Result 1 - 3 of total 3
Chest
| Keywords | covid19 |
|---|---|
| Publisher | Elsevier; PMC |
| Document type | Article ; Online |
| DOI | 10.1016/j.chest.2020.08.1746 |
| Database | COVID19 |
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2022 Volume 10, Issue 4
Abstract: Ataxia-telangiectasia is an autosomal recessive disorder that usually manifests in childhood due to mutations in the Ataxia-Telangiectasia Mutated (ATM) gene. It is believed that there is an association between this gene mutation/polymorphism and cancer ... ...
| Abstract | Ataxia-telangiectasia is an autosomal recessive disorder that usually manifests in childhood due to mutations in the Ataxia-Telangiectasia Mutated (ATM) gene. It is believed that there is an association between this gene mutation/polymorphism and cancer risk, including breast, lung, and pancreatic cancers. We report a rare case of a 69-year-old woman who developed three different primary cancers, including non-small cell lung cancer (NSCLC) in both lungs and pancreatic adenocarcinoma, and was later found to have a rarely reported variant mutation in the ATM gene, namely Exon 39, c.5644 C > T. We hypothesize that the ATM gene, c.5644 C > T mutation could be a plausible contributor in the pathogenesis of these three cancers. This hypothesis has yet to be validated by larger studies that focus on a mechanistic approach involving DNA repair genes such as the ATM. More importantly, this paves the way to developing new patient-specific targeted therapies and inaugurating precision medicine as a cornerstone in cancer therapeutics. |
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| Language | English |
| Publishing date | 2022-12-01 |
| Publishing country | Switzerland |
| Document type | Case Reports |
| ZDB-ID | 2720869-2 |
| ISSN | 2079-9721 |
| ISSN | 2079-9721 |
| DOI | 10.3390/diseases10040115 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Cardio-oncology (London, England)
2017 Volume 3, Page(s) 2
Abstract: Atrial fibrillation (AF) is frequently observed in patients being treated for cancer and can lead to increased morbidity and mortality in this population. With the use of newer, targeted cancer therapies, several drug-drug interactions have emerged that ... ...
| Abstract | Atrial fibrillation (AF) is frequently observed in patients being treated for cancer and can lead to increased morbidity and mortality in this population. With the use of newer, targeted cancer therapies, several drug-drug interactions have emerged that complicate the use of antiarrhythmic drugs (AADs) in patients with active malignancy. Moreover, specific targeted therapies such as ibrutinib may contribute directly to the development of AF. The decision to pursue systemic anticoagulation can be challenging in patients with malignancy due to a number of factors, including the need for frequent procedures, the presence of malignancy-related risk factors for bleeding, and limited data regarding the safety of the novel oral anticoagulants (NOACs) in cancer patients. This review describes the challenges associated with AF management in patients with cancer and highlights a number of important drug-drug interactions that can impact patient management. |
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| Language | English |
| Publishing date | 2017-03-09 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ISSN | 2057-3804 |
| ISSN (online) | 2057-3804 |
| DOI | 10.1186/s40959-017-0021-y |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.
Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.