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  1. Book: Myelodysplastic syndromes

    Steensma, David P.

    (Hematology/oncology clinics of North America ; volume 34, number 2 (April 2020))

    2020  

    Author's details editor David P. Steensma
    Series title Hematology/oncology clinics of North America ; volume 34, number 2 (April 2020)
    Hematology, oncology clinics of North America
    Collection Hematology, oncology clinics of North America
    Language English
    Size xvi Seiten, Seite 321-489, Illustrationen, Diagramme
    Publisher Elsevier
    Publishing place Philadelphia, Pennsylvania
    Publishing country United States
    Document type Book
    HBZ-ID HT020422160
    ISBN 978-0-323-72259-9 ; 0-323-72259-8
    Database Catalogue ZB MED Medicine, Health

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    Se 1077 -34,2- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Children's Author and Cartoonist Dr. Seuss: Not That Kind of Doctor, But a Medical School Bears His Name.

    Steensma, David P

    Mayo Clinic proceedings

    2024  Volume 99, Issue 3, Page(s) 513–514

    MeSH term(s) Humans ; Names ; Schools, Medical
    Language English
    Publishing date 2024-02-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2024.01.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Altered Oxidative Phosphorylation Confers Vulnerability on IDH1-Mutant Leukemia Cells: Is This Therapeutically Tractable?

    Steensma, David P

    Blood cancer discovery

    2024  Volume 5, Issue 2, Page(s) 83–85

    Abstract: ... will this susceptibility prove amenable to therapy? See related article by Landberg et al., p. 114 (10). ...

    Abstract Summary: Isocitrate dehydrogenase (IDH)-mutant acute myeloid leukemia (AML) is treatable with inhibitors of mutant IDH and also responds well to combination therapies including venetoclax, but most patients with IDH-mutant AML either never achieve complete remission or relapse because mutant hematopoietic stem cells persist despite treatment. An interesting new study in Blood Cancer Discovery characterizes a specific vulnerability in the mitochondrial oxidative phosphorylation system in preleukemic hematopoietic stem cells from patients with IDH1 mutations that is not present in those with IDH2 mutations; will this susceptibility prove amenable to therapy? See related article by Landberg et al., p. 114 (10).
    MeSH term(s) Humans ; Oxidative Phosphorylation ; Combined Modality Therapy ; Hematologic Neoplasms ; Hematopoietic Stem Cells ; Isocitrate Dehydrogenase/genetics ; Leukemia, Myeloid, Acute/genetics
    Chemical Substances Isocitrate Dehydrogenase (EC 1.1.1.41) ; IDH1 protein, human (EC 1.1.1.42.)
    Language English
    Publishing date 2024-02-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028898-8
    ISSN 2643-3249 ; 2643-3230
    ISSN (online) 2643-3249
    ISSN 2643-3230
    DOI 10.1158/2643-3230.BCD-23-0255
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Revisiting the first reported case of aplastic anaemia.

    Steensma, David P

    British journal of haematology

    2023  Volume 204, Issue 2, Page(s) 455–458

    Abstract: The great pathologist Paul Ehrlich in Berlin is commonly credited with describing the first clear case of aplastic anaemia in 1888: a 21-year-old woman who presented with haemorrhage and signs and symptoms of severe anaemia, quickly succumbing to her ... ...

    Abstract The great pathologist Paul Ehrlich in Berlin is commonly credited with describing the first clear case of aplastic anaemia in 1888: a 21-year-old woman who presented with haemorrhage and signs and symptoms of severe anaemia, quickly succumbing to her illness. Ehrlich's description of this patient's background and clinical course allowed individual identification. Re-analysis of this case suggests an inherited bone marrow failure syndrome as a possible additional diagnosis.
    MeSH term(s) Female ; Humans ; Young Adult ; Anemia, Aplastic/diagnosis
    Language English
    Publishing date 2023-12-03
    Publishing country England
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19241
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  5. Article ; Online: "Life Magnified:" The Beauty of the Microscopic World.

    Steensma, David P

    Mayo Clinic proceedings

    2022  Volume 98, Issue 7, Page(s) 1102–1103

    Language English
    Publishing date 2022-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.05.019
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  6. Article ; Online: Gedeon Richter: Hungarian Pharmaceutical Pioneer and Holocaust Victim.

    Steensma, David P / Kyle, Robert A

    Mayo Clinic proceedings

    2023  Volume 98, Issue 5, Page(s) 810–811

    MeSH term(s) Humans ; Holocaust ; Hungary ; Drug Industry ; Pharmaceutical Preparations
    Chemical Substances Pharmaceutical Preparations
    Language English
    Publishing date 2023-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.03.005
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  7. Article ; Online: Six Decades of Philatelic Vignettes: In Honor of Dr Robert A. Kyle's Contributions to Medicine and Stamps.

    Steensma, David P / Witzig, Thomas E

    Mayo Clinic proceedings

    2023  Volume 98, Issue 11, Page(s) 1737–1739

    MeSH term(s) Humans ; Medicine ; Philately
    Language English
    Publishing date 2023-11-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.09.012
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  8. Article ; Online: Misleading Medical Stamps: The 2022 "Monkeypox" Issues.

    Steensma, David P / Witzig, Thomas E

    Mayo Clinic proceedings

    2023  Volume 99, Issue 1, Page(s) 179–180

    MeSH term(s) Humans ; Mpox (monkeypox) ; Philately
    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 124027-4
    ISSN 1942-5546 ; 0025-6196
    ISSN (online) 1942-5546
    ISSN 0025-6196
    DOI 10.1016/j.mayocp.2023.11.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: How predictive is the finding of clonal hematopoiesis for the development of myelodysplastic syndromes (MDS) or acute myeloid leukemia (AML)?

    Steensma, David P

    Best practice & research. Clinical haematology

    2021  Volume 34, Issue 4, Page(s) 101327

    Abstract: Clonal hematopoiesis (CH) - a biological state in which one or a small number of hematopoietic stem or progenitor cells contribute disproportionately to blood cell production, usually as a result of somatic gene mutations in the stem cells - is often ... ...

    Abstract Clonal hematopoiesis (CH) - a biological state in which one or a small number of hematopoietic stem or progenitor cells contribute disproportionately to blood cell production, usually as a result of somatic gene mutations in the stem cells - is often considered to be a precursor to myeloid neoplasia, especially myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). However, the majority of people with CH never develop an overt myeloid neoplasm, and CH can be a precursor to lymphoid cancers as well as myeloid neoplasms. In addition, CH increases all-cause mortality and augments the risk of several non-neoplastic medical conditions, including atherosclerotic cardiovascular disease. CH can arise during aging, or in the context of an inherited marrow failure syndrome, aplastic anemia, or hematopoietic cell transplantation. Risk factors for progression of CH to myeloid neoplasia include larger clone size; the presence of a TP53, IDH1/2, or splicing mutation; multiple mutations; and associated cytopenias or abnormal red blood cell indices. The receipt of genotoxic chemotherapy or radiation, which can promote clonal expansion of mutant clones at the expense of healthy progenitor cells, may result in therapy-related MDS/AML.
    MeSH term(s) Clonal Hematopoiesis ; Hematopoiesis ; Humans ; Leukemia, Myeloid, Acute/genetics ; Mutation ; Myelodysplastic Syndromes/genetics ; Myelodysplastic Syndromes/therapy ; Myeloproliferative Disorders
    Language English
    Publishing date 2021-10-23
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2021.101327
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Does clonal hematopoiesis explain unexplained anemia?

    Steensma, David P

    Blood

    2020  Volume 135, Issue 14, Page(s) 1080–1082

    MeSH term(s) Anemia ; Hematopoiesis/genetics ; Humans
    Language English
    Publishing date 2020-04-24
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2020005293
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