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  1. Article: Inequity in the global distribution of monkeypox vaccines.

    Tovani-Palone, Marcos Roberto / Doshi, Neel / Pedersini, Paolo

    World journal of clinical cases

    2023  Volume 11, Issue 19, Page(s) 4498–4503

    Abstract: Monkeypox (mpox) has been a public health emergency of international concern that emerged in mid-2022 and has spread to 110 countries. The clinical findings of the disease vary according to the seriousness of the cases. Although its case fatality risk ... ...

    Abstract Monkeypox (mpox) has been a public health emergency of international concern that emerged in mid-2022 and has spread to 110 countries. The clinical findings of the disease vary according to the seriousness of the cases. Although its case fatality risk has not been high, a significant percentage of patients require hospitalization. In this context, local initiatives were taken to extend the limited supply of vaccines against the disease; however, such measures have not been sufficient to contain the spread of cases and ensure an equitable distribution of health resources. As a result, endemic regions of low-income countries continue to have insufficient access to mpox vaccination. Despite this and considering the global scope of the disease, there is still little discussion in the literature about the difficulties in achieving adequate vaccination coverage rates for the target population of interest. In this article, we briefly discussed general aspects of the disease, including its surveillance, the current global context of challenges for mpox vaccination, and issues on global allocation of health resources as well as proposed related recommendations.
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2307-8960
    ISSN 2307-8960
    DOI 10.12998/wjcc.v11.i19.4498
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Potential role of the microbiome in liver injury during COVID-19: Further research is needed.

    Tovani-Palone, Marcos Roberto / Pedersini, Paolo

    World journal of gastroenterology

    2022  Volume 29, Issue 3, Page(s) 503–507

    Abstract: Although different studies have associated coronavirus disease 2019 (COVID-19) with the occurrence of liver injury, the hepatic injury route during the COVID-19 course is not yet fully understood. In order to better understand the mechanisms of the ... ...

    Abstract Although different studies have associated coronavirus disease 2019 (COVID-19) with the occurrence of liver injury, the hepatic injury route during the COVID-19 course is not yet fully understood. In order to better understand the mechanisms of the disease, the human gut microbiota has been the subject of extensive discussion in the context of COVID-19 pathophysiology. However, many questions remain, including the risks of liver injury due to COVID-19 specific populations. Further research in this field could allow the discovery of new personalized treatment strategies aimed at improving the microbiota composition, thereby reducing COVID-19 severity and its complications in different populations. In this article, we discussed basic mechanisms of severe acute respiratory syndrome coronavirus 2 infection and recent evidence on the relationship between COVID-19, the gut microbiome and liver injury as well as proposed recommendations for further research.
    MeSH term(s) Humans ; COVID-19/complications ; SARS-CoV-2 ; Microbiota ; Liver ; Gastrointestinal Microbiome ; Dysbiosis
    Language English
    Publishing date 2022-12-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v29.i3.503
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  3. Article ; Online: Declining rates of global routine vaccination coverage amidst the COVID-19 syndemic: a serious public health concern.

    Khawaja, Uzzam Ahmed / Franchi, Thomas / Pedersini, Paolo / Tovani-Palone, Marcos Roberto

    Einstein (Sao Paulo, Brazil)

    2022  Volume 19, Page(s) eED6552

    MeSH term(s) COVID-19 ; Humans ; Public Health ; SARS-CoV-2 ; Syndemic ; Vaccination ; Vaccination Coverage
    Language Portuguese
    Publishing date 2022-01-05
    Publishing country Brazil
    Document type Editorial
    ZDB-ID 2418293-X
    ISSN 2317-6385 ; 1679-4508
    ISSN (online) 2317-6385
    ISSN 1679-4508
    DOI 10.31744/einstein_journal/2021ED6552
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  4. Article ; Online: Epigenetics in Osteoarthritis Related Pain: An Update.

    VillafaÑe, Jorge Hugo / Pedersini, Paolo / Berjano, Pedro

    Archives of rheumatology

    2020  Volume 35, Issue 3, Page(s) 456–457

    Language English
    Publishing date 2020-01-08
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 3012972-2
    ISSN 2618-6500 ; 2148-5046
    ISSN (online) 2618-6500
    ISSN 2148-5046
    DOI 10.46497/ArchRheumatol.2020.7663
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  5. Article: The Efficacy of Electromagnetic Diathermy for the Treatment of Musculoskeletal Disorders: A Systematic Review with Meta-Analysis.

    Pollet, Joel / Ranica, Giorgia / Pedersini, Paolo / Lazzarini, Stefano G / Pancera, Simone / Buraschi, Riccardo

    Journal of clinical medicine

    2023  Volume 12, Issue 12

    Abstract: Objective: This study aims to establish the effect of electromagnetic diathermy therapies (e.g., shortwave, microwave, capacitive resistive electric transfer) on pain, function, and quality of life in treating musculoskeletal disorders.: Methods: We ... ...

    Abstract Objective: This study aims to establish the effect of electromagnetic diathermy therapies (e.g., shortwave, microwave, capacitive resistive electric transfer) on pain, function, and quality of life in treating musculoskeletal disorders.
    Methods: We conducted a systematic review according to the PRISMA statement and Cochrane Handbook 6.3. The protocol has been registered in PROSPERO: CRD42021239466. The search was conducted in PubMed, PEDro, CENTRAL, EMBASE, and CINAHL.
    Results: We retrieved 13,323 records; 68 studies were included. Many pathologies were treated with diathermy against placebo, as a standalone intervention or alongside other therapies. Most of the pooled studies did not show significant improvements in the primary outcomes. While the analysis of single studies shows several significant results in favour of diathermy, all comparisons considered had a GRADE quality of evidence between low and very low.
    Conclusions: The included studies show controversial results. Most of the pooled studies present very low quality of evidence and no significant results, while single studies have significant results with a slightly higher quality of evidence (low), highlighting a critical lack of evidence in the field. The results did not support the adoption of diathermy in a clinical context, preferring therapies supported by evidence.
    Language English
    Publishing date 2023-06-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12123956
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  6. Article ; Online: The Human Gut Microbiome and Its Relationship with Osteoarthritis Pain.

    Turroni, Silvia / Pedersini, Paolo / Villafañe, Jorge Hugo

    Pain medicine (Malden, Mass.)

    2020  Volume 22, Issue 7, Page(s) 1467–1469

    MeSH term(s) Gastrointestinal Microbiome ; Humans ; Inflammation ; Osteoarthritis/complications ; Pain
    Language English
    Publishing date 2020-12-11
    Publishing country England
    Document type Editorial
    ZDB-ID 2015903-1
    ISSN 1526-4637 ; 1526-2375
    ISSN (online) 1526-4637
    ISSN 1526-2375
    DOI 10.1093/pm/pnaa422
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6119: Show issues Location:
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  7. Article ; Online: Italian Physical Therapists' Response to the Novel COVID-19 Emergency.

    Pedersini, Paolo / Corbellini, Camilo / Villafañe, Jorge Hugo

    Physical therapy

    2020  Volume 100, Issue 7, Page(s) 1049–1051

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Italy ; Pandemics ; Physical Therapists ; Physical Therapy Specialty ; Pneumonia, Viral/epidemiology ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-03-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 415886-6
    ISSN 1538-6724 ; 0031-9023
    ISSN (online) 1538-6724
    ISSN 0031-9023
    DOI 10.1093/ptj/pzaa060
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    Ue I Zs.270: Show issues Location:
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  8. Article ; Online: Gut microbiota and physical activity: Is there an evidence-based link?

    Pedersini, Paolo / Turroni, Silvia / Villafañe, Jorge Hugo

    The Science of the total environment

    2020  Volume 727, Page(s) 138648

    Abstract: The gut microbiota appears to be a significant contributor to musculoskeletal health and disease. Genetic background, age, gender, diet, lifestyle and socio-economic aspects are also important factors that contribute to musculoskeletal health, as well as ...

    Abstract The gut microbiota appears to be a significant contributor to musculoskeletal health and disease. Genetic background, age, gender, diet, lifestyle and socio-economic aspects are also important factors that contribute to musculoskeletal health, as well as to the normal balance of the intestinal microbiota. Through the production of a large and diverse pool of bioactive small molecules, the gut microbiota can in fact signal to extra-intestinal organs, establishing a systems-level connection with the host metabolic, endocrine, immune and nervous apparatus. The gut microbiota has therefore been extensively studied in recent years, for health promotion, disease prevention and disease treatment, as well as for exercise performance. Practically, physical activity is recommended as a useful tool to prevent disease and improve prognosis when an athlete gets sick or injured. Therefore, the findings of studies performed on athletes should not be automatically transferred to all subjects undertaking non-competitive exercise.
    MeSH term(s) Diet ; Exercise ; Gastrointestinal Microbiome ; Humans ; Intestines ; Life Style
    Language English
    Publishing date 2020-04-16
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2020.138648
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    Zs.A 949: Show issues Location:
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  9. Article ; Online: The Efficacy of Electromagnetic Diathermy for the Treatment of Musculoskeletal Disorders

    Joel Pollet / Giorgia Ranica / Paolo Pedersini / Stefano G. Lazzarini / Simone Pancera / Riccardo Buraschi

    Journal of Clinical Medicine, Vol 12, Iss 3956, p

    A Systematic Review with Meta-Analysis

    2023  Volume 3956

    Abstract: OBJECTIVE: This study aims to establish the effect of electromagnetic diathermy therapies (e.g., shortwave, microwave, capacitive resistive electric transfer) on pain, function, and quality of life in treating musculoskeletal disorders. METHODS: We ... ...

    Abstract OBJECTIVE: This study aims to establish the effect of electromagnetic diathermy therapies (e.g., shortwave, microwave, capacitive resistive electric transfer) on pain, function, and quality of life in treating musculoskeletal disorders. METHODS: We conducted a systematic review according to the PRISMA statement and Cochrane Handbook 6.3. The protocol has been registered in PROSPERO: CRD42021239466. The search was conducted in PubMed, PEDro, CENTRAL, EMBASE, and CINAHL. RESULTS: We retrieved 13,323 records; 68 studies were included. Many pathologies were treated with diathermy against placebo, as a standalone intervention or alongside other therapies. Most of the pooled studies did not show significant improvements in the primary outcomes. While the analysis of single studies shows several significant results in favour of diathermy, all comparisons considered had a GRADE quality of evidence between low and very low. CONCLUSIONS: The included studies show controversial results. Most of the pooled studies present very low quality of evidence and no significant results, while single studies have significant results with a slightly higher quality of evidence (low), highlighting a critical lack of evidence in the field. The results did not support the adoption of diathermy in a clinical context, preferring therapies supported by evidence.
    Keywords musculoskeletal diseases ; physical therapy modalities ; diathermy ; Medicine ; R
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: A probiotic intervention on pain hypersensitivity and microbiota composition in patients with osteoarthritis pain: Study protocol for a randomized controlled trial.

    Pedersini, Paolo / Savoldi, Marco / Berjano, Pedro / Villafañe, Jorge Hugo

    Archives of rheumatology

    2021  Volume 36, Issue 2, Page(s) 296–301

    Abstract: Objectives: This study aims to examine the effects of probiotics on pain hypersensitivity at the end of a six-week intervention program in patients with osteoarthritis (OA)-related pain.: Patients and methods: This double-blind randomized controlled ... ...

    Abstract Objectives: This study aims to examine the effects of probiotics on pain hypersensitivity at the end of a six-week intervention program in patients with osteoarthritis (OA)-related pain.
    Patients and methods: This double-blind randomized controlled clinical trial with two parallel arms will be conducted between January 2021 and July 2022. At least 30 participants (age range, 50 to 90 years) of both sexes with a diagnosis of symptomatic hip or knee (Kellgren-Lawrence scale ≥3) will be recruited in each arm (total n=60) to achieve adequate statistical power in the analyses. The intervention will be administered for six weeks followed by a four-week follow-up period. The experimental group will receive a probiotic product plus the usual medical care. The control group will receive a probiotical sham plus the usual medical care. Assessment points will be measured at baseline, end of intervention, and one-month post-intervention. The outcomes of this intervention will be a change in visual analog scale pain and the gut microbiota composition. Group by time effects will be compared using mixed-model analysis of variance.
    Conclusion: A reduction in pain hypersensitivity in patients with knee OA-related pain could suggest an involvement of microbiota, or part of it, in chronic pain state mechanisms.
    Language English
    Publishing date 2021-01-27
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 3012972-2
    ISSN 2618-6500 ; 2148-5046
    ISSN (online) 2618-6500
    ISSN 2148-5046
    DOI 10.46497/ArchRheumatol.2021.7719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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