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  1. Book ; Online: Promoting sustainable local economic development initiatives

    Venter, Marius / Baur, Peter / Khosa, Tsakani V / Chitambala, Chika / Swanepoel, Elana / Maimele, Seutame O / Rashied, Naiefa / Eastcott-Layton, Maxwell T / Wheeler, Leone / Kanye, Matshepo / Meyer, Natanya / Meyer, Daniel F / de Bruyn, Chané / Steynberg, Lizl / Jiang, Shimei / Grundling, Jan P / Li, Yuan

    Case studies

    (Centre for Local Economic Development: Topics in Local Development)

    2022  

    Series title Centre for Local Economic Development: Topics in Local Development
    Keywords Economics ; Case study ; local government ; sustainable development ; local economic development ; women entrepreneurs ; Local Economic Development initiatives ; local government leadership
    Language English
    Size 1 electronic resource (262 pages)
    Publisher AOSIS
    Publishing place Cape Town
    Document type Book ; Online
    Note English
    HBZ-ID HT030376474
    ISBN 9781779952356 ; 177995235X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article: CLR (C-Reactive Protein to Lymphocyte Ratio) Served as a Promising Predictive Biomarker for Cerebral Vasospasm in Aneurysmal Subarachnoid Hemorrhage (aSAH): A Retrospective Cohort Study.

    Li, Ke / Khan, Dilaware / Fischer, Igor / Hänggi, Daniel / Cornelius, Jan F / Muhammad, Sajjad

    Journal of clinical medicine

    2024  Volume 13, Issue 4

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-02-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13040940
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Comparative exploration of mammalian deafness gene homologues in the Drosophila auditory organ shows genetic correlation between insect and vertebrate hearing.

    Sutton, Daniel C / Andrews, Jonathan C / Dolezal, Dylan M / Park, Ye Jin / Li, Hongjie / Eberl, Daniel F / Yamamoto, Shinya / Groves, Andrew K

    PloS one

    2024  Volume 19, Issue 2, Page(s) e0297846

    Abstract: Johnston's organ, the Drosophila auditory organ, is anatomically very different from the mammalian organ of Corti. However, recent evidence indicates significant cellular and molecular similarities exist between vertebrate and invertebrate hearing, ... ...

    Abstract Johnston's organ, the Drosophila auditory organ, is anatomically very different from the mammalian organ of Corti. However, recent evidence indicates significant cellular and molecular similarities exist between vertebrate and invertebrate hearing, suggesting that Drosophila may be a useful platform to determine the function of the many mammalian deafness genes whose underlying biological mechanisms are poorly characterized. Our goal was a comprehensive screen of all known orthologues of mammalian deafness genes in the fruit fly to better understand conservation of hearing mechanisms between the insect and the fly and ultimately gain insight into human hereditary deafness. We used bioinformatic comparisons to screen previously reported human and mouse deafness genes and found that 156 of them have orthologues in Drosophila melanogaster. We used fluorescent imaging of T2A-GAL4 gene trap and GFP or YFP fluorescent protein trap lines for 54 of the Drosophila genes and found 38 to be expressed in different cell types in Johnston's organ. We phenotypically characterized the function of strong loss-of-function mutants in three genes expressed in Johnston's organ (Cad99C, Msp-300, and Koi) using a courtship assay and electrophysiological recordings of sound-evoked potentials. Cad99C and Koi were found to have significant courtship defects. However, when we tested these genes for electrophysiological defects in hearing response, we did not see a significant difference suggesting the courtship defects were not caused by hearing deficiencies. Furthermore, we used a UAS/RNAi approach to test the function of seven genes and found two additional genes, CG5921 and Myo10a, that gave a statistically significant delay in courtship but not in sound-evoked potentials. Our results suggest that many mammalian deafness genes have Drosophila homologues expressed in the Johnston's organ, but that their requirement for hearing may not necessarily be the same as in mammals.
    MeSH term(s) Animals ; Humans ; Mice ; Drosophila/genetics ; Drosophila melanogaster/genetics ; Hearing/genetics ; Vertebrates ; Deafness ; Mammals
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297846
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  4. Article ; Online: Platelet-derived growth factor D expression in adrenal cells is modulated by corticosteroids: putative role in adrenal suppression.

    Parry, Christopher M / Chan, Li F / Carr, Daniel F / Hawcutt, Daniel B

    Pediatric research

    2022  Volume 93, Issue 1, Page(s) 97–101

    Abstract: Background: Adrenal suppression is a clinically concerning side effect of inhaled corticosteroid (ICS) treatment in patients with asthma. Increased susceptibility to ICS-induced adrenal suppression has previously been identified in those with the ... ...

    Abstract Background: Adrenal suppression is a clinically concerning side effect of inhaled corticosteroid (ICS) treatment in patients with asthma. Increased susceptibility to ICS-induced adrenal suppression has previously been identified in those with the rs591118 polymorphism in platelet-derived growth factor D (PDGFD). The mechanism underpinning this relationship is not known.
    Methods: H295R cells were genotyped for rs591118 using a validated Taqman PCR allelic discrimination assay. H295R cell viability was determined after treatment with beclometasone and fluticasone (range 0-330 μM). Cortisol was measured in cell culture medium using competitive enzyme immunoassay.
    Results: PDGFD protein expression in H295R cells was confirmed using Western blotting. When ACTH and forskolin were added to H295R cells, a reduction in PDGFD expression was seen, which was then restored by incubation with prochloraz, a known inhibitor of steroidogenesis. A dose-dependent, decrease in PDGFD expression was observed with beclometasone (over a 24 h incubation period) but not with beclometasone incubations beyond 24 h nor with fluticasone (at 24 or 48 h).
    Conclusions: H295R cells express PDGFD protein, which can be modulated by incubation with steroidogenesis agonists and antagonists and additionally with exogenous beclometasone.
    Impact: PDGFD is expressed in the human adrenal cell line, H295R, and expression can be modulated by beclometasone as well as agonists/antagonists of steroidogenesis. This builds on previous research that identified a SNP in PDGFD (rs591118) as an independent risk factor for adrenal suppression in adults and children with obstructive airway disease treated with inhaled corticosteroids. First in vitro experiments to support a link between the PDGF and cortisol production pathways, supporting the hypothesis that PDGFD variants can affect an individual's sensitivity to corticosteroid-induced adrenal suppression.
    MeSH term(s) Child ; Adult ; Humans ; Hydrocortisone/metabolism ; Beclomethasone/adverse effects ; Adrenal Cortex Hormones/adverse effects ; Fluticasone ; Platelet-Derived Growth Factor
    Chemical Substances Hydrocortisone (WI4X0X7BPJ) ; Beclomethasone (KGZ1SLC28Z) ; Adrenal Cortex Hormones ; Fluticasone (CUT2W21N7U) ; Platelet-Derived Growth Factor
    Language English
    Publishing date 2022-05-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 4411-8
    ISSN 1530-0447 ; 0031-3998
    ISSN (online) 1530-0447
    ISSN 0031-3998
    DOI 10.1038/s41390-022-02094-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 564: Show issues Location:
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  5. Article ; Online: PDPR

    Brock, Pamela / Sevigny, Myriam / Liyanarachchi, Sandya / Comiskey, Daniel F / Li, Wei / Saarinen, Saila / Yilmaz, Ayse Selen / Nieminen, Anni I / Ringel, Matthew D / Peltomäki, Päivi / Ollila, Saara / Nieminen, Taina T

    Thyroid : official journal of the American Thyroid Association

    2024  

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1086044-7
    ISSN 1557-9077 ; 1050-7256
    ISSN (online) 1557-9077
    ISSN 1050-7256
    DOI 10.1089/thy.2023.0560
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3307: Show issues Location:
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    Zs.MO 106: Show issues

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  6. Book ; Online: Multicut Problems in Embedded Graphs

    Focke, Jacob / Hörsch, Florian / Li, Shaohua / Marx, Dániel

    The Dependency of Complexity on the Demand Pattern

    2023  

    Abstract: ... with $t$ terminals on a graph $G$ of genus $g$ can be solved in time $f(t,g)n^{O(\sqrt{g^2+gt+t})}$. Cohen ... close to being a complete bipartite graph, then Multicut can be solved faster than $f(t,g)n^{O(\sqrt ...

    Abstract The Multicut problem asks for a minimum cut separating certain pairs of vertices: formally, given a graph $G$ and demand graph $H$ on a set $T\subseteq V(G)$ of terminals, the task is to find a minimum-weight set $C$ of edges of $G$ such that whenever two vertices of $T$ are adjacent in $H$, they are in different components of $G\setminus C$. Colin de Verdi\`{e}re [Algorithmica, 2017] showed that Multicut with $t$ terminals on a graph $G$ of genus $g$ can be solved in time $f(t,g)n^{O(\sqrt{g^2+gt+t})}$. Cohen-Addad et al. [JACM, 2021] proved a matching lower bound showing that the exponent of $n$ is essentially best possible (for fixed values of $t$ and $g$), even in the special case of Multiway Cut, where the demand graph $H$ is a complete graph. However, this lower bound tells us nothing about other special cases of Multicut such as Group 3-Terminal Cut. We show that if the demand pattern is, in some sense, close to being a complete bipartite graph, then Multicut can be solved faster than $f(t,g)n^{O(\sqrt{g^2+gt+t})}$, and furthermore this is the only property that allows such an improvement. Formally, for a class $\mathcal{H}$ of graphs, Multicut$(\mathcal{H})$ is the special case where the demand graph $H$ is in $\mathcal{H}$. For every fixed class $\mathcal{H}$ (satisfying some mild closure property), fixed $g$, and fixed $t$, our main result gives tight upper and lower bounds on the exponent of $n$ in algorithms solving Multicut$(\mathcal{H})$. In addition, we investigate a similar setting where, instead of parameterizing by the genus $g$ of $G$, we parameterize by the minimum number $k$ of edges of $G$ that need to be deleted to obtain a planar graph. Interestingly, in this setting it makes a significant difference whether the graph $G$ is weighted or unweighted: further nontrivial algorithmic techniques give substantial improvements in the unweighted case.
    Keywords Computer Science - Computational Complexity ; Computer Science - Data Structures and Algorithms
    Subject code 511
    Publishing date 2023-12-18
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: AI-aided geometric design of anti-infection catheters.

    Zhou, Tingtao / Wan, Xuan / Huang, Daniel Zhengyu / Li, Zongyi / Peng, Zhiwei / Anandkumar, Anima / Brady, John F / Sternberg, Paul W / Daraio, Chiara

    Science advances

    2024  Volume 10, Issue 1, Page(s) eadj1741

    Abstract: Bacteria can swim upstream in a narrow tube and pose a clinical threat of urinary tract infection to patients implanted with catheters. Coatings and structured surfaces have been proposed to repel bacteria, but no such approach thoroughly addresses the ... ...

    Abstract Bacteria can swim upstream in a narrow tube and pose a clinical threat of urinary tract infection to patients implanted with catheters. Coatings and structured surfaces have been proposed to repel bacteria, but no such approach thoroughly addresses the contamination problem in catheters. Here, on the basis of the physical mechanism of upstream swimming, we propose a novel geometric design, optimized by an artificial intelligence model. Using
    MeSH term(s) Humans ; Urinary Catheters/microbiology ; Artificial Intelligence ; Urinary Tract Infections/prevention & control ; Urinary Tract Infections/microbiology ; Bacteria ; Escherichia coli ; Hydrolases
    Chemical Substances Hydrolases (EC 3.-)
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.adj1741
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Invited Editorial Commentary: More Than One Way to Treat the Mass Effect.

    Hanley, Daniel F / Li, Yunke

    Neurocritical care

    2019  Volume 32, Issue 2, Page(s) 363–364

    MeSH term(s) Cerebral Hemorrhage ; Decompressive Craniectomy ; Humans
    Language English
    Publishing date 2019-12-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-019-00851-z
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    Zs.A 6538: Show issues Location:
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  9. Article ; Online: Impaired neurogenesis and neural progenitor fate choice in a human stem cell model of SETBP1 disorder.

    Cardo, Lucia F / de la Fuente, Daniel C / Li, Meng

    Molecular autism

    2023  Volume 14, Issue 1, Page(s) 8

    Abstract: Background: Disruptions of SETBP1 (SET binding protein 1) on 18q12.3 by heterozygous gene deletion or loss-of-function variants cause SETBP1 disorder. Clinical features are frequently associated with moderate to severe intellectual disability, autistic ... ...

    Abstract Background: Disruptions of SETBP1 (SET binding protein 1) on 18q12.3 by heterozygous gene deletion or loss-of-function variants cause SETBP1 disorder. Clinical features are frequently associated with moderate to severe intellectual disability, autistic traits and speech and motor delays. Despite the association of SETBP1 with neurodevelopmental disorders, little is known about its role in brain development.
    Methods: Using CRISPR/Cas9 genome editing technology, we generated a SETBP1 deletion model in human embryonic stem cells (hESCs) and examined the effects of SETBP1-deficiency in neural progenitors (NPCs) and neurons derived from these stem cells using a battery of cellular assays, genome-wide transcriptomic profiling and drug-based phenotypic rescue.
    Results: Neural induction occurred efficiently in all SETBP1 deletion models as indicated by uniform transition into neural rosettes. However, SETBP1-deficient NPCs exhibited an extended proliferative window and a decrease in neurogenesis coupled with a deficiency in their ability to acquire ventral forebrain fate. Genome-wide transcriptome profiling and protein biochemical analysis revealed enhanced activation of Wnt/β-catenin signaling in SETBP1 deleted cells. Crucially, treatment of the SETBP1-deficient NPCs with a small molecule Wnt inhibitor XAV939 restored hyper canonical β-catenin activity and restored both cortical and MGE neuronal differentiation.
    Limitations: The current study is based on analysis of isogenic hESC lines with genome-edited SETBP1 deletion and further studies would benefit from the use of patient-derived iPSC lines that may harbor additional genetic risk that aggravate brain pathology of SETBP1 disorder.
    Conclusions: We identified an important role for SETBP1 in controlling forebrain progenitor expansion and neurogenic differentiation. Our study establishes a novel regulatory link between SETBP1 and Wnt/β-catenin signaling during human cortical neurogenesis and provides mechanistic insights into structural abnormalities and potential therapeutic avenues for SETBP1 disorder.
    MeSH term(s) Humans ; beta Catenin ; Neurogenesis ; Stem Cells ; Neurons ; Neurodevelopmental Disorders ; Carrier Proteins/genetics ; Nuclear Proteins
    Chemical Substances beta Catenin ; SETBP1 protein, human ; Carrier Proteins ; Nuclear Proteins
    Language English
    Publishing date 2023-02-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2540930-X
    ISSN 2040-2392 ; 2040-2392
    ISSN (online) 2040-2392
    ISSN 2040-2392
    DOI 10.1186/s13229-023-00540-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Corrigendum: Ultrastructural characteristics of neuronal death and white matter injury in mouse brain tissues after intracerebral hemorrhage: coexistence of ferroptosis, autophagy, and necrosis.

    Li, Qian / Weiland, Abigail / Chen, Xuemei / Lan, Xi / Han, Xiaoning / Durham, Frederick / Liu, Xi / Wan, Jieru / Ziai, Wendy C / Hanley, Daniel F / Wang, Jian

    Frontiers in neurology

    2024  Volume 15, Page(s) 1385719

    Abstract: This corrects the article DOI: 10.3389/fneur.2018.00581.]. ...

    Abstract [This corrects the article DOI: 10.3389/fneur.2018.00581.].
    Language English
    Publishing date 2024-03-01
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1385719
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