Article ; Online: Traditional Chinese Medicine Formula "Xiaofeng granules" suppressed gouty arthritis animal models and inhibited the proteoglycan degradation on chondrocytes induced by monosodium urate.
2016 Volume 191, Page(s) 254–263
Abstract: Ethnopharmacological relevance: Xiaofeng Granules (XF) is a kind of granules prepared ...
| Abstract | Ethnopharmacological relevance: Xiaofeng Granules (XF) is a kind of granules prepared by the famous traditional Chinese medicine formula for its efficiency in treating gouty diseases. Aim of the study: We investigated the relevance between XF that made from Modified simiaowan (MSW) as the anti-gouty arthritis drugs and protective mechanisms for cartilage matrix in order to provide the evidence for new drug application. Materials and methods: In the present study, we evaluated the anti-gouty arthritis activity of XF in rats and rabbits models induced by MSU together with chondrocytes focusing on the link to proteoglycan degradation in vitro studies. Results: The results demonstrated that XF significantly reduced the swelling rate and attenuated the pathological changes in joints. The XF-containing serum were used medicated serum in cellular experiments. The in vitro data were in accordance with the in vivo results, showing that the constituents in XF-containing serum had obvious inhibitory effects on the activation of pro-inflammatory mediators in chondrocytes. Moreover, XF-containing serum substantially inhibited MSU-induced expression of glycosaminoglycans(GAG) and hydroxyproline(Hyp), and up regulated proteoglycan, which might be associated with the regulation of the balance of MMP-3/TIMP-1and ADAMTS-4/TIMP-3 inchondrocytes. Conclusion: In conclusion, XF that made from MSW showed obvious effects on acute gouty arthritis, which also provided an effective protection on cartilage matrix degradation. |
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| MeSH term(s) | ADAMTS4 Protein/metabolism ; Animals ; Arthritis, Gouty/chemically induced ; Arthritis, Gouty/metabolism ; Arthritis, Gouty/pathology ; Arthritis, Gouty/prevention & control ; Cells, Cultured ; Chondrocytes/drug effects ; Chondrocytes/metabolism ; Cytokines/metabolism ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/pharmacology ; Glycosaminoglycans/metabolism ; Gout Suppressants/pharmacology ; Hydroxyproline/metabolism ; Inflammation Mediators/metabolism ; Joints/drug effects ; Joints/metabolism ; Joints/pathology ; Male ; Matrix Metalloproteinase 3/metabolism ; Proteoglycans/metabolism ; Proteolysis ; Rabbits ; Rats, Sprague-Dawley ; Time Factors ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Tissue Inhibitor of Metalloproteinase-3/metabolism ; Uric Acid |
| Chemical Substances | Cytokines ; Drugs, Chinese Herbal ; Glycosaminoglycans ; Gout Suppressants ; Inflammation Mediators ; Proteoglycans ; TIMP1 protein, rat ; Tissue Inhibitor of Metalloproteinase-1 ; Tissue Inhibitor of Metalloproteinase-3 ; xiaofeng granules ; Uric Acid (268B43MJ25) ; ADAMTS4 protein, rat (EC 3.4.24.-) ; Matrix Metalloproteinase 3 (EC 3.4.24.17) ; ADAMTS4 Protein (EC 3.4.24.82) ; Hydroxyproline (RMB44WO89X) |
| Language | English |
| Publishing date | 2016-06-04 |
| Publishing country | Ireland |
| Document type | Journal Article |
| ZDB-ID | 134511-4 |
| ISSN | 1872-7573 ; 0378-8741 |
| ISSN (online) | 1872-7573 |
| ISSN | 0378-8741 |
| DOI | 10.1016/j.jep.2016.06.008 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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