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Book ; Online ; E-Book: Manual of splinting and casting

Thompson, Stephen R. / Zlotolow, Dan A. / O'Doherty, Brian

2023

Abstract: Now in vibrant full color, Manual of Splinting and Casting, 2nd Edition, provides highly visual, step-by-step instructions on the most common, need-to-know techniques for initial orthopaedic injury management. This practical point-of-care reference uses ...

Author's details	Stephen R. Thompson, Dan A. Zlotolow ; photography by Brian O'Doherty
Abstract	"Now in vibrant full color, Manual of Splinting and Casting, 2nd Edition, provides highly visual, step-by-step instructions on the most common, need-to-know techniques for initial orthopaedic injury management. This practical point-of-care reference uses a highly templated format with hundreds of illustrations and photographs so you can quickly grasp exactly how to perform each technique. It's an ideal resource for orthopaedic and sports medicine residents, nurses, medical students, emergency physicians, and orthopaedic technologists--anyone who needs a concise, easy-to-follow guide to splinting and casting at the point of care."--Provided by publisher.
MeSH term(s)	Splints ; Casts, Surgical
Keywords	Surgical plaster casts ; Splints (Surgery) ; Orthopedic traction ; Surgical casts
Subject code	617.9
Language	English
Dates of publication	2023-2024
Size	1 online resource (696 pages) :, illustrations.
Edition	Second edition.
Publisher	Elsevier
Publishing place	Philadelphia, Pennsylvania
Document type	Book ; Online ; E-Book
Note	Revision of: Handbook of splinting and casting / Stephen R. Thompson, Dan A. Zlotolow, 2012.
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	978-0-323-87829-6 ; 978-0-323-87830-2 ; 0-323-87830-X ; 0-323-87829-6
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Casting a wide net to find the molar tooth: A study on Joubert syndrome.

Coffman, Keith A / Doherty, Dan

Neurology

2020 Volume 94, Issue 8, Page(s) 337–338

MeSH term(s)	Abnormalities, Multiple ; Cerebellum ; Eye Abnormalities ; Humans ; Italy ; Kidney Diseases, Cystic ; Magnetic Resonance Imaging ; Molar ; Prevalence ; Retina
Language	English
Publishing date	2020-01-22
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	207147-2
ISSN	1526-632X ; 0028-3878
ISSN (online)	1526-632X
ISSN	0028-3878
DOI	10.1212/WNL.0000000000008992
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Article ; Online: Central sleep apnea in patients with pontine tegmental cap dysplasia treated with supplemental oxygen: a case report.

Ju Wang, Jia-Der / Doherty, Dan / Ramirez, Jan-Marino / Chen, Maida

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine

2023 Volume 19, Issue 4, Page(s) 843–849

Abstract: ... of noninvasive positive pressure ventilation treatment.: Citation: Ju Wang J-D, Doherty D, Ramirez J-M, Chen M ...

Abstract	This is the first case report of sleep-disordered breathing in patients with pontine tegmental cap dysplasia, a very rare neurological disorder characterized by an anatomic malformation in the pons. Patients present with hypotonia, cognitive dysfunction, and cranial nerve palsies (eg, hearing loss, trigeminal anesthesia, and swallow dysfunction). Extensive studies have demonstrated the relevance of different pontine neuronal nuclei in breathing regulation, which are structurally abnormal in pontine tegmental cap dysplasia. We present detailed polysomnography data for 3 patients aged 41 years, 20 years, and 1.5 years revealing significant central sleep apnea. We discuss our experience with managing their sleep-disordered breathing in the setting of multiple cranial nerve palsies and corneal anesthesia, and its relative contraindication of noninvasive positive pressure ventilation treatment. Citation: Ju Wang J-D, Doherty D, Ramirez J-M, Chen M. Central sleep apnea in patients with pontine tegmental cap dysplasia treated with supplemental oxygen: a case report.
MeSH term(s)	Humans ; Sleep Apnea, Central/complications ; Sleep Apnea, Central/therapy ; Cranial Nerve Diseases ; Abnormalities, Multiple ; Positive-Pressure Respiration ; Oxygen
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2023-01-21
Publishing country	United States
Document type	Case Reports ; Research Support, N.I.H., Extramural
ZDB-ID	2397213-0
ISSN	1550-9397 ; 1550-9389
ISSN (online)	1550-9397
ISSN	1550-9389
DOI	10.5664/jcsm.10452
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Article ; Online: Examining the transnational preventive healthcare utilisation of a group of Eastern European migrants living full-time in another European state.

Kelleher, Dan / Doherty, Edel / O'Neill, Ciaran

Health policy (Amsterdam, Netherlands)

2022 Volume 126, Issue 4, Page(s) 318–324

Abstract: Migrants in Europe are shown to have consistently lower uptake of preventive healthcare compared to European host populations. This paper examines how the transnational preventive care use of Eastern European migrants in their country of origin may be ... ...

Abstract	Migrants in Europe are shown to have consistently lower uptake of preventive healthcare compared to European host populations. This paper examines how the transnational preventive care use of Eastern European migrants in their country of origin may be associated with preventive care uptake in their European host country. Preventive care use data in Ireland was collected on 119 Polish migrants and 123 native Irish from June 2018 to September 2019. Preventive care use data was also collected on the Polish migrant group in Poland during the same period. Preventive care use was captured by examining general practitioner visits, blood or urine test uptake, and cancer screening uptake. Probit models were first estimated to examine whether the Polish migrants were more or less likely to have used each service in Ireland than the native Irish. Second, three bivariate probit models were estimated to examine the use of each service by the Polish migrants only in Ireland and Poland as the two dependant variables. The Polish migrants are less likely to have GP visits, blood or urine test uptake, and cancer screening uptake in Ireland compared to the native Irish. The Polish migrants from this study are also shown to potentially substitute blood or urine test uptake in Ireland for uptake in Poland. Transnational ties can determine the preventive care utilisation of migrants in Europe.
MeSH term(s)	Delivery of Health Care ; Employment ; Europe ; Humans ; Patient Acceptance of Health Care ; Transients and Migrants
Language	English
Publishing date	2022-02-19
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	605805-x
ISSN	1872-6054 ; 0168-8510
ISSN (online)	1872-6054
ISSN	0168-8510
DOI	10.1016/j.healthpol.2022.02.006
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Article ; Online: The Joubert-Meckel-Nephronophthisis Spectrum of Ciliopathies.

Van De Weghe, Julie C / Gomez, Arianna / Doherty, Dan

Annual review of genomics and human genetics

2022 Volume 23, Page(s) 301–329

Abstract: The Joubert syndrome (JS), Meckel syndrome (MKS), and nephronophthisis (NPH) ciliopathy spectrum could be the poster child for advances and challenges in Mendelian human genetics over the past half century. Progress in understanding these conditions ... ...

Abstract	The Joubert syndrome (JS), Meckel syndrome (MKS), and nephronophthisis (NPH) ciliopathy spectrum could be the poster child for advances and challenges in Mendelian human genetics over the past half century. Progress in understanding these conditions illustrates many core concepts of human genetics. The JS phenotype alone is caused by pathogenic variants in more than 40 genes; remarkably, all of the associated proteins function in and around the primary cilium. Primary cilia are near-ubiquitous, microtubule-based organelles that play crucial roles in development and homeostasis. Protruding from the cell, these cellular antennae sense diverse signals and mediate Hedgehog and other critical signaling pathways. Ciliary dysfunction causes many human conditions termed ciliopathies, which range from multiple congenital malformations to adult-onset single-organ failure. Research on the genetics of the JS-MKS-NPH spectrum has spurred extensive functional work exploring the broadly important role of primary cilia in health and disease. This functional work promises to illuminate the mechanisms underlying JS-MKS-NPH in humans, identify therapeutic targets across genetic causes, and generate future precision treatments.
MeSH term(s)	Abnormalities, Multiple/genetics ; Abnormalities, Multiple/metabolism ; Abnormalities, Multiple/pathology ; Cerebellum/abnormalities ; Cerebellum/metabolism ; Cerebellum/pathology ; Child ; Cilia/genetics ; Cilia/metabolism ; Cilia/pathology ; Ciliary Motility Disorders ; Ciliopathies/genetics ; Ciliopathies/metabolism ; Ciliopathies/pathology ; Encephalocele ; Eye Abnormalities/genetics ; Eye Abnormalities/metabolism ; Eye Abnormalities/pathology ; Hedgehog Proteins/metabolism ; Humans ; Kidney Diseases, Cystic ; Polycystic Kidney Diseases/genetics ; Polycystic Kidney Diseases/metabolism ; Polycystic Kidney Diseases/pathology ; Retina/abnormalities ; Retina/metabolism ; Retina/pathology ; Retinitis Pigmentosa
Chemical Substances	Hedgehog Proteins
Language	English
Publishing date	2022-06-02
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2037670-4
ISSN	1545-293X ; 1527-8204
ISSN (online)	1545-293X
ISSN	1527-8204
DOI	10.1146/annurev-genom-121321-093528
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Article: Health preferences and preventive care utilisation: How EQ-5D-5L health preferences may affect uptake.

Kelleher, Dan / Doherty, Edel / O'Neill, Ciaran

Preventive medicine reports

2021 Volume 24, Page(s) 101514

Abstract: Despite the economic and health benefits of preventive care being well established, the uptake of many cost-effective preventive services remains lower than desired in many cases, especially among specific sub-populations. The value an individual places ... ...

Abstract	Despite the economic and health benefits of preventive care being well established, the uptake of many cost-effective preventive services remains lower than desired in many cases, especially among specific sub-populations. The value an individual places on health can influence their uptake of preventive care. One way to capture the value an individual places on health and future health status is to examine their health preferences. This study used a novel use of EQ-5D-5L health preferences to determine if health preferences are associated with the uptake of a range of preventive care services, including a cancer screening, blood pressure check, cholesterol check, blood test and urine test. We collected EQ-5D-5L composite time trade-off data in 2018/2019 on 242 respondents residing in Ireland. We estimated an initial tobit model to predict an individual's health preference to capture health preferences as a regressor. We then estimated a bivariate probit model to examine the uptake of each preventive service and GP use. Each model controlled for health preferences, education, sex, type of health coverage, self-reported health, employment status, age and marital status. Health preferences are a significant determinant of all five preventive services while controlling for other covariates. The results shows that the higher an individual values good health, the more likely they are to avail of preventive care. Health preferences can be noted as a potential determinant of preventive care use that could guide policy responses seeking to increase demand-side factors for preventive care uptake.
Language	English
Publishing date	2021-08-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2785569-7
ISSN	2211-3355
ISSN	2211-3355
DOI	10.1016/j.pmedr.2021.101514
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Article ; Online: Mortality in pediatric hydrocephalus.

Tully, Hannah M / Doherty, Dan / Wainwright, Mark

Developmental medicine and child neurology

2021 Volume 64, Issue 1, Page(s) 112–117

Abstract: Aim: To clarify the extent to which medical comorbidities and goals-of-care decisions influence death among individuals with childhood-onset hydrocephalus.: Method: This was a retrospective cohort study of 1705 individuals (759 males, 946 females, ... ...

Abstract	Aim: To clarify the extent to which medical comorbidities and goals-of-care decisions influence death among individuals with childhood-onset hydrocephalus. Method: This was a retrospective cohort study of 1705 individuals (759 males, 946 females, mean age 11y 5mo, SD 6y 6mo, range 0-37y 7mo at last follow-up) with childhood-onset hydrocephalus, of whom 88 (5.2%) were deceased. Existing medical records, death records, and publicly available internet sources were analyzed. We estimated hazard ratios for putative risk factors through Cox regression based upon 10 529 person-years of data and quantitatively and qualitatively analyzed the circumstances surrounding each death. Results: Mortality did not differ statistically by demographic factors, although higher proportions of non-White and Hispanic individuals were deceased. Most deaths were related to medical comorbidities rather than hydrocephalus itself. Of the 14 deaths directly related to hydrocephalus, seven were caused by shunt complications and four occurred after decisions to forgo treatment, apparently in response to poor outcomes predicted by the medical team. Half the deaths were preceded by shifts to comfort-based care; however, these decisions appeared to substantially change the patient's clinical trajectory only half the time. Interpretation: Children are more likely to die with, rather than from, hydrocephalus. Our results emphasize the complexities of medical decision-making and the influence of clinicians in guiding these choices.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Child ; Child, Preschool ; Female ; Humans ; Hydrocephalus/mortality ; Infant ; Infant, Newborn ; Male ; Retrospective Studies ; Young Adult
Language	English
Publishing date	2021-07-15
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80369-8
ISSN	1469-8749 ; 0012-1622
ISSN (online)	1469-8749
ISSN	0012-1622
DOI	10.1111/dmcn.14975
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Article ; Online: Health preferences and preventive care utilisation

Dan Kelleher / Edel Doherty / Ciaran O'Neill

Preventive Medicine Reports, Vol 24, Iss , Pp 101514- (2021)

How EQ-5D-5L health preferences may affect uptake

2021

Abstract	Despite the economic and health benefits of preventive care being well established, the uptake of many cost-effective preventive services remains lower than desired in many cases, especially among specific sub-populations. The value an individual places on health can influence their uptake of preventive care. One way to capture the value an individual places on health and future health status is to examine their health preferences. This study used a novel use of EQ-5D-5L health preferences to determine if health preferences are associated with the uptake of a range of preventive care services, including a cancer screening, blood pressure check, cholesterol check, blood test and urine test. We collected EQ-5D-5L composite time trade-off data in 2018/2019 on 242 respondents residing in Ireland. We estimated an initial tobit model to predict an individual’s health preference to capture health preferences as a regressor. We then estimated a bivariate probit model to examine the uptake of each preventive service and GP use. Each model controlled for health preferences, education, sex, type of health coverage, self-reported health, employment status, age and marital status. Health preferences are a significant determinant of all five preventive services while controlling for other covariates. The results shows that the higher an individual values good health, the more likely they are to avail of preventive care. Health preferences can be noted as a potential determinant of preventive care use that could guide policy responses seeking to increase demand-side factors for preventive care uptake.
Keywords	Ireland ; EQ-5D-5L ; Health preferences ; Health-related behaviours ; Health outcomes ; Preventive care determinants ; Medicine ; R
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Systematic analysis of cilia characteristics and Hedgehog signaling in five immortal cell lines.

Gómez, Arianna Ericka / Christman, Angela K / Van De Weghe, Julie Craft / Finn, Malaney / Doherty, Dan

PloS one

2022 Volume 17, Issue 12, Page(s) e0266433

Abstract: Dysfunction of the primary cilium, a microtubule-based signaling organelle, leads to genetic conditions called ciliopathies. Hedgehog (Hh) signaling is mediated by the primary cilium in vertebrates and is therefore implicated in ciliopathies; however, it ...

Abstract	Dysfunction of the primary cilium, a microtubule-based signaling organelle, leads to genetic conditions called ciliopathies. Hedgehog (Hh) signaling is mediated by the primary cilium in vertebrates and is therefore implicated in ciliopathies; however, it is not clear which immortal cell lines are the most appropriate for modeling pathway response in human disease; therefore, we systematically evaluated Hh in five commercially available, immortal mammalian cell lines: ARPE-19, HEK293T, hTERT RPE-1, NIH/3T3, and SH-SY5Y. Under proper conditions, all of the cell lines ciliated adequately for our subsequent experiments, except for SH-SY5Y which were excluded from further analysis. hTERT RPE-1 and NIH/3T3 cells relocalized Hh pathway components Smoothened (SMO) and GPR161 and upregulated Hh target genes in response to pathway stimulation. In contrast, pathway stimulation did not induce target gene expression in ARPE-19 and HEK293T cells, despite SMO and GPR161 relocalization. These data indicate that human hTERT RPE-1 cells and murine NIH/3T3 cells, but not ARPE-19 and HEK293T cells, are suitable for modeling the role of Hh signaling in ciliopathies.
MeSH term(s)	Humans ; Animals ; Mice ; Hedgehog Proteins/metabolism ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/metabolism ; Cilia/metabolism ; HEK293 Cells ; Neuroblastoma/metabolism ; Smoothened Receptor/genetics ; Smoothened Receptor/metabolism ; Mammals/metabolism
Chemical Substances	Hedgehog Proteins ; Receptors, G-Protein-Coupled ; Smoothened Receptor
Language	English
Publishing date	2022-12-29
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0266433
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Article ; Online: Examining the Association between Polish Migrant Status and Health Preferences Using a Novel Application of a Smaller Design EQ-5D-5L Valuation Study.

Kelleher, Dan / Kharroubi, Samer / Doherty, Edel / Baio, Gianluca / O'Neill, Ciaran

PharmacoEconomics - open

2022 Volume 6, Issue 3, Page(s) 425–435

Abstract: Introduction: Migrants have different utilisation of healthcare services and health-related behaviours than host populations. A potential factor that may contribute to the notable differences in healthcare use and health-related behaviours between ... ...

Abstract	Introduction: Migrants have different utilisation of healthcare services and health-related behaviours than host populations. A potential factor that may contribute to the notable differences in healthcare use and health-related behaviours between migrants and host populations is how these groups value health. Those who place a high value on health have greater healthcare-seeking practices than those who do not. Objective: The aim of this study was to examine how Polish migrants and native Irish differ in health state utility valuations using a novel application of a smaller design EQ-5D-5L valuation study. Methods: This study uses health preferences as a predictor of how one values health. We examined the EQ-5D-5L health preferences of 119 Polish migrants and 123 native Irish, both residing full-time in Ireland. To do so, we used a novel application of a smaller design EQ-5D-5L valuation study that consisted of 30 health states and a targeted sampling strategy coupled with a Bayesian statistical nonparametric model. We collected data from June 2018 to September 2019. Results: Our results highlight that Polish migrants and native Irish differ in their health preferences for and valuation of severe health states. Polish migrants place meaningfully higher utility valuations of 0.1 or more on the three most severe health states compared with the native Irish. Conclusion: This study can provide an understanding of a potential new factor underpinning some of the disparities in healthcare utilisation and health-related behaviours among migrants and host populations in Europe. This study also provides proof of principle for using a smaller design EQ-5D-5L valuation study to explore differences in health preferences among other minority subgroups, which can otherwise be hard to uncover when using the secondary analysis of national EQ-5D-5L valuation studies.
Language	English
Publishing date	2022-01-26
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2874287-4
ISSN	2509-4254 ; 2509-4262
ISSN (online)	2509-4254
ISSN	2509-4262
DOI	10.1007/s41669-021-00314-2
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