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  1. Article ; Online: Antiaggreganti piastrinici e anticoagulanti

    Francesco Dentali / Mauro Silingardi

    Italian Journal of Medicine, Vol 11, Iss

    le competenze dell’internista

    2023  Volume 1

    Abstract: ... Giustozzi, C. Becattini La terapia del tromboembolismo venoso. F. Dentali La terapia anticoagulante ...

    Abstract La terapia antiaggregante nelle sindromi coronariche acute. S. De Servi, A. Landi, C. Montalto, G. Crimi, S. Savonitto La terapia antiaggregante nella vasculopatia cerebrale acuta. M. Giorgi Pierfranceschi Impiego degli anticoagulanti nella fibrillazione atriale. B. Broccatelli, A. Patriarchi, M. Giustozzi, C. Becattini La terapia del tromboembolismo venoso. F. Dentali La terapia anticoagulante nel paziente oncologico. M. Ziliotti, L. Terroni, M.C. Ugolotti, C. Cademartiri La terapia anticoagulante orale nel paziente anziano, fragile o complesso. A. Dellasalda, A.Tedde, D. Arioli
    Keywords Antiaggreganti piastrinici ; Anticoagulanti ; Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: The Use of Risk Scores for Thromboprophylaxis in Medically Ill Patients-Rationale and Design of the RICO trial.

    Dentali, Francesco / Campanini, Mauro / Bonaventura, Aldo / Fontanella, Luca / Zuretti, Francesca / Tavecchia, Luca / Mumoli, Nicola / Gnerre, Paola / Ventrella, Francesco / Giustozzi, Michela / Valerio, Antonella / Fontanella, Andrea

    TH open : companion journal to thrombosis and haemostasis

    2024  Volume 8, Issue 1, Page(s) e55–e60

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-01-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2901738-5
    ISSN 2512-9465 ; 2567-3459
    ISSN (online) 2512-9465
    ISSN 2567-3459
    DOI 10.1055/a-2209-4708
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  3. Article ; Online: Lack of efficacy of direct oral anticoagulants compared to warfarin in antiphospholipid antibody syndrome.

    Giarretta, Igor / Ageno, Walter / Dentali, Francesco

    Haematologica

    2022  Volume 107, Issue 11, Page(s) 2737–2741

    MeSH term(s) Humans ; Warfarin/therapeutic use ; Antiphospholipid Syndrome/drug therapy ; Anticoagulants/therapeutic use ; Rivaroxaban/therapeutic use ; Administration, Oral
    Chemical Substances Warfarin (5Q7ZVV76EI) ; Anticoagulants ; Rivaroxaban (9NDF7JZ4M3)
    Language English
    Publishing date 2022-11-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2333-4
    ISSN 1592-8721 ; 0017-6567 ; 0390-6078
    ISSN (online) 1592-8721
    ISSN 0017-6567 ; 0390-6078
    DOI 10.3324/haematol.2022.281586
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  4. Article ; Online: A FADOI survey on the quality of discharge summary in internal medicine wards.

    Gnerre, Paola / Barbagelata, Elena / Tangianu, Flavio / Zuretti, Francesca / Dentali, Francesco

    Internal and emergency medicine

    2022  Volume 17, Issue 7, Page(s) 2175–2178

    MeSH term(s) Hospitals ; Humans ; Internal Medicine ; Patient Discharge ; Surveys and Questionnaires
    Language English
    Publishing date 2022-05-28
    Publishing country Italy
    Document type Letter
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-022-03013-w
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  5. Article ; Online: No contraindication to internal jugular central venous catheter insertion in patients at increased risk of bleeding: Results from a prospective observational study in a internal medicine department.

    Mumoli, Nicola / Mereghetti, Marco / Capra, Riccardo / Pistoia, Matteo / Dalla Torre, Laura / Dentali, Francesco / Giarretta, Igor

    The journal of vascular access

    2024  , Page(s) 11297298241227248

    Abstract: Implantation of centrally inserted central venous catheter (CICC) may be complicated by bleedings particularly in patients with severe coagulopathy or taking antithrombotic drugs. It has been shown that the application of the Italian Group for Venous ... ...

    Abstract Implantation of centrally inserted central venous catheter (CICC) may be complicated by bleedings particularly in patients with severe coagulopathy or taking antithrombotic drugs. It has been shown that the application of the Italian Group for Venous Access Devices (GAVeCeLT) bundle reduces the incidence of bleeding in patients admitted to intensive care units (ICU), but its effectiveness has never been demonstrated in different contexts. In this study we evaluated the incidence of bleeding after urgent internal jugular CICC (J-CICC) implantation in patients with increased or no risk of bleeding complications when recommended preventive strategies are applied systematically. We included 185 patients admitted to Internal Medicine Units who underwent urgent J-CICC implantation from April 2016 to December 2018. The incidence of major and minor bleeding immediately after the procedure and in the following 30 days was recorded. None of the enrolled patients showed major bleeding. The incidence of minor bleedings was 2.1% (95% IC: 0.03-4.2) with two patients requiring line removal and repositioning (1.1%; 95% IC: -0.45 to 2.6). Bleeds were not correlated with age or sex, although they all occurred in female subjects. The incidence of bleeds was not increased in patients with increased risk of bleeding compared with those without (5.0% vs 1.3%;
    Language English
    Publishing date 2024-02-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2252820-9
    ISSN 1724-6032 ; 1129-7298
    ISSN (online) 1724-6032
    ISSN 1129-7298
    DOI 10.1177/11297298241227248
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  6. Article ; Online: Progetto FADOI “EUCLIDE”. Clinica, comunicazione, telemedicina e governance

    Dario Manfellotto / Francesco Dentali / Andrea Fontanella

    Italian Journal of Medicine, Vol 10, Iss

    le esperienze da COVID-19 per il futuro della Medicina Interna

    2022  Volume 1

    Abstract: Introduzione Dario Manfellotto, Francesco Dentali, Andrea Fontanella Materiali e Metodi Dario ... Manfellotto, Francesco Dentali, Andrea Fontanella Gestione clinica del paziente complesso con patologie ... Considerazioni conclusive Dario Manfellotto, Francesco Dentali, Andrea Fontanella ...

    Abstract Introduzione Dario Manfellotto, Francesco Dentali, Andrea Fontanella Materiali e Metodi Dario Manfellotto, Francesco Dentali, Andrea Fontanella Gestione clinica del paziente complesso con patologie cardiovascolari e comorbilità Giuseppe Campagna, Claudia Ferrigno, Franco Mastroianni Gestione clinica del paziente complesso con diabete e comorbilità Ada Maffettone, Ernesto De Menis, Maria Serena Fiore Cura e comunicazione: l’esperienza nella pandemia e le prospettive future Luigi Magnani, Lara Bellardita, Salvatore Lenti Gestione a distanza del paziente complesso: la medicina digitale Filippo Pieralli, Flavio Tangianu, Maria Gabriella Coppola Governance per la Medicina Interna Andrea Montagnani, Roberta Re, Ilario Stefani Considerazioni conclusive Dario Manfellotto, Francesco Dentali, Andrea Fontanella
    Keywords Progetto EUCLIDE ; Medicine ; R
    Language English
    Publishing date 2022-09-01T00:00:00Z
    Publisher PAGEPress Publications
    Document type Article ; Online
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  7. Article ; Online: Rates of venous thromboembolism and use of thromboprophylaxis after major orthopedic surgery in patients with congenital hemophilia A or B: a systematic review.

    Santagata, Davide / Abenante, Alessia / Squizzato, Alessandro / Dentali, Francesco / Donadini, Marco Paolo / Ageno, Walter / Pabinger, Ingrid / Tiede, Andreas / Ay, Cihan

    Journal of thrombosis and haemostasis : JTH

    2024  Volume 22, Issue 4, Page(s) 1117–1131

    Abstract: Background: Venous thromboembolism (VTE) is a well-recognized complication after total joint replacement (TJR). Persons with hemophilia A or B are considered at low postoperative VTE risk due to their coagulation factor deficiencies, and administering ... ...

    Abstract Background: Venous thromboembolism (VTE) is a well-recognized complication after total joint replacement (TJR). Persons with hemophilia A or B are considered at low postoperative VTE risk due to their coagulation factor deficiencies, and administering pharmacologic thromboprophylaxis is often considered contraindicated. However, using factor replacement therapy could increase the postoperative VTE risk.
    Objectives: To analyze best available evidences of VTE rates in persons with hemophilia A or B undergoing lower limb TJR and the use of postoperative pharmacologic thromboprophylaxis.
    Methods: We systematically screened 4 online biomedical databases to identify studies reporting VTE rates in patients with hemophilia after TJR. Case reports and case series with less than 10 patients were excluded.
    Results: Twenty-six observational studies were included in this systematic review, reporting 1181 TJRs in patients with hemophilia A or B. Eight studies had VTE rates as the primary outcome. Five studies reported screen-detected VTE, while 21 reported symptomatic VTE events. Overall, 17 VTE events were reported (1.4%; 95% CI, 0.9%-2.3%), including 10 (6.6%) after 151 surgeries with postoperative VTE screening and 7 (0.7%) after 1080 surgeries without postoperative screening. Thromboprophylaxis protocols were specified in 21 studies; postoperative thromboprophylaxis was used in 15 (1.3%) surgeries. This information was not available for 29.0% of the analyzed population.
    Conclusion: Despite the low thromboprophylaxis use in patients with hemophilia, rates of symptomatic VTE after TJR appeared to be low. We also highlighted the need to better report the thrombotic outcome in persons with hemophilia to face the ongoing changes in the hemophilia landscape.
    MeSH term(s) Humans ; Anticoagulants/therapeutic use ; Hemophilia A/complications ; Hemophilia A/drug therapy ; Hemophilia A/surgery ; Venous Thromboembolism/diagnosis ; Venous Thromboembolism/epidemiology ; Venous Thromboembolism/etiology ; Arthroplasty, Replacement/adverse effects ; Postoperative Complications/prevention & control ; Postoperative Complications/epidemiology
    Chemical Substances Anticoagulants
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Systematic Review ; Journal Article
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1016/j.jtha.2023.12.036
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  8. Article ; Online: Recommendations for the management of hyperkalemia in patients receiving renin-angiotensin-aldosterone system inhibitors.

    De Nicola, Luca / Ferraro, Pietro Manuel / Montagnani, Andrea / Pontremoli, Roberto / Dentali, Francesco / Sesti, Giorgio

    Internal and emergency medicine

    2023  Volume 19, Issue 2, Page(s) 295–306

    Abstract: Hyperkalemia is common in clinical practice and can be caused by medications used to treat cardiovascular diseases, particularly renin-angiotensin-aldosterone system inhibitors (RAASis). This narrative review discusses the epidemiology, etiology, and ... ...

    Abstract Hyperkalemia is common in clinical practice and can be caused by medications used to treat cardiovascular diseases, particularly renin-angiotensin-aldosterone system inhibitors (RAASis). This narrative review discusses the epidemiology, etiology, and consequences of hyperkalemia, and recommends strategies for the prevention and management of hyperkalemia, mainly focusing on guideline recommendations, while recognizing the gaps or differences between the guidelines. Available evidence emphasizes the importance of healthcare professionals (HCPs) taking a proactive approach to hyperkalemia management by prioritizing patient identification and acknowledging that hyperkalemia is often a long-term condition requiring ongoing treatment. Given the risk of hyperkalemia during RAASi treatment, it is advisable to monitor serum potassium levels prior to initiating these treatments, and then regularly throughout treatment. If RAASi therapy is indicated in patients with cardiorenal disease, HCPs should first treat chronic hyperkalemia before reducing the dose or discontinuing RAASis, as reduction or interruption of RAASi treatment can increase the risk of adverse cardiovascular and renal outcomes or death. Moreover, management of hyperkalemia should involve the use of newer potassium binders, such as sodium zirconium cyclosilicate or patiromer, as these agents can effectively enable optimal RAASi treatment. Finally, patients should receive education regarding hyperkalemia, the risks of discontinuing their current treatments, and need to avoid excessive dietary potassium intake.
    MeSH term(s) Humans ; Renin-Angiotensin System ; Hyperkalemia ; Renal Insufficiency, Chronic/complications ; Potassium ; Kidney ; Heart Failure/complications
    Chemical Substances Potassium (RWP5GA015D)
    Language English
    Publishing date 2023-09-29
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03427-0
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  9. Article ; Online: PCSK9 as a New Player in Cancer: New Opportunity or Red Herring?

    Bonaventura, Aldo / Vecchié, Alessandra / Ruscica, Massimiliano / Grossi, Francesco / Dentali, Francesco

    Current medicinal chemistry

    2021  Volume 29, Issue 6, Page(s) 960–969

    Abstract: Initially described as a factor involved in liver regeneration and neuronal differentiation, proprotein convertase subtilisin/kexin type 9 (PCSK9) has become one of the key regulators of low-density lipoprotein cholesterol. Beside that, a number of ... ...

    Abstract Initially described as a factor involved in liver regeneration and neuronal differentiation, proprotein convertase subtilisin/kexin type 9 (PCSK9) has become one of the key regulators of low-density lipoprotein cholesterol. Beside that, a number of studies have suggested PCSK9 may play a role in cancer biology. This is particularly true for gastroenteric (gastric and liver cancers) and lung cancers, where higher PCSK9 levels were associated with the increased ability of the tumor to develop and give metastasis as well as with reduced overall survival. Accordingly, monoclonal antibodies blocking PCSK9 were recently shown to synergize with immunotherapy in different types of cancers to achieve tumor growth suppression through an increased intratumoral infiltration of cytotoxic T cells. Anti-PCSK9 vaccines have been tested in animal models with encouraging results only in colon carcinoma. As most of this evidence is based on pre-clinical studies, this has led to some controversies and inconsistencies, thus suggesting that additional research is needed to clarify the topic. Finally, modulation of intracellular PCSK9 levels by silencing RNA (siRNA) may help understand the physiological and pathological mechanisms of PCSK9.
    MeSH term(s) Animals ; Cholesterol, LDL ; Humans ; Liver Neoplasms ; Proprotein Convertase 9 ; Receptors, LDL
    Chemical Substances Cholesterol, LDL ; Receptors, LDL ; PCSK9 protein, human (EC 3.4.21.-) ; Proprotein Convertase 9 (EC 3.4.21.-)
    Language English
    Publishing date 2021-11-15
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1319315-6
    ISSN 1875-533X ; 0929-8673
    ISSN (online) 1875-533X
    ISSN 0929-8673
    DOI 10.2174/0929867328666211115122324
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  10. Article ; Online: ACP Journal Club. Less-frequent warfarin dose assessment was noninferior for patients with stable INRs.

    Dentali, Francesco

    Annals of internal medicine

    2012  Volume 156, Issue 6, Page(s) JC3–3

    Language English
    Publishing date 2012-03-20
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 336-0
    ISSN 1539-3704 ; 0003-4819
    ISSN (online) 1539-3704
    ISSN 0003-4819
    DOI 10.7326/0003-4819-156-6-201203200-02003
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