Article: [Two new sesquiterpenes in Qi-nan Aquilariae Lignum Resinatum].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
2024 Volume 48, Issue 23, Page(s) 6403–6407
Abstract: This study aimed to investigate the chemical constituents of supercritical extract from Qi-nan ...
Abstract | This study aimed to investigate the chemical constituents of supercritical extract from Qi-nan Aquilariae Lignum Resinatum by silica gel column chromatography, thin-layer chromatography, and semi-preparative high-performance liquid chromatography. One new elemane-type and one new eudesmane-type sesquiterpene compounds were isolated from the extract, and their structures were identified by MS, UV, IR, NMR, and ECD spectroscopic techniques, and named aquqinanol C(1) and aquqinanol D(2). Both compounds are novel compounds. The neuroprotective effect of the compounds on CORT-induced PC12 cell damage was determined in vitro. The results showed that compounds 1 and 2 exhibited a certain protective effect against CORT-induced damage in PC12 cells. |
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MeSH term(s) | Rats ; Animals ; Qi ; Sesquiterpenes/pharmacology ; Molecular Structure |
Chemical Substances | Sesquiterpenes |
Language | Chinese |
Publishing date | 2024-01-09 |
Publishing country | China |
Document type | English Abstract ; Journal Article |
ZDB-ID | 1004649-5 |
ISSN | 1001-5302 ; 0254-0029 |
ISSN | 1001-5302 ; 0254-0029 |
DOI | 10.19540/j.cnki.cjcmm.20230618.203 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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