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Article ; Online: The blurred line between the art and science of medicine.

Bertuzzi, Alexia Francesca / Gennaro, Nicolò / Marrari, Andrea / Santoro, Armando

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

2020 Volume 150, Page(s) 61

Keywords	covid19
Language	English
Publishing date	2020-05-28
Publishing country	Ireland
Document type	Letter
ZDB-ID	605646-5
ISSN	1879-0887 ; 0167-8140
ISSN (online)	1879-0887
ISSN	0167-8140
DOI	10.1016/j.radonc.2020.05.030
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Article ; Online: It was hard enough: the spectre of COVID-19 on the management of sarcoma patients.

Marrari, Andrea / Gennaro, Nicolò / Cariboni, Umberto / Quagliuolo, Vittorio Lorenzo / D'Orazio, Federico / Cananzi, Ferdinando / Santoro, Armando / Bertuzzi, Alexia Francesca

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)

2022 Volume 32, Issue 1, Page(s) 69–70

MeSH term(s)	Humans ; COVID-19 ; Sarcoma/therapy
Language	English
Publishing date	2022-05-07
Publishing country	England
Document type	Journal Article
ZDB-ID	1137033-6
ISSN	1473-5709 ; 0959-8278
ISSN (online)	1473-5709
ISSN	0959-8278
DOI	10.1097/CEJ.0000000000000692
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Article: The blurred line between the art and science of medicine

Bertuzzi, Alexia Francesca / Gennaro, Nicolò / Marrari, Andrea / Santoro, Armando

Radiother Oncol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #401595
Database	COVID19

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Article ; Online: The radiologist empowerment through virtual multidisciplinary tumor boards: The commitment of oncologic care during COVID-19 pandemic.

Gennaro, Nicolò / Marrari, Andrea / Bertuzzi, Alexia F / Balzarini, Luca / Santoro, Armando / Politi, Letterio S

Clinical imaging

2020 Volume 70, Page(s) 49–50

MeSH term(s)	COVID-19 ; Humans ; Neoplasms/diagnostic imaging ; Neoplasms/epidemiology ; Pandemics ; Radiologists ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-10-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2020.10.023
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Article: Multi-Step Combined Upfront Surgery for Locally Advanced Paravertebral Sarcoma: A Case Report.

Cariboni, Umberto / Gennaro, Nicolò / Costa, Francesco / Renne, Salvatore Lorenzo / Novellis, Pierluigi / Marrari, Andrea / Bertuzzi, Alexia Francesca / Civilini, Efrem

Frontiers in surgery

2021 Volume 8, Page(s) 664089

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-04-26
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2773823-1
ISSN	2296-875X
ISSN	2296-875X
DOI	10.3389/fsurg.2021.664089
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Article ; Online: Multidisciplinary management of adolescents and young adults (AYA) sarcoma: A successful effort of an adult high-volume cancer center.

Bertuzzi, Alexia Francesca / Grimaudo, Maria Susanna / Laffi, Alice / Giordano, Laura / Gennaro, Nicolò / Cariboni, Umberto / Siracusano, Licia Vanessa / Quagliuolo, Vittorio / Colombo, Piergiuseppe / Federico, D'Orazio / Renne, Salvatore Lorenzo / Specchia, Cristina / Cananzi, Ferdinando / Marrari, Andrea / Navarria, Pierina / Daolio, Primo Andrea / Bastoni, Stefano / Santoro, Armando

Cancer medicine

2023 Volume 12, Issue 15, Page(s) 16254–16263

Abstract: Introduction: The aim of this retrospective study was to investigate the clinicopathological characteristics of AYA sarcomas and their clinical outcomes at a high-volume single center.: Methods: Demographic, clinicopathological data on the diagnosis, ...

Abstract	Introduction: The aim of this retrospective study was to investigate the clinicopathological characteristics of AYA sarcomas and their clinical outcomes at a high-volume single center. Methods: Demographic, clinicopathological data on the diagnosis, treatment and follow-up of all sarcoma patients aged 16-39 years (ys) observed at our Institute between January 2010 and December 2021 were retrospectively collected, including diagnostic (TTD) and treatment delay(TTT), clinical outcomes (OS and PFS), and late-treatment effects. Results: We identified 228 AYA patients, median age 30 years, 29% ≤ 25 years, 57% males, 88% soft tissue sarcomas (STS), and 12% bone sarcomas (BS). Among STSs, 13% were small round cell tumors (SRCT), 52% intermediate-high-grade, 24% low-grade STSs. Among BS, 32% were high-grade. Median TTD and TTT were 120 (0-8255) and 7 days (0-83), respectively. Surgery was performed in 83%, radiotherapy in 29%, and systemic therapy in 27%. Median follow-up was 72.9 months(1.6-145), 5-year and 10-year OS were 78.5% and 62%, respectively. Kaplan-Meyer analysis showed a significantly better 5-year OS and PFS for patients with >92 days of TTD (OS 85.7% vs. 66.7%, p = 0.001, PFS 50.2% vs. 24.9%, p = 0.009). According to age (≤25 years vs. > 25 years), 5-year OS was 69.8% versus 82.2%, respectively (p = 0.047). Conclusion: Our analysis confirmed previous data on sarcoma AYA patients followed in a referral center. Unexpectedly, diagnostic delay was not associated with poor OS and PFS. Patients <25 years showed a poorer prognosis due to the higher incidence of SRCT.
MeSH term(s)	Male ; Humans ; Young Adult ; Adolescent ; Adult ; Female ; Retrospective Studies ; Sarcoma/diagnosis ; Sarcoma/epidemiology ; Sarcoma/therapy ; Osteosarcoma/epidemiology ; Soft Tissue Neoplasms ; Bone Neoplasms/diagnosis ; Bone Neoplasms/epidemiology ; Bone Neoplasms/therapy
Language	English
Publishing date	2023-06-27
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2659751-2
ISSN	2045-7634 ; 2045-7634
ISSN (online)	2045-7634
ISSN	2045-7634
DOI	10.1002/cam4.6289
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Article ; Online: Oncological outcomes of squamous cell carcinoma of the cervical esophagus treated with definitive (chemo-)radiotherapy: a systematic review and meta-analysis.

De Virgilio, Armando / Costantino, Andrea / Festa, Bianca Maria / Mercante, Giuseppe / Franceschini, Davide / Franzese, Ciro / Scorsetti, Marta / Marrari, Andrea / Cavina, Raffaele / Marano, Salvatore / Castoro, Carlo / Spriano, Giuseppe

Journal of cancer research and clinical oncology

2022 Volume 149, Issue 3, Page(s) 1029–1041

Abstract: Purpose: To determine the oncological outcomes of cervical esophageal squamous cell carcinoma (CESCC) treated with definitive chemoradiotherapy (CRT).: Methods: A systematic review and meta-analysis was performed according to the PRISMA guidelines.!## ...

Abstract	Purpose: To determine the oncological outcomes of cervical esophageal squamous cell carcinoma (CESCC) treated with definitive chemoradiotherapy (CRT). Methods: A systematic review and meta-analysis was performed according to the PRISMA guidelines. Results: A total of 1222 patients (median age: 63.0 years, 95% CI 61.0-65.0) were included from 22 studies. The median follow-up time was 34.0 months (n = 1181, 95% CI 26.4-36.0). Estimated pooled OS rates (95% CI) at 1, 3, and 5 years were 77.9% (73.9-82.2), 48.4% (43.2-54.3), and 35.3% (29.7-41.9), respectively. The median OS (95% CI) was 33.4 months (25.8-42.2). Estimated pooled PFS rates (n = 595; 95% CI) at 1, 3, and 5 years were 64.1% (57.9-71.0), 38.0% (33.3-45.5), and 29.8% (23.9-37.1), respectively. The median PFS (95% CI) was 19.8 months (14.9-26.6). Conclusions: Definitive CRT is a valuable first-line treatment for the management of CESCC. Further studies should focus on survival predictors able to define stage-based clinical guidelines.
MeSH term(s)	Humans ; Middle Aged ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Neoplasms/pathology ; Retrospective Studies ; Carcinoma, Squamous Cell/drug therapy ; Chemoradiotherapy
Language	English
Publishing date	2022-03-02
Publishing country	Germany
Document type	Meta-Analysis ; Systematic Review ; Journal Article
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-022-03965-8
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Article ; Online: Reply to Letter to the Editor regarding "Oncological outcomes of squamous cell carcinoma of the cervical esophagus treated with definitive (chemo-)radiotherapy: a systematic review and meta-analysis".

Journal of cancer research and clinical oncology

2022 Volume 149, Issue 3, Page(s) 1369–1371

Abstract: In a previous study, we performed a meta-analysis of the oncological outcomes of patients suffering from cervical esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Further analysis was performed, and a random effect modeling ... ...

Abstract	In a previous study, we performed a meta-analysis of the oncological outcomes of patients suffering from cervical esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Further analysis was performed, and a random effect modeling showed a pooled local-regional failure rate of 41.4% (95% CI 32.2-50.8), and a pooled distant failure rate of 21.6% (95% CI 17.0-26.5). The included studies used a median radiotherapy (RT) dose of 61.2 Gy (95% CI 60.0-62.0, range 56.0-66.0), but we measured a non-significant impact of the RT dose on the pooled overall survival (OS), suggesting that an increased RT dose might not be related to an improved OS (p = 0.23). Further research should be conducted to define predictors and prognostic categories that may select the best treatment option for each patient.
MeSH term(s)	Humans ; Esophageal Squamous Cell Carcinoma/pathology ; Esophageal Neoplasms/pathology ; Carcinoma, Squamous Cell/pathology ; Prognosis ; Chemoradiotherapy
Language	English
Publishing date	2022-10-29
Publishing country	Germany
Document type	Meta-Analysis ; Systematic Review ; Letter
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-022-04441-z
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Article ; Online: Oncological outcomes of cervical esophageal cancer treated primarily with surgery: a systematic review and meta-analysis.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery

2022

Abstract: Purpose: To determine the oncological outcomes of cervical esophageal cancer (CEC) treated primarily with surgery.: Methods: A systematic review and meta-analysis was performed according to the PRISMA guidelines.: Results: A total of 868 patients ... ...

Abstract	Purpose: To determine the oncological outcomes of cervical esophageal cancer (CEC) treated primarily with surgery. Methods: A systematic review and meta-analysis was performed according to the PRISMA guidelines. Results: A total of 868 patients were included from 18 studies. Estimated pooled Overall Survival (OS) rates (95% Confidence Interval, CI) at 1 and 5 years were 74.4% (66.5-83.3), and 26.6% (20.3-34.7), respectively. Larynx non-preserving surgery (n = 229) showed an estimated pooled OS rates (95% CI) at 1 and 5 years of 59.3% (51.5-68.2) and 14.6% (8.8-24.3), respectively. On the other hand, larynx preserving surgery (n = 213) showed an estimated pooled OS rates (95% CI) at 1 and 5 years of 83.6% (78.2-89.4) and 35.1% (24.9-49.6), respectively. Conclusions: Primary larynx-preserving surgery remains a valuable option for the management of CEC, with similar survival outcomes compared to primary chemoradiotherapy (CRT). On the other hand, larynx non-preserving surgery showed a significantly reduced survival, that may reflect the more advanced T classification of these tumors. Further studies are mandatory to directly compare primary surgery and primary CRT, distinguishing larynx preserving and non-preserving surgery.
Language	English
Publishing date	2022-08-15
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1017359-6
ISSN	1434-4726 ; 0937-4477
ISSN (online)	1434-4726
ISSN	0937-4477
DOI	10.1007/s00405-022-07589-z
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Article ; Online: Oncological outcomes of squamous cell carcinoma of the cervical esophagus treated with definitive (chemo-)radiotherapy: a systematic review and meta-analysis

J Cancer Res Clin Oncol. 2023 Mar., v. 149, no. 3, p. 1029-1041

2023 , Page(s) 1029–1041

Abstract: PURPOSE: To determine the oncological outcomes of cervical esophageal squamous cell carcinoma (CESCC) treated with definitive chemoradiotherapy (CRT). METHODS: A systematic review and meta-analysis was performed according to the PRISMA guidelines. ... ...

Abstract	PURPOSE: To determine the oncological outcomes of cervical esophageal squamous cell carcinoma (CESCC) treated with definitive chemoradiotherapy (CRT). METHODS: A systematic review and meta-analysis was performed according to the PRISMA guidelines. RESULTS: A total of 1222 patients (median age: 63.0 years, 95% CI 61.0–65.0) were included from 22 studies. The median follow-up time was 34.0 months (n = 1181, 95% CI 26.4–36.0). Estimated pooled OS rates (95% CI) at 1, 3, and 5 years were 77.9% (73.9–82.2), 48.4% (43.2–54.3), and 35.3% (29.7–41.9), respectively. The median OS (95% CI) was 33.4 months (25.8–42.2). Estimated pooled PFS rates (n = 595; 95% CI) at 1, 3, and 5 years were 64.1% (57.9–71.0), 38.0% (33.3–45.5), and 29.8% (23.9–37.1), respectively. The median PFS (95% CI) was 19.8 months (14.9–26.6). CONCLUSIONS: Definitive CRT is a valuable first-line treatment for the management of CESCC. Further studies should focus on survival predictors able to define stage-based clinical guidelines.
Keywords	esophagus ; meta-analysis ; radiotherapy ; squamous cell carcinoma ; systematic review
Language	English
Dates of publication	2023-03
Size	p. 1029-1041
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	134792-5
ISSN	1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
ISSN (online)	1432-1335
ISSN	0171-5216 ; 0084-5353 ; 0943-9382
DOI	10.1007/s00432-022-03965-8
Database	NAL-Catalogue (AGRICOLA)

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