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Article ; Online: Climate Change Perception and Mental Health. Results from a Systematic Review of the Literature.

Gianfredi, Vincenza / Mazziotta, Francesco / Clerici, Giovanna / Astorri, Elisa / Oliani, Francesco / Cappellina, Martina / Catalini, Alessandro / Dell'Osso, Bernardo Maria / Pregliasco, Fabrizio Ernesto / Castaldi, Silvana / Benatti, Beatrice

European journal of investigation in health, psychology and education

2024 Volume 14, Issue 1, Page(s) 215–229

Abstract: Climate change is one of the main global challenges and influences various aspects of human health. Numerous studies have indeed demonstrated an association between extreme climate-related events and physical and mental health outcomes, but little is ... ...

Abstract	Climate change is one of the main global challenges and influences various aspects of human health. Numerous studies have indeed demonstrated an association between extreme climate-related events and physical and mental health outcomes, but little is still known about the association between the perception/awareness of climate change and mental health. In accordance with the PRISMA 2020 guidelines, a search was conducted on PubMed and Scopus. The protocol was registered on PROSPERO. The included studies were original observational studies published in English, reporting the association between the perception/awareness of climate change and mental health. A total of 3018 articles were identified. A total of 10 observational studies were included. The period covered in the included studies ranged between 2012 and 2022. Climate change perception is consistently associated with adverse mental health effects across different types of estimates. In particular, the studies identified an association between a higher level of perception/awareness of climate change and depression, anxiety, eco-anxiety, stress, adjustment disorder, substance use, dysphoria, and even thoughts of suicide. Qualitative data underscore the impact on daily activities, contributing to feelings of loss and suicidal ideation. Moreover, climate change perception correlates with lower well-being and resilience. The association between awareness of climate change and mental health is a complex and still poorly explored phenomenon. The main limitations are the high heterogeneity in terms of exposure assessment and data reporting, which hinders quantitative analysis. These results show that climate change perception impacts mental health. Better understanding the phenomenon represents an opportunity to inform public health interventions that promote mental well-being.
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	3041279-1
ISSN	2254-9625 ; 2174-8144
ISSN (online)	2254-9625
ISSN	2174-8144
DOI	10.3390/ejihpe14010014
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Article ; Online: Antigenic rapid test for SARS-CoV2 screening of individuals newly admitted to detention facilities: sensibility in an asymptomatic cohort.

Mazzilli, Sara / Oliani, Francesco / Restivo, Andrea / Giuliani, Ruggero / Tavoschi, Lara / Ranieri, Roberto

Journal of clinical virology plus

2021 Volume 1, Issue 1, Page(s) 100019

Abstract: Background: Since the start of the Sars-CoV-2 pandemic, attention was called on the potential risk of COVID-19 outbreaks occurring inside prisons. In detention facilities, timely and accurate diagnosis is essential for allowing case isolation and ... ...

Abstract	Background: Since the start of the Sars-CoV-2 pandemic, attention was called on the potential risk of COVID-19 outbreaks occurring inside prisons. In detention facilities, timely and accurate diagnosis is essential for allowing case isolation and contact tracing to avoid the spread of the infection. Until recently, reverse-transcriptase polymerase chain reaction (rt-PCR) was the recommended method to diagnose SARS-CoV-2 infection. However, antigen-detecting rapid diagnostic tests (ag-RDT) have emerged as point-of-care testing techniques. Objectives: Here, we evaluate the use of ag-RDT for screening of individuals newly admitted to San Vittore prison (SV), a pre-trial prison, in Milan (Lombardy region, Italy), during the second SARS-CoV2 epidemic peak. Methods: During the period 1 October-31 December 2020, ag-RDT and rt-PCR were performed individuals newly admitted to SV. Results: Among 504 detained individuals tested, 21 (4,2%) resulted positive to rt-PCR. Of these, 10 had tested negative with ag-RDT and 11 had concordant results. Rt-PCR cycle threshold (CT) values were above 35 for the individuals with ag-RDT negative test, therefore the cases missed by the ag-RDT are unlikely to transmit disease. For all the individuals with ag-RDT positive results, CT values were below or equal to 27. In our study population, ag-RDT sensitivity was 52.4% (29.8%-74.3%), positive predictive value (PPV) was 100% and negative predictive value was 98.0% (96.8%-98.7%). Discussion: Our study showed that ag-RDT is a promising and useful component of serial testing strategies in prison settings to perform SARS-CoV2 screening at admission based to its high PPV, ease of use, lower costs and resource needs.
Language	English
Publishing date	2021-05-11
Publishing country	England
Document type	Journal Article
ISSN	2667-0380
ISSN (online)	2667-0380
DOI	10.1016/j.jcvp.2021.100019
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Article: Italy’s rollout of COVID-19 vaccinations: The crucial contribution of the first experimental mass vaccination site in Lombardy

Oliani, Francesco / Savoia, Antonella / Gallo, Giulia / Tiwana, Navpreet / Letzgus, Matteo / Gentiloni, Flaminia / Piatti, Alessandra / Chiappa, Laura / Bisesti, Alberto / Laquintana, Dario / Castaldi, Silvana

Vaccine. 2022 Mar. 01, v. 40, no. 10

2022

Abstract: In occurrence of the coronavirusdisease 19 (COVID-19) pandemic, carrying out an efficient large-scale vaccination campaign is vital in order to control the virus. Especially in high prevalence areas of COVID – 19, it is crucial to implement an effective ... ...

Abstract	In occurrence of the coronavirusdisease 19 (COVID-19) pandemic, carrying out an efficient large-scale vaccination campaign is vital in order to control the virus. Especially in high prevalence areas of COVID – 19, it is crucial to implement an effective vaccination strategy. In Italy, programming an efficient COVID-19 mass vaccination campaign has been the main target of the Ministry of Health. This paper gives a comprehensive overview of how the mass vaccination campaign is performed in Milan, one of the cities that has been mostly affected by the COVID-19 pandemic in Italy. We analyze the vaccination strategy implemented by Fondazione Ca’ Granda – Ospedale Maggiore Policlinico located in Milan. Furthermore, we compare the organization of this campaign in regards of those carried out across EU and UK. The data derive from an analysis of the different vaccination plans implemented across EU and UK from the 27/12/2020 to the 15/06/2020. In addition, we discuss the data collected from the internal data server of IRCCS Fondazione Ca’ Granda – Ospedale Maggiore Policlinico from the 15/02/2021 to the 15/06/2021.The collected data are examined by means of descriptive statistics. From the analysis of the internal data server, we observe that the modular organization of Fiera Milano City guarantees up to 5000 vaccinations/day. Moreover, the precise flow organization of users and a series of strategies adopted to avoid identification errors or vaccine type administration errors are crucial to reach the aforementioned target. The institution of mass vaccination centers thanks to the optimization of all the involved processes and the meticulous organization of these structures, allows to avoid crowds and guarantees the administration of elevated amounts of vaccines. All these elements assure a rapid vaccination coverage of the population in Lombardy, with a meaningful increase in daily administration doses.
Keywords	COVID-19 infection ; descriptive statistics ; pandemic ; vaccination ; vaccines ; viruses ; Italy
Language	English
Dates of publication	2022-0301
Size	p. 1397-1403.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.01.059
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Article ; Online: Italy's rollout of COVID-19 vaccinations: The crucial contribution of the first experimental mass vaccination site in Lombardy.

Vaccine

2022 Volume 40, Issue 10, Page(s) 1397–1403

Abstract: Background: In occurrence of the coronavirusdisease 19 (COVID-19) pandemic, carrying out an efficient large-scale vaccination campaign is vital in order to control the virus. Especially in high prevalence areas of COVID - 19, it is crucial to implement ... ...

Abstract	Background: In occurrence of the coronavirusdisease 19 (COVID-19) pandemic, carrying out an efficient large-scale vaccination campaign is vital in order to control the virus. Especially in high prevalence areas of COVID - 19, it is crucial to implement an effective vaccination strategy. In Italy, programming an efficient COVID-19 mass vaccination campaign has been the main target of the Ministry of Health. Aims: This paper gives a comprehensive overview of how the mass vaccination campaign is performed in Milan, one of the cities that has been mostly affected by the COVID-19 pandemic in Italy. We analyze the vaccination strategy implemented by Fondazione Ca' Granda - Ospedale Maggiore Policlinico located in Milan. Furthermore, we compare the organization of this campaign in regards of those carried out across EU and UK. Materials and methods: The data derive from an analysis of the different vaccination plans implemented across EU and UK from the 27/12/2020 to the 15/06/2020. In addition, we discuss the data collected from the internal data server of IRCCS Fondazione Ca' Granda - Ospedale Maggiore Policlinico from the 15/02/2021 to the 15/06/2021.The collected data are examined by means of descriptive statistics. Results: From the analysis of the internal data server, we observe that the modular organization of Fiera Milano City guarantees up to 5000 vaccinations/day. Moreover, the precise flow organization of users and a series of strategies adopted to avoid identification errors or vaccine type administration errors are crucial to reach the aforementioned target. Conclusions: The institution of mass vaccination centers thanks to the optimization of all the involved processes and the meticulous organization of these structures, allows to avoid crowds and guarantees the administration of elevated amounts of vaccines. All these elements assure a rapid vaccination coverage of the population in Lombardy, with a meaningful increase in daily administration doses.
MeSH term(s)	COVID-19 ; COVID-19 Vaccines ; Humans ; Italy/epidemiology ; Mass Vaccination ; Pandemics ; SARS-CoV-2 ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-02-03
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	605674-x
ISSN	1873-2518 ; 0264-410X
ISSN (online)	1873-2518
ISSN	0264-410X
DOI	10.1016/j.vaccine.2022.01.059
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Article ; Online: From Diagnostic-Therapeutic Pathways to Real-World Data: A Multicenter Prospective Study on Upfront Treatment for

Pasello, Giulia / Vicario, Giovanni / Zustovich, Fable / Oniga, Francesco / Gori, Stefania / Rosetti, Francesco / Bonetti, Andrea / Favaretto, Adolfo / Toso, Silvia / Redelotti, Roberta / Santo, Antonio / Bernardi, Daniele / Giovanis, Petros / Oliani, Cristina / Calvetti, Lorenzo / Gatti, Carlo / Palazzolo, Giovanni / Baretta, Zora / Bortolami, Alberto /

Bonanno, Laura / Basso, Marco / Menis, Jessica / Corte, Donatella Da / Frega, Stefano / Guarneri, Valentina / Conte, PierFranco

The oncologist

2019 Volume 24, Issue 6, Page(s) e318–e326

Abstract: Introduction: Gefitinib, erlotinib, and afatinib represent the approved first-line options for epidermal growth factor receptor (: Methods: MOST is a multicenter observational study promoted by the Veneto Oncology Network, aiming at monitoring the ... ...

Abstract	Introduction: Gefitinib, erlotinib, and afatinib represent the approved first-line options for epidermal growth factor receptor ( Methods: MOST is a multicenter observational study promoted by the Veneto Oncology Network, aiming at monitoring the diagnostic-therapeutic pathway of patients with nonsquamous Results: An Conclusion: Good regional adherence and compliance to the diagnostic-therapeutic pathway defined for patients with nonsquamous NSCLC was shown. mTTF did not significantly differ among the three targeted TKIs. Our budget impact analysis suggests the potential application of real-world data in the process of drug price negotiation. Implications for practice: The MOST study is a real-world data collection reporting a multicenter adherence and compliance to diagnostic-therapeutic pathways defined for patients with epidermal growth factor receptor-mutant non-small cell lung cancer. This represents an essential element of evidence-based medicine, providing information on patients and situations that may be challenging to assess using only data from randomized controlled trials, e.g., turn-around time of diagnostic tests, treatment compliance and persistence, guideline adherence, challenging-to-treat populations, drug safety, comparative effectiveness, and cost effectiveness. This study may be of interest to various stakeholders (patients, clinicians, and payers), providing a meaningful picture of the value of a given therapy in routine clinical practice.
MeSH term(s)	Adult ; Afatinib/economics ; Afatinib/therapeutic use ; Aged ; Aged, 80 and over ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/economics ; Carcinoma, Non-Small-Cell Lung/genetics ; Cost-Benefit Analysis ; Critical Pathways/standards ; Critical Pathways/statistics & numerical data ; DNA Mutational Analysis/standards ; DNA Mutational Analysis/statistics & numerical data ; Disease Progression ; Disease-Free Survival ; ErbB Receptors/antagonists & inhibitors ; ErbB Receptors/genetics ; Erlotinib Hydrochloride/economics ; Erlotinib Hydrochloride/therapeutic use ; Female ; Follow-Up Studies ; Gefitinib/economics ; Gefitinib/therapeutic use ; Guideline Adherence/standards ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Lung Neoplasms/economics ; Lung Neoplasms/genetics ; Male ; Medication Adherence/statistics & numerical data ; Middle Aged ; Mutation ; Practice Guidelines as Topic ; Progression-Free Survival ; Prospective Studies ; Protein Kinase Inhibitors/economics ; Protein Kinase Inhibitors/therapeutic use ; Time Factors ; Treatment Failure
Chemical Substances	Protein Kinase Inhibitors ; Afatinib (41UD74L59M) ; Erlotinib Hydrochloride (DA87705X9K) ; EGFR protein, human (EC 2.7.10.1) ; ErbB Receptors (EC 2.7.10.1) ; Gefitinib (S65743JHBS)
Language	English
Publishing date	2019-03-07
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	1409038-7
ISSN	1549-490X ; 1083-7159
ISSN (online)	1549-490X
ISSN	1083-7159
DOI	10.1634/theoncologist.2018-0712
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Zs.MO 494: Show issues

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Article ; Online: Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.

Cavestro, Giulia Martina / Mannucci, Alessandro / Balaguer, Francesc / Hampel, Heather / Kupfer, Sonia S / Repici, Alessandro / Sartore-Bianchi, Andrea / Seppälä, Toni T / Valentini, Vincenzo / Boland, Clement Richard / Brand, Randall E / Buffart, Tineke E / Burke, Carol A / Caccialanza, Riccardo / Cannizzaro, Renato / Cascinu, Stefano / Cercek, Andrea / Crosbie, Emma J / Danese, Silvio /

Dekker, Evelien / Daca-Alvarez, Maria / Deni, Francesco / Dominguez-Valentin, Mev / Eng, Cathy / Goel, Ajay / Guillem, Josè G / Houwen, Britt B S L / Kahi, Charles / Kalady, Matthew F / Kastrinos, Fay / Kühn, Florian / Laghi, Luigi / Latchford, Andrew / Liska, David / Lynch, Patrick / Malesci, Alberto / Mauri, Gianluca / Meldolesi, Elisa / Møller, Pål / Monahan, Kevin J / Möslein, Gabriela / Murphy, Caitlin C / Nass, Karlijn / Ng, Kimmie / Oliani, Cristina / Papaleo, Enrico / Patel, Swati G / Puzzono, Marta / Remo, Andrea / Ricciardiello, Luigi / Ripamonti, Carla Ida / Siena, Salvatore / Singh, Satish K / Stadler, Zsofia K / Stanich, Peter P / Syngal, Sapna / Turi, Stefano / Urso, Emanuele Damiano / Valle, Laura / Vanni, Valeria Stella / Vilar, Eduardo / Vitellaro, Marco / You, Yi-Qian Nancy / Yurgelun, Matthew B / Zuppardo, Raffaella Alessia / Stoffel, Elena M

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

2022 Volume 21, Issue 3, Page(s) 581–603.e33

Abstract: Background & aims: Patients with early-onset colorectal cancer (eoCRC) are managed according to guidelines that are not age-specific. A multidisciplinary international group (DIRECt), composed of 69 experts, was convened to develop the first evidence- ... ...

Abstract	Background & aims: Patients with early-onset colorectal cancer (eoCRC) are managed according to guidelines that are not age-specific. A multidisciplinary international group (DIRECt), composed of 69 experts, was convened to develop the first evidence-based consensus recommendations for eoCRC. Methods: After reviewing the published literature, a Delphi methodology was used to draft and respond to clinically relevant questions. Each statement underwent 3 rounds of voting and reached a consensus level of agreement of ≥80%. Results: The DIRECt group produced 31 statements in 7 areas of interest: diagnosis, risk factors, genetics, pathology-oncology, endoscopy, therapy, and supportive care. There was strong consensus that all individuals younger than 50 should undergo CRC risk stratification and prompt symptom assessment. All newly diagnosed eoCRC patients should receive germline genetic testing, ideally before surgery. On the basis of current evidence, endoscopic, surgical, and oncologic treatment of eoCRC should not differ from later-onset CRC, except for individuals with pathogenic or likely pathogenic germline variants. The evidence on chemotherapy is not sufficient to recommend changes to established therapeutic protocols. Fertility preservation and sexual health are important to address in eoCRC survivors. The DIRECt group highlighted areas with knowledge gaps that should be prioritized in future research efforts, including age at first screening for the general population, use of fecal immunochemical tests, chemotherapy, endoscopic therapy, and post-treatment surveillance for eoCRC patients. Conclusions: The DIRECt group produced the first consensus recommendations on eoCRC. All statements should be considered together with the accompanying comments and literature reviews. We highlighted areas where research should be prioritized. These guidelines represent a useful tool for clinicians caring for patients with eoCRC.
MeSH term(s)	Humans ; Endoscopy ; Genetic Testing ; Colorectal Neoplasms/diagnosis
Language	English
Publishing date	2022-12-20
Publishing country	United States
Document type	Practice Guideline ; Research Support, U.S. Gov't, Non-P.H.S. ; Journal Article
ZDB-ID	2119789-1
ISSN	1542-7714 ; 1542-3565
ISSN (online)	1542-7714
ISSN	1542-3565
DOI	10.1016/j.cgh.2022.12.006
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Article ; Online: Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis.

Headland, Sarah E / Jones, Hefin R / Norling, Lucy V / Kim, Andrew / Souza, Patricia R / Corsiero, Elisa / Gil, Cristiane D / Nerviani, Alessandra / Dell'Accio, Francesco / Pitzalis, Costantino / Oliani, Sonia M / Jan, Lily Y / Perretti, Mauro

Science translational medicine

2015 Volume 7, Issue 315, Page(s) 315ra190

Abstract: Microvesicles (MVs) are emerging as a new mechanism of intercellular communication by transferring cellular lipid and protein components to target cells, yet their function in disease is only now being explored. We found that neutrophil-derived MVs were ... ...

Abstract	Microvesicles (MVs) are emerging as a new mechanism of intercellular communication by transferring cellular lipid and protein components to target cells, yet their function in disease is only now being explored. We found that neutrophil-derived MVs were increased in concentration in synovial fluid from rheumatoid arthritis patients compared to paired plasma. Synovial MVs overexpressed the proresolving, anti-inflammatory protein annexin A1 (AnxA1). Mice deficient in TMEM16F, a lipid scramblase required for microvesiculation, exhibited exacerbated cartilage damage when subjected to inflammatory arthritis. To determine the function of MVs in inflammatory arthritis, toward the possibility of MV-based therapeutics, we examined the role of immune cell-derived MVs in rodent models and in human primary chondrocytes. In vitro, exogenous neutrophil-derived AnxA1(+) MVs activated anabolic gene expression in chondrocytes, leading to extracellular matrix accumulation and cartilage protection through the reduction in stress-adaptive homeostatic mediators interleukin-8 and prostaglandin E2. In vivo, intra-articular injection of AnxA1(+) MV lessened cartilage degradation caused by inflammatory arthritis. Arthritic mice receiving adoptive transfer of whole neutrophils displayed abundant MVs within cartilage matrix and revealed that MVs, but not neutrophils themselves, can penetrate cartilage. Mechanistic studies support a model whereby MV-associated AnxA1 interacts with its receptor FPR2 (formyl peptide receptor 2)/ALX, increasing transforming growth factor-β production by chondrocytes, ultimately leading to cartilage protection. We envisage that MVs, either directly or loaded with therapeutics, can be harnessed as a unique therapeutic strategy for protection in diseases associated with cartilage degeneration.
MeSH term(s)	Animals ; Arthritis, Rheumatoid/pathology ; Cartilage, Articular/pathology ; Humans ; Mice ; Neutrophils/metabolism ; Synovial Fluid/metabolism ; Transforming Growth Factor beta/biosynthesis
Chemical Substances	Transforming Growth Factor beta
Language	English
Publishing date	2015-10-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.aac5608
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Article ; Online: Mild/Moderate Asthma Network in Italy (MANI): a long-term observational study.

Braido, Fulvio / Blasi, Francesco / Canonica, Giorgio Walter / Paggiaro, Pierluigi / Beghè, Bianca / Bonini, Matteo / Carpagnano, Giovanna Elisiana / Del Giacco, Stefano / Lavorini, Federico / Milanese, Manlio / Patella, Vincenzo / Santus, Pierachille / Contoli, Marco / Allegrini, Chiara / Baiardini, Ilaria / Bonzano, Laura / Caiaffa, Maria Filomena / Castelnuovo, Paolo / Corsico, Angelo Guido /

Cosmi, Lorenzo / Costantino, Maria Teresa / Cottini, Marcello / Crimi, Nunzio / Crivellaro, Maria Angiola / D'Alò, Simona / Folletti, Ilenia / Fornari, Dario / Foschino-Barbaro, Maria Pia / Franceschini, Laura / Gargano, Domenico / Oliani, Kim Lokar / Maniscalco, Mauro / Melissari, Laura / Montagni, Marcello / Montuschi, Paolo / Murgia, Nicola / Pannofino, Alessandro / Papi, Alberto / Parente, Roberta / Pelaia, Girolamo / Pini, Laura / Puggioni, Francesca / Pulerà, Nolita / Resta, Onofrio / Ricciardi, Luisa / Ridolo, Erminia / Savi, Eleonora / Savoia, Francesca / Scala, Guglielmo / Senna, Gianenrico / Tripodi, Salvatore / Vatrella, Alessandro / Ventura, Maria Teresa / Viviano, Vittorio Maria / Yacoub, Mona-Rita

The Journal of asthma : official journal of the Association for the Care of Asthma

2021 Volume 59, Issue 9, Page(s) 1908–1913

Abstract: Objective: The prevalence of asthma in Italy is estimated to be around 4%; it affects approximately 2,000,000 citizens, and up to 80-90% of patients have mild-to-moderate asthma. Despite the clinical relevance of mild-to-moderate asthma, longitudinal ... ...

Abstract	Objective: The prevalence of asthma in Italy is estimated to be around 4%; it affects approximately 2,000,000 citizens, and up to 80-90% of patients have mild-to-moderate asthma. Despite the clinical relevance of mild-to-moderate asthma, longitudinal observational data are very limited, including data on disease progression (worsening vs. improvement), the response to treatment, and prognosis. Studies are needed to develop long-term, observational, real-life research in large cohorts. The primary outcomes of this study will be based on prospective observation and the epidemiological evolution of mild and moderate asthma. Secondary outcomes will include patient-reported outcomes, treatments over time, disease-related functional and inflammatory patterns, and environmental and life-style influences. Methods: This study, called the Mild/Moderate Asthma Network of Italy (MANI), is a research initiative launched by the Italian Respiratory Society and the Italian Society of Allergology, Asthma and Clinical Immunology. MANI is a cluster-based, real world, cross-sectional, prospective, observational cohort study that includes 20,000 patients with mild-to-moderate asthma. (ClinicalTrials.gov Identifier: NCT04796844). Results and conclusion: Despite advances in asthma care, several research gaps remain to be addressed through clinical research. This study will add important new knowledge about long-term disease history, the transferability of clinical research results to daily practice, the efficacy of currently recommended strategies, and their impact on the burden and evolution of the disease. Abbreviations: MANI:Mild/Moderate Asthma Network of ItalySANI:Severe Asthma Network ItalyGINA:Global Initiative for AsthmaSABA:short acting β2-agonistsICS:inhaled corticosteroidsCRF:Case Report Form.
MeSH term(s)	Administration, Inhalation ; Anti-Asthmatic Agents/therapeutic use ; Asthma/drug therapy ; Asthma/epidemiology ; Cross-Sectional Studies ; Disease Progression ; Humans ; Prospective Studies ; Quality of Life
Chemical Substances	Anti-Asthmatic Agents
Language	English
Publishing date	2021-09-01
Publishing country	England
Document type	Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
ZDB-ID	603816-5
ISSN	1532-4303 ; 0277-0903
ISSN (online)	1532-4303
ISSN	0277-0903
DOI	10.1080/02770903.2021.1968895
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Article: Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients.

Piepoli, Ada / Gentile, Annamaria / Valvano, Maria Rosa / Barana, Daniela / Oliani, Cristina / Cotugno, Rosa / Quitadamo, Michele / Andriulli, Angelo / Perri, Francesco

World journal of gastroenterology

2005 Volume 12, Issue 39, Page(s) 6343–6348

Abstract: Aim: To investigate simultaneously UGT1A7, UGT1A9, ARP, SPINK and CFTR genes to verify whether genetic polymorphisms predispose to the development of pancreatic cancer (PC).: Methods: Genomic DNA of 61 pancreatic cancer patients and 105 healthy ... ...

Abstract	Aim: To investigate simultaneously UGT1A7, UGT1A9, ARP, SPINK and CFTR genes to verify whether genetic polymorphisms predispose to the development of pancreatic cancer (PC). Methods: Genomic DNA of 61 pancreatic cancer patients and 105 healthy controls (HC) were analyzed. UGT1A7 genotyping was determined by PCR-RFLP analysis. Specific PCR and sequencing were used to analyze genetic variants of UGT1A9, ARP, SPINK1 and CFTR genes. Results: Four different alleles (1: WT; 2: N129K and R131K; 3: N129K, R131K, and W208R; and 4: W208R) in UGT1A7 and three different alleles (1: WT; 4: Y242X; and 5: D256N) in UGT1A9 were detected. All UGT1A polymorphisms were observed at similar frequency in PC patients and HC. Seven different alleles in ARP were found in PC patients and HC at similar frequency. The SPINK1 mutations N34S and P55S occurred in five PC patients with a prevalence (4.1%) not significantly different from that observed (2.0%) in HC. The only CFTR DeltaF508 mutation was recognized in three PC patients with a prevalence (4.9%) similar to HC. Conclusion:* UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms are not associated with PC in Italian patients.
MeSH term(s)	Adult ; Age Factors ; Aged ; Aged, 80 and over ; Carrier Proteins/genetics ; Case-Control Studies ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Female ; Genetic Predisposition to Disease/epidemiology ; Genetic Predisposition to Disease/genetics ; Glucuronosyltransferase/genetics ; Humans ; Italy/epidemiology ; Male ; Middle Aged ; Mutation/genetics ; Nerve Growth Factors ; Pancreatic Neoplasms/genetics ; Polymorphism, Genetic ; Proteins/genetics ; Risk Factors ; Smoking ; Trypsin Inhibitor, Kazal Pancreatic
Chemical Substances	CFTR protein, human ; Carrier Proteins ; MANF protein, human ; Nerve Growth Factors ; Proteins ; SPINK1 protein, human ; Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; Trypsin Inhibitor, Kazal Pancreatic (50936-63-5) ; Glucuronosyltransferase (EC 2.4.1.17) ; UDP-glucuronosyltransferase 1A9 (EC 2.4.1.17) ; UDP-glucuronosyltransferase, UGT1A7 (EC 2.4.1.17)
Language	English
Publishing date	2005-07-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2185929-2
ISSN	2219-2840 ; 1007-9327
ISSN (online)	2219-2840
ISSN	1007-9327
DOI	10.3748/wjg.v12.i39.6343
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Article ; Online: The Effect of Omeprazole on Serum Concentrations of Theophylline, Pepsinogens A and C, and Gastrin in Elderly Duodenal Ulcer Patients.

Pilotto, Alberto / Franceschi, Marilisa / Lagni, Mirka / Fabrello, Renato / Fortunato, Antonio / Meggiato, Tamara / Soffiati, Giuliano / Oliani, Gigliola / Di Mario, Francesco

American journal of therapeutics

2002 Volume 2, Issue 1, Page(s) 43–46

Abstract: With the aim of verifying the effect of omeprazole treatment on theophyline serum concentration in elderly peptic ulcer patients, we studied 10 male subjects aged >65 years (mean age = 75.2, range = 67--86) with chronic obstructive bronchopneumonia and ... ...

Abstract	With the aim of verifying the effect of omeprazole treatment on theophyline serum concentration in elderly peptic ulcer patients, we studied 10 male subjects aged >65 years (mean age = 75.2, range = 67--86) with chronic obstructive bronchopneumonia and endoscopically diagnosed duodenal ulcer in acute phase. All subjects were treated with a slow-release formulation of theophylline 200 mg b.i.d. plus omeprazole 20 mg daily for 4 weeks. In all subjects serum concentrations of azote, creatinine, theophylline were determined at the beginning and after 1 and 4 weeks; at the beginning and end of the study, pepsinogen group A (PGA), pepsinogen group C(PGC) and gastrin were measured. Statistical analysis was performed with the Student's t-test for paired data. The results showed no statistically significant differences after 1 and 4 weeks of omeprazole treatment in serum concentrations of theophylline (T(0) = 7.4, T(1 week) = 7.5, T(4 weeks) = 6.0, p = ns), azote (T(0) = 45.2, T(1 week) = 30.5, T(4 weeks) = 36.1, p = ns), creatinine (T(0) = 1.27, T(1 week) = 1.02, T(4 weeks) = 1.16, p = ns), PGA (T(0) = 99.5, T(4 weeks) = 126.2, p = ns), and PGC (T(0) = 10.6, T(4 weeks) = 12.1, p = ns); however serum gastrin increased from T(0) = 70.2 plus minus 13.2 to T(4 weeks) = 130.3 plus minus 18.3 (p < 0.0001). It was concluded that (1) serum concentration of theophylline is not affected by the concomitant omeprazole treatment lasting 1 month in elderly patients suffering from chronic obstructive bronchopneumonia and peptic ulcer, (2) modifications of dosages of theophylline and/or omeprazole are not necessary in the elderly with normal renal function, (3) the increase in fasting serum gastrin after 4 weeks of treatment may indicate that omeprazole 20 mg daily is efficacious in inhibiting gastric acid secretion in the elderly people.
Language	English
Publishing date	2002-01-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1280786-2
ISSN	1536-3686 ; 1075-2765
ISSN (online)	1536-3686
ISSN	1075-2765
DOI	10.1097/00045391-199501000-00008
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