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Article ; Online: Arsenic pollution concerning surface water and sediment of Jie River: A pilot area where gold smelting enterprises are concentrated.

Jin, Yan / Zhu, Weichen / Li, Jia / Cui, Dayong / Zhang, Zhibin / Sun, Guoxin / Zhu, Yongguan / Yang, Huanhuan / Zhang, Xu

Environmental research

2024 Volume 249, Page(s) 118384

Abstract: ... and sediment is performed in the Jie River basin, where gold smelting enterprises are concentrated ... euglena are the main phytoplankton in the Jie River while toxic cyanobacteria exhibits lower resistance ...

Abstract	A comprehensive monitoring and risk assessment of arsenic (As) pollution concerning surface water and sediment is performed in the Jie River basin, where gold smelting enterprises are concentrated. The study area is divide into six regions, labeled as A, B, C, D, E, and F, from sewage outlets to downstream. Results shows that with far away from the sewage outlets, the total As concentrations in water and sediment gradually decrease from regions A to F. However, in region F, the concentration of bioavailable As significantly increases in the sediment due to the higher pH, leading to the transformation of As(V) into more mobile As(III). In sediment, Paracladius sp. exhibits strong resistance to As pollution in sediment, which can potentially elevate the risk of disease transmission. In water bodies, diatoms and euglena are the main phytoplankton in the Jie River while toxic cyanobacteria exhibits lower resistance to As pollution. Overall, measures should be taken to ecologically remediate the sediment in downstream while implementing appropriate isolation methods to prevent the spread of highly contaminated sediments from regions near sewage outlets.
Language	English
Publishing date	2024-02-01
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2024.118384
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Zs.A 726: Show issues

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Article ; Online: Huang-Lian-Jie-Du decoction alleviates depressive-like behaviors in dextran sulfate sodium-induced colitis mice via Trem2/Dap12 pathway.

Zheng, Jia-Yi / Li, Xiao-Xiao / Lin, Wei-Yao / Su, Shan / Wu, Hai-Cui / Hu, Rui-Dan / Pan, Hua-Feng / Ye, Jiang-Hong / Cai, Ye-Feng / Zhang, Shi-Jie

Journal of ethnopharmacology

2023 Volume 315, Page(s) 116658

Abstract: Ethnopharmacological relevance: Huang-Lian-Jie-Du decoction (HLJD), a traditional Chinese medicine ...

Abstract	Ethnopharmacological relevance: Huang-Lian-Jie-Du decoction (HLJD), a traditional Chinese medicine prescription, has been implicated as effective in treating colitis, depression and inflammation-related diseases. Whether HLJD decoction could ameliorate colitis-induced depression was still unknown and the underlying mechanism was needed to be clarified. Aim of the study: Our study aimed to explore the effect and the underlying mechanism of HLJD treatment on colitis-induced depression and the involvement of the inflammatory factors and microglial-activated related genes. Materials and methods: The chronic colitis model was established by treating male mice with 1% dextran sulfate sodium (DSS) for 8 weeks. One week after DSS-treated, HLJD decoction was administered orally with 2 and 4 g/kg daily for 7 weeks. Behavior tests (Open field/Elevated plus maze/Novel object recognition) and TUNEL staining were then assessed. The expression of inflammatory-related genes and microglial dysregulation were measured by RT-PCR and the expression of Trem2, Danp12 and Iba1 were assessed by immunofluorescence methods. Results: Depressive-like behaviors were observed in mice treated with DSS, which suffered colitis. Compared to normal control (NC-V) mice, the density of TUNEL + cells in the habenula (Hb), hippocampus (HIP), and cortex were significantly higher in colitis (DSS-V) mice, especially in Hb. Compared to NC-V and several brain regions, the expression levels of the Il-1β, Il-10 and Dap12 mRNA were significantly increased in the lateral habenula (LHb) of colitis mice. Moreover, the expression of Trem2, Dap12 and Iba1 were increased in LHb of DSS-V mice. HLJD treatment could alleviate depressive-like behaviors, reduce the density of TUNEL + cells in Hb and the expression of Il-6, Il-10 and Dap12 mRNA in LHb of DSS-V mice. The overexpression of Trem2, Dap12 and Iba1 in LHb of DSS-V mice were reversed after HLJD treatment. Conclusion: These results reveal LHb is an important brain region during the process of colitis-induced depression. HLJD treatment could alleviates depressive-like behaviors in colitis mice via inhibiting the Trem2/Dap12 pathway in microglia of LHb, which would contribute to the precise treatment. It provides a potential mechanistic explanation for the effectiveness of HLJD treatment in colitis patients with depression.
MeSH term(s)	Male ; Animals ; Mice ; Interleukin-10/metabolism ; Dextran Sulfate ; Colitis/chemically induced ; Colitis/drug therapy ; Colitis/metabolism ; Drugs, Chinese Herbal/adverse effects ; Mice, Inbred C57BL ; Disease Models, Animal ; Colitis, Ulcerative/drug therapy ; Colon ; Membrane Glycoproteins/metabolism ; Receptors, Immunologic/metabolism
Chemical Substances	oren gedoku to ; Interleukin-10 (130068-27-8) ; Dextran Sulfate (9042-14-2) ; Drugs, Chinese Herbal ; Trem2 protein, mouse ; Membrane Glycoproteins ; Receptors, Immunologic
Language	English
Publishing date	2023-05-30
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116658
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Zs.A 1494: Show issues

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Article ; Online: San Jie Tong Mai Fang Protects Against Atherosclerosis Progression by Regulating Macroautophagy through the PI3K/AKT/mTOR Signaling Pathway.

Li, Pengfei / Li, Hongyu / Li, Xiaohui / Li, Shuangdi / Xu, Hanying / Cui, Junfeng / Cheng, Guangyu / Liu, Yinghui / Xu, Xiaolin / Xin, Yuning / Liu, Aidong

Journal of cardiovascular pharmacology

2023 Volume 82, Issue 4, Page(s) 333–343

Abstract: ... autophagy. We previously reported that the herbal formula San Jie Tong Mai Fang (SJTMF) elicits lipid ...

Abstract	Abstract: Many studies have confirmed that macrophage autophagy injury negatively impacts the pathogenesis of atherosclerosis (AS). Meanwhile, the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway affects AS progression by regulating macrophage autophagy. We previously reported that the herbal formula San Jie Tong Mai Fang (SJTMF) elicits lipid regulatory and anti-inflammatory properties. Hence, the current study used an ApoE -/- high-fat diet-fed mouse model to determine whether SJTMF elicits protective effects against AS progression by means of the regulation of macrophage autophagy through the PI3K/AKT/mTOR signaling pathway. Our results show that SJTMF reduced the number of atherosclerotic plaques, foam cell formation, and intimal thickness in mouse aorta. In addition, SJTMF improved blood lipid metabolism and inflammatory levels in mice. We also observed that SJTMF caused macrophages to be polarized toward the M2 phenotype through the inhibition of the PI3K/AKT/mTOR signaling pathway. In addition, the abundances of LC3-II/I and beclin1 proteins-key autophagy molecules-were increased, whereas that of p62 was decreased, resulting in the promotion of macrophage autophagy. Taken together, these findings indicate that SJTMF may regulate the polarization of macrophages by inhibiting the PI3K/AKT/mTOR signaling pathway, thereby reducing atherosclerotic plaque damage in ApoE -/- mice, thereby promoting macrophage autophagy and eliciting a significant antiarteriosclerosis effect. Hence, SJTMF may represent a promising new candidate drug for the treatment of AS.
MeSH term(s)	Mice ; Animals ; Proto-Oncogene Proteins c-akt/metabolism ; Phosphatidylinositol 3-Kinases/metabolism ; Phosphatidylinositol 3-Kinase/metabolism ; Macroautophagy ; TOR Serine-Threonine Kinases/metabolism ; Mice, Knockout, ApoE ; Signal Transduction ; Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Atherosclerosis/genetics ; Plaque, Atherosclerotic ; Autophagy ; Apolipoproteins E/pharmacology ; Mammals/metabolism
Chemical Substances	Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Phosphatidylinositol 3-Kinase (EC 2.7.1.137) ; TOR Serine-Threonine Kinases (EC 2.7.11.1) ; Apolipoproteins E
Language	English
Publishing date	2023-10-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	391970-5
ISSN	1533-4023 ; 0160-2446
ISSN (online)	1533-4023
ISSN	0160-2446
DOI	10.1097/FJC.0000000000001452
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Zs.A 1471: Show issues

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Article: He-Jie-Shen-Shi Decoction as an Adjuvant Therapy on Severe Coronavirus Disease 2019: A Retrospective Cohort and Potential Mechanistic Study.

Hu, Haibo / Wang, Kun / Wang, Li / Du, Yanjun / Chen, Juan / Li, Yongchun / Fan, Chuanbo / Li, Ning / Sun, Ying / Tu, Shenghao / Lu, Xuechao / Zhou, Zhaoshan / Cui, Huantian

Frontiers in pharmacology

2021 Volume 12, Page(s) 700498

Abstract: ... on coronavirus disease 2019 (COVID-19). The He-Jie-Shen-Shi decoction (HJSS), composed of ...

Abstract	Combination therapy using Western and traditional Chinese medicines has shown notable effects on coronavirus disease 2019 (COVID-19). The He-Jie-Shen-Shi decoction (HJSS), composed of
Language	English
Publishing date	2021-06-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.700498
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Article: Qing-Wen-Jie-Re Mixture Ameliorates Poly (I:C)-Induced Viral Pneumonia Through Regulating the Inflammatory Response and Serum Metabolism.

Li, Qin / Zhang, Tingrui / Wang, Yuming / Yang, Shangsong / Luo, Junyu / Fang, Fang / Liao, Jiabao / Wen, Weibo / Cui, Huantian / Shang, Hongcai

Frontiers in pharmacology

2022 Volume 13, Page(s) 891851

Abstract: Qing-Wen-Jie-Re mixture (QWJR) has been used in the treatment of the coronavirus disease 2019 ...

Abstract	Qing-Wen-Jie-Re mixture (QWJR) has been used in the treatment of the coronavirus disease 2019 (COVID-19) in China. However, the protective mechanisms of QWJR on viral pneumonia remain unclear. In the present study, we first investigated the therapeutic effects of QWJR on a rat viral pneumonia model established by using polyinosinic-polycytidylic acid (poly (I:C)). The results indicated that QWJR could relieve the destruction of alveolar-capillary barrier in viral pneumonia rats, as represented by the decreased wet/dry weight (W/D) ratio in lung, total cell count and total protein concentration in bronchoalveolar lavage fluid (BALF). Besides, QWJR could also down-regulate the expression of inflammatory factors such as tumor necrosis factor-alpha (TNF-α), interleukin (IL)-1β and IL-6. More M1-type macrophage polarization was detected by calculating CD86
Language	English
Publishing date	2022-06-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.891851
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Article: Qu-Yu-Jie-Du Decoction Ameliorates Dextran Sulfate Sodium-Induced Colitis in Mice by Modulation of Neutrophils and Macrophage Infiltration.

Zhao, Hongwei / Sun, Lingling / Xiao, Xi / Lin, Jietao / Shao, Cui / Lin, Lizhu

Evidence-based complementary and alternative medicine : eCAM

2022 Volume 2022, Page(s) 3762591

Abstract: ... patients will not react to therapy or will lose their response. Qu-Yu-Jie-Du Decoction (QYJD) is ...

Abstract	Background: Inflammatory bowel disease (IBD) is becoming a global disease. A percentage of IBD patients will not react to therapy or will lose their response. Qu-Yu-Jie-Du Decoction (QYJD) is a traditional Chinese medicine formula commonly used for intestinal diseases. It has been reported that QYJD has an anti-inflammatory effect, but the mechanism is not fully understood. In this study, we mainly evaluated the anti-inflammatory effect of QYJD and explored the possible mechanisms. Methods: Twenty-four BALB/ Results: QYJD alleviated the weight loss and colitis symptoms of mice caused by DSS. QYJD fought against the shortening of the intestine caused by DSS; that is, it improved the decline of intestinal compliance in mice and had a protective effect on colon tissues. The mechanisms were related to downregulating macrophages and neutrophils in colon tissues of infiltration. Besides, QYJD simultaneously reduced the activity of myeloperoxidase activity (MPO) and the contents of IL-1 Conclusions: QYJD can ameliorate DSS-induced colitis in mice and the mechanism is connected with a reduction in neutrophil and macrophage infiltration.
Language	English
Publishing date	2022-12-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2022/3762591
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Zs.A 5995: Show issues

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Article ; Online: Dynamical Variations of the Global COVID-19 Pandemic Based on a SEICR Disease Model: A New Approach of Yi Hua Jie Mu.

Wang, Xia / Yin, Gang / Hu, Zengyun / He, Daihai / Cui, Qianqian / Feng, Xiaomei / Teng, Zhidong / Hu, Qi / Li, Jiansen / Zhou, Qiming

GeoHealth

2021 Volume 5, Issue 8, Page(s) e2021GH000455

Abstract: ... Jie Mu is proposed to obtain the transmission rates based on the COVID-19 data between the countries ...

Abstract	The ongoing coronavirus disease 2019 (COVID-19) pandemic has caused more than 150 million cases of infection to date and poses a serious threat to global public health. In this study, global COVID-19 data were used to examine the dynamical variations from the perspectives of immunity and contact of 84 countries across the five climate regions: tropical, arid, temperate, and cold. A new approach named Yi Hua Jie Mu is proposed to obtain the transmission rates based on the COVID-19 data between the countries with the same climate region over the Northern Hemisphere and Southern Hemisphere. Our results suggest that the COVID-19 pandemic will persist over a long period of time or enter into regular circulation in multiple periods of 1-2 years. Moreover, based on the simulated results by the COVID-19 data, it is found that the temperate and cold climate regions have higher infection rates than the tropical and arid climate regions, which indicates that climate may modulate the transmission of COVID-19. The role of the climate on the COVID-19 variations should be concluded with more data and more cautions. The non-pharmaceutical interventions still play the key role in controlling and prevention this global pandemic.
Language	English
Publishing date	2021-08-01
Publishing country	United States
Document type	Journal Article
ISSN	2471-1403
ISSN (online)	2471-1403
DOI	10.1029/2021GH000455
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Book: Ying xiang jie pou xue tu jie

Cui, Lei

zheng chang, bian yi, wu pan

(Ying xiang jie pou yu lin chuang tu jie cong shu)

2014

Author's details	zhu bian Cui Lei
Series title	Ying xiang jie pou yu lin chuang tu jie cong shu
MeSH term(s)	Anatomy/methods ; Diagnostic Imaging/methods
Language	Chinese
Size	3, 248 pages :, illustrations
Edition	Di 1 ban.
Document type	Book
ISBN	9787509174302 ; 7509174309
Database	Catalogue of the US National Library of Medicine (NLM)

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Book ; Audio / Video: Xin HSK ying shi quan jie xi. Wu ji

Dong, Cui

2014

Author's details	edited by Dong Cui
Language	Chinese ; English
Size	IV, 4, 324 S., 1 CD-ROM
Edition	1. Auflage
Publisher	Beijing language and culture university press
Publishing place	Beijing
Document type	Book ; Audio / Video
ISBN	9787561937587 ; 756193758X
Database	Former special subject collection: coastal and deep sea fishing

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Article: Effect of Yi-nao-jie-yu decoction on γ-aminobutyric acid type A receptor in the hippocampus and serum inflammatory factors in a rat model of poststroke anxiety.

Zhang, Wen / Zhao, Ruizhen / Li, Xiaoli / Cui, Xia / Zhao, Zijun / Mao, Yingqiu / Wu, Fengzhi / Tang, Qisheng

Neuropsychiatric disease and treatment

2016 Volume 12, Page(s) 2827–2837

Abstract: Background: The Yi-nao-jie-yu decoction (YNJYD) is a herbal preparation widely used in the clinics ...

Abstract	Background: The Yi-nao-jie-yu decoction (YNJYD) is a herbal preparation widely used in the clinics of traditional Chinese medicine and has been recently used as an important new therapeutic agent in poststroke anxiety (PSA). The neuroendocrine-immune system plays an important role in PSA mechanisms, although the modulating effects of YNJYD remain unknown. This study investigated the potential effects of YNJYD on the neuroendocrine-immune system in a rat model of PSA. Materials and methods: The PSA model was induced by injecting collagenase (type VII) into the right globus pallidus, accompanied by empty water bottle stimulation for 2 weeks. The sham group and the PSA model group were gavaged with saline, while the treatment groups received buspirone (BuSpar) or YNJYD. Behavior was evaluated with the open field test and elevated plus maze once a week. Pathological changes were observed by hematoxylin and eosin staining. Serum levels of tumor necrosis factor, interleukin (IL)-6, adrenocorticotropic hormone, thyroid stimulating hormone, free triiodothyronine, free thyroxine, IL-1α, and cortisol were detected by radioimmunoassay. Expression of the γ-aminobutyric acid type A receptor (GABA Results: YNJYD-treated rats exhibited significantly better recovery than BuSpar-treated rats at 21 days and 28 days in the open field test and elevated plus maze. Hematoxylin and eosin staining revealed neural repair in the hippocampus in the treatment groups. Serum levels of IL-1α in the YNJYD group were significantly less than those in the model group and the BuSpar group. GABA Conclusion: YNJYD alleviated the symptoms of PSA mainly by decreasing IL-1α levels and downregulating GABA
Language	English
Publishing date	2016-11-01
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2186503-6
ISSN	1178-2021 ; 1176-6328
ISSN (online)	1178-2021
ISSN	1176-6328
DOI	10.2147/NDT.S115116
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