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Article ; Online: Comprehensive Profiling of EBV Gene Expression and Promoter Methylation Reveals Latency II Viral Infection and Sporadic Abortive Lytic Activation in Peripheral T-Cell Lymphomas.

Ho, Joanna W Y / Li, Lili / Wong, Kai Yau / Srivastava, Gopesh / Tao, Qian

2023 Volume 15, Issue 2

Abstract: Epstein-Barr virus (EBV) latency patterns are well defined in EBV-associated epithelial, NK/T-cell, and B-cell malignancies, with links between latency stage and tumorigenesis deciphered in various studies. ...

Abstract	Epstein-Barr virus (EBV) latency patterns are well defined in EBV-associated epithelial, NK/T-cell, and B-cell malignancies, with links between latency stage and tumorigenesis deciphered in various studies.
MeSH term(s)	Humans ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/genetics ; Gene Expression ; Herpesvirus 4, Human/genetics ; Latent Infection ; Lymphoma, T-Cell, Peripheral/genetics ; Methylation ; Promoter Regions, Genetic
Language	English
Publishing date	2023-02-02
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v15020423
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Systematic language input improved productions of elaborated verb phrases of Cantonese-speaking children with language difficulties.

Lau, Dustin Kai-Yan / Tang, Tempo Po-Yi / Wong, Christy Choi-Yan / Yau, Teresa Siu-Kwan / Lam, Iris Hang-Ching

Clinical linguistics & phonetics

2023 Volume 37, Issue 4-6, Page(s) 473–490

Abstract: It has been well-documented that language input designed according to the principles of statistical learning can promote language acquisition among children with or without language disorder. Cantonese-speaking children with language disorder were ... ...

Abstract	It has been well-documented that language input designed according to the principles of statistical learning can promote language acquisition among children with or without language disorder. Cantonese-speaking children with language disorder were reported to have difficulties using expanded verb phrases and prepositional phrases, but the corresponding intervention is relatively unexplored. The current study evaluated the efficacy of an intervention designed using the statistical learning principles to promote the acquisition of these two structures. A retrospective study of existing data collected from a total of 16 Cantonese-speaking children (four female; mean age = 6.70 years) with suspected language disorder was conducted. The participants were initially divided into the 'Treatment' and the 'Control' groups. A total of eight sessions of language treatment, which focused on giving systematic language input of expanded verb phrases and prepositional phrases, were conducted on each child. Results showed that the Treatment group produced significantly more expanded verb phrases in the post-treatment language samples, while the Control group did not. The final pre- and post-comparison conducted after the Control group also received treatment indicated overall significant increased number of expanded verb phrases produced across time. On the contrary, improvement in the production of prepositional phrases was not significant. It is suggested that the unique thematic roles coded by individual prepositions possibly restricted the generalisation effect of treatment, which explains the non-significant improvement across time. Theoretical and clinical implications were discussed.
MeSH term(s)	Child ; Humans ; Female ; Retrospective Studies ; Language ; Language Disorders ; Language Development ; Learning
Language	English
Publishing date	2023-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	639459-0
ISSN	1464-5076 ; 0269-9206
ISSN (online)	1464-5076
ISSN	0269-9206
DOI	10.1080/02699206.2022.2157330
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Article ; Online: Views on Workplace Policies and its Impact on Health-Related Quality of Life During Coronavirus Disease (COVID-19) Pandemic: Cross-Sectional Survey of Employees.

Wong, Eliza Lai-Yi / Ho, Kai-Fai / Wong, Samuel Yeung-Shan / Cheung, Annie Wai-Ling / Yau, Peter Sen-Yung / Dong, Dong / Yeoh, Eng-Kiong

International journal of health policy and management

2022 Volume 11, Issue 3, Page(s) 344–353

Abstract: Background: This study explored the degree of views towards supportive workplace policies among employees during coronavirus disease 2019 (COVID-19) pandemic and its association with health-related quality of life (HRQoL) in Hong Kong.: Methods: A ... ...

Abstract	Background: This study explored the degree of views towards supportive workplace policies among employees during coronavirus disease 2019 (COVID-19) pandemic and its association with health-related quality of life (HRQoL) in Hong Kong. Methods: A cross-sectional study was conducted in 1049 employees using online self-administered questionnaire. Views on workplace policies were measured in term of agreement on its comprehensiveness, timeliness and transparency whereas HRQoL was measured using EQ-5D-5L Hong Kong version. Univariate estimates on the impact of HRQoL from views of measures in workplace was done. Qualitative comments on the suggestions to strengthen workplace measures were collected and presented descriptively. Results: Of 1048 respondents, 16% reported that no workplace measures nor guidelines were existed in their company related to the COVID-19 pandemics. Those who reported having workplace policy were not satisfied with the arrangement in term of comprehensiveness (36%), timeliness (38%), and transparency (63%). Regarding to the policy measure, only 68% respondents reported that their workplace supplied face masks to them. The health index was 0897, which was lower than the norm of 0.924. 64% of respondents reported having a health problem in at least 1 of 5 dimension of EQ-5D-5L with the highest proportion of having problem in anxiety/depression (55%). In addition, the workplace policy and measure had a direct effect of 0.131 on health outcome. Perception of infection risk had a direct effect of 0.218 on health outcome and partly mediated the relationship between workplace policy and measure and health outcome (0.066). Conclusion: The study highlighted the workplace policy and measure is an important mean to minimize infection risk at workplace so as to reduce tremendous stress and health outcome caused by a COVID-19 pandemic. Workplace measures related to COVID-19 pandemic should be further strengthen to mitigate the risk of infection and protect employee's health.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; Cross-Sectional Studies ; Humans ; Pandemics ; Policy ; Quality of Life ; SARS-CoV-2 ; Workplace
Keywords	covid19
Language	English
Publishing date	2022-03-01
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2724317-5
ISSN	2322-5939 ; 2322-5939
ISSN (online)	2322-5939
ISSN	2322-5939
DOI	10.34172/ijhpm.2020.127
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Article: High-density lipoprotein cholesterol subfraction HDL2 is associated with improved endothelial function in systemic lupus erythematosus.

Lee, Ainsley Ryan Yan Bin / Yau, Chun En / Chua, Cheryl Kai Ting / Cheng, Wan Ling / Chia, Avery Joy Li / Wong, Shi Yin / Kow, Nien Yee / Gong, Lingli / Lee, Bernett Teck Kwong / Ling, Lieng Hsi / Mak, Anselm / Loh, Tze Ping / Tay, Sen Hee

Lupus science & medicine

2024 Volume 11, Issue 1

Abstract: Objective: Patients with systemic lupus erythematosus (SLE) have increased risk of premature atherosclerosis but the exact mechanisms remains unclear. Flow-mediated dilatation (FMD) is an established non-invasive assessment of vascular endothelial ... ...

Abstract	Objective: Patients with systemic lupus erythematosus (SLE) have increased risk of premature atherosclerosis but the exact mechanisms remains unclear. Flow-mediated dilatation (FMD) is an established non-invasive assessment of vascular endothelial function. Lipoprotein subfractions may be better predictors of FMD than conventional cholesterol measurements. We tested the hypothesis that lipoprotein subfractions are independently associated with FMD. Methods: Forty-one consecutive adult patients with SLE without known cardiovascular risk factors or disease were recruited in this cross-sectional study. Endothelial function and early atherosclerosis were assessed by brachial FMD and common carotid artery (CCA) intima-media thickness (IMT). High-density lipoprotein (HDL)/low-density lipoprotein (LDL) subfractions were measured. Machine learning models were also constructed to predict FMD and CCA IMT. Results: Median FMD was 4.48% (IQR 5.00%) while median IMT was 0.54 mm (IQR 0.12 mm). Univariate analysis showed lower LDL1 (r=-0.313, p<0.05) and higher HDL2 subfractions (r=0.313, p<0.05) were significantly associated with higher log-transformed FMD. In a multiple linear regression model, HDL2 (β=0.024, SE=0.012, p<0.05) remained an independent predictor of higher FMD after adjusting for age, body mass index, LDL1 and systolic blood pressure. The machine learning model included parameters such as HDL2 (positive association), prednisolone dose, LDL cholesterol and LDL1 for prediction of FMD (r=0.433, p<0.01). Age, LDL cholesterol and systolic blood pressure were independently associated with higher CCA IMT after adjusting for body mass index and HDL2. Conclusions: HDL 2, a large HDL particle, was independently associated with greater FMD and may be a biomarker of vascular health in SLE.
MeSH term(s)	Adult ; Humans ; Lipoproteins, HDL2 ; Lupus Erythematosus, Systemic ; Cholesterol, LDL ; Carotid Intima-Media Thickness ; Cross-Sectional Studies ; Cholesterol ; Lipoproteins, HDL ; Atherosclerosis
Chemical Substances	Lipoproteins, HDL2 ; Cholesterol, LDL ; Cholesterol (97C5T2UQ7J) ; Lipoproteins, HDL
Language	English
Publishing date	2024-01-22
Publishing country	England
Document type	Journal Article
ZDB-ID	2779620-6
ISSN	2053-8790
ISSN	2053-8790
DOI	10.1136/lupus-2023-001030
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Article: The Hong Kong consensus recommendations on the diagnosis and management of pancreatic cystic lesions.

Cheung, Tan-To / Lee, Yuk Tong / Tang, Raymond Shing-Yan / She, Wong Hoi / Cheng, Kai Chi / Cheung, Chin Cheung / Chiu, Keith Wan Hang / Chok, Kenneth Siu Ho / Chow, Wing Sun / Lai, Tak Wing / Seto, Wai-Kay / Yau, Thomas

Hepatobiliary surgery and nutrition

2023 Volume 12, Issue 5, Page(s) 715–735

Abstract: Background: The finding of pancreatic cystic lesions (PCL) on incidental imaging is becoming increasingly common. International studies report a prevalence of 2.2-44.7% depending on the population, imaging modality and indication for imaging, and the ... ...

Abstract	Background: The finding of pancreatic cystic lesions (PCL) on incidental imaging is becoming increasingly common. International studies report a prevalence of 2.2-44.7% depending on the population, imaging modality and indication for imaging, and the prevalence increases with age. Patients with PCL are at risk of developing pancreatic cancer, a disease with a poor prognosis. This publication summarizes recommendations for the diagnosis and management of PCL and post-operative pancreatic exocrine insufficiency (PEI) from a group of local specialists. Methods: Clinical evidence was consolidated from narrative reviews and consensus statements formulated during two online meetings in March 2022. The expert panel included gastroenterologists, hepatobiliary surgeons, oncologists, radiologists, and endocrinologists. Results: Patients with PCL require careful investigation and follow-up due to the risk of malignant transformation of these lesions. They should undergo clinical investigation and pancreas-specific imaging to classify lesions and understand the risk profile of the patient. Where indicated, patients should undergo pancreatectomy to excise PCL. Following pancreatectomy, patients are at risk of PEI, leading to gastrointestinal dysfunction and malnutrition. Therefore, such patients should be monitored for symptoms of PEI, and promptly treated with pancreatic enzyme replacement therapy (PERT). Patients with poor response to PERT may require increases in dose, addition of a proton pump inhibitor, and/or further investigation, including tests for pancreatic function. Patients are also at risk of new-onset diabetes mellitus after pancreatectomy; they should be screened and treated with insulin if indicated. Conclusions: These statements are an accurate summary of our approach to the diagnosis and management of patients with PCL and will be of assistance to clinicians treating these patients in a similar clinical landscape.
Language	English
Publishing date	2023-07-06
Publishing country	China (Republic : 1949- )
Document type	Journal Article ; Review
ZDB-ID	2812398-0
ISSN	2304-389X ; 2304-3881
ISSN (online)	2304-389X
ISSN	2304-3881
DOI	10.21037/hbsn-22-471
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Article ; Online: Trial watch: immunotherapeutic strategies on the horizon for hepatocellular carcinoma.

Koh, Benjamin / Tan, Darren Jun Hao / Lim, Wen Hui / Wong, Jeffrey S L / Ng, Cheng Han / Chan, Kai En / Wang, Meng / Yong, Wei Peng / Dan, Yock Young / Wang, Louis Z / Tan, Nigel / Muthiah, Mark / Kow, Alfred / Syn, Nicholas L / Huang, Daniel Q / Yau, Thomas

Oncoimmunology

2023 Volume 12, Issue 1, Page(s) 2214478

Abstract: The use of immune checkpoint inhibitors (ICIs) targeting PD-L1/PD-1 and CTLA-4 has transformed the oncology practice of hepatocellular carcinoma. However, only 25-30% of the patients with advanced HCC treated with atezolizumab-bevacizumab or tremelimumab- ...

Abstract	The use of immune checkpoint inhibitors (ICIs) targeting PD-L1/PD-1 and CTLA-4 has transformed the oncology practice of hepatocellular carcinoma. However, only 25-30% of the patients with advanced HCC treated with atezolizumab-bevacizumab or tremelimumab-durvalumab (STRIDE) respond initially, and mechanistic biomarkers and novel treatment strategies are urgently needed for patients who present with or acquire resistance to first-line ICI-based therapies. The recent approval of the STRIDE regimen has also engendered new questions, such as patient selection factors (e.g. portal hypertension and history of variceal bleed) and biomarkers, and the optimal combination and sequencing of ICI-based regimens. Triumphs in the setting of advanced HCC have also galvanized considerable interest in the broader application of ICIs to early- and intermediate-stage diseases, including clinical combination of ICIs with locoregional therapies. Among these clinical contexts, the role of ICIs in liver transplantation - which is a potentially curative strategy unique to HCC management - as a bridge to liver transplant in potential candidates or in the setting of post-transplant recurrence, warrants investigation in view of the notable theoretical risk of allograft rejection. In this review, we summarize and chart the landscape of seminal immuno-oncology trials in HCC and envision future clinical developments.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/therapy ; Liver Neoplasms/therapy ; Immune Checkpoint Inhibitors/therapeutic use ; Immunotherapy
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2023-06-03
Publishing country	United States
Document type	Review ; News ; Research Support, Non-U.S. Gov't
ZDB-ID	2645309-5
ISSN	2162-402X ; 2162-402X
ISSN (online)	2162-402X
ISSN	2162-402X
DOI	10.1080/2162402X.2023.2214478
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Article ; Online: Erratum: Epigenomic characterization of a p53-regulated 3p22.2 tumor suppressor that inhibits STAT3 phosphorylation via protein docking and is frequently methylated in esophageal and other carcinomas: Erratum.

Li, Lili / Xu, Juan / Qiu, Guohua / Ying, Jianming / Du, Zhenfang / Xiang, Tingxiu / Wong, Kai Yau / Srivastava, Gopesh / Zhu, Xiao-Feng / Mok, Tony S / Chan, Anthony Tc / Chan, Francis Kl / Ambinder, Richard F / Tao, Qian

Theranostics

2022 Volume 12, Issue 4, Page(s) 1736–1737

Abstract: This corrects the article DOI: 10.7150/thno.20893.]. ...

Abstract	[This corrects the article DOI: 10.7150/thno.20893.].
Language	English
Publishing date	2022-01-21
Publishing country	Australia
Document type	Published Erratum
ZDB-ID	2592097-2
ISSN	1838-7640 ; 1838-7640
ISSN (online)	1838-7640
ISSN	1838-7640
DOI	10.7150/thno.70351
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Article ; Online: Evaluation of a Low-Intensity Online Intervention (LiON) for Reducing Distress and Mental Health Symptoms in Young People.

Suen, Yi Nam / Leung, Chung Ming / Wan, Yau Sum / Chan, Kai Tai / Wong, Michael Tak Hing / Hui, Christy Lai Ming / Chan, Kit Wa Sherry / Lee, Edwin Ho Ming / Chen, Eric Yu Hai

The Journal of adolescent health : official publication of the Society for Adolescent Medicine

2023 Volume 74, Issue 1, Page(s) 89–97

Abstract: Purpose: Enhancing young people's mental health is crucial given that most adult mental disorders develop before age 24 years. However, it is unclear whether low-intensity interventions delivered online can be effective. This study aimed to provide ... ...

Abstract	Purpose: Enhancing young people's mental health is crucial given that most adult mental disorders develop before age 24 years. However, it is unclear whether low-intensity interventions delivered online can be effective. This study aimed to provide preliminary evidence on whether a low-intensity online intervention (LiON) can effectively lower young people's distress levels and mental health symptoms. Methods: We compared the preintervention and postintervention changes in distress level and severity of depression and anxiety symptoms in 137 young people aged 15-24 years who used the LiON service with the three-month changes in a 1:1 propensity score-matched control group of community young people who did not use the service. They participated in one of the following modules for the first time: (1) sleep and relaxation, (2) stress-coping, and (3) problem-solving. Results: Participants who received LiON intervention (mean age 22.88 [standard deviation 3.67] years, 65.7% female) showed significantly greater reductions in distress level (Cohen's f Discussion: The findings suggest that the LiON intervention has the potential to effectively reduce distress and mental health symptoms in young people. Future research should aim to confirm these findings through randomized controlled trials and explore the cost-effectiveness of the intervention.
MeSH term(s)	Adolescent ; Adult ; Female ; Humans ; Male ; Young Adult ; Depression/prevention & control ; Depression/diagnosis ; Internet-Based Intervention ; Mental Disorders ; Mental Health
Language	English
Publishing date	2023-10-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	1063374-1
ISSN	1879-1972 ; 1054-139X
ISSN (online)	1879-1972
ISSN	1054-139X
DOI	10.1016/j.jadohealth.2023.08.022
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Article ; Online: Development and Evaluation of Loop-Mediated Isothermal Amplification (LAMP) as a Preliminary Diagnostic Tool for Brown Root Rot Disease Caused by Phellinus noxius (Corner) G. H. Cunningham in Hong Kong Urban Tree Management

Hao Zhang / Tze Kwun Ng / Kai Chun Lee / Zoen Wing Leung / Wai Fu Yau / Wai Shing Wong

Sustainability, Vol 14, Iss 15, p

2022 Volume 9708

Abstract: Brown Root Rot Disease (BRRD) is one of the most devastating urban tree diseases in tropical and subtropical areas, including Hong Kong. It can result in tree death in a few months and is difficult to detect in the early stages of development. Fungal ... ...

Abstract	Brown Root Rot Disease (BRRD) is one of the most devastating urban tree diseases in tropical and subtropical areas, including Hong Kong. It can result in tree death in a few months and is difficult to detect in the early stages of development. Fungal isolation and PCR methods are currently the most widely adopted methods to diagnose the disease. However, they are both time and technically demanding. Loop-mediated isothermal amplification (LAMP) is a superior molecular-based diagnostic method with great specificity, accessibility, and effectivity. In this study, 15 BRRD-positive and 15 BRRD-negative trees were sampled from 19 roadside slopes in Hong Kong from the end of 2020 to the middle of 2021. The wood tissues were isolated and cultivated in PN3 and PDA agars for the disease diagnosis. The mycelium samples in PDA were directly conducted in LAMP kits (mLAMP) to substitute the purified DNA materials. Wood tissues were also used in LAMP kits (wLAMP) as impurified and highly contaminated samples. The results of mLAMP and wLAMP were compared with the results of isolation to evaluate the specificity and sensitivity of LAMP method. The results showed that mLAMP had 100% sensitivity and 73.3% specificity. For wLAMP, both the sensitivity and specificity were 73.3%. For symptomless trees, 85.7% and 64.3% congruencies were found in mLAMP and wLAMP, respectively. Based on the results of this study, the co-application of LAMP in the current tree management work was also discussed. We envisaged LAMP is a sensitive, prompt, and user-friendly method to diagnose BRRD and it could favor the BRRD diagnosis in fields by accelerating and promoting large-scale screening.
Keywords	loop-mediated isothermal amplification ; fungal isolation ; direct LAMP ; Brown Root Rot Disease (BRRD) ; Phellinus noxius ; Environmental effects of industries and plants ; TD194-195 ; Renewable energy sources ; TJ807-830 ; Environmental sciences ; GE1-350
Subject code	630
Language	English
Publishing date	2022-08-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: John Ching-Kwong Kwok (1951-2020): The Renaissance Man of Hong Kong Neurosurgery.

Woo, Peter Yat-Ming / Rehman, Safi Ur / Chan, Yung / Chu, Alberto Chi-Ho / Kwan, Marco Cheuk-Lun / Wong, Alain Kai-Sing / Wong, Hoi-Tung / Chan, Kwong-Yau

Asian journal of neurosurgery

2021 Volume 16, Issue 2, Page(s) 443–444

Language	English
Publishing date	2021-04-08
Publishing country	India
Document type	Journal Article
ZDB-ID	2621446-5
ISSN	2248-9614 ; 1793-5482
ISSN (online)	2248-9614
ISSN	1793-5482
DOI	10.4103/ajns.AJNS_23_21
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