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Article ; Online: Improved and ligand-free copper-catalyzed cyclization for an efficient synthesis of benzimidazoles from

Bonku, Emmanuel Mintah / Qin, Hongjian / Odilov, Abdullajon / Abduahadi, Safomuddin / Guma, Samuel Desta / Yang, Feipu / Zhu, Fuqiang / Aisa, Haji A / Shen, Jingshan

RSC advances

2024 Volume 14, Issue 10, Page(s) 6906–6916

Abstract: We present an improved copper-catalyzed cyclization for an efficient synthesis of benzimidazoles ... ...

Abstract	We present an improved copper-catalyzed cyclization for an efficient synthesis of benzimidazoles from
Language	English
Publishing date	2024-02-26
Publishing country	England
Document type	Journal Article
ISSN	2046-2069
ISSN (online)	2046-2069
DOI	10.1039/d4ra00245h
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Direct esterification of amides by the dimethylsulfate-mediated activation of amide C-N bonds.

Qin, Hongjian / Han, Zijian / Bonku, Emmanuel Mintah / Sun, Haiguo / Odilov, Abdullajon / Zhu, Fuqiang / Abduahadi, Safomuddin / Zhu, Weiliang / Shen, Jingshan / Aisa, Haji A

Communications chemistry

2024 Volume 7, Issue 1, Page(s) 93

Abstract: Amides are important intermediates in organic chemistry and the pharmaceutical industry, but their low reactivity requires catalysts and/or severe reaction conditions for esterification. Here, a novel approach was devised to convert amides into esters ... ...

Abstract	Amides are important intermediates in organic chemistry and the pharmaceutical industry, but their low reactivity requires catalysts and/or severe reaction conditions for esterification. Here, a novel approach was devised to convert amides into esters without the use of transition metals. The method effectively overcomes the inherent low reactivity of amides by employing dimethylsulfate-mediated reaction to activate the C-N bonds. To confirm the proposed reaction mechanism, control experiments and density functional theory (DFT) calculations were conducted. The method demonstrates a wide array of substrates, including amides with typical H/alkyl/aryl substitutions, N,N-disubstituted amides, amides derived from alkyl, aryl, or vinyl carboxylic acids, and even amino acid substrates with stereocentres. Furthermore, we have shown the effectiveness of dimethylsulfate in removing acyl protective groups in amino derivatives. This study presents a method that offers efficiency and cost-effectiveness in broadening the esterification capabilities of amides, thereby facilitating their increased utilization as synthetic compounds in diverse transformations.
Language	English
Publishing date	2024-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2929562-2
ISSN	2399-3669 ; 2399-3669
ISSN (online)	2399-3669
ISSN	2399-3669
DOI	10.1038/s42004-024-01180-9
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Izmeneniya organov, vyyavlennye pri posmertnom issledovanii patsientov s COVID-19.

Odilov, A A / Tsimbalist, N S / Volkov, A V / Babichenko, I I

Arkhiv patologii

2020 Volume 82, Issue 6, Page(s) 63–69

Abstract: The postmortem study results presented in 20 sources of literature on 186 COVID-19 patients were analyzed. Pathological changes were noted in multiple organs, by involving predominantly the respiratory, circulatory, and excretory systems. The changes in ... ...

Title translation	Organ changes found by postmortem examination in COVID-19 patients.
Abstract	The postmortem study results presented in 20 sources of literature on 186 COVID-19 patients were analyzed. Pathological changes were noted in multiple organs, by involving predominantly the respiratory, circulatory, and excretory systems. The changes in the lungs were characterized by an increase in organ weight (59.3%), a dark red color of the parenchyma (47.4%), compaction of lung tissue (56%), and signs of lung congestion (37.3%). The histological characteristics found during postmortem lung tissue examination, which were indicative of diffuse alveolar damage, were proliferation of type II alveolocytes in 65.2% of cases, the appearance of hyaline membranes lining the alveoli in 64.4%, and interstitial edema in 54.2%. In the analyzed sources, 22% of cases were noticed to have severe thrombosis and pulmonary artery branch embolism that was associated with lower extremity deep vein thrombosis. In all the sources of literature, acute tubular necrosis, tubular luminal dilatation, and interstitial edema were detected in the kidneys.
MeSH term(s)	Autopsy ; COVID-19 ; Humans ; Kidney/pathology ; Lung/pathology ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
Language	Russian
Publishing date	2020-12-03
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	127285-8
ISSN	0004-1955
ISSN	0004-1955
DOI	10.17116/patol20208206163
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: COVID-19: Multiorgan Dissemination of SARS-CoV-2 Is Driven by Pulmonary Factors

Odilov, Akmaljon / Volkov, Alexey / Abdullaev, Adhamjon / Gasanova, Tatiana / Lipina, Tatiana / Babichenko, Igor

Viruses. 2021 Dec. 26, v. 14, no. 1

2021

Abstract: Multi-organ failure is one of the common causes of fatal outcome in COVID-19 patients. However, the pathogenetic association of the SARS-CoV-2 viral load (VL) level with fatal dysfunctions of the lungs, liver, kidneys, heart, spleen and brain, as well as ...

Abstract	Multi-organ failure is one of the common causes of fatal outcome in COVID-19 patients. However, the pathogenetic association of the SARS-CoV-2 viral load (VL) level with fatal dysfunctions of the lungs, liver, kidneys, heart, spleen and brain, as well as with the risk of death in COVID-19 patients remains poorly understood. SARS-CoV-2 VL in the lungs, heart, liver, kidneys, brain, spleen and lymph nodes have been measured by RT qPCR using the following formula: NSᴬᴿS⁻Cᵒⱽ⁻²/Nᴬᴮᴸ¹ × 100. Dissemination of SARS-CoV-2 in 30.5% of cases was mono-organ, and in 63.9% of cases, it was multi-organ. The average SARS-CoV-2 VL in the exudative phase of diffuse alveolar damage (DAD) was 60 times higher than in the proliferative phase. The SARS-CoV-2 VL in the lungs ranged from 0 to 250,281 copies. The “pulmonary factors” of SARS-CoV-2 multi-organ dissemination are the high level of SARS-CoV-2 VL (≥4909) and the exudative phase of DAD. The frequency of SARS-CoV-2 dissemination to lymph nodes was 86.9%, heart–56.5%, spleen–52.2%, liver–47.8%, kidney–26%, and brain–13%. We found no link between the SARS-CoV-2 VL level in the liver, kidneys, and heart and the serum level of CPK, LDH, ALP, ALT, AST and Cr of COVID-19 patients. Isolated detection of SARS-CoV-2 RNA in the myocardium of COVID-19 patients who died from heart failure is possible. The pathogenesis of COVID-19-associated multi-organ failure requires further research in a larger cohort of patients.
Keywords	COVID-19 infection ; RNA ; Severe acute respiratory syndrome coronavirus 2 ; blood serum ; brain ; death ; heart failure ; liver ; lymph ; myocardium ; pathogenesis ; risk ; spleen ; viral load
Language	English
Dates of publication	2021-1226
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v14010039
Database	NAL-Catalogue (AGRICOLA)

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Article: An Improved Iodine-Catalyzed Aromatization Reaction and Its Application in the Synthesis of a Key Intermediate of Cannabidiol

Abduahadi, Safomuddin / Mintah Bonku, Emmanuel / Qin, Hongjian / Odilov, Abdullajon / Zhu, Fuqiang / Aisa, Haji Akber / Shen, Jingshan

Synlett

2024

Abstract: In this study, the development of an improved process for the synthesis of a key cannabidiol intermediate, methyl olivetolate, is described. The process involves an improvement of the iodine-catalyzed aromatization of cyclohexanone using potassium ... ...

Abstract	In this study, the development of an improved process for the synthesis of a key cannabidiol intermediate, methyl olivetolate, is described. The process involves an improvement of the iodine-catalyzed aromatization of cyclohexanone using potassium persulfate as an oxidant. This approach enabled for the efficient synthesis of methyl olivetolate with a 90% yield and 99.84% HPLC purity on a 5 kg scale. Additionally, a total of 19 cyclohexanone substrates afforded higher yields (71–92%) of m -diphenol compounds compared to the established methods.
Keywords	methyl olivetolate ; potassium persulfate ; aromatization ; oxidation ; iodine-catalyst ; cannabidiol
Language	English
Publishing date	2024-04-09
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2042012-2
ISSN	1437-2096 ; 0936-5214
ISSN (online)	1437-2096
ISSN	0936-5214
DOI	10.1055/a-2301-2431
Database	Thieme publisher's database

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Article ; Online: COVID-19: Multiorgan Dissemination of SARS-CoV-2 Is Driven by Pulmonary Factors.

Odilov, Akmaljon / Volkov, Alexey / Abdullaev, Adhamjon / Gasanova, Tatiana / Lipina, Tatiana / Babichenko, Igor

Viruses

2021 Volume 14, Issue 1

Abstract	Multi-organ failure is one of the common causes of fatal outcome in COVID-19 patients. However, the pathogenetic association of the SARS-CoV-2 viral load (VL) level with fatal dysfunctions of the lungs, liver, kidneys, heart, spleen and brain, as well as with the risk of death in COVID-19 patients remains poorly understood. SARS-CoV-2 VL in the lungs, heart, liver, kidneys, brain, spleen and lymph nodes have been measured by RT qPCR using the following formula: N
MeSH term(s)	Aged ; Aged, 80 and over ; Autopsy ; COVID-19/pathology ; COVID-19/virology ; Female ; Humans ; Lung/pathology ; Lung/virology ; Male ; Middle Aged ; Multiple Organ Failure/pathology ; Multiple Organ Failure/virology ; RNA, Viral/genetics ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; SARS-CoV-2/metabolism ; SARS-CoV-2/pathogenicity ; Viral Load ; Viral Proteins/metabolism
Chemical Substances	RNA, Viral ; Viral Proteins
Language	English
Publishing date	2021-12-26
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14010039
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Article ; Online: Viral Load and Patterns of SARS-CoV-2 Dissemination to the Lungs, Mediastinal Lymph Nodes, and Spleen of Patients with COVID-19 Associated Lymphopenia.

Abdullaev, Adhamjon / Odilov, Akmaljon / Ershler, Maxim / Volkov, Alexey / Lipina, Tatiana / Gasanova, Tatiana / Lebedin, Yuri / Babichenko, Igor / Sudarikov, Andrey

Viruses

2021 Volume 13, Issue 7

Abstract: Lymphopenia is a frequent hematological manifestation, associated with a severe course of COVID-19, with an insufficiently understood pathogenesis. We present molecular genetic immunohistochemical, and electron microscopic data on SARS-CoV-2 ... ...

Abstract	Lymphopenia is a frequent hematological manifestation, associated with a severe course of COVID-19, with an insufficiently understood pathogenesis. We present molecular genetic immunohistochemical, and electron microscopic data on SARS-CoV-2 dissemination and viral load (VL) in lungs, mediastinum lymph nodes, and the spleen of 36 patients who died from COVID-19. Lymphopenia <1 × 10
MeSH term(s)	Aged ; Aged, 80 and over ; COVID-19/virology ; COVID-19 Testing ; Female ; Humans ; Immunohistochemistry ; Lung/pathology ; Lung/virology ; Lymph Nodes/virology ; Lymphopenia/immunology ; Lymphopenia/virology ; Male ; Mediastinum/virology ; Middle Aged ; Multiplex Polymerase Chain Reaction ; SARS-CoV-2/genetics ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/genetics ; Spleen/virology ; Viral Load
Chemical Substances	Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
Language	English
Publishing date	2021-07-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13071410
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Article ; Online: Comparative analysis of short-term results of retroperitoneoscopic and laparoscopic radical nephrectomy for large kidney tumors

Z. A. Kadyrov / A. Yu. Odilov / D. M. Yagudaev

Onkourologiâ, Vol 15, Iss 1, Pp 42-

2019 Volume 49

Abstract: The study objectiveis to perform comparative analysis of short-term results of retroperitoneoscopic and laparoscopic radical nephrectomy for large kidney tumors.Materials and methods. The study is based on the results of examination and treatment of 108 ... ...

Abstract	The study objectiveis to perform comparative analysis of short-term results of retroperitoneoscopic and laparoscopic radical nephrectomy for large kidney tumors.Materials and methods. The study is based on the results of examination and treatment of 108 patients with stage Т1—3аrenal cell carcinoma.Results. For retroperitoneoscopic radical nephrectomy, significant decrease in operative time, ligation and transection of the renal hilum, lower carbon dioxide expenditure, less intense pain sensations on day 1 after the surgery, lower analgesics expenditure, and hospitalization time.Conclusion. The results show the advantages of retroperitoneoscopic radical nephrectomy compared to laparoscopic nephrectomy.
Keywords	renal cancer ; laparoscopic nephrectomy ; retroperitoneoscopic nephrectomy ; lymph node dissection ; Medicine ; R
Language	Russian
Publishing date	2019-03-01T00:00:00Z
Publisher	ABV-press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Comparative analysis of intra- and postoperative complications of retroperitoneoscopic and laparoscopic nephrectomy for large tumors

Z. A. Kadyrov / A. Yu. Odilov / D. M. Yagudaev

Onkourologiâ, Vol 14, Iss 4, Pp 22-

2018 Volume 28

Abstract: The objective is to perform comparative analysis of intra- and postoperative complications of retroperitoneoscopic radical nephrectomy (RRN) and laparoscopic radical nephrectomy (LRN) for large tumors.Materials and methods. The study includes examination ...

Abstract	The objective is to perform comparative analysis of intra- and postoperative complications of retroperitoneoscopic radical nephrectomy (RRN) and laparoscopic radical nephrectomy (LRN) for large tumors.Materials and methods. The study includes examination and treatment data for 108 patients with stage T1—3a renal cell carcinoma.Results and conclusion. A number of advantages of RRN compared to LRN were demonstrated associated with shorter surgery duration with fast processing of the renal pedicle, lower blood loss, lower use of analgesics in the postoperative period, shorter duration of hospitalization, and quick recovery after the surgery. The rate of intra- and postoperative complications for RRN was 19.2 and 17.3 %, for LRN — 33.9 and 37.5 %, respectively. Complications associated with abdominal organs were absent for RRN. After LRN, the rate of serious complications was significantly higher than after RRN.
Keywords	renal cancer ; laparoscopic nephrectomy ; retroperitoneoscopic nephrectomy ; lymph node dissection ; complication ; Medicine ; R
Subject code	616
Language	Russian
Publishing date	2018-12-01T00:00:00Z
Publisher	ABV-press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Pharmacokinetics, mass balance, and metabolism of [

He, Yi-Fei / Liu, Yin / Yu, Jing-Hua / Cheng, Huan / Odilov, Abdullajon / Yang, Fei-Pu / Tian, Guang-Hui / Yao, Xiu-Mei / Duan, Hua-Qing / Yu, Cheng-Yin / Yu, Chen / Liu, Yan-Mei / Liu, Gang-Yi / Shen, Jing-Shan / Wang, Zhen / Diao, Xing-Xing

Acta pharmacologica Sinica

2022

Abstract: TPN171 is a novel phosphodiesterase-5 (PDE5) inhibitor used to treat pulmonary arterial hypertension (PAH) and erectile dysfunction (ED), which currently is undergoing phase II clinical trials in China. In this single-center, single-dose, nonrandomized, ... ...

Abstract	TPN171 is a novel phosphodiesterase-5 (PDE5) inhibitor used to treat pulmonary arterial hypertension (PAH) and erectile dysfunction (ED), which currently is undergoing phase II clinical trials in China. In this single-center, single-dose, nonrandomized, and open design study, radiolabeled [
Language	English
Publishing date	2022-06-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	1360774-1
ISSN	1745-7254 ; 0253-9756 ; 1671-4083
ISSN (online)	1745-7254
ISSN	0253-9756 ; 1671-4083
DOI	10.1038/s41401-022-00922-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1904: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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