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  1. Article ; Online: The effect of Jian Gan powder on the proliferation, migration and polarization of macrophages and relative mechanism.

    Li, Kun / Zheng, Xue / Zhang, Jian / Yan, Zhanpeng / Ji, Yu / Ge, Fei / Zhu, Fangshi

    Pharmaceutical biology

    2024  Volume 62, Issue 1, Page(s) 162–169

    Abstract: Context: Jian Gan powder (JGP) is a Chinese medicine compound comprised ginseng, Radix Paeoniae ...

    Abstract Context: Jian Gan powder (JGP) is a Chinese medicine compound comprised ginseng, Radix Paeoniae Alba, Radix Astragali, Salvia miltiorrhiza, Yujin, Rhizoma Cyperi, Fructus aurantii, Sophora flavescens, Yinchen, Bupleurum and licorice.
    Objective: This study explored the inhibitory effects, polarization and potential mechanisms associated with JGP in macrophages.
    Materials and methods: RAW264.7 cells were randomly divided into six groups for 24 h: control, lipopolysaccharide (LPS), overexpression, 1% JGP, 2% JGP, 4% JGP, 8% JGP and 16% JGP. The effects of JGP on RAW264.7 cell proliferation were assessed using colony formation assays and cell counting kit-8 (CCK-8) assays. The Transwell assay was used to evaluate its impact on RAW264.7 cell migration. Moreover, we analysed the interleukin-6 (IL-6)/signal transducer and activator of the transcription 3 (IL-6/STAT3) signaling pathway using quantitative real-time PCR and Western blotting. Furthermore, we examined the M1/M2 polarization levels.
    Results: Unlike LPS stimulation, JGP serum treatment markedly suppressed macrophage proliferation and migration capacity, while STAT3 overexpression enhanced RAW264.7 cell proliferation and migration. JGP inhibited the proliferation and migration of RAW264.7 cells by attenuating the IL-6/STAT3 signaling pathway. Furthermore, it inhibited macrophage M1 polarization, promoting M2 polarization.
    Discussion and conclusions: JGP effectively suppressed the cellular function of RAW264.7 cells by down-regulating the IL-6/STAT3 signaling pathway and modulating macrophage M1/M2 polarization. These findings provide valuable theoretical and experimental basis for considering the potential clinical application of JGP in the treatment of immune-mediated liver injury in clinical practice.
    MeSH term(s) Powders/metabolism ; Powders/pharmacology ; Interleukin-6/metabolism ; Lipopolysaccharides/pharmacology ; Macrophages ; Cell Proliferation
    Chemical Substances Powders ; Interleukin-6 ; Lipopolysaccharides
    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2024.2309864
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 1300: Show issues Location:
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  2. Article ; Online: Jian Gan powder ameliorates immunological liver injury in mice by modulating the gut microbiota and metabolic profiles.

    Li, Kun / Cui, Yadong / Zheng, Xue / Min, Chunyan / Zhang, Jian / Yan, Zhanpeng / Ji, Yu / Ge, Fei / Ji, Hualiang / Zhu, Fangshi

    European journal of medical research

    2024  Volume 29, Issue 1, Page(s) 240

    Abstract: ... with the microbiota-gut-liver axis. Jian Gan powder (JGP) exhibits both protective and therapeutic effects ...

    Abstract Background: Immunological liver injury (ILI) is a common liver disease associated with the microbiota-gut-liver axis. Jian Gan powder (JGP) exhibits both protective and therapeutic effects on hepatitis virus-induced ILI in the clinic. However, the underlying mechanisms remain elusive. The aim of this study is to investigate the hepatoprotective effects and associated mechanisms of JGP in the context of gut microbiota, utilizing a mouse model of ILI.
    Methods: The mouse model was established employing Bacillus Calmette-Guérin (BCG) plus lipopolysaccharide (LPS). Following treatment with JGP (7.5, 15, or 30 g/kg), serum, liver, and fresh fecal samples were analyzed. 16S rRNA gene sequencing and untargeted metabolomics profiling were performed to assess the role of JGP on the gut microbiota and its metabolites.
    Results: JGP treatment markedly reduced serum IFN-γ, IL-6, IL-22, and hepatic p-STAT3 (phosphorylated transducer and activator of transcription-3) expression. In contrast, JGP increased the percentage of proliferating cell nuclear antigen-positive liver cells in treated mice. Fecal 16S rRNA gene sequencing revealed that JGP treatment restored the levels of Alloprevotella, Burkholderia-Caballeronia-Paraburkholderia, Muribaculum, Streptococcus, and Stenotrophomonas. Additionally, metabolomics analysis of fecal samples showed that JGP restored the levels of allylestrenol, eplerenone, phosphatidylethanolamine (PE) (P-20:0/0:0), sphingomyelin (SM) d27:1, soyasapogenol C, chrysin, and soyasaponin I.
    Conclusions: JGP intervention improves ILI by restoring gut microbiota and modifying its metabolic profiles. These results provide a novel insight into the mechanism of JGP in treating ILI and the scientific basis to support its clinical application.
    MeSH term(s) Mice ; Animals ; Gastrointestinal Microbiome/genetics ; Powders/metabolism ; Powders/pharmacology ; RNA, Ribosomal, 16S/genetics ; RNA, Ribosomal, 16S/analysis ; RNA, Ribosomal, 16S/metabolism ; Liver/metabolism ; Metabolome
    Chemical Substances Powders ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2024-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1329381-3
    ISSN 2047-783X ; 0949-2321
    ISSN (online) 2047-783X
    ISSN 0949-2321
    DOI 10.1186/s40001-024-01827-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4636: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Correction for: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

    Jiang, Xiao-Lin / Tai, He / Kuang, Jin-Song / Zhang, Jing-Yi / Cui, Shi-Chao / Lu, Yu-Xuan / Qi, Shu-Bo / Zhang, Shi-Yu / Li, Shun-Min / Chen, Jian-Ping / Meng, Xian-Sheng

    Aging

    2023  Volume 15, Issue 6, Page(s) 2358–2360

    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Jian-Pi-Gu-Shen-Hua-Yu Decoction Alleviated Diabetic Nephropathy in Mice through Reducing Ferroptosis.

    Lv, Shuquan / Fan, Lirong / Chen, Xiaoting / Su, Xiuhai / Dong, Li / Wang, Qinghai / Wang, Yuansong / Zhang, Hui / Cui, Huantian / Zhang, Shufang / Wang, Lixin

    Journal of diabetes research

    2024  Volume 2024, Page(s) 9990304

    Abstract: ... effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment ...

    Abstract Background: Diabetic nephropathy (DN), one of the most frequent complications of diabetes mellitus, is a leading cause of end-stage renal disease. However, the current treatment methods still cannot effectively halt the progression of DN. Jian-Pi-Gu-Shen-Hua-Yu (JPGS) decoction can be used for the treatment of chronic kidney diseases such as DN, but the specific mechanism of action has not been fully elucidated yet.
    Purpose: The aim of this study is to clarify whether JPGS alleviates the progression of diabetic nephropathy by inhibiting ferroptosis.
    Materials and methods: We established a DN mouse model to investigate the therapeutic effect of JPGS in a DN mouse model. Subsequently, we examined the effects of JPGS on ferroptosis- and glutathione peroxidase 4 (GPX4) pathway-related indices. Finally, we validated whether JPGS inhibited ferroptosis in DN mice via the GPX4 pathway using GPX4 inhibitor and ferroptosis inhibitors.
    Results: The results indicate that JPGS has a therapeutic effect on DN mice by improving kidney function and reducing inflammation. Additionally, JPGS treatment decreased iron overload and oxidative stress levels while upregulating the expression of GPX4 pathway-related proteins. Moreover, JPGS demonstrated a similar therapeutic effect as Fer-1 in the context of DN treatment, and RSL3 was able to counteract the therapeutic effect of JPGS and antiferroptotic effect.
    Conclusion: JPGS has significant therapeutic and anti-inflammatory effects on DN mice, and its mechanism is mainly achieved by upregulating the expression of GPX4 pathway-related proteins, thereby alleviating iron overload and ultimately reducing ferroptosis.
    MeSH term(s) Animals ; Mice ; Diabetic Nephropathies/drug therapy ; Ferroptosis ; Disease Models, Animal ; Inflammation ; Iron Overload/complications ; Iron Overload/drug therapy ; Diabetes Mellitus
    Language English
    Publishing date 2024-03-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6753
    ISSN (online) 2314-6753
    ISSN 2314-6753
    DOI 10.1155/2024/9990304
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Chinese herbal decoction, Yi-Qi-Jian-Pi formula exerts anti-hepatic fibrosis effects in mouse models of CCl

    Yang, Shiyan / Cheng, Yajun / Wang, Xiaolong / Yue, Suyang / Wang, Xi / Tang, Li / Li, Hailun / Zhang, Jie / Xiong, Qingping / Tan, Shanzhong

    Heliyon

    2024  Volume 10, Issue 5, Page(s) e26129

    Abstract: Background: Yi-Qi-Jian-Pi Formula (YQJPF) is a herbal medicine that is used to treat patients ...

    Abstract Background: Yi-Qi-Jian-Pi Formula (YQJPF) is a herbal medicine that is used to treat patients with liver failure. However, scientific evidence supporting the treatment of hepatic fibrosis with YQJPF has not been forthcoming. The present study aimed to determine the mechanisms underlying the anti-fibrotic effects of YQJPF in mouse models of hepatic fibrosis.
    Methods: Mice were randomly assigned to control, hepatic fibrosis model, silymarin (positive treated), and low-, medium- and high-dose YQJPF (7.5, 15, and 30 g/kg, respectively) groups. Liver function, inflammatory cytokines, and oxygen stress were analyzed using ELISA kits. Sections were histopathologically stained with hematoxylin-eosin, Masson trichrome, and Sirius red. Macrophage polarization was measured by flow cytometry and immunofluorescence. Potential targets of YQJPF against hepatic fibrosis were analyzed by network pharmacology of Chinese herbal compound and the effects of YQJPF on the transforming growth factor-beta (TGF-β)/Suppressor of Mothers against Decapentaplegic family member 3 (Smad3) signaling pathway were assessed using qRT-PCR and immunohistochemical staining. Finally, metagenomics and LC-MS/MS were used to detect the intestinal flora and metabolites of the mice, and an in-depth correlation analysis was performed by spearman correlation analysis. The data were compared by one-way ANOVA and least significant differences (LSDs) or ANOVA-Dunnett's T3 method used when no homogeneity was detected.
    Results: We induced hepatic fibrosis using CCl
    Conclusions: YQJPF can reverse liver fibrosis by inhibiting inflammation, suppressing oxidative stress, regulating the immunological response initiated by macrophages, inhibiting TGF-β/Smad3 signaling and regulating intestinal flora homeostasis. Therefore, YQJPF may be included in clinical regimens to treat hepatic fibrosis.
    Language English
    Publishing date 2024-02-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e26129
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

    Jiang, Xiao-Lin / Tai, He / Kuang, Jin-Song / Zhang, Jing-Yi / Cui, Shi-Chao / Lu, Yu-Xuan / Qi, Shu-Bo / Zhang, Shi-Yu / Li, Shun-Min / Chen, Jian-Ping / Meng, Xian-Sheng

    Aging

    2022  Volume 14, Issue 20, Page(s) 8321–8345

    Abstract: As a widely applied traditional Chinese medicine (TCM), Jian-Pi-Yi-Shen (JPYS) decoction maybe ...

    Abstract As a widely applied traditional Chinese medicine (TCM), Jian-Pi-Yi-Shen (JPYS) decoction maybe applied in curing premature ovarian failure (POF) besides chronic kidney disease (CKD).
    MeSH term(s) Rats ; Female ; Humans ; Animals ; Primary Ovarian Insufficiency/metabolism ; Triptorelin Pamoate/metabolism ; Triptorelin Pamoate/pharmacology ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Apoptosis ; Granulosa Cells/metabolism ; Mitochondria/metabolism
    Chemical Substances Triptorelin Pamoate (08AN7WA2G0) ; Drugs, Chinese Herbal
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula.

    Yan, Jing / Tang, Yan / Yu, Wei / Jiang, Lu / Liu, Chen / Li, Qi / Zhang, Zhiqiang / Shao, Changlei / Zheng, Yang / Liu, Xihao / Liu, Xincheng

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 9110704

    Abstract: ... to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application ...

    Abstract Background: Inflammatory bowel disease (IBD) is a major cause of morbidity and mortality due to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application in the clinic to combat gastrointestinal disorders. The investigation aimed to explore the molecular and cellular mechanisms of JW.
    Methods: 2% dextran sodium sulfate (DSS) was diluted in drinking water and given to mice for 5 days to establish murine models of experimental colitis, and different doses of JW solution were administered for 14 days. Network pharmacology analysis and weighted gene co-expression network analysis (WGCNA) were utilized to predict the therapeutic role of JW against experimental colitis and colitis-associated colorectal cancer (CAC). 16S rRNA sequencing and untargeted metabolomics were conducted using murine feces. Western blotting, immunocytochemistry, and wound healing experiments were performed to confirm the molecular mechanisms.
    Results: (1) Liquid chromatography with mass spectrometry was utilized to confirm the validity of the JW formula. The high dose of JW treatment markedly attenuated DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis. (2) The JW targets were related to the survival probability in patients with colorectal cancer, underlying a potential therapeutic value in CRC intervention. (3) Moreover, the JW therapy successfully rescued the decreased richness and diversity of microbiota, suppressed the potentially pathogenic phenotype of the gut microorganisms, and increased cytochrome P450 activity in murine colitis models. (4) Our
    Conclusion: The JW capsule attenuated the progression of murine colitis by a prompt resolution of inflammation and bloody stool and by re-establishing a microbiome profile that favors re-epithelization and prevents carcinogenesis.
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/9110704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5995: Show issues Location:
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  8. Article ; Online: Investigation of the mechanism of nephrotoxicity of nux-vomica by PTGS2/CYP2C9-mediated arachidonic acid pathway and Jian Pi Tong Luo compound's protective effect.

    Zhang, Na / An, Baisong / Zhao, Liangyou / Zhao, Dapeng / Lv, Bochuan / Liu, Shumin

    Biomedical chromatography : BMC

    2024  , Page(s) e5859

    Abstract: ... the efficacy of the Jian Pi Tong Luo (JPTL) compound in mitigating this toxicity. Kidney metabolomics, using ...

    Abstract The clinical effectiveness of nux-vomica in treating rheumatism and arthralgia is noteworthy; however, its nephrotoxicity has sparked global concerns. Hence, there is value in conducting studies on detoxification methods based on traditional Chinese medicine compatibility theory. Blood biochemistry, enzyme-linked immunosorbent assay, and pathological sections were used to evaluate both the nephrotoxicity of nux-vomica and the efficacy of the Jian Pi Tong Luo (JPTL) compound in mitigating this toxicity. Kidney metabolomics, using ultra-high-performance liquid chromatography-quadrupole-time-of-flight-MS (UPLC-Q-TOF-MS), was applied to elucidate the alterations in small-molecule metabolites in vivo. In addition, network pharmacology analysis was used to verify the mechanism and pathways underlying the nephrotoxicity associated with nux-vomica. Finally, essential targets were validated through molecular docking and western blotting. The findings indicated significant nephrotoxicity associated with nux-vomica, while the JPTL compound demonstrated the ability to alleviate this toxicity. The mechanism potentially involves nux-vomica activating the "PTGS2/CYP2C9-phosphatidylcholine-arachidonic acid metabolic pathway." This study establishes a scientific foundation for the clinical use of nux-vomica and lays groundwork for further research and safety assessment of toxic Chinese herbal medicines.
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 632848-9
    ISSN 1099-0801 ; 0269-3879
    ISSN (online) 1099-0801
    ISSN 0269-3879
    DOI 10.1002/bmc.5859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2166: Show issues Location:
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  9. Article: Tibetan medicine Bang Jian: a comprehensive review on botanical characterization, traditional use, phytochemistry, and pharmacology.

    Li, Yuan / Zhang, Jie / Fan, Jin-Ya / Zhong, Shi-Hong / Gu, Rui

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1295789

    Abstract: Tibetan medicine Bang Jian refers to a range of botanical drugs within the ...

    Abstract Tibetan medicine Bang Jian refers to a range of botanical drugs within the
    Language English
    Publishing date 2023-12-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1295789
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  10. Article: Bidirectional Effects of Mao Jian Green Tea and Its Flavonoid Glycosides on Gastrointestinal Motility.

    Wu, Lei / Jin, Xiang / Zheng, Canwen / Ma, Fengjing / Zhang, Xue / Gao, Pengfei / Gao, Jianhua / Zhang, Liwei

    Foods (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: Mao Jian Tea (MJT) has been generally consumed as a digestive aid for more than a hundred years ... investigated the effect of Mao Jian Green Tea (MJGT) on gastrointestinal motility. The biphasic effects ...

    Abstract Mao Jian Tea (MJT) has been generally consumed as a digestive aid for more than a hundred years in the Shanxi province of China. However, determination of its efficacy still remains elusive. This study investigated the effect of Mao Jian Green Tea (MJGT) on gastrointestinal motility. The biphasic effects of the hydro extracts of MJGT on gastric emptying and small intestinal propulsion of rats were identified in vivo; namely, the low (MJGT_L) and medium (MJGT_M) concentrations promoted gastrointestinal motility (
    Language English
    Publishing date 2023-02-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods12040854
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