LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 126

Search options

  1. Article ; Online: Antiviral Research: At age 41, a transition.

    Bray, Mike

    Antiviral research

    2022  Volume 208, Page(s) 105447

    Abstract: This article marks the transition from Mike Bray to Subhash Vasudevan as editor-in-chief ...

    Abstract This article marks the transition from Mike Bray to Subhash Vasudevan as editor-in-chief of Antiviral Research, in the journal's 41st year of publication. It reviews AVR's experience since 2011, when the founder and first editor-in-chief, Erik De Clercq, wrote a paper describing the journal's first 30 years. Since that time, the editorial team has doubled in size, with editors now located in 8 countries; half are women. There has been a corresponding increase in the number of published papers, covering research on antiviral drugs, vaccines and pathogenesis for a wide range of endemic and epidemic viral diseases of humans and livestock animals, and there has been a significant rise in the journal's impact factor. AVR's experience during the COVID-19 pandemic is also briefly summarized.
    MeSH term(s) Humans ; Female ; Adult ; Male ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Pandemics/prevention & control ; COVID-19 Drug Treatment
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2022-10-15
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2022.105447
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article ; Online: Understanding smallpox vaccination.

    Bray, Mike

    The Journal of infectious diseases

    2011  Volume 203, Issue 8, Page(s) 1037–1039

    MeSH term(s) Antibodies, Viral/therapeutic use ; B-Lymphocytes/physiology ; CD4-Positive T-Lymphocytes/physiology ; CD8-Positive T-Lymphocytes/physiology ; Humans ; Lymphocyte Depletion ; Skin/pathology ; Smallpox/prevention & control ; Smallpox Vaccine/administration & dosage ; Smallpox Vaccine/adverse effects ; Smallpox Vaccine/immunology ; Vaccination
    Chemical Substances Antibodies, Viral ; Smallpox Vaccine
    Language English
    Publishing date 2011-04-15
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiq164
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 445: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: A clinical trial lacking a control group.

    Bray, Mike / McKimm-Breschkin, Jennifer

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2019  Volume 89, Page(s) 189

    MeSH term(s) Adult ; Antibodies ; Control Groups ; Humans ; Orthomyxoviridae ; Oseltamivir ; Outpatients ; Safety ; Seasons
    Chemical Substances Antibodies ; ergoferon ; Oseltamivir (20O93L6F9H)
    Language English
    Publishing date 2019-10-16
    Publishing country Canada
    Document type Letter ; Comment
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2019.09.030
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4516: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses.

    Bray, Mike / Rayner, Craig / Noël, François / Jans, David / Wagstaff, Kylie

    Antiviral research

    2020  Volume 178, Page(s) 104805

    MeSH term(s) Antiviral Agents ; Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Ivermectin ; Pandemics ; Pneumonia, Viral ; SARS Virus ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Ivermectin (70288-86-7)
    Keywords covid19
    Language English
    Publishing date 2020-04-21
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2020.104805
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  5. Article ; Online: Keeping an eye on poxviruses.

    Bray, Mike

    The American journal of tropical medicine and hygiene

    2009  Volume 80, Issue 4, Page(s) 499–500

    MeSH term(s) Communicable Diseases, Emerging/diagnosis ; Humans ; Poxviridae/classification ; Poxviridae/isolation & purification ; Poxviridae Infections/diagnosis ; Serologic Tests/methods
    Language English
    Publishing date 2009-04
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.61: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Identifying areas of Australia with high out-of-hospital cardiac arrest incidence and low bystander cardiopulmonary resuscitation rates: A retrospective, observational study.

    Doan, Tan / Howell, Stuart / Ball, Stephen / Finn, Judith / Cameron, Peter / Bosley, Emma / Dicker, Bridget / Faddy, Steven / Nehme, Ziad / Heriot, Natalie / Swain, Andy / Thorrowgood, Melanie / Thomas, Andrew / Perillo, Samuel / McDermott, Mike / Smith, Tony / Smith, Karen / Belcher, Jason / Bray, Janet

    PloS one

    2024  Volume 19, Issue 4, Page(s) e0301176

    Abstract: Aim: This study aims to explore regional variation and identify regions within Australia with high incidence of out-of-hospital cardiac arrest (OHCA) and low rates of bystander cardiopulmonary resuscitation (CPR).: Method: Adult OHCAs of presumed ... ...

    Abstract Aim: This study aims to explore regional variation and identify regions within Australia with high incidence of out-of-hospital cardiac arrest (OHCA) and low rates of bystander cardiopulmonary resuscitation (CPR).
    Method: Adult OHCAs of presumed medical aetiology occurring across Australia between 2017 and 2019 were mapped onto local government areas (LGA) using the location of arrest coordinates. Bayesian spatial models were applied to provide "smoothed" estimates of OHCA incidence and bystander CPR rates (for bystander-witnessed OHCAs) for each LGA. For each state and territory, high-risk LGAs were defined as those with an incidence rate greater than the state or territory's 75th percentile and a bystander CPR rate less than the state or territory's 25th percentile.
    Results: A total of 62,579 OHCA cases attended by emergency medical services across 543 LGAs nationwide were included in the study. Nationally, the OHCA incidence rate across LGA ranged from 58.5 to 198.3 persons per 100,000, while bystander CPR rates ranged from 45% to 75%. We identified 60 high-risk LGAs, which were predominantly located in the state of New South Wales. Within each region, high-risk LGAs were typically located in regional and remote areas of the country, except for four metropolitan areas-two in Adelaide and two in Perth.
    Conclusions: We have identified high-risk LGAs, characterised by high incidence and low bystander CPR rates, which are predominantly in regional and remote areas of Australia. Strategies for reducing OHCA and improving bystander response may be best targeted at these regions.
    MeSH term(s) Out-of-Hospital Cardiac Arrest/epidemiology ; Out-of-Hospital Cardiac Arrest/therapy ; Humans ; Cardiopulmonary Resuscitation ; Retrospective Studies ; Incidence ; Australia/epidemiology ; Male ; Emergency Medical Services/statistics & numerical data ; Female ; Aged ; Middle Aged ; Adult
    Language English
    Publishing date 2024-04-23
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0301176
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: A saturation mutagenesis screen uncovers resistant and sensitizing secondary

    Feng, Siyu / Callow, Marinella G / Fortin, Jean-Philippe / Khan, Zia / Bray, David / Costa, Mike / Shi, Zhen / Wang, Weiru / Evangelista, Marie

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 18, Page(s) e2120512119

    Abstract: Mutant-specific inhibitors of KRASG12C, such as AMG510 (sotorasib) and MRTX849 (adagrasib), offer the unprecedented opportunity to inhibit KRAS, the most frequently mutated and heretofore undruggable oncoprotein. While clinical data are still limited, on- ...

    Abstract Mutant-specific inhibitors of KRASG12C, such as AMG510 (sotorasib) and MRTX849 (adagrasib), offer the unprecedented opportunity to inhibit KRAS, the most frequently mutated and heretofore undruggable oncoprotein. While clinical data are still limited, on-target mutations in KRASG12C at position 12 and other sites are emerging as major drivers of clinical relapse. We identified additional mutations in KRASG12C that impact inhibitor sensitivity through a saturation mutagenesis screen in the KRASG12C NCI-H358 non–small-cell lung cancer (NSCLC) cell line. We also identified individuals in population genetic databases harboring these resistance mutations in their germline and in tumors, including a subset that co-occur with KRASG12C, indicating that these mutations may preexist in patients treated with KRASG12C inhibitors. Notably, through structural modeling, we found that one such mutation (R68L) interferes with the critical protein–drug interface, conferring resistance to both inhibitors. Finally, we uncovered a mutant (S17E) that demonstrated a strong sensitizing phenotype to both inhibitors. Functional studies suggest that S17E sensitizes KRASG12C cells to KRASG12C inhibition by impacting signaling through PI3K/AKT/mTOR but not the MAPK signaling pathway. Our studies highlight the utility of unbiased mutation profiling to understand the functional consequences of all variants of a disease-causing genetic mutant and predict acquired resistant mutations in the targeted therapeutics.
    MeSH term(s) Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Mutagenesis ; Mutation ; Piperazines ; Proto-Oncogene Proteins p21(ras)/genetics ; Pyridines ; Pyrimidines
    Chemical Substances KRAS protein, human ; Piperazines ; Pyridines ; Pyrimidines ; Proto-Oncogene Proteins p21(ras) (EC 3.6.5.2)
    Language English
    Publishing date 2022-04-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2120512119
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article: Highly pathogenic RNA viral infections: challenges for antiviral research.

    Bray, Mike

    Antiviral research

    2008  Volume 78, Issue 1, Page(s) 1–8

    Abstract: A number of RNA viruses can cause severe disease when transmitted to humans from an animal reservoir. One of them, the recently emerged H5N1 subtype of influenza A virus, has caused several hundred cases of severe disease when transferred directly from ... ...

    Abstract A number of RNA viruses can cause severe disease when transmitted to humans from an animal reservoir. One of them, the recently emerged H5N1 subtype of influenza A virus, has caused several hundred cases of severe disease when transferred directly from domestic poultry. This or another avian subtype could potentially evolve to a form more transmissible by the respiratory route or reassort with a circulating strain to initiate a pandemic. Other zoonotic RNA viruses cause sporadic single cases or outbreaks of hemorrhagic fever or encephalitis that spread inefficiently from person-to-person, and thus remain confined to the geographic range of the maintenance host. RNA viral infections of farm animals, such as foot and mouth disease and classical swine fever, also pose a major threat to human well-being through economic loss and impaired nutrition. Only a few licensed antiviral drugs are available to prevent or treat these conditions. Medications that inhibit the replication of influenza virus might be used in an epidemic both to treat severe disease and to block the spread of infection. The guanosine analog ribavirin has been used to treat a few types of hemorrhagic fever, but there is no specific therapy for the others, or for any type of RNA viral encephalitis. The quest for new antivirals is being supported by government programs and new collaborative research networks. Major efforts will be required to identify active compounds, test their efficacy in laboratory animals, obtain approval for human use and develop rapid diagnostic methods that can identify patients early enough in the disease course for treatment to be of benefit.
    MeSH term(s) Animals ; Animals, Domestic/virology ; Antiviral Agents/therapeutic use ; Disease Outbreaks ; Humans ; Public Health ; RNA Virus Infections/drug therapy ; RNA Virus Infections/epidemiology ; RNA Virus Infections/virology ; RNA Viruses/classification ; RNA Viruses/drug effects ; RNA Viruses/pathogenicity ; Research/trends ; Zoonoses
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2008-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/j.antiviral.2007.12.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 1627: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article: Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses

    Bray, Mike / Rayner, Craig / Noël, François / Jans, David / Wagstaff, Kylie

    Antiviral Res

    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #100693
    Database COVID19

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top