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  1. Book: Contemporary approaches to myeloproliferative neoplasms

    McLornan, Donal

    a practical update

    (Best practice & research. Clinical haematology ; volume 35, issue 2 (June 2022))

    2022  

    Author's details Donal McLornan guest editors
    Series title Best practice & research. Clinical haematology ; volume 35, issue 2 (June 2022)
    Best practice & research
    Collection Best practice & research
    Language English
    Size 86 Seiten in verschiedenen Seitenzählungen, Illustrationen
    Publisher Elsevier
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT030011971
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 1029 -35,2- not available for loan Lesesaal EG

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  2. Book ; Online: Fast facts

    MCLornan, Donal / Harrison, Claire

    myelofibrosis

    (Fast Facts)

    2022  

    Abstract: This concise handbook is an indispensable read for anyone wanting to get up to speed with best practice in the diagnosis and care of people with myelofibrosis."-- ...

    Title variant Myleofibrosis
    Author's details Donal MCLornan, Claire Harrison
    Series title Fast Facts
    Abstract "This concise handbook is an indispensable read for anyone wanting to get up to speed with best practice in the diagnosis and care of people with myelofibrosis."--
    MeSH term(s) Primary Myelofibrosis
    Keywords Myelofibrosis ; Myelofibrosis/Treatment ; Molecular biology
    Subject code 572.8
    Language English
    Dates of publication 2022-2022
    Size 1 online resource (100 pages) :, illustrations.
    Edition First edition.
    Publisher S. Karger Publishers Ltd
    Publishing place Abingdon, Oxford
    Document type Book ; Online
    Note R2 Digital Library does not include index.
    ISBN 3-318-07109-9 ; 3-318-07080-7 ; 978-3-318-07080-4 ; 978-3-318-07109-2
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Preface.

    McLornan, Donal

    Best practice & research. Clinical haematology

    2022  Volume 35, Issue 2, Page(s) 101383

    Language English
    Publishing date 2022-09-09
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2022.101383
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: 'Fine tuning' Conditioning Protocols for Myelofibrosis to Reduce Graft Failure: are we making progress?

    McLornan, Dr Donal P

    Transplantation and cellular therapy

    2022  Volume 28, Issue 9, Page(s) 519–520

    MeSH term(s) Hematopoietic Stem Cell Transplantation ; Humans ; Primary Myelofibrosis ; Transplantation Conditioning
    Language English
    Publishing date 2022-08-27
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3062231-1
    ISSN 2666-6367
    ISSN (online) 2666-6367
    DOI 10.1016/j.jtct.2022.08.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5082: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article: Editorial: 50 years of BMT: risk stratification, donor matching and stem cell collection for transplantation.

    Hamerschlak, Nelson / Gómez-Almaguer, David / McLornan, Donal P

    Frontiers in oncology

    2023  Volume 13, Page(s) 1321334

    Language English
    Publishing date 2023-12-19
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1321334
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  6. Article ; Online: Diagnostic evaluation in bone marrow failure disorders: what have we learnt to help inform the transplant decision in 2024 and beyond?

    Ciangola, Giulia / Santinelli, Enrico / McLornan, Donal P / Pagliuca, Simona / Gurnari, Carmelo

    Bone marrow transplantation

    2024  Volume 59, Issue 4, Page(s) 444–450

    Abstract: Aplastic anemia (AA) is the prototypical bone marrow failure syndrome. In the current era of readily available 'molecular annotation', application of comprehensive next-generation sequencing panels has generated novel insights into underlying ... ...

    Abstract Aplastic anemia (AA) is the prototypical bone marrow failure syndrome. In the current era of readily available 'molecular annotation', application of comprehensive next-generation sequencing panels has generated novel insights into underlying pathogenetic mechanisms, potentially leading to improvements in personalized therapeutic approaches. New evidence has emerged as to the role of somatic loss of HLA class I allele expression in 'immune-mediated' AA, associated molecular aberrations, and risk of clonal evolution. A deeper understanding has emerged regarding the role of 'myeloid' gene mutations in this context, translating patho-mechanistic insights derived from wider clinical and translational research within the myeloid disorder arena. Here, we review contemporary 'tools' which aid in confirmation of a diagnosis of AA, with an additional focus on their potential in guiding therapeutic options. A specific emphasis is placed upon interpretation and integration of this detailed diagnostic information and how this may inform optimal transplantation strategies.
    MeSH term(s) Humans ; Anemia, Aplastic/diagnosis ; Anemia, Aplastic/genetics ; Anemia, Aplastic/therapy ; Bone Marrow Failure Disorders ; Mutation
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-024-02213-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The role of maintenance therapy following autologous stem cell transplantation in newly diagnosed multiple myeloma: Considerations on behalf of the Chronic Malignancies Working Party of the EBMT.

    Hwang, Angela / Hayden, Patrick / Pawlyn, Charlotte / McLornan, Donal / Garderet, Laurent

    British journal of haematology

    2024  Volume 204, Issue 4, Page(s) 1159–1175

    Abstract: Recent treatment advancements in multiple myeloma have led to significant improvements in patient outcomes. Maintenance therapy following autologous haematopoietic stem cell transplantation (AHCT) is now standard of care and has been demonstrated to ... ...

    Abstract Recent treatment advancements in multiple myeloma have led to significant improvements in patient outcomes. Maintenance therapy following autologous haematopoietic stem cell transplantation (AHCT) is now standard of care and has been demonstrated to prolong and deepen treatment responses. Currently, lenalidomide remains the single agent that has been approved for maintenance post-AHCT in Europe and the USA which, if tolerated, is continued until disease progression. The treatment landscape is rapidly expanding however, and the optimal personalised maintenance approach for a patient is becoming more complex. Treatment outcomes for patients with high-risk disease remain poor and choice of maintenance in this population also remains unclear. This review article evaluates up-to-date literature regarding established maintenance approaches. It further analyses ongoing studies exploring maintenance regimens using combination and novel agents, approaches to maintenance in patients with cytogenetic high-risk disease and minimal residual disease response-adapted strategies that reflect the current evolving treatment paradigm.
    MeSH term(s) Humans ; Multiple Myeloma/therapy ; Multiple Myeloma/drug therapy ; Hematopoietic Stem Cell Transplantation/adverse effects ; Transplantation, Autologous ; Lenalidomide ; Treatment Outcome ; Antineoplastic Combined Chemotherapy Protocols ; Stem Cell Transplantation
    Chemical Substances Lenalidomide (F0P408N6V4)
    Language English
    Publishing date 2024-02-23
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 80077-6
    ISSN 1365-2141 ; 0007-1048
    ISSN (online) 1365-2141
    ISSN 0007-1048
    DOI 10.1111/bjh.19353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Challenges of diagnosing and managing pre-fibrotic myelofibrosis: A case-based and practical approach.

    Rampotas, Alexandros / Hargreaves, Rupen / McLornan, Donal P

    Best practice & research. Clinical haematology

    2022  Volume 35, Issue 2, Page(s) 101378

    Abstract: Pre-Fibrotic Myelofibrosis is a frequently under-recognised entity that has distinct features separate to those of both Essential Thrombocythaemia and overt Primary Myelofibrosis. Misdiagnosis is relatively common due to subtle differences in bone marrow ...

    Abstract Pre-Fibrotic Myelofibrosis is a frequently under-recognised entity that has distinct features separate to those of both Essential Thrombocythaemia and overt Primary Myelofibrosis. Misdiagnosis is relatively common due to subtle differences in bone marrow trephine morphology and multidisciplinary approaches are required. The clinical phenotype and disease course is heterogeneous and hence management approaches tend to vary widely. Although patients may initially be asymptomatic, disease-related complications can include troublesome symptom burdens, increased incidence of both arterial and venous thromboses, haemorrhage, anaemia and an inherent risk of disease evolution to either overt myelofibrosis or blastic phase disease. Specific prognostic tools with high discriminatory power are lacking. Within this review we use case-based approaches to review the current literature, highlight challenges in both diagnostics and disease management and suggest contemporary approaches to improve patient outcomes.
    MeSH term(s) Humans ; Primary Myelofibrosis/diagnosis ; Primary Myelofibrosis/genetics ; Primary Myelofibrosis/therapy ; Thrombocythemia, Essential/diagnosis ; Thrombocythemia, Essential/genetics ; Thrombocythemia, Essential/therapy ; Bone Marrow ; Prognosis ; Disease Progression
    Language English
    Publishing date 2022-08-24
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2048027-1
    ISSN 1532-1924 ; 1521-6926
    ISSN (online) 1532-1924
    ISSN 1521-6926
    DOI 10.1016/j.beha.2022.101378
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  9. Article ; Online: Diagnostic and management strategies for Myeloproliferative Neoplasm-Unclassifiable (MPN-U): An international survey of contemporary practice.

    Hargreaves, Rupen / Harrison, Claire N / McLornan, Donal P

    Current research in translational medicine

    2022  Volume 70, Issue 3, Page(s) 103338

    Abstract: Myeloproliferative Neoplasm-Unclassifiable (MPN-U) is defined as an MPN that fails to meet the diagnostic criteria for any of the other defined classical or 'non-classical' MPNs. The reported incidence is variable, dependent on appropriate recognition, ... ...

    Abstract Myeloproliferative Neoplasm-Unclassifiable (MPN-U) is defined as an MPN that fails to meet the diagnostic criteria for any of the other defined classical or 'non-classical' MPNs. The reported incidence is variable, dependent on appropriate recognition, and the clinical course can be highly variable ranging from an indolent disorder through to an aggressive disease course with a significant risk of thrombosis, bulky splenomegaly, and debilitating symptom burden. Clinicians frequently manage these conditions according to the clinical concerns e.g. splenomegaly akin to the phenotype, but no evidence base exists. Currently, there are no widely accepted guidelines to deal with both the diagnostic work up and subsequent clinical management of this entity. We hence surveyed major International MPN centres to gain an understanding of common challenges in MPN-U management in 2021 and aid identification of considerable practice variations where harmonisation would be desirable. Such information is vital to support future consensus guidelines in addition to informing further collaborative studies.
    MeSH term(s) Humans ; Incidence ; Myeloproliferative Disorders/diagnosis ; Myeloproliferative Disorders/epidemiology ; Myeloproliferative Disorders/therapy ; Neoplasms ; Splenomegaly/diagnosis ; Splenomegaly/epidemiology ; Splenomegaly/etiology ; Surveys and Questionnaires
    Language English
    Publishing date 2022-02-23
    Publishing country France
    Document type Journal Article
    ISSN 2452-3186
    ISSN (online) 2452-3186
    DOI 10.1016/j.retram.2022.103338
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Update on VEXAS and role of allogeneic bone marrow transplant: Considerations on behalf of the Chronic Malignancies Working Party of the EBMT.

    Gurnari, Carmelo / McLornan, Donal P

    Bone marrow transplantation

    2022  Volume 57, Issue 11, Page(s) 1642–1648

    Abstract: VEXAS (acronym for Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a fascinating new entity encompassing a variety of clinical manifestations, spanning from auto-inflammatory symptoms to hematologic disorders, including myelodysplastic ... ...

    Abstract VEXAS (acronym for Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) is a fascinating new entity encompassing a variety of clinical manifestations, spanning from auto-inflammatory symptoms to hematologic disorders, including myelodysplastic syndromes and plasma cell dyscrasias. Genetically defined by somatic mutations of the X-linked gene UBA1 in hematopoietic stem and progenitor cells, VEXAS typically manifests in males during the fifth/sixth decade of life. Since its discovery, several groups have documented pleomorphic clinical phenotypes, in addition to a plethora of therapeutic options (e.g., JAK inhibitors, hypomethylating agents, and allogeneic stem cell transplant, allo-HCT) in retrospective case series. However, no treatment guidelines have been validated to date, VEXAS patients are typically steroid-dependent and may manifest life-threatening inflammatory symptoms refractory to multiple lines of therapy. To date, the only curative option appears to be allo-HCT in suitable individuals. Nonetheless, this procedure carries an inherent risk of morbidity and mortality that must be judiciously evaluated against a phenotypically diverse disorder where the optimal therapeutic algorithm remains ill-defined. Herein, we provide an overview of the current VEXAS data/ therapeutic evidence and discuss the curative potential of allo-HCT whilst highlighting the efforts required for generation of robust data able to inform therapeutic decisions.
    MeSH term(s) Male ; Humans ; Bone Marrow Transplantation ; Retrospective Studies ; Neoplasm Recurrence, Local ; Graft vs Host Disease ; Hematopoietic Stem Cell Transplantation/methods
    Language English
    Publishing date 2022-08-08
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 632854-4
    ISSN 1476-5365 ; 0268-3369 ; 0951-3078
    ISSN (online) 1476-5365
    ISSN 0268-3369 ; 0951-3078
    DOI 10.1038/s41409-022-01774-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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