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  1. Article ; Online: Air pollution is a risk factor for multiple sclerosis - No.

    Delgado-García, Guillermo / Corona, Teresa

    Multiple sclerosis (Houndmills, Basingstoke, England)

    2021  Volume 27, Issue 14, Page(s) 2138–2139

    MeSH term(s) Air Pollution/statistics & numerical data ; Humans ; Multiple Sclerosis/epidemiology ; Multiple Sclerosis/etiology ; Particulate Matter/toxicity ; Risk Factors
    Chemical Substances Particulate Matter
    Language English
    Publishing date 2021-10-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 1290669-4
    ISSN 1477-0970 ; 1352-4585
    ISSN (online) 1477-0970
    ISSN 1352-4585
    DOI 10.1177/13524585211026875
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  2. Article ; Online: Hashimoto's Encephalopathy: Back to Square One.

    Delgado-García, Guillermo / Balint, Bettina

    Movement disorders clinical practice

    2020  Volume 7, Issue 6, Page(s) 627–628

    Language English
    Publishing date 2020-07-16
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13012
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  3. Article ; Online: Future of Neurology & Technology: Stereoelectroencephalography in Presurgical Epilepsy Evaluation.

    Delgado-Garcia, Guillermo / Frauscher, Birgit

    Neurology

    2022  Volume 98, Issue 4, Page(s) e437–e440

    Abstract: Stereoelectroencephalography (SEEG) is not only a sophisticated and highly technological investigation but a new and better way to conceptualize the spatial and temporal dynamics of epileptic activity. The first intracranial investigations with SEEG were ...

    Abstract Stereoelectroencephalography (SEEG) is not only a sophisticated and highly technological investigation but a new and better way to conceptualize the spatial and temporal dynamics of epileptic activity. The first intracranial investigations with SEEG were performed in France in the mid-twentieth century; however, its use in North America is much more recent. Given its significantly lower risk of complications and its ability to sample both superficial and deep structures and both hemispheres simultaneously, SEEG has become the preferred method to conduct intracranial EEG monitoring in most comprehensive epilepsy centers in North America. SEEG is an invasive neurophysiologic methodology used for advanced presurgical workup in the 20% of drug-resistant patients with more complex focal epilepsy in whom noninvasive investigations do not allow to decide on surgical candidacy. SEEG uses stereotactically implanted depth electrodes to map the origin and propagation of epileptic seizures by creating a 3-dimensional representation of the abnormal electrical activity in the brain. SEEG analysis takes into account the background, interictal, and ictal activity, as well as the results of cortical electrical stimulation procedures, to reliably delineate the epileptogenic network. By means of a clinical vignette, this article will walk general neurologists, but especially neurology trainees through the immense potential of this methodology. In summary, SEEG enables to accurately identify the epileptogenic zone in patients with drug-resistant focal epilepsy who otherwise would be not amenable to surgical treatment. In this patient population, SEEG is the best way to improve seizure control and achieve seizure freedom.
    Language English
    Publishing date 2022-01-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000013088
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  4. Article ; Online: New Technique, New Antibody: Phage Display Identifies Kelch-Like Protein-11 Antibodies.

    Delgado-García, Guillermo / Balint, Bettina

    Movement disorders clinical practice

    2020  Volume 8, Issue 2, Page(s) 215–216

    Language English
    Publishing date 2020-12-30
    Publishing country United States
    Document type Journal Article
    ISSN 2330-1619
    ISSN (online) 2330-1619
    DOI 10.1002/mdc3.13136
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  5. Article ; Online: The use of patient-reported measures in epilepsy care: the Calgary Comprehensive Epilepsy Program experience.

    Delgado-García, Guillermo / Wiebe, Samuel / Josephson, Colin B

    Journal of patient-reported outcomes

    2021  Volume 5, Issue Suppl 2, Page(s) 83

    Abstract: The regular use of patient-reported measures (PRMs) has been associated with greater patient satisfaction and outcomes. In this article, we will review the Calgary Comprehensive Epilepsy Program's successful experience with PRMs in both clinical and ... ...

    Abstract The regular use of patient-reported measures (PRMs) has been associated with greater patient satisfaction and outcomes. In this article, we will review the Calgary Comprehensive Epilepsy Program's successful experience with PRMs in both clinical and research settings, as well as our current challenges and future directions. Our experience will illustrate that is feasible and convenient to implement PRMs, and especially electronic PRMs (ePRMs), into epilepsy clinics. These PRMs have direct clinical and research applications. They inform clinical decision making through readily interpretable scales to which clinicians can expeditiously respond. Equally, they are increasingly forming an integral and central component of intervention and outcomes-based research. However, implementation studies are necessary to address knowledge gaps and facilitate adoption and dissemination of this approach. A natural symbiosis of the clinical and research realms is precision medicine. The foundations of precision-based interventions are now being set whereby we can maximize the quality of life and psychosocial functioning on an individual level. As illustrated in this article, this exciting prospect crucially depends on the routine use of ePRMs in the everyday care of people with epilepsy. Increasing ePRMs uptake will clearly be a catalyst propelling precision epilepsy from aspiration to clinical reality.
    Language English
    Publishing date 2021-10-12
    Publishing country Germany
    Document type Journal Article
    ISSN 2509-8020
    ISSN (online) 2509-8020
    DOI 10.1186/s41687-021-00356-4
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  6. Article ; Online: Extensor plantar response elicited by neck extension.

    Estañol, Bruno / Mendizábal-Méndez, José Luis / Delgado-García, Guillermo

    Acta neurologica Belgica

    2021  Volume 122, Issue 6, Page(s) 1649–1650

    MeSH term(s) Humans ; Reflex, Babinski ; Neck
    Language English
    Publishing date 2021-09-16
    Publishing country Italy
    Document type Letter
    ZDB-ID 127315-2
    ISSN 2240-2993 ; 0300-9009
    ISSN (online) 2240-2993
    ISSN 0300-9009
    DOI 10.1007/s13760-021-01803-1
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  7. Article ; Online: Journal Club: Scoping review of prevalence of neurologic comorbidities in patients hospitalized for COVID-19.

    Delgado-García, Guillermo / Arauz, Antonio / Corona, Teresa

    Neurology

    2020  Volume 95, Issue 15, Page(s) 701–704

    MeSH term(s) Betacoronavirus ; COVID-19 ; Comorbidity ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; Prevalence ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000010534
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  8. Article: Diagnostic bias in COVID-19 times.

    Rodríguez-Rivas, Roberto / Delgado-García, Guillermo / Abundes-Corona, Arturo / Corona, Teresa

    Gaceta medica de Mexico

    2022  Volume 157, Issue 6, Page(s) 557–558

    Title translation Sesgo diagnóstico en época de COVID-19.
    MeSH term(s) Bias ; COVID-19 ; Humans ; SARS-CoV-2
    Language English
    Publishing date 2022-02-02
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 425456-9
    ISSN 0016-3813
    ISSN 0016-3813
    DOI 10.24875/GMM.M21000616
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    Ua VI Zs.38: Show issues Location:
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  9. Article: Neurological manifestations in coronavirus disease 2019.

    Corona, Teresita / Rodríguez-Violante, Mayela / Delgado-García, Guillermo

    Gaceta medica de Mexico

    2020  Volume 156, Issue 4, Page(s) 317–320

    Abstract: Coronavirus disease 2019 (COVID-19), an infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently hitting the world in the form of a pandemic. Given that some reports suggest that this infection can also occur with ... ...

    Title translation Manifestaciones neurológicas en la enfermedad del coronavirus 2019.
    Abstract Coronavirus disease 2019 (COVID-19), an infection caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is currently hitting the world in the form of a pandemic. Given that some reports suggest that this infection can also occur with neurologic manifestations, this narrative review addresses the basic and clinical aspects concerning the nervous system involvement associated with this disease. More than one third of patients hospitalized for COVID-19 can present with both central and peripheral neurological manifestations. The former include dizziness and headache, while the latter include taste and smell disturbances. Other reported neurological manifestations are cerebrovascular disease and epileptic seizures. According to published reports, neurological disorders are not uncommon in COVID-19 and can sometimes represent the first manifestation of the disease; therefore, neurologists should consider this diagnostic possibility in their daily practice. Since maybe not all COVID-19 neurological manifestations are due to SARS-CoV-2 direct effects, it is important to monitor the rest of the clinical parameters such as, for example, oxygen saturation. Similarly, follow-up of patients is advisable, since whether neurological complications may develop lately is thus far unknown.
    MeSH term(s) Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques ; Coronavirus Infections/complications ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Dizziness/virology ; Headache/virology ; Humans ; Nervous System Diseases/diagnosis ; Nervous System Diseases/epidemiology ; Nervous System Diseases/virology ; Olfaction Disorders/virology ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Taste Disorders/virology
    Keywords covid19
    Language English
    Publishing date 2020-08-24
    Publishing country Mexico
    Document type Journal Article ; Review
    ZDB-ID 425456-9
    ISSN 0016-3813
    ISSN 0016-3813
    DOI 10.24875/GMM.20000195
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  10. Article: The patient journey with NMOSD: From initial diagnosis to chronic condition.

    Delgado-Garcia, Guillermo / Lapidus, Sheryl / Talero, Rosa / Levy, Michael

    Frontiers in neurology

    2022  Volume 13, Page(s) 966428

    Abstract: Objective: To better understand the patient experience with neuromyelitis optica spectrum disorder (NMOSD) through the course of the illness.: Background: NMOSD is a rare autoimmune disorder that causes recurrent inflammatory attacks of the optic ... ...

    Abstract Objective: To better understand the patient experience with neuromyelitis optica spectrum disorder (NMOSD) through the course of the illness.
    Background: NMOSD is a rare autoimmune disorder that causes recurrent inflammatory attacks of the optic nerve, spinal cord, and brain. Knowledge and awareness of NMOSD in the general medical community are often limited, resulting in potential delays in diagnosis and treatment.
    Design/methods: We developed a comprehensive 101-question survey to understand the patient's perspective on their journey from initial presentation to present condition. The survey covered basic demographics, symptoms, medical tests used to reach a diagnosis, and the patient's psychosocial responses to their diagnosis. The survey included questions to determine internal consistency in responses. We shared the survey with members of the Neuromyelitis Optica (NMO) Clinic Facebook group and received responses from 151 patients. All data collected were self-reported and presented as summary statistics.
    Results: The majority of survey responses were from patients who were female (83%) and White (76%), Asian (7%), or African American (7%). Initial symptoms of disease included fatigue, pain, stiffness/spasticity, bladder and bowel dysfunction, cognitive/emotional symptoms, and visual disturbances. Initial reactions to NMOSD diagnosis were frequently fear, anxiety, and/or depression. Mean (SD) time to diagnosis was 2.2 (3.2) years. First contact with a medical professional was felt to be not helpful or somewhat helpful for many patients (71%), in part due to uncertain diagnosis and/or treatment. However, once referred to specialists (primarily neurologists), the majority of patients (87%) reported finding a professional who could help. Tests leading to diagnosis included magnetic resonance imaging, lumbar puncture, and blood tests for autoantibodies including aquaporin-4 (AQP4) and myelin oligodendrocyte glycoprotein (MOG). While approximately 30% of patients still felt challenged for a variety of reasons, most patients reported that having a diagnosis and being under the care of a specialist contributed to a comprehensive plan with hope for their future.
    Conclusions: The NMOSD patient journey frequently begins with anxiety, fear, and frustration. Finding the right specialist and identifying appropriate screening tests can lead to earlier diagnosis and progression toward better patient outcomes.
    Language English
    Publishing date 2022-09-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.966428
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