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Article: Joint cracking and popping: understanding noises that accompany articular release.

Protopapas, Marina G / Cymet, Tyler C / Protapapas, Marina G

The Journal of the American Osteopathic Association

2002 Volume 102, Issue 5, Page(s) 283–287

Abstract: Articular release is a physiologic event that may or may not be audible. It is seen in patients with healthy joints as well as those with somatic dysfunction. After an articular release, there is a difference in joint spacing-with the release increasing ... ...

Abstract	Articular release is a physiologic event that may or may not be audible. It is seen in patients with healthy joints as well as those with somatic dysfunction. After an articular release, there is a difference in joint spacing-with the release increasing the distance between articular surfaces. Not all noise that emanates from a joint signifies an articular release. A hypothesis about the noise that frequently accompanies this release is offered and includes anatomic, physiologic, and functional models of articular release. Repeated performance of articular release may decrease the occurrence of arthritis. Potential problems from repeated articular release (eg, hypermobility) are also examined.
MeSH term(s)	Humans ; Joint Diseases/therapy ; Manipulation, Osteopathic/methods ; Musculoskeletal Diseases/therapy ; Range of Motion, Articular/physiology ; Sensitivity and Specificity ; Severity of Illness Index ; Sound
Language	English
Publishing date	2002-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	410350-6
ISSN	1945-1997 ; 0098-6151 ; 0003-0287
ISSN (online)	1945-1997
ISSN	0098-6151 ; 0003-0287
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Article: The complications of scar formation associated with intrathecal pump placement.

Protopapas, Marina G / Bundock, Elizabeth / Westmoreland, Susan / Nero, Christopher / Graham, W Andrew / Nesathurai, Shanker

Archives of physical medicine and rehabilitation

2007 Volume 88, Issue 3, Page(s) 389–390

Abstract: A 40-year-old man had an intrathecal morphine-baclofen pump inserted for the treatment of severe dystonia affecting all limbs and severe low back pain. The etiology of his dystonic symptoms, despite thorough investigations, was uncertain. At age 45, the ... ...

Abstract	A 40-year-old man had an intrathecal morphine-baclofen pump inserted for the treatment of severe dystonia affecting all limbs and severe low back pain. The etiology of his dystonic symptoms, despite thorough investigations, was uncertain. At age 45, the patient fell resulting in a cervical spinal cord injury. He underwent C2 through C5 instrumentation and fusion for cervical spine stabilization. Subsequently, an intrathecal morphine-baclofen pump was implanted to control pain and decrease spasticity. The patient ultimately died at age 48 from complications of pneumonia, and an autopsy was performed. Gross pathologic examination revealed that the intrathecal catheter entered the posterior aspect of the lumbar thecal sac, but coursed superiorly in the anterior intradural space. The catheter tip exited the thecal sac in the upper thoracic spine and became embedded in a fibrotic scar. Displacement of the catheter tip of the intrathecal morphine-baclofen pump and subsequent formation of scar tissue resulted in decreased drug delivery, contributing to diminished pain control and functional status. Catheter displacement and epidural scar formation must be considered as a potential cause of ineffective pain control and decreased functional status in patients with intrathecal morphine-baclofen pumps.
MeSH term(s)	Adult ; Analgesics, Opioid/administration & dosage ; Baclofen/administration & dosage ; Catheters, Indwelling/adverse effects ; Cicatrix/complications ; Dystonia/drug therapy ; Equipment Failure Analysis ; Foreign-Body Migration/complications ; Humans ; Infusion Pumps, Implantable/adverse effects ; Injections, Spinal/instrumentation ; Low Back Pain/drug therapy ; Male ; Morphine/administration & dosage ; Muscle Relaxants, Central/administration & dosage
Chemical Substances	Analgesics, Opioid ; Muscle Relaxants, Central ; Morphine (76I7G6D29C) ; Baclofen (H789N3FKE8)
Language	English
Publishing date	2007-03
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	80057-0
ISSN	1532-821X ; 0003-9993
ISSN (online)	1532-821X
ISSN	0003-9993
DOI	10.1016/j.apmr.2006.12.023
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Article: Oxygen consumption of the semi-terrestrial crab Pachygrapsus marmoratus in relation to body mass and temperature: an information theory approach

Katsanevakis, Stelios / George Verriopoulos / John Xanthopoulos / Nikos Protopapas

Marine biology. 2007 Mar., v. 151, no. 1

2007

Abstract: ... between 43 mg and 18.0 g, and five test temperatures were used between 13.5 and 28.0°C. Six candidate ... for many other marine invertebrates (at normal temperatures). Q 10 values were relatively low, indicating wide thermal ...

Abstract	Pachygrapsus marmoratus is a semi-terrestrial crab and the most common grapsid crab in the intertidal belt of rocky shores throughout the Mediterranean Sea, Black Sea and northeastern Atlantic. In this study, the combined effects of temperature (T), body mass (M), and sex (S) on the routine oxygen consumption rate (R) in P. marmoratus were quantified. The blotted wet body mass of the specimens ranged between 43 mg and 18.0 g, and five test temperatures were used between 13.5 and 28.0°C. Six candidate models that reflected different assumptions regarding the dependence of R on S and T were compared. Model selection was based on Kullback–Leibler’s information theory and Akaike’s information criterion (AIC). The model [Formula: see text] had the highest support by the data (E is the activation energy, B = 8.618 × 10−5 eV K−1 is Boltzmann’s constant, T a is the absolute temperature in Kelvin, and b the allometric scaling exponent); for P. marmoratus it was found that [Formula: see text] No sex dependence of R was supported by the data. Following a multi-model inference (MMI) approach, the mean (± SE) allometric exponent [Formula: see text] was 0.750 (± 0.013) having a 95% (bootstrap) confidence interval of 0.726–0.774. Thus, it was established that P. marmoratus follows Kleiber’s 3/4 law, as seems to be generally true for intertidal crabs. The allometric exponent was independent of temperature as has also been reported for many other marine invertebrates (at normal temperatures). Q 10 values were relatively low, indicating wide thermal tolerance of the species. Model selection based on information theory is recommended for respiration studies, as an effective method in finding a parsimonious approximating model. MMI by model averaging, based on Akaike weights, is an effective way to make robust parameter estimations and deal with model selection uncertainty.
Keywords	activation energy ; allometry ; aquatic invertebrates ; confidence interval ; crabs ; heat tolerance ; littoral zone ; mathematical theory ; models ; oxygen consumption ; temperature ; uncertainty ; Black Sea ; Mediterranean Sea
Language	English
Dates of publication	2007-03
Size	p. 343-352.
Publishing place	Springer Berlin Heidelberg
Document type	Article
ZDB-ID	1117-4
ISSN	1432-1793 ; 0025-3162
ISSN (online)	1432-1793
ISSN	0025-3162
DOI	10.1007/s00227-006-0485-z
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection.

Papadopoulos, Antonios I / Ferwerda, Bart / Antoniadou, Anastasia / Sakka, Vissaria / Galani, Lambrini / Kavatha, Dimitra / Panagopoulos, Periklis / Poulakou, Garyphalia / Protopapas, Konstantinos / van der Meer, Jos W M / Netea, Mihai G / Giamarellos-Bourboulis, Evangelos J

Cytokine

2012 Volume 60, Issue 1, Page(s) 104–107

Abstract: Objectives: MyD88 adaptor-like (Mal/TIRAP) is an adaptor protein bridging activation of Toll-like receptors 2 and 4 after stimulation by exogenous and endogenous ligands. We investigated the association between the presence of the S180L SNP of Mal and ... ...

Abstract	Objectives: MyD88 adaptor-like (Mal/TIRAP) is an adaptor protein bridging activation of Toll-like receptors 2 and 4 after stimulation by exogenous and endogenous ligands. We investigated the association between the presence of the S180L SNP of Mal and the risk of severe infection in individuals with human immunodeficiency virus (HIV)-1 infection. Methods: The SNP S180L was determined in a cohort of 179 HIV-1 infected Greek patients. Analysis of the prevalence of this SNP in relation to the infectious complications was evaluated. Results: One hundred and thirty-two (73.3%) patients were bearing the wild type haplotype, 43 (24%) were heterozygous for the SNP, and four (2.2%) were homozygous for the variant allele. The individuals with a nadir CD4 count <200 cells/mm(3) who carried the 180L variant demonstrated a 4-fold decrease in the odds ratio (OR) for any serious infection compared with those who carried the wild-type 180S genotype (OR 0.58 vs OR 2.6, p=0.016). Conclusions: This study suggest a protection effect of the Mal S180L SNP against serious infections in HIV-1 infected individuals with low CD4 cell counts.
MeSH term(s)	Adult ; Amino Acid Substitution ; CD4 Lymphocyte Count ; Cohort Studies ; Female ; Gene Frequency ; Genetic Predisposition to Disease/genetics ; Genotype ; HIV Infections/complications ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/immunology ; Haplotypes ; Humans ; Male ; Membrane Glycoproteins/genetics ; Middle Aged ; Opportunistic Infections/complications ; Opportunistic Infections/genetics ; Opportunistic Infections/immunology ; Polymorphism, Single Nucleotide ; Receptors, Interleukin-1/genetics ; Risk Factors ; Young Adult
Chemical Substances	Membrane Glycoproteins ; Receptors, Interleukin-1 ; TIRAP protein, human
Language	English
Publishing date	2012-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2012.05.008
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 : A Randomized Controlled Trial.

Barkauskas, Christina / Mylonakis, Eleftherios / Poulakou, Garyfallia / Young, Barnaby E / Vock, David M / Siegel, Lianne / Engen, Nicole / Grandits, Greg / Mosaly, Nilima R / Vekstein, Andrew M / Rogers, Ralph / Shehadeh, Fadi / Kaczynski, Matthew / Mylona, Evangelia K / Syrigos, Konstantinos N / Rapti, Vasiliki / Lye, David C / Hui, Diong Shiau / Leither, Lindsay /

Knowlton, Kirk U / Jain, Mamta K / Marines-Price, Rubria / Osuji, Alice / Overcash, J Scott / Kalomenidis, Ioannis / Barmparessou, Zafeiria / Waters, Michael / Zepeda, Karla / Chen, Peter / Torbati, Sam / Kiweewa, Francis / Sebudde, Nicholus / Almasri, Eyad / Hughes, Alyssa / Bhagani, Sanjay R / Rodger, Alison / Sandkovsky, Uriel / Gottlieb, Robert L / Nnakelu, Eriobu / Trautner, Barbara / Menon, Vidya / Lutaakome, Joseph / Matthay, Michael / Robinson, Philip / Protopapas, Konstantinos / Koulouris, Nikolaos / Kimuli, Ivan / Baduashvili, Amiran / Braun, Dominique L / Günthard, Huldrych F / Ramachandruni, Srikanth / Kidega, Robert / Kim, Kami / Hatlen, Timothy J / Phillips, Andrew N / Murray, Daniel D / Jensen, Tomas O / Padilla, Maria L / Accardi, Evan X / Shaw-Saliba, Katy / Dewar, Robin L / Teitelbaum, Marc / Natarajan, Ven / Laverdure, Sylvain / Highbarger, Helene C / Rehman, M Tauseef / Vogel, Susan / Vallée, David / Crew, Page / Atri, Negin / Schechner, Adam J / Pett, Sarah / Hudson, Fleur / Badrock, Jonathan / Touloumi, Giota / Brown, Samuel M / Self, Wesley H / North, Crystal M / Ginde, Adit A / Chang, Christina C / Kelleher, Anthony / Nagy-Agren, Stephanie / Vasudeva, Shikha / Looney, David / Nguyen, Hien H / Sánchez, Adriana / Weintrob, Amy C / Grund, Birgit / Sharma, Shweta / Reilly, Cavan S / Paredes, Roger / Bednarska, Agnieszka / Gerry, Norman P / Babiker, Abdel G / Davey, Victoria J / Gelijns, Annetine C / Higgs, Elizabeth S / Kan, Virginia / Matthews, Gail / Thompson, B Taylor / Legenne, Philippe / Chandra, Richa / Lane, H Clifford / Neaton, James D / Lundgren, Jens D

Annals of internal medicine

2022 Volume 175, Issue 9, Page(s) 1266–1274

Abstract: Background: Ensovibep (MP0420) is a designed ankyrin repeat protein, a novel class of engineered proteins, under investigation as a treatment of SARS-CoV-2 infection.: Objective: To investigate if ensovibep, in addition to remdesivir and other ... ...

Abstract	Background: Ensovibep (MP0420) is a designed ankyrin repeat protein, a novel class of engineered proteins, under investigation as a treatment of SARS-CoV-2 infection. Objective: To investigate if ensovibep, in addition to remdesivir and other standard care, improves clinical outcomes among patients hospitalized with COVID-19 compared with standard care alone. Design: Double-blind, randomized, placebo-controlled, clinical trial. (ClinicalTrials.gov: NCT04501978). Setting: Multinational, multicenter trial. Participants: Adults hospitalized with COVID-19. Intervention: Intravenous ensovibep, 600 mg, or placebo. Measurements: Ensovibep was assessed for early futility on the basis of pulmonary ordinal scores at day 5. The primary outcome was time to sustained recovery through day 90, defined as 14 consecutive days at home or place of usual residence after hospital discharge. A composite safety outcome that included death, serious adverse events, end-organ disease, and serious infections was assessed through day 90. Results: An independent data and safety monitoring board recommended that enrollment be halted for early futility after 485 patients were randomly assigned and received an infusion of ensovibep ( Limitation: The trial was prematurely stopped because of futility, limiting power for the primary outcome. Conclusion: Compared with placebo, ensovibep did not improve clinical outcomes for hospitalized participants with COVID-19 receiving standard care, including remdesivir; no safety concerns were identified. Primary funding source: National Institutes of Health.
MeSH term(s)	Adult ; Designed Ankyrin Repeat Proteins ; Double-Blind Method ; Humans ; Recombinant Fusion Proteins ; SARS-CoV-2 ; Treatment Outcome ; COVID-19 Drug Treatment
Chemical Substances	Designed Ankyrin Repeat Proteins ; Recombinant Fusion Proteins ; ensovibep (PV6AA88RDU)
Language	English
Publishing date	2022-08-09
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	336-0
ISSN	1539-3704 ; 0003-4819
ISSN (online)	1539-3704
ISSN	0003-4819
DOI	10.7326/M22-1503
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Article: Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection

Papadopoulos, Antonios I / Ferwerda, Bart / Antoniadou, Anastasia / Sakka, Vissaria / Galani, Lambrini / Kavatha, Dimitra / Panagopoulos, Periklis / Poulakou, Garyphalia / Protopapas, Konstantinos / van der Meer, Jos W.M / Netea, Mihai G / Giamarellos-Bourboulis, Evangelos J

Cytokine. 2012 Oct., v. 60, no. 1

2012

Abstract: OBJECTIVES: MyD88 adaptor-like (Mal/TIRAP) is an adaptor protein bridging activation of Toll-like receptors 2 and 4 after stimulation by exogenous and endogenous ligands. We investigated the association between the presence of the S180L SNP of Mal and ... ...

Abstract	OBJECTIVES: MyD88 adaptor-like (Mal/TIRAP) is an adaptor protein bridging activation of Toll-like receptors 2 and 4 after stimulation by exogenous and endogenous ligands. We investigated the association between the presence of the S180L SNP of Mal and the risk of severe infection in individuals with human immunodeficiency virus (HIV)-1 infection. METHODS: The SNP S180L was determined in a cohort of 179 HIV-1 infected Greek patients. Analysis of the prevalence of this SNP in relation to the infectious complications was evaluated. RESULTS: One hundred and thirty-two (73.3%) patients were bearing the wild type haplotype, 43 (24%) were heterozygous for the SNP, and four (2.2%) were homozygous for the variant allele. The individuals with a nadir CD4 count <200cells/mm³ who carried the 180L variant demonstrated a 4-fold decrease in the odds ratio (OR) for any serious infection compared with those who carried the wild-type 180S genotype (OR 0.58 vs OR 2.6, p=0.016). CONCLUSIONS: This study suggest a protection effect of the Mal S180L SNP against serious infections in HIV-1 infected individuals with low CD4 cell counts.
Keywords	HIV infections ; Human immunodeficiency virus ; alleles ; cytokines ; haplotypes ; heterozygosity ; homozygosity ; odds ratio ; patients ; receptors ; risk
Language	English
Dates of publication	2012-10
Size	p. 104-107.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	1018055-2
ISSN	1096-0023 ; 1043-4666
ISSN (online)	1096-0023
ISSN	1043-4666
DOI	10.1016/j.cyto.2012.05.008
Database	NAL-Catalogue (AGRICOLA)

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Article: Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection

Papadopoulos, Antonios I. / Ferwerda, Bart / Antoniadou, Anastasia / Sakka, Vissaria / Galani, Lambrini / Kavatha, Dimitra / Panagopoulos, Periklis / Poulakou, Garyphalia / Protopapas, Konstantinos / van der Meer, Jos W.M. / Netea, Mihai G. / Giamarellos-Bourboulis, Evangelos J.

Cytokine

Volume v. 60,, Issue no. 1

Abstract	OBJECTIVES: MyD88 adaptor-like (Mal/TIRAP) is an adaptor protein bridging activation of Toll-like receptors 2 and 4 after stimulation by exogenous and endogenous ligands. We investigated the association between the presence of the S180L SNP of Mal and the risk of severe infection in individuals with human immunodeficiency virus (HIV)-1 infection. METHODS: The SNP S180L was determined in a cohort of 179 HIV-1 infected Greek patients. Analysis of the prevalence of this SNP in relation to the infectious complications was evaluated. RESULTS: One hundred and thirty-two (73.3%) patients were bearing the wild type haplotype, 43 (24%) were heterozygous for the SNP, and four (2.2%) were homozygous for the variant allele. The individuals with a nadir CD4 count <200cells/mm³ who carried the 180L variant demonstrated a 4-fold decrease in the odds ratio (OR) for any serious infection compared with those who carried the wild-type 180S genotype (OR 0.58 vs OR 2.6, p=0.016). CONCLUSIONS: This study suggest a protection effect of the Mal S180L SNP against serious infections in HIV-1 infected individuals with low CD4 cell counts.
Keywords	risk ; cytokines ; patients ; heterozygosity ; HIV infections ; Human immunodeficiency virus ; odds ratio ; homozygosity ; alleles ; receptors ; haplotypes
Language	English
Document type	Article
ISSN	1043-4666
Database	AGRIS - International Information System for the Agricultural Sciences and Technology

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Article: Joint cracking and popping: understanding noises that accompany articular release.

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Article: The complications of scar formation associated with intrathecal pump placement.

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Article: Oxygen consumption of the semi-terrestrial crab Pachygrapsus marmoratus in relation to body mass and temperature: an information theory approach

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Article ; Online: Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection.

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Article ; Online: Efficacy and Safety of Ensovibep for Adults Hospitalized With COVID-19 : A Randomized Controlled Trial.

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Article: Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection

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In stock of ZB MED Cologne/Königswinter

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Article: Association of Mal/TIRAP S180L variant polymorphism with decreased infection risk in patients with advanced HIV-1 infection

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