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  1. Article ; Online: Salivary Biomarkers for Alzheimer's Disease: A Systematic Review with Meta-Analysis.

    Nijakowski, Kacper / Owecki, Wojciech / Jankowski, Jakub / Surdacka, Anna

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Alzheimer's Disease (AD) is the most common neurodegenerative disease which manifests with progressive cognitive impairment, leading to dementia. Considering the noninvasive collection of saliva, we designed the systematic review to answer the question " ... ...

    Abstract Alzheimer's Disease (AD) is the most common neurodegenerative disease which manifests with progressive cognitive impairment, leading to dementia. Considering the noninvasive collection of saliva, we designed the systematic review to answer the question "Are salivary biomarkers reliable for the diagnosis of Alzheimer's Disease?" Following the inclusion and exclusion criteria, 30 studies were included in this systematic review (according to the PRISMA statement guidelines). Potential biomarkers include mainly proteins, metabolites and even miRNAs. Based on meta-analysis, in AD patients, salivary levels of beta-amyloid42 and p-tau levels were significantly increased, and t-tau and lactoferrin were decreased at borderline statistical significance. However, according to pooled AUC, lactoferrin and beta-amyloid42 showed a significant predictive value for salivary-based AD diagnosis. In conclusion, potential markers such as beta-amyloid42, tau and lactoferrin can be detected in the saliva of AD patients, which could reliably support the early diagnosis of this neurodegenerative disease.
    MeSH term(s) Humans ; Alzheimer Disease/diagnosis ; Neurodegenerative Diseases ; Lactoferrin ; MicroRNAs ; Biomarkers
    Chemical Substances Lactoferrin (EC 3.4.21.-) ; MicroRNAs ; Biomarkers
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25021168
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Salivary Biomarkers for Parkinson's Disease: A Systematic Review with Meta-Analysis.

    Nijakowski, Kacper / Owecki, Wojciech / Jankowski, Jakub / Surdacka, Anna

    Cells

    2024  Volume 13, Issue 4

    Abstract: Parkinson's Disease (PD) is a common neurodegenerative disease which manifests with motor features, such as bradykinesia, resting tremor, rigidity, and postural instability. Using the non-invasive technique of saliva collection, we designed a systematic ... ...

    Abstract Parkinson's Disease (PD) is a common neurodegenerative disease which manifests with motor features, such as bradykinesia, resting tremor, rigidity, and postural instability. Using the non-invasive technique of saliva collection, we designed a systematic review to answer the question "Are salivary biomarkers reliable for the diagnosis of Parkinson's Disease?". Following inclusion and exclusion criteria, 30 studies were included in this systematic review (according to the PRISMA statement guidelines). Mostly proteins were reported as potential biomarkers in saliva. Based on meta-analysis, in PD patients, salivary levels of total alpha-synuclein were significantly decreased, and those of oligomeric alpha-synuclein were significantly increased. Also, according to pooled AUC, heme oxygenase-1 demonstrated significant predictive value for saliva-based PD diagnosis. In conclusion, some potential biomarkers, especially alpha-synuclein, can be altered in the saliva of PD patients, which could be reliably useful for early diagnosis of this neurodegenerative disease differentiating other synucleopathies.
    MeSH term(s) Humans ; Parkinson Disease/diagnosis ; Parkinson Disease/metabolism ; alpha-Synuclein/metabolism ; Neurodegenerative Diseases/metabolism ; Saliva/metabolism ; Biomarkers/metabolism
    Chemical Substances alpha-Synuclein ; Biomarkers
    Language English
    Publishing date 2024-02-14
    Publishing country Switzerland
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13040340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Salivary Alterations of Myeloperoxidase in Patients with Systemic Diseases: A Systematic Review.

    Nijakowski, Kacper / Jankowski, Jakub / Gruszczyński, Dawid / Surdacka, Anna

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Salivary myeloperoxidase (MPO) is a key mediator of the oral immune system, acting as an enzyme that utilises ... ...

    Abstract Salivary myeloperoxidase (MPO) is a key mediator of the oral immune system, acting as an enzyme that utilises H
    MeSH term(s) Humans ; Enzyme-Linked Immunosorbent Assay ; Hydrogen Peroxide ; Peroxidase/analysis ; Saliva/chemistry
    Chemical Substances Hydrogen Peroxide (BBX060AN9V) ; Peroxidase (EC 1.11.1.7) ; MPO protein, human (EC 1.11.1.7)
    Language English
    Publishing date 2023-07-28
    Publishing country Switzerland
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Sexually dimorphic renal expression of

    Jankowski, Jakub / Lee, Hye Kyung / Liu, Chengyu / Wilflingseder, Julia / Hennighausen, Lothar

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Transcription enhancers are genomic sequences regulating common and tissue-specific genes and their disruption can contribute to human disease development and progression. ...

    Abstract Transcription enhancers are genomic sequences regulating common and tissue-specific genes and their disruption can contribute to human disease development and progression.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.02.29.582831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Eating Disorders and Dental Erosion: A Systematic Review.

    Nijakowski, Kacper / Jankowski, Jakub / Gruszczyński, Dawid / Surdacka, Anna

    Journal of clinical medicine

    2023  Volume 12, Issue 19

    Abstract: Both eating disorders and dental erosion are increasingly affecting adolescents and young adults. Thus, our systematic review was designed to answer the question: "Is there a relationship between dental erosion and eating disorders?" Following the ... ...

    Abstract Both eating disorders and dental erosion are increasingly affecting adolescents and young adults. Thus, our systematic review was designed to answer the question: "Is there a relationship between dental erosion and eating disorders?" Following the inclusion and exclusion criteria, 31 studies were included in this systematic review (according to the PRISMA statement guidelines). Based on the meta-analysis, 54.4% of patients with bulimia nervosa and 26.7% with anorexia nervosa experienced tooth erosion. For the whole group of 1699 patients with eating disorders, erosive lesions were observed in 42.1% of patients. Bulimics were more than 10 times more likely to experience dental erosion compared to healthy individuals (OR = 10.383 [95%CI: 4.882-22.086]). Similarly, more than 16 times increased odds of tooth erosion were found in patients with self-induced vomiting (OR = 16.176 [95%CI: 1.438-181.918]). In conclusion, eating disorders are associated with an increased risk of developing erosive lesions, especially in patients with bulimia nervosa.
    Language English
    Publishing date 2023-09-24
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12196161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Two-Axial Measurement of the Angular Microdeflection of a Laser Beam Using One Single-Axis Sensor.

    Dobosz, Marek / Jankowski, Michał / Mruk, Jakub

    Sensors (Basel, Switzerland)

    2023  Volume 23, Issue 22

    Abstract: The majority of current methods for measuring the angular deflection of a laser beam enable measurement only in one selected plane. However, there are tasks in which measurements of laser beam deflections in 3D are required. In this paper, we present a ... ...

    Abstract The majority of current methods for measuring the angular deflection of a laser beam enable measurement only in one selected plane. However, there are tasks in which measurements of laser beam deflections in 3D are required. In this paper, we present a way of enabling two-axial measurements of the deflection of a beam based on a single-axis sensor. The key idea is to direct a laser beam, alternately, into one of two arms of a measurement system. In the first arm, the beam is transmitted directly to the angular sensor, while in the second, the beam is directed to the sensor via a special optical element that rotates the plane of the beam deflection; in other words, this element changes the deflection in the horizontal plane into a deflection in the vertical plane, and vice versa. To alternate the path of the beam, a variable phase retarder and a polarising beamsplitter are used. The proposed technique was experimentally verified, and the results confirm its effectiveness.
    Language English
    Publishing date 2023-11-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2052857-7
    ISSN 1424-8220 ; 1424-8220
    ISSN (online) 1424-8220
    ISSN 1424-8220
    DOI 10.3390/s23229276
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Kleefstra Syndrome-Dental Manifestations and Needs: A Case Report with a Literature Review.

    Karlak, Victoria / Jankowski, Jakub / Kolasińska, Julia / Nijakowski, Kacper

    Case reports in dentistry

    2023  Volume 2023, Page(s) 2478465

    Abstract: Kleefstra syndrome (KS) is a rare genetic disorder (prevalence < 1/1 000 000) characterised by autistic spectrum disorder (ASD), childhood hypotonia, and seizures. A typical facial appearance includes microcephaly, arched eyebrows, synophrism, ... ...

    Abstract Kleefstra syndrome (KS) is a rare genetic disorder (prevalence < 1/1 000 000) characterised by autistic spectrum disorder (ASD), childhood hypotonia, and seizures. A typical facial appearance includes microcephaly, arched eyebrows, synophrism, hypertelorism, a short nose, midface hypoplasia, prognathism, and tongue protrusion. This case report presents a 19-year-old female with KS from a dentist's perspective. The patient demonstrates limited mouth opening with a slight deviation of the mandible on the left side. The mandibular prognathism and anterior open bite are visible. A generalised inflammatory gingival enlargement is most likely a response to local irritants like plaque and calculus but is enhanced by the patient's mouth breathing habit. Also, the tongue is unusually large-macroglossia. Dental anomalies were diagnosed by digital panoramic radiograph, including dilaceration of the maxillary left second premolar and taurodontism. The patient was qualified to be treated under general anaesthesia with multiple extractions, restorations, hygienisation procedures, and tooth remineralisation. This individual should also be considered for orthodontic treatment and an eventual tongue reduction procedure. In the case of KS, multidisciplinary cooperation as well as frequent dental check-ups with fluoride prophylaxis are recommended. Unfortunately, dental treatment is still not an integral part of taking care of disabled children and youth with rare diseases.
    Language English
    Publishing date 2023-09-22
    Publishing country Egypt
    Document type Case Reports
    ZDB-ID 2627632-X
    ISSN 2090-6455 ; 2090-6447
    ISSN (online) 2090-6455
    ISSN 2090-6447
    DOI 10.1155/2023/2478465
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Potential Immunohistochemical Biomarkers for Grading Oral Dysplasia: A Literature Review.

    Zdrojewski, Jakub / Nowak, Monika / Nijakowski, Kacper / Jankowski, Jakub / Scribante, Andrea / Gallo, Simone / Pascadopoli, Maurizio / Surdacka, Anna

    Biomedicines

    2024  Volume 12, Issue 3

    Abstract: Oral cancer is a prevalent global health issue, with significant morbidity and mortality rates. Despite available preventive measures, it remains one of the most common cancers, emphasising the need for improved diagnostic and prognostic tools. This ... ...

    Abstract Oral cancer is a prevalent global health issue, with significant morbidity and mortality rates. Despite available preventive measures, it remains one of the most common cancers, emphasising the need for improved diagnostic and prognostic tools. This review focuses on oral potentially malignant disorders (OPMDs), precursors to oral cancer, specifically emphasising oral epithelial dysplasia (OED). The World Health Organisation (WHO) provides a three-tier grading system for OED, and recent updates have expanded the criteria to enhance diagnostic precision. In the prognostic evaluation of OED, histological grading is presently regarded as the gold standard; however, its subjectivity and unreliability in anticipating malignant transformation or recurrence pose notable limitations. The primary objective is to investigate whether specific immunohistochemical biomarkers can enhance OED grading assessment according to the WHO classification. Biomarkers exhibit significant potential for comprehensive cancer risk evaluation, early detection, diagnosis, prognosis, and treatment optimisation. Technological advancements, including sequencing and nanotechnology, have expanded detection capabilities. Some analysed biomarkers are most frequently chosen, such as p53, Ki-67, cadherins/catenins, and other proteins used to differentiate OED grades. However, further research is needed to confirm these findings and discover new potential biomarkers for precise dysplasia grading and minimally invasive assessment of the risk of malignant transformation.
    Language English
    Publishing date 2024-03-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2720867-9
    ISSN 2227-9059
    ISSN 2227-9059
    DOI 10.3390/biomedicines12030577
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The relation between uric acid level and blood pressure values among patients hospitalized in a department of internal medicine.

    Szydlik, Julia / Nieznański, Jakub / Bałażyk, Konstancja / Pokrzywnicki, Jakub / Sawicka, Ada / Jankowski, Piotr

    Postepy w kardiologii interwencyjnej = Advances in interventional cardiology

    2023  Volume 19, Issue 2, Page(s) 142–151

    Abstract: Introduction: The relationship between uric acid (UA) level and blood pressure (BP) is not clear, although most studies suggest BP reduction in patients treated with UA level lowering agents.: Aim: The aim of the study was to evaluate the ... ...

    Abstract Introduction: The relationship between uric acid (UA) level and blood pressure (BP) is not clear, although most studies suggest BP reduction in patients treated with UA level lowering agents.
    Aim: The aim of the study was to evaluate the relationship between UA level and BP among patients hospitalized in a department of internal medicine. We also intended to investigate the relation between the allopurinol dose prescribed and BP.
    Material and methods: We reviewed hospital records of 561 patients (mean age: 65.46 ±17.46 years) hospitalized in a department of internal medicine, in whom UA level was determined on admission.
    Results: We did not find a significant correlation between UA level and BP values in the whole group, nor in patients not taking any BP-lowering or any UA-lowering drug. Multivariable analysis showed that allopurinol dose was not independently related to BP. Age (OR = 1.04, 95% CI: 1.03-1.06 per 1 year), diabetes (OR = 1.90, 95% CI: 1.14-3.16), stage 2 (OR = 4.96, 95% CI: 2.15-11.46) and stage 3 obesity (OR = 13.66, 95% CI: 5.90-31.60), both vs. patients without stage 2/3 obesity, but not UA level, were independently related to the diagnosis of hypertension.
    Conclusions: Our study does not confirm an independent relationship between UA level and BP nor between UA lowering and BP in a population of hospitalized patients.
    Language English
    Publishing date 2023-06-30
    Publishing country Poland
    Document type Journal Article
    ISSN 1734-9338
    ISSN 1734-9338
    DOI 10.5114/aic.2023.129213
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  10. Article ; Online: Analyzing the dynamics of meningococcal vaccinations initiatives by local government units in Poland (2017-2021) - Scope, challenges and recommendations.

    Świtalski, Jakub / Miazga, Wojciech / Wnuk, Katarzyna / Tatara, Tomasz / Olszewski, Paweł / Jankowski, Mateusz / Augustynowicz, Anna

    Vaccine

    2024  

    Abstract: Introduction: Meningococcal vaccinations are recommended by Polish public health authorities but lack coverage under health insurance, prompting Local Government Units (LGUs) to implement local health policy programs. This study examines the ... ...

    Abstract Introduction: Meningococcal vaccinations are recommended by Polish public health authorities but lack coverage under health insurance, prompting Local Government Units (LGUs) to implement local health policy programs. This study examines the effectiveness and impact of LGU-driven meningococcal vaccination initiatives in Poland between 2017 and 2021.
    Material and methods: A retrospective analysis utilized data from reports on local public health interventions submitted annually to the Ministry of Health in Poland. The study focused on the number of meningococcal vaccination programs, their scope, the vaccinated population, and associated program costs. Additionally, nationwide data on meningococcal disease incidence and vaccine uptake were analyzed.
    Results: Within LGUs programs, 48,617 individuals received meningococcal vaccinations, constituting approximately 10% of all vaccinations in Poland during the study period. Notably, cities with poviat rights spearheaded programs covering 54% of the total participants. The total cost incurred by these initiatives amounted to EUR 2,553,661.
    Conclusions: While LGUs activities positively contributed to increased meningococcal vaccination rates, the overall engagement of local governments remains limited. The findings underscore the importance of expanding local government involvement in meningococcal vaccination programs to address public health needs effectively. Improved collaboration and increased funding may enhance the reach and impact of these initiatives.
    Language English
    Publishing date 2024-04-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 605674-x
    ISSN 1873-2518 ; 0264-410X
    ISSN (online) 1873-2518
    ISSN 0264-410X
    DOI 10.1016/j.vaccine.2024.04.046
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