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  1. Article ; Online: Corrigendum to "itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens".

    Liesenborghs, Laurens / Spriet, Isabel / Jochmans, Dirk / Belmans, Ann / Gyselinck, Iwein / Teuwen, Laure-Anne / Ter Horst, Sebastiaan / Dreesen, Erwin / Geukens, Tatjana / Engelen, Matthias M / Landeloos, Ewout / Geldhof, Vincent / Ceunen, Helga / Debaveye, Barbara / Vandenberk, Bert / Van der Linden, Lorenz / Jacobs, Sofie / Langendries, Lana / Boudewijns, Robbert /
    Dan Do, Thuc Nguyen / Chiu, Winston / Wang, Xinyu / Zhang, Xin / Weynand, Birgit / Vanassche, Thomas / Devos, Timothy / Meyfroidt, Geert / Janssens, Wim / Vos, Robin / Vermeersch, Pieter / Wauters, Joost / Verbeke, Geert / De Munter, Paul / Kaptein, Suzanne J F / Rocha-Pereira, Joana / Delang, Leen / Van Wijngaerden, Eric / Neyts, Johan / Verhamme, Peter

    EBioMedicine

    2021  Volume 69, Page(s) 103454

    Language English
    Publishing date 2021-06-26
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2021.103454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7090: Show issues Location:
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  2. Article: Not only vaccine hesitancy, but also vaccination campaign hesitancy drives measles epidemics in conflict-torn eastern DR Congo.

    Van Brusselen, Daan / Dubois, Ali Heshima / Bindu, Lucien Kandundao / Moluh, Zakari / Nzomukunda, Yvonne / Liesenborghs, Laurens

    Conflict and health

    2024  Volume 18, Issue 1, Page(s) 14

    Abstract: The COVID-19 pandemic and vaccine hesitancy are not the only causes of the increase in measles cases in low- and middle-income countries. Measles epidemics, like the recent one in eastern DRC, are often quickly halted by mass vaccination in 'easy to ... ...

    Abstract The COVID-19 pandemic and vaccine hesitancy are not the only causes of the increase in measles cases in low- and middle-income countries. Measles epidemics, like the recent one in eastern DRC, are often quickly halted by mass vaccination in 'easy to reach' refugee camps. However, governmental and humanitarian actors fail to respond effectively in 'hard-to-reach' areas like Masisi, frequently limiting themselves to more accessible areas close to big cities.
    Language English
    Publishing date 2024-02-01
    Publishing country England
    Document type Letter
    ZDB-ID 2273783-2
    ISSN 1752-1505
    ISSN 1752-1505
    DOI 10.1186/s13031-024-00569-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: No Evidence for Clade I Monkeypox Virus Circulation, Belgium.

    Liesenborghs, Laurens / Coppens, Jasmine / Van Dijck, Christophe / Brosius, Isabel / De Baetselier, Irith / Vercauteren, Koen / Van Esbroeck, Marjan

    Emerging infectious diseases

    2024  Volume 30, Issue 2, Page(s) 402

    MeSH term(s) Belgium/epidemiology ; Monkeypox virus
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Letter
    ZDB-ID 1380686-5
    ISSN 1080-6059 ; 1080-6040
    ISSN (online) 1080-6059
    ISSN 1080-6040
    DOI 10.3201/eid3002.231746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4778: Show issues Location:
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  4. Article ; Online: No Varicella Zoster Virus Infection among Mpox Cases in Antwerp, Belgium.

    Coppens, Jasmine / Liesenborghs, Laurens / Vercauteren, Koen / Van Esbroeck, Marjan / Van Dijck, Christophe

    The American journal of tropical medicine and hygiene

    2023  Volume 109, Issue 6, Page(s) 1282–1283

    Abstract: Several studies in tropical settings have reported that ∼20% of patients infected with Monkeypox virus (MPXV) also tested polymerase chain reaction (PCR) positive for Varicella zoster virus (VZV). Researchers have hypothesized that VZV infection ... ...

    Abstract Several studies in tropical settings have reported that ∼20% of patients infected with Monkeypox virus (MPXV) also tested polymerase chain reaction (PCR) positive for Varicella zoster virus (VZV). Researchers have hypothesized that VZV infection predisposes to monkeypox (mpox), or vice versa, or that MPXV triggers the reactivation of VZV. We tested samples for VZV from a cohort of patients infected with clade IIb MPXV diagnosed between May 23 and October 14, 2022 in Antwerp, Belgium. Leftover DNA extracts of skin lesion samples from 108 mpox patients were tested with in-house PCR for VZV. No VZV infections were found. The absence of concurrent VZV-MPXV infections in our cohort indicates that VZV did not cocirculate in the population at risk for MPXV during the Belgian 2022 outbreak, but also that MPXV does not commonly trigger reactivation of latent VZV in adult men.
    MeSH term(s) Adult ; Male ; Humans ; Herpesvirus 3, Human/genetics ; Belgium/epidemiology ; Mpox (monkeypox) ; Herpes Zoster ; Chickenpox ; Monkeypox virus
    Language English
    Publishing date 2023-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.23-0353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ud II Zs.61: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: COVID-19 and microbiome diversity in sub-Saharan Africa.

    Van Damme, Wim / Wamai, Richard / Assefa, Yibeltal / Liesenborghs, Laurens / Mumba, Dieudonné

    Lancet (London, England)

    2022  Volume 400, Issue 10350, Page(s) 429

    MeSH term(s) Africa South of the Sahara/epidemiology ; COVID-19 ; Humans ; Microbiota
    Language English
    Publishing date 2022-08-03
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)01333-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.5: Show issues Location:
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    Zs.MG 94: Show issues

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  6. Article ; Online: Urethritis Without Skin Lesions as the Primary Manifestation of Mpox Virus Infection.

    Liesenborghs, Laurens / Huyst, Veerle / Van Dijck, Christophe / Rutgers, Jojanneke / De Baetselier, Irith / Kenyon, Chris / Van Esbroeck, Marjan / Vercauteren, Koen

    European urology

    2023  Volume 83, Issue 4, Page(s) 378–379

    MeSH term(s) Humans ; Urethritis ; Mpox (monkeypox)
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Letter ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2022.12.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1247: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 294: Show issues

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  7. Article ; Online: Coagulation: At the heart of infective endocarditis.

    Liesenborghs, Laurens / Meyers, Severien / Vanassche, Thomas / Verhamme, Peter

    Journal of thrombosis and haemostasis : JTH

    2020  Volume 18, Issue 5, Page(s) 995–1008

    Abstract: Infective endocarditis is a life-threatening and enigmatic disease with a mortality of 30% and a pathophysiology that is poorly understood. However, at its core, an endocarditis lesion is mainly a fibrin and platelet blood clot infested with bacteria, ... ...

    Abstract Infective endocarditis is a life-threatening and enigmatic disease with a mortality of 30% and a pathophysiology that is poorly understood. However, at its core, an endocarditis lesion is mainly a fibrin and platelet blood clot infested with bacteria, clinging at the cardiac valves. Infective endocarditis therefore serves as a paradigm of immunothrombosis gone wrong. Immunothrombosis refers to the entanglement of the coagulation system with innate immunity and the role of coagulation in the isolation and clearance of invading pathogens. However, in the case of infective endocarditis, instead of containing the infection, immunothrombosis inadvertently creates the optimal shelter from the immune system and allows some bacteria to grow almost unimpeded. In every step of the disease, the coagulation system is heavily involved. It mediates the initial adhesion of bacteria to the leaflets, fuels the growth and maturation of a vegetation, and facilitates complications such as embolization and valve destruction. In addition, the number one cause of infective endocarditis, Staphylococcus aureus, has proven to be a true manipulator of immunothrombosis and thrives in the fibrin rich environment of an endocarditis vegetation. Considering its central role in infective endocarditis, the coagulation system is an attractive therapeutic target for this deadly disease. There is, however, a very delicate balance at play and the use of antithrombotic drugs in patients with endocarditis is often accompanied with a high bleeding risk.
    MeSH term(s) Blood Coagulation ; Endocarditis/diagnosis ; Endocarditis/therapy ; Endocarditis, Bacterial/diagnosis ; Endocarditis, Bacterial/therapy ; Humans ; Staphylococcal Infections ; Staphylococcus aureus
    Language English
    Publishing date 2020-02-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5805: Show issues Location:
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    Zs.MO 295: Show issues

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  8. Article ; Online: Air pollution and bronchiolitis: a case-control study in Antwerp, Belgium.

    Van Brusselen, Daan / De Troeyer, Katrien / van Vliet, Marinus Pieter / Avonts, Dirk / Nemery, Benoit / Liesenborghs, Laurens / Verhulst, Stijn / Van Herck, Koen / De Bacquer, Dirk

    European journal of pediatrics

    2024  Volume 183, Issue 5, Page(s) 2431–2442

    Abstract: This case-control study aimed to investigate the association between short-term (1 to 5 days) and medium-term (31 days) exposure to air pollutants ( ... ...

    Abstract This case-control study aimed to investigate the association between short-term (1 to 5 days) and medium-term (31 days) exposure to air pollutants (PM
    MeSH term(s) Humans ; Bronchiolitis/epidemiology ; Bronchiolitis/etiology ; Belgium/epidemiology ; Case-Control Studies ; Infant ; Male ; Female ; Air Pollution/adverse effects ; Environmental Exposure/adverse effects ; Particulate Matter/adverse effects ; Particulate Matter/analysis ; Air Pollutants/adverse effects ; Air Pollutants/analysis ; Hospitalization/statistics & numerical data ; Infant, Newborn ; Risk Factors ; Logistic Models
    Chemical Substances Particulate Matter ; Air Pollutants
    Language English
    Publishing date 2024-03-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 194196-3
    ISSN 1432-1076 ; 0340-6199 ; 0943-9676
    ISSN (online) 1432-1076
    ISSN 0340-6199 ; 0943-9676
    DOI 10.1007/s00431-024-05493-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Um IV Zs.75: Show issues Location:
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  9. Article ; Online: Emergence of mpox in the post-smallpox era-a narrative review on mpox epidemiology.

    Van Dijck, Christophe / Hoff, Nicole A / Mbala-Kingebeni, Placide / Low, Nicola / Cevik, Muge / Rimoin, Anne W / Kindrachuk, Jason / Liesenborghs, Laurens

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2023  Volume 29, Issue 12, Page(s) 1487–1492

    Abstract: Background: The 2022 mpox outbreak drew global attention to this neglected pathogen. While most of the world was taken by surprise, some countries have seen this pathogen emerge and become endemic several decades prior to this epidemic.: Objectives: ... ...

    Abstract Background: The 2022 mpox outbreak drew global attention to this neglected pathogen. While most of the world was taken by surprise, some countries have seen this pathogen emerge and become endemic several decades prior to this epidemic.
    Objectives: This narrative review provides an overview of mpox epidemiology since its discovery through the 2022 global outbreak.
    Sources: We searched PubMed for relevant literature about mpox epidemiology and transmission through 28 February 2023.
    Content: The emergence of human mpox is intertwined with the eradication of smallpox and the cessation of the global smallpox vaccination campaign. The first human clade I and II monkeypox virus (MPXV) infections were reported as zoonoses in Central and West Africa, respectively, around 1970 with sporadic infections reported throughout the rest of the decade. Over the next five decades, Clade I MPXV was more common and caused outbreaks of increasing size and frequency, mainly in the Democratic Republic of the Congo. Clade II MPXV was rarely observed, until its re-emergence and ongoing transmission in Nigeria, since 2017. Both clades showed a shift from zoonotic to human-to-human transmission, with potential transmission through sexual contact being observed in Nigeria. In 2022, clade II MPXV caused a large human outbreak which to date has caused over 86,000 cases in 110 countries, with strong evidence of transmission during sexual contact. By February 2023, the global epidemic has waned in most countries, but endemic regions continue to suffer from mpox.
    Implications: The changing epidemiology of mpox demonstrates how neglected zoonosis turned into a global health threat within a few decades. Thus, mpox pathophysiology and transmission dynamics need to be further investigated, and preventive and therapeutic interventions need to be evaluated. Outbreak response systems need to be strengthened and sustained in endemic regions to reduce the global threat of mpox.
    MeSH term(s) Animals ; Humans ; Smallpox/epidemiology ; Smallpox/prevention & control ; Mpox (monkeypox)/epidemiology ; Variola virus ; Zoonoses/epidemiology ; Disease Outbreaks
    Language English
    Publishing date 2023-08-11
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2023.08.008
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    Zs.A 4541: Show issues Location:
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    Zs.MO 284: Show issues

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  10. Article ; Online: Mpox screening in high-risk populations finds no asymptomatic cases.

    Van Dijck, Christophe / De Baetselier, Irith / Kenyon, Chris / Liesenborghs, Laurens / Vercauteren, Koen / Van Esbroeck, Marjan

    The Lancet. Microbe

    2022  Volume 4, Issue 3, Page(s) e132–e133

    MeSH term(s) Humans ; Mpox (monkeypox) ; Risk Factors
    Language English
    Publishing date 2022-12-09
    Publishing country England
    Document type Letter ; Comment
    ISSN 2666-5247
    ISSN (online) 2666-5247
    DOI 10.1016/S2666-5247(22)00357-3
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