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Article: Recurrent gynandroblastoma of the ovary with germline

Mercier, Ann Marie / Zorn, Kristin K / Quick, Charles M / Huffman, Laura B

2021 Volume 37, Page(s) 100806

Abstract: Sex cord-stromal tumors (SCSTs) are ovarian tumors that generally present with an adnexal mass and signs/symptoms of hormone excess. Gynandroblastoma is a rare subtype of SCST with a combination of female and male sex cord differentiation. These tumors ... ...

Abstract	Sex cord-stromal tumors (SCSTs) are ovarian tumors that generally present with an adnexal mass and signs/symptoms of hormone excess. Gynandroblastoma is a rare subtype of SCST with a combination of female and male sex cord differentiation. These tumors typically present in premenopausal women and are diagnosed at early stages with benign clinical courses. Here, we present a rare case of recurrent gynandroblastoma in a premenopausal woman with a
Language	English
Publishing date	2021-06-07
Publishing country	Netherlands
Document type	Case Reports
ZDB-ID	2818505-5
ISSN	2352-5789
ISSN	2352-5789
DOI	10.1016/j.gore.2021.100806
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Article ; Online: Does the addition of radiation improve survival compared to chemotherapy alone in women with stage IV endometrial carcinoma? Analysis of the NCDB and SEER databases.

Barrington, David A / Fox, Brandon / Meade, Caitlin / Quick, Allison / Felix, Ashley S / Chambers, Laura M

Gynecologic oncology

2022 Volume 165, Issue 3, Page(s) 522–529

Abstract: Objective: To evaluate whether the addition of radiation to adjuvant chemotherapy is associated with improved survival in women with stage IV endometrial cancer following surgery.: Methods: The National Cancer Database (NCDB) and Surveillance, ... ...

Abstract	Objective: To evaluate whether the addition of radiation to adjuvant chemotherapy is associated with improved survival in women with stage IV endometrial cancer following surgery. Methods: The National Cancer Database (NCDB) and Surveillance, Epidemiology, and End Results Program (SEER) registries were queried for patients with stage IV endometrial cancer from 2004 to 2017. Treatment was categorized as chemotherapy alone, chemotherapy with external beam radiation therapy (EBRT), chemotherapy with vaginal brachytherapy (VBT), or chemotherapy with EBRT+VBT. Multivariable Cox regression models assessed associations between treatment modality and overall survival (OS). Results: This analysis included 17,890 (NCDB: 12,812, SEER: 5078) women with stage IV endometrial cancer, including 1757 (9.8%) with IVA disease and 16,133 (90.2%) with IVB. The majority of stage IV patients received chemotherapy alone (NCDB 78.8%, SEER 77.0%). When radiation was utilized in addition to chemotherapy, EBRT was most common (NCDB 15.8%, SEER: 15.4%). In both databases, use of any radiation in addition to chemotherapy was associated with improved OS. Stage IV patients treated with chemotherapy plus EBRT had better survival than those receiving chemotherapy alone [NCDB: HR 0.75 (95% CI 0.70, 0.79), SEER: HR 0.85 (95% CI 0.77, 0.94)]. This benefit was more pronounced in patients with IVA disease [NCDB: HR 0.66 (95% CI 0.55, 0.79), SEER: HR 0.63 (95% CI 0.46, 0.85)]. In histology-stratified analyses, the addition of radiation to chemotherapy was associated with improved OS in all histologies, except clear cell. Conclusions: In this analysis of the NCDB and SEER registries, the use of multimodality treatment with radiation and chemotherapy was associated with improved OS compared to chemotherapy alone in women with stage IVA and IVB endometrial cancer.
MeSH term(s)	Brachytherapy ; Chemotherapy, Adjuvant ; Endometrial Neoplasms/drug therapy ; Endometrial Neoplasms/radiotherapy ; Female ; Humans ; Neoplasm Staging ; Radiotherapy, Adjuvant/methods ; Retrospective Studies
Language	English
Publishing date	2022-04-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	801461-9
ISSN	1095-6859 ; 0090-8258
ISSN (online)	1095-6859
ISSN	0090-8258
DOI	10.1016/j.ygyno.2022.04.007
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Zs.A 885: Show issues

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Article ; Online: Natural Killer Cell Activation by Ubiquitin-specific Protease 6 Mediates Tumor Suppression in Ewing Sarcoma.

Jain, Kanika / Henrich, Ian C / Quick, Laura / Young, Robert / Mondal, Shreya / Oliveira, Andre M / Blobel, Gerd A / Chou, Margaret M

Cancer research communications

2023 Volume 3, Issue 8, Page(s) 1615–1627

Abstract: Ewing sarcoma is a rare and deadly pediatric bone cancer for which survival rates and treatment options have stagnated for decades. Ewing sarcoma has not benefited from immunotherapy due to poor understanding of how its immune landscape is regulated. We ... ...

Abstract	Ewing sarcoma is a rare and deadly pediatric bone cancer for which survival rates and treatment options have stagnated for decades. Ewing sarcoma has not benefited from immunotherapy due to poor understanding of how its immune landscape is regulated. We recently reported that ubiquitin-specific protease 6 (USP6) functions as a tumor suppressor in Ewing sarcoma, and identified it as the first cell-intrinsic factor to modulate the Ewing sarcoma immune tumor microenvironment (TME). USP6 induces intratumoral infiltration and activation of multiple innate immune lineages in xenografted nude mice. Here we report that natural killer (NK) cells are essential for its tumor-inhibitory functions, as NK cell depletion reverses USP6-mediated suppression of Ewing sarcoma xenograft growth. USP6 expression in Ewing sarcoma cells directly stimulates NK cell activation and degranulation Significance: This study provides novel insights into the immunomodulatory functions of USP6, the only cancer cell-intrinsic factor demonstrated to regulate the immune TME in Ewing sarcoma. We demonstrate that USP6-mediated suppression of Ewing sarcoma tumorigenesis is dependent on NK cells. USP6 directly activates NK cell cytolytic function, inducing both intratumoral and systemic activation of NK cells in an Ewing sarcoma xenograft model.
MeSH term(s)	Humans ; Animals ; Mice ; Sarcoma, Ewing ; Intrinsic Factor ; Ligands ; Mice, Nude ; Neuroectodermal Tumors, Primitive, Peripheral ; Apoptosis Inducing Factor ; Bone Neoplasms ; Ubiquitin-Specific Proteases ; Tumor Microenvironment ; Ubiquitin Thiolesterase
Chemical Substances	Intrinsic Factor (9008-12-2) ; Ligands ; Apoptosis Inducing Factor ; Ubiquitin-Specific Proteases (EC 3.4.19.12) ; USP6 protein, human (EC 3.4.19.12) ; Ubiquitin Thiolesterase (EC 3.4.19.12)
Language	English
Publishing date	2023-08-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ISSN	2767-9764
ISSN (online)	2767-9764
DOI	10.1158/2767-9764.CRC-22-0505
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Article ; Online: The microbiome and gynecologic cancer: cellular mechanisms and clinical applications.

Chalif, Julia / Wang, Heather / Spakowicz, Daniel / Quick, Allison / Arthur, Elizabeth K / O'Malley, David / Chambers, Laura M

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2023

Abstract: The microbiome plays a vital function in maintaining human health and homeostasis. Each microbiota has unique characteristics, including those of the gastrointestinal and female reproductive tract. Dysbiosis, or alterations to the composition of the ... ...

Abstract	The microbiome plays a vital function in maintaining human health and homeostasis. Each microbiota has unique characteristics, including those of the gastrointestinal and female reproductive tract. Dysbiosis, or alterations to the composition of the microbial communities, impacts the microbiota-host relationship and is linked to diseases, including cancer. In addition, studies have demonstrated that the microbiota can contribute to a pro-carcinogenic state through altered host immunologic response, modulation of cell proliferation, signaling, gene expression, and dysregulated metabolism of nutrients and hormones.In recent years, the microbiota of the gut and female reproductive tracts have been linked to many diseases, including gynecologic cancers. Numerous pre-clinical and clinical studies have demonstrated that specific bacteria or microbial communities may contribute to the development of gynecologic cancers. Further, the microbiota may also impact the toxicity and efficacy of cancer therapies, including chemotherapy, immunotherapy, and radiation therapy in women with gynecologic malignancies. The microbiota is highly dynamic and may be altered through various mechanisms, including diet, exercise, medications, and fecal microbiota transplantation. This review provides an overview of the current literature detailing the relationship between gynecologic cancers and the microbiota of the female reproductive and gastrointestinal tracts, focusing on mechanisms of carcinogenesis and strategies for modulating the microbiota for cancer prevention and treatment. Advancing our understanding of the complex relationship between the microbiota and gynecologic cancer will provide a novel approach for prevention and therapeutic modulation in the future.
Language	English
Publishing date	2023-12-07
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2023-004894
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Zs.A 3198: Show issues

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Article: Modeling Coding Intensity of Procedures in a U.S. Population-Based Hip/Knee Arthroplasty Inpatient Cohort Adjusting for Patient- and Facility-Level Characteristics.

Rios, Nancy G / Oldiges, Paige E / Lizano, Marcela S / Doucet Wadford, Danielle S / Quick, David L / Martin, John / Korvink, Michael / Gunn, Laura H

Healthcare (Basel, Switzerland)

2022 Volume 10, Issue 8

Abstract: Variations in procedure coding intensity, defined as excess coding of procedures versus industry (instead of clinical) standards, can result in differentials in quality of care for patients and have additional implications for facilities and payors. The ... ...

Abstract	Variations in procedure coding intensity, defined as excess coding of procedures versus industry (instead of clinical) standards, can result in differentials in quality of care for patients and have additional implications for facilities and payors. The literature regarding coding intensity of procedures is limited, with a need for risk-adjusted methods that help identify over- and under-coding using commonly available data, such as administrative claims. Risk-adjusted metrics are needed for quality control and enhancement. We propose a two-step approach to risk adjustment, using a zero-inflated Poisson model, applied to a hip-knee arthroplasty cohort discharged during 2019 (
Language	English
Publishing date	2022-07-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare10081368
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Article ; Online: National-scale geodatabase of catchment characteristics in the Philippines for river management applications.

Boothroyd, Richard J / Williams, Richard D / Hoey, Trevor B / MacDonell, Craig / Tolentino, Pamela L M / Quick, Laura / Guardian, Esmael L / Reyes, Juan C M O / Sabillo, Cathrine J / Perez, John E G / David, Carlos P C

PloS one

2023 Volume 18, Issue 3, Page(s) e0281933

Abstract: Quantitative descriptions of stream network and river catchment characteristics provide valuable context for enabling geomorphologically-informed sustainable river management. For countries where high-quality topographic data are available, there are ... ...

Abstract	Quantitative descriptions of stream network and river catchment characteristics provide valuable context for enabling geomorphologically-informed sustainable river management. For countries where high-quality topographic data are available, there are opportunities to enable open access availability of baseline products from systematic assessment of morphometric and topographic characteristics. In this study, we present a national-scale assessment of fundamental topographic characteristics of Philippine river systems. We applied a consistent workflow using TopoToolbox V2 to delineate stream networks and river catchments using a nationwide digital elevation model (DEM) acquired in 2013 and generated through airborne Interferometric Synthetic Aperture Radar (IfSAR). We assessed morphometric and topographic characteristics for 128 medium- to large-sized catchments (catchment area > 250 km2) and organised the results in a national-scale geodatabase. The dataset realises the potential of topographic data as part of river management applications, by enabling variations in hydromorphology to be characterised and contextualised. The dataset is used to reveal the diversity of stream networks and river catchments in the Philippines. Catchments have a continuum of shapes (Gravelius compactness coefficient ranges from 1.05 to 3.29) with drainage densities that range from 0.65 to 1.23 km/km2. Average catchment slope ranges from 3.1 to 28.1° and average stream slope varies by more than an order of magnitude from 0.004 to 0.107 m/m. Inter-catchment analyses show the distinctive topographic signatures of adjacent river catchments; examples from NW Luzon highlight topographic similarity between catchments whereas examples from Panay Island shown marked topographic differences. These contrasts underline the importance of using place-based analyses for sustainable river management applications. By designing an interactive ArcGIS web-application to display the national-scale geodatabase, we improve data accessibility and enable users to freely access, explore and download the data (https://glasgow-uni.maps.arcgis.com/apps/webappviewer/index.html?id=a88b9ca0919f4400881eab4a26370cee). The national-scale geodatabase provides a baseline understanding of fundamental topographic characteristics in support of varied geomorphological, hydrological and geohazard susceptibility applications.
MeSH term(s)	Rivers ; Philippines ; Hydrology
Language	English
Publishing date	2023-03-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0281933
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Article ; Online: Additional PfCRT mutations driven by selective pressure for improved fitness can result in the loss of piperaquine resistance and altered

Hagenah, Laura M / Dhingra, Satish K / Small-Saunders, Jennifer L / Qahash, Tarrick / Willems, Andreas / Schindler, Kyra A / Rangel, Gabriel W / Gil-Iturbe, Eva / Kim, Jonathan / Akhundova, Emiliya / Yeo, Tomas / Okombo, John / Mancia, Filippo / Quick, Matthias / Roepe, Paul D / Llinás, Manuel / Fidock, David A

mBio

2023 Volume 15, Issue 1, Page(s) e0183223

Abstract: Importance: Our study leverages gene editing techniques ... ...

Abstract	Importance: Our study leverages gene editing techniques in
MeSH term(s)	Animals ; Plasmodium falciparum ; Quinolines/pharmacology ; Quinolines/chemistry ; Chloroquine/pharmacology ; Antimalarials/pharmacology ; Drug Resistance/genetics ; Parasites ; Mutation ; Protozoan Proteins/genetics ; Protozoan Proteins/chemistry ; Malaria, Falciparum/parasitology ; Piperazines
Chemical Substances	piperaquine (A0HV2Q956Y) ; Quinolines ; Chloroquine (886U3H6UFF) ; Antimalarials ; Protozoan Proteins ; Piperazines
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.01832-23
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Article ; Online: Community College Students' Health Insurance Enrollment, Maintenance, and Talking With Parents Intentions: An Application of the Reasoned Action Approach.

Huhman, Marian / Quick, Brian L / Payne, Laura

Journal of health communication

2016 Volume 21, Issue 5, Page(s) 487–495

Abstract: A primary objective of health care reform is to provide affordable and quality health insurance to individuals. Currently, promotional efforts have been moderately successful in registering older, more mature adults yet comparatively less successful in ... ...

Abstract	A primary objective of health care reform is to provide affordable and quality health insurance to individuals. Currently, promotional efforts have been moderately successful in registering older, more mature adults yet comparatively less successful in registering younger adults. With this challenge in mind, we conducted extensive formative research to better understand the attitudes, subjective norms, and perceived behavioral control of community college students. More specifically, we examined how each relates to their intentions to enroll in a health insurance plan, maintain their current health insurance plan, and talk with their parents about their parents having health insurance. In doing so, we relied on the revised reasoned action approach advanced by Fishbein and his associates (Fishbein & Ajzen, 2010; Yzer, 2012, 2013). Results showed that the constructs predicted intentions to enroll in health insurance for those with no insurance and for those with government-sponsored insurance and intentions to maintain insurance for those currently insured. Our study demonstrates the applicability of the revised reasoned action framework within this context and is discussed with an emphasis on the practical and theoretical contributions.
MeSH term(s)	Adolescent ; Adult ; Female ; Health Care Reform ; Humans ; Illinois ; Insurance, Health/statistics & numerical data ; Intention ; Male ; Parent-Child Relations ; Students/psychology ; Students/statistics & numerical data ; Surveys and Questionnaires ; Universities ; Young Adult
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ZDB-ID	1427988-5
ISSN	1087-0415 ; 1081-0730
ISSN (online)	1087-0415
ISSN	1081-0730
DOI	10.1080/10810730.2015.1103327
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Zs.A 5899: Show issues

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Article ; Online: Use, Acceptability, Performance, and Health Impact of Hollow Fiber Ultrafilters for Water Treatment in Rural Kenyan Households, 2009-2011.

Fagerli, Kirsten / Gieraltowski, Laura / Nygren, Benjamin / Foote, Eric / Gaines, Joanna / Oremo, Jared / Odhiambo, Aloyce / Kim, Sunkyung / Quick, Robert

The American journal of tropical medicine and hygiene

2020 Volume 103, Issue 1, Page(s) 465–471

Abstract: Diarrheal illness remains a leading cause of morbidity and mortality in children < 5 years in developing countries, and contaminated water contributes to diarrhea risk. To address this problem, a novel hollow fiber ultrafilter (HFU) was developed for ... ...

Abstract	Diarrheal illness remains a leading cause of morbidity and mortality in children < 5 years in developing countries, and contaminated water contributes to diarrhea risk. To address this problem, a novel hollow fiber ultrafilter (HFU) was developed for household water treatment. To test its impact on water quality and infant health, we conducted a cluster-randomized longitudinal evaluation in 10 intervention and 10 comparison villages in Kenya, attempting to enroll all households with infants (< 12 months old). We conducted a baseline survey, distributed HFUs to intervention households, made biweekly home visits for 1 year to assess water treatment practices and diarrhea in infants, and tested water samples from both groups every 2 months for
MeSH term(s)	Adolescent ; Adult ; Aged ; Drinking Water/microbiology ; Dysentery/epidemiology ; Escherichia coli/isolation & purification ; Female ; Humans ; Infant ; Kenya/epidemiology ; Male ; Middle Aged ; Odds Ratio ; Patient Acceptance of Health Care ; Rural Population ; Water Microbiology ; Water Purification/instrumentation ; Water Purification/methods ; Young Adult
Chemical Substances	Drinking Water
Language	English
Publishing date	2020-04-02
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	2942-7
ISSN	1476-1645 ; 0002-9637
ISSN (online)	1476-1645
ISSN	0002-9637
DOI	10.4269/ajtmh.19-0862
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Article: Reduction of Leukocyte Microvascular Adherence and Preservation of Blood-Brain Barrier Function by Superoxide-Lowering Therapies in a Piglet Model of Neonatal Asphyxia.

Ruden, Jacob B / Quick, Kevin L / Gonzales, Ernesto R / Shah, Aarti R / Park, T S / Kennedy, Nan / Dugan, Laura L / Gidday, Jeffrey M

Frontiers in neurology

2019 Volume 10, Page(s) 447

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2019-05-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2019.00447
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