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  1. Article: Ivermectin-induced drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome.

    Kerneuzet, Ines / Blind, Eline / Darrieux, Laure / Moreau, Stéphanie / Safa, Gilles

    JAAD case reports

    2018  Volume 4, Issue 6, Page(s) 524–527

    Language English
    Publishing date 2018-06-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2018.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Positive Association Between Location of Melanoma, Ultraviolet Signature, Tumor Mutational Burden, and Response to Anti-PD-1 Therapy.

    Dousset, Léa / Poizeau, Florence / Robert, Caroline / Mansard, Sandrine / Mortier, Laurent / Caumont, Charline / Routier, Émilie / Dupuy, Alain / Rouanet, Jacques / Battistella, Maxime / Greliak, Anna / Cappellen, David / Galibert, Marie-Dominique / Allayous, Clara / Lespagnol, Alexandra / Gerard, Émilie / Kerneuzet, Inès / Roy, Séverine / Dutriaux, Caroline /
    Merlio, Jean-Philippe / Vergier, Beatrice / Schrock, Alexa B / Lee, Jessica / Ali, Siraj M / Kammerer-Jacquet, Solène-Florence / Lebbé, Céleste / Beylot-Barry, Marie / Boussemart, Lise

    JCO precision oncology

    2021  Volume 5

    Abstract: Emerging evidence suggests a correlation between the tumor mutational burden (TMB) and the response to programmed cell death-1 protein (PD-1) monotherapy across multiple cancer types. In skin cancers, as high TMB is mostly because of ultraviolet (UV) ... ...

    Abstract Emerging evidence suggests a correlation between the tumor mutational burden (TMB) and the response to programmed cell death-1 protein (PD-1) monotherapy across multiple cancer types. In skin cancers, as high TMB is mostly because of ultraviolet (UV) exposure, we hypothesized a correlation between the primary melanoma cutaneous location according to sun exposure and response to anti-PD-1 monotherapy.
    Methods: The aim of this study was to analyze, in advanced melanoma, the relationship between TMB, locations according to sun exposure, and response to PD-1 inhibitors. We conducted a prospective multicentric analysis, by sequencing the most recent metastatic sample before PD-1 inhibitors using FoundationOne assay.
    Results: One hundred two patients were included, with TMB available for 94 cases. In univariate and multivariate linear regression, TMB was significantly associated with sun-exposed areas of the primary melanoma location and with age (coefficients of the association with log-TMB: non-UV location, -1.05; chronic sun-exposed area, 1.12;
    Conclusion: Cumulative sun exposure related to skin location and molecular UV signature present on the metastatic site appear to be relevant biomarkers directly linked to TMB. Because TMB is not yet available to all for routine clinical use, the location of the primary melanoma in a sun-exposed area may play an important role in clinical decisions regarding therapeutic choice.
    MeSH term(s) B7-H1 Antigen/genetics ; Biomarkers, Tumor ; Child, Preschool ; Humans ; Infant, Newborn ; Melanoma/drug therapy ; Mutation ; Prospective Studies
    Chemical Substances B7-H1 Antigen ; Biomarkers, Tumor
    Language English
    Publishing date 2021-12-16
    Publishing country United States
    Document type Journal Article
    ISSN 2473-4284
    ISSN (online) 2473-4284
    DOI 10.1200/PO.21.00084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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