.

    Ferguson, Kyle / Caplan, Arthur

    Journal of medical ethics

    2021  Volume 47, Issue 11, Page(s) 775–776

    Language English
    Publishing date 2021-05-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 194927-5
    ISSN 1473-4257 ; 0306-6800
    ISSN (online) 1473-4257
    ISSN 0306-6800
    DOI 10.1136/medethics-2021-107404
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1163: Show issues Location:
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  5. Article ; Online: In vitro modulation of mTOR and mGlur5 influence α-synuclein accumulation.

    Xing, Viktoria / Biggar, Kyle / Ferguson, Stephen S G / Hayley, Shawn

    Molecular brain

    2024  Volume 17, Issue 1, Page(s) 9

    Abstract: One of the main hallmarks of Parkinson's disease (PD) is abnormal alpha-synuclein (α-syn) aggregation which forms the main component of intracellular Lewy body inclusions. This short report used preformed α-syn fibrils, as well as an A53T mutant α-syn ... ...

    Abstract One of the main hallmarks of Parkinson's disease (PD) is abnormal alpha-synuclein (α-syn) aggregation which forms the main component of intracellular Lewy body inclusions. This short report used preformed α-syn fibrils, as well as an A53T mutant α-syn adenovirus to mimic conditions of pathological protein aggregation in dopaminergic human derived SH-SY5Y neural cells. Since there is evidence that the mTOR pathway and glutamatergic signaling each influence protein aggregation, we also assessed the impact of the mTOR inhibitor, rapamycin and the mGluR5 allosteric modulator, CTEP. We found that both rapamycin and CTEP induced a significant reduction of α-syn fibrils in SH-SY5Y cells and this effect was associated with a reduction in mTOR signaling and enhancement in autophagic pathway factors. These data support the possibility that CTEP (or rapamycin) might be a useful pharmacological approach to target abnormal α-syn accumulation by promoting intracellular degradation or enhanced clearance.
    MeSH term(s) Humans ; alpha-Synuclein/metabolism ; Parkinson Disease/metabolism ; Sirolimus/pharmacology ; TOR Serine-Threonine Kinases ; Receptor, Metabotropic Glutamate 5/metabolism
    Chemical Substances alpha-Synuclein ; Sirolimus (W36ZG6FT64) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Receptor, Metabotropic Glutamate 5
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2436057-0
    ISSN 1756-6606 ; 1756-6606
    ISSN (online) 1756-6606
    ISSN 1756-6606
    DOI 10.1186/s13041-023-01074-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Does Medicine Need to Accommodate Positive Conscientious Objections to Morally Self-Correct?

    Kim, Eric J / Ferguson, Kyle

    The American journal of bioethics : AJOB

    2021  Volume 21, Issue 8, Page(s) 74–76

    MeSH term(s) Conscience ; Humans ; Refusal to Treat
    Language English
    Publishing date 2021-07-23
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2021.1940362
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6814: Show issues Location:
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  7. Article ; Online: Conscientious objections, the nature of medicine, and the need for reformability.

    Kim, Eric J / Ferguson, Kyle

    Bioethics

    2021  Volume 36, Issue 1, Page(s) 63–70

    Abstract: The debate over whether the medical profession should accommodate its members' conscientious objections (COs) has raged on in the bioethics literature and on legislative floors for decades. Unfortunately, participants on all sides of the debate fail to ... ...

    Abstract The debate over whether the medical profession should accommodate its members' conscientious objections (COs) has raged on in the bioethics literature and on legislative floors for decades. Unfortunately, participants on all sides of the debate fail to distinguish among different types of CO, a failure that obstructs the view of which cases warrant accommodation and why. In this paper, we identify one type of CO that warrants consideration for accommodation, called Nature of Medicine COs (NoMCOs). NoMCOs involve the refusal of physicians to perform actions they reasonably judge to be contrary to the nature of medicine and their professional obligations. We argue that accommodating NoMCOs can be justified based on the profession's need to preserve reformability. Importantly, this previously underdeveloped position evades some of the concerns commonly raised by opponents of CO accommodations.
    MeSH term(s) Conscience ; Humans ; Physicians ; Refusal to Treat
    Language English
    Publishing date 2021-08-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 632984-6
    ISSN 1467-8519 ; 0269-9702
    ISSN (online) 1467-8519
    ISSN 0269-9702
    DOI 10.1111/bioe.12943
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2998: Show issues Location:
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  8. Article ; Online: It's Not Easy Bein' Fair.

    Ferguson, Kyle / Caplan, Arthur

    The American journal of bioethics : AJOB

    2020  Volume 20, Issue 7, Page(s) 160–162

    MeSH term(s) Betacoronavirus ; Bioethics ; COVID-19 ; Coronavirus Infections ; Humans ; Morals ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2060433-6
    ISSN 1536-0075 ; 1526-5161
    ISSN (online) 1536-0075
    ISSN 1526-5161
    DOI 10.1080/15265161.2020.1777352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6814: Show issues Location:
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  9. Article ; Online: Love thy neighbour? Allocating vaccines in a world of competing obligations.

    Ferguson, Kyle / Caplan, Arthur

    Journal of medical ethics

    2020  

    Abstract: Although a safe, effective, and licensed coronavirus vaccine does not yet exist, there is already controversy over how it ought to be allocated. Justice is clearly at stake, but it is unclear what justice requires in the international distribution of a ... ...

    Abstract Although a safe, effective, and licensed coronavirus vaccine does not yet exist, there is already controversy over how it ought to be allocated. Justice is clearly at stake, but it is unclear what justice requires in the international distribution of a scarce vaccine during a pandemic. Many are condemning 'vaccine nationalism' as an obstacle to equitable global distribution. We argue that limited national partiality in allocating vaccines will be a component of justice rather than an obstacle to it. For there are role-based and community-embedded responsibilities to take care of one's own, which constitute legitimate moral reasons for some identity-related prioritisation. Furthermore, a good form of vaccine nationalism prioritises one's own without denying or ignoring duties derived from a principle of equal worth, according to which all persons, regardless of citizenship or identity, equally deserve vaccine-induced protection from COVID-19. Rather than dismissing nationalism as a tragic obstacle, it is necessary to acknowledge that a limited form of it is valuable and expresses moral commitments. Only then can one understand our world of competing obligations, a world where cosmopolitan duties of benevolence sometimes conflict with special obligations of community membership. Once these competing obligations are recognised as such, we can begin the work of designing sound ethical frameworks for achieving justice in the global distribution of a coronavirus vaccine and developing practical strategies for avoiding, mitigating or resolving conflicts of duty.
    Language English
    Publishing date 2020-12-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 194927-5
    ISSN 1473-4257 ; 0306-6800
    ISSN (online) 1473-4257
    ISSN 0306-6800
    DOI 10.1136/medethics-2020-106887
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Clinician communication strategies associated with increased uptake of the human papillomavirus (HPV) vaccine: A systematic review.

    Constable, Catherine / Ferguson, Kyle / Nicholson, Joey / Quinn, Gwendolyn P

    CA: a cancer journal for clinicians

    2022  Volume 72, Issue 6, Page(s) 561–569

    Abstract: Human papillomavirus (HPV) is currently linked to almost 35,000 new cases of cancer in women and men each year in the United States. Gardasil-9 (Merck & Company), the only HPV vaccine now available in the United States, is nearly 100% effective at ... ...

    Abstract Human papillomavirus (HPV) is currently linked to almost 35,000 new cases of cancer in women and men each year in the United States. Gardasil-9 (Merck & Company), the only HPV vaccine now available in the United States, is nearly 100% effective at preventing precancers caused by oncogenic HPV types. In the United States, however, only about one half of adolescents are up to date with HPV vaccination. It is well known that health care clinicians' recommendations play a significant role in parents' decisions regarding HPV vaccination. A growing body of literature examines specific communication strategies for promoting uptake of the HPV vaccine. A comprehensive review of the evidence for each of these strategies is needed. The authors searched the PubMed, EMBASE, Cochrane Central Register of Controlled Trials, PsycINFO, Cumulative Index to Nursing and Allied Health Literature, and Web of Science Complete databases for original articles with a defined clinician communication strategy and an outcome of HPV vaccine uptake or intention to vaccinate (PROSPERO registry no. CRD42020107602). In total, 46 studies were included. The authors identified two main strategies with strong evidence supporting their positive impact on vaccine uptake: strong recommendation and presumptive recommendation. Determinations about a causal relationship were limited by the small numbers of randomized controlled trials. There is also opportunity for more research to determine the effects of motivational interviewing and cancer-prevention messaging.
    MeSH term(s) Adolescent ; Male ; Female ; Humans ; United States ; Papillomavirus Infections/prevention & control ; Papillomavirus Infections/complications ; Papillomavirus Vaccines/therapeutic use ; Vaccination ; Alphapapillomavirus ; Communication ; Parents ; Neoplasms/prevention & control
    Chemical Substances Papillomavirus Vaccines
    Language English
    Publishing date 2022-08-15
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603553-x
    ISSN 1542-4863 ; 0007-9235
    ISSN (online) 1542-4863
    ISSN 0007-9235
    DOI 10.3322/caac.21753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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