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  1. Article ; Online: Ca

    Erickson, Jeffrey D / Kyllo, Thomas / Wulff, Heike

    Current research in physiology

    2023  Volume 6, Page(s) 100109

    Abstract: High affinity methylaminoisobutyric acid(MeAIB)/glutamine(Gln) transport activity regulated by neuronal firing occurs at the plasma membrane in mature rat hippocampal neuron-enriched cultures. Spontaneous ... ...

    Abstract High affinity methylaminoisobutyric acid(MeAIB)/glutamine(Gln) transport activity regulated by neuronal firing occurs at the plasma membrane in mature rat hippocampal neuron-enriched cultures. Spontaneous Ca
    Language English
    Publishing date 2023-10-14
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2665-9441
    ISSN (online) 2665-9441
    DOI 10.1016/j.crphys.2023.100109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Endothelial KCa channels: Novel targets to reduce atherosclerosis-driven vascular dysfunction.

    Vera, O Daniel / Wulff, Heike / Braun, Andrew P

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1151244

    Abstract: Elevated levels of cholesterol in the blood can induce endothelial dysfunction, a condition characterized by impaired nitric oxide production and decreased vasodilatory capacity. Endothelial dysfunction can promote vascular disease, such as ... ...

    Abstract Elevated levels of cholesterol in the blood can induce endothelial dysfunction, a condition characterized by impaired nitric oxide production and decreased vasodilatory capacity. Endothelial dysfunction can promote vascular disease, such as atherosclerosis, where macrophages accumulate in the vascular intima and fatty plaques form that impair normal blood flow in conduit arteries. Current pharmacological strategies to treat atherosclerosis mostly focus on lipid lowering to prevent high levels of plasma cholesterol that induce endothelial dysfunction and atherosclerosis. While this approach is effective for most patients with atherosclerosis, for some, lipid lowering is not enough to reduce their cardiovascular risk factors associated with atherosclerosis (e.g., hypertension, cardiac dysfunction, stroke, etc.). For such patients, additional strategies targeted at reducing endothelial dysfunction may be beneficial. One novel strategy to restore endothelial function and mitigate atherosclerosis risk is to enhance the activity of Ca
    Language English
    Publishing date 2023-03-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1151244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Thesis: Alkoxypsoralene - eine neue Klasse nicht-peptidischer Blocker von Kalziumkanälen der Shaker-Familie

    Wulff, Heike

    Synthese und In-vitro-Untersuchungen zur Phototoxizität

    1998  

    Author's details vorgelegt von Heike Wulff
    Language German
    Size III, 223 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Kiel, Univ., Diss., 1998
    HBZ-ID HT008951547
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    98 D 2427 order for loan Magazin

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  4. Article: Editorial: Ion Channels and Transporters in Ca

    Hajdu, Peter / Wulff, Heike / Niemeyer, Barbara A / Szabó, Ildikó

    Frontiers in physiology

    2022  Volume 13, Page(s) 962110

    Language English
    Publishing date 2022-07-07
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2022.962110
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  5. Article ; Online: Can KCa3.1 channel activators serve as novel inhibitors of platelet aggregation?

    Wulff, Heike / Braun, Andrew P / Alper, Seth L

    Journal of thrombosis and haemostasis : JTH

    2022  Volume 20, Issue 11, Page(s) 2488–2490

    MeSH term(s) Humans ; Platelet Aggregation ; Pyrazoles/pharmacology ; Pyrazoles/therapeutic use ; Platelet Function Tests ; Intermediate-Conductance Calcium-Activated Potassium Channels
    Chemical Substances Pyrazoles ; Intermediate-Conductance Calcium-Activated Potassium Channels
    Language English
    Publishing date 2022-10-18
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.15863
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    Zs.A 5805: Show issues Location:
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    Zs.MO 295: Show issues

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  6. Article ; Online: Ca2+-regulated expression of high affinity methylaminoisobutryic acid transport in hippocampal neurons inhibited by riluzole and novel neuroprotective aminothiazoles

    Jeffrey D. Erickson / Thomas Kyllo / Heike Wulff

    Current Research in Physiology, Vol 6, Iss , Pp 100109- (2023)

    2023  

    Abstract: High affinity methylaminoisobutyric acid(MeAIB)/glutamine(Gln) transport activity regulated by neuronal firing occurs at the plasma membrane in mature rat hippocampal neuron-enriched cultures. Spontaneous Ca2+-regulated transport activity was similarly ... ...

    Abstract High affinity methylaminoisobutyric acid(MeAIB)/glutamine(Gln) transport activity regulated by neuronal firing occurs at the plasma membrane in mature rat hippocampal neuron-enriched cultures. Spontaneous Ca2+-regulated transport activity was similarly inhibited by riluzole, a benzothiazole anticonvulsant agent, and by novel naphthalenyl substituted aminothiazole derivatives such as SKA-378. Here, we report that spontaneous transport activity is stimulated by 4-aminopyridine (4-AP) and that phorbol-myristate acetate (PMA) increases high K+ stimulated transport activity that is inhibited by staurosporine. 4-AP-stimulated spontaneous and PMA-stimulated high K+-induced transport is not present at 7 days in vitro (DIV) and is maximal by DIV∼21. The relative affinity for MeAIB is similar for spontaneous and high K+-stimulated transport (Km ∼ 50 μM) suggesting that a single transporter is involved. While riluzole and SKA-378 inhibit spontaneous transport with equal potency (IC50 ∼ 1 μM), they exhibit decreased (∼3-5 X) potency for 4-AP-stimulated spontaneous transport. Interestingly, high K+-stimulated MeAIB transport displays lower and differential sensitivity to the two compounds. SKA-378-related halogenated derivatives of SKA-75 (SKA-219, SKA-377 and SKA-375) preferentially inhibit high K+-induced expression of MeAIB transport activity at the plasma membrane (IC50 < 25 μM), compared to SKA-75 and riluzole (IC50 > 100 μM). Ca2+-dependent spontaneous and high K+-stimulated MeAIB transport activity is blocked by ω-conotoxin MVIIC, ω-agatoxin IVA, ω-agatoxin TK (IC50 ∼ 500 nM) or cadmium ion (IC50 ∼ 20 μM) demonstrating that P/Q-type CaV channels that are required for activity-regulated presynaptic vesicular glutamate (Glu) release are also required for high-affinity MeAIB transport expression at the plasma membrane. We suggest that neural activity driven and Ca2+ dependent trafficking of the high affinity MeAIB transporter to the plasma membrane is a unique target to understand mechanisms of Glu/Gln recycling in ...
    Keywords Glutamate/glutamine cycle ; Vesicle recycling ; Methylaminoisobutyric acid/glutamine transporter ; Hippocampal neurons ; Riluzole ; SKA-378 ; Physiology ; QP1-981 ; Specialties of internal medicine ; RC581-951
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Immunocytoprotection after reperfusion with Kv1.3 inhibitors has an extended treatment window for ischemic stroke.

    Lee, Ruth D / Chen, Yi-Je / Singh, Latika / Nguyen, Hai M / Wulff, Heike

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1190476

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1190476
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  8. Article ; Online: Determining the Gibbs Energy Contributions of Ion and Electron Transfer for Proton Insertion in ϵ-MnO

    Malaie, Keyvan / Scholz, Fritz / Schröder, Uwe / Wulff, Harm / Kahlert, Heike

    Chemphyschem : a European journal of chemical physics and physical chemistry

    2022  Volume 23, Issue 24, Page(s) e202200364

    Abstract: Electrochemically active ϵ- ... ...

    Abstract Electrochemically active ϵ-MnO
    MeSH term(s) Manganese Compounds/chemistry ; Oxides/chemistry ; Protons ; Electrons ; Electrodes
    Chemical Substances Manganese Compounds ; Oxides ; Protons
    Language English
    Publishing date 2022-10-17
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2025223-7
    ISSN 1439-7641 ; 1439-4235
    ISSN (online) 1439-7641
    ISSN 1439-4235
    DOI 10.1002/cphc.202200364
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  9. Article ; Online: Pose Classification Using Three-Dimensional Atomic Structure-Based Neural Networks Applied to Ion Channel-Ligand Docking.

    Shim, Heesung / Kim, Hyojin / Allen, Jonathan E / Wulff, Heike

    Journal of chemical information and modeling

    2022  Volume 62, Issue 10, Page(s) 2301–2315

    Abstract: The identification of promising lead compounds showing pharmacological activities toward a biological target is essential in early stage drug discovery. With the recent increase in available small-molecule databases, virtual high-throughput screening ... ...

    Abstract The identification of promising lead compounds showing pharmacological activities toward a biological target is essential in early stage drug discovery. With the recent increase in available small-molecule databases, virtual high-throughput screening using physics-based molecular docking has emerged as an essential tool in assisting fast and cost-efficient lead discovery and optimization. However, the best scored docking poses are often suboptimal, resulting in incorrect screening and chemical property calculation. We address the pose classification problem by leveraging data-driven machine learning approaches to identify correct docking poses from AutoDock Vina and Glide screens. To enable effective classification of docking poses, we present two convolutional neural network approaches: a three-dimensional convolutional neural network (3D-CNN) and an attention-based point cloud network (PCN) trained on the PDBbind
    MeSH term(s) Ion Channels ; Ligands ; Molecular Docking Simulation ; Neural Networks, Computer ; Protein Binding
    Chemical Substances Ion Channels ; Ligands
    Language English
    Publishing date 2022-04-21
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural
    ZDB-ID 190019-5
    ISSN 1549-960X ; 0095-2338
    ISSN (online) 1549-960X
    ISSN 0095-2338
    DOI 10.1021/acs.jcim.1c01510
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    Zs.A 1230: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Kv1.3 inhibition attenuates neuroinflammation through disruption of microglial calcium signaling.

    Fomina, Alla F / Nguyen, Hai M / Wulff, Heike

    Channels (Austin, Tex.)

    2020  Volume 15, Issue 1, Page(s) 67–78

    Abstract: In the last 5 years inhibitors of the potassium channel ... ...

    Abstract In the last 5 years inhibitors of the potassium channel K
    MeSH term(s) Alzheimer Disease ; Calcium Signaling ; Membrane Potentials ; Microglia ; Neuroinflammatory Diseases ; Potassium Channels, Voltage-Gated
    Chemical Substances Potassium Channels, Voltage-Gated
    Language English
    Publishing date 2020-12-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2262854-X
    ISSN 1933-6969 ; 1933-6969
    ISSN (online) 1933-6969
    ISSN 1933-6969
    DOI 10.1080/19336950.2020.1853943
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