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Article ; Online: Serum levels of interleukin 17 and 22 in patients with systemic sclerosis: a single-center cross-sectional study.

Kardum, Željka / Milas-Ahić, Jasminka / Šahinović, Ines / Masle, Ana Marija / Uršić, Dora / Kos, Martina

2022 Volume 43, Issue 2, Page(s) 345–354

Abstract: Systemic sclerosis (SSc) is a chronic, autoimmune disease characterized by inflammation, vasculopathy, and fibrosis of the skin and internal organs. Immunological response in SSc is still poorly understood. Cytokines play a significant role in this ... ...

Abstract	Systemic sclerosis (SSc) is a chronic, autoimmune disease characterized by inflammation, vasculopathy, and fibrosis of the skin and internal organs. Immunological response in SSc is still poorly understood. Cytokines play a significant role in this process leading to vasculopathy and fibrosis. In this cross-sectional study, we aimed to investigate serum levels of Th-17-related cytokines, IL-17 and IL-22, and to determine their correlation to the clinical association in SSc patients. Serum IL-17 and IL-22 levels were examined in 42 SSc patients and 29 healthy individuals. Associations between serum IL-17 and IL-22 levels and the duration of the disease, the extent of skin fibrosis, capillaroscopic findings, and involvement of the internal organs were explored. Serum IL-17 levels were not different in SSc and the control group. Serum IL-22 levels were significantly elevated in SSc patients compared to healthy individuals (p = 0.04). A positive correlation was found between the IL-22 sera levels and interstitial lung disease (p = 0.007). These results suggest IL-22 as a potential biomarker in SSc-related interstitial lung disease.
MeSH term(s)	Humans ; Interleukin-17 ; Cross-Sectional Studies ; Scleroderma, Systemic/complications ; Lung Diseases, Interstitial/complications ; Cytokines ; Fibrosis
Chemical Substances	Interleukin-17 ; Cytokines
Language	English
Publishing date	2022-11-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-022-05250-w
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Article ; Online: The influence of habitual salt intake on bone remodelling in young healthy people

Erna Davidović-Cvetko / Anita Matić / Jasminka Milas-Ahić / Ines Drenjančević

Zdravniški Vestnik, Vol 90, Iss 7-8, Pp 380-

2021 Volume 389

Abstract: Introduction: Sodium alters calcium metabolism by increasing calcium excretion, thus possibly influencing bone metabolism. The hypothesis of the present study is that amount of dietary sodium intake affects the bone remodelling. This study aimed to ... ...

Abstract	Introduction: Sodium alters calcium metabolism by increasing calcium excretion, thus possibly influencing bone metabolism. The hypothesis of the present study is that amount of dietary sodium intake affects the bone remodelling. This study aimed to assess whether a habitual intake of sodium has an effect on peak bone mass and biochemical indicators of bone metabolism. Subjects and Methods: In a cross-sectional study that involved 41 young men and women, six biochemical markers were assessed from blood samples using ELISA: osteocalcin, C-terminal procollagen type I peptide, receptor activator kappa B ligand, pyridinoline, parathyroid hormone, and osteoprotegerin, while bone mineral density (BMD) and bone mineral content (BMC) were measured by dual x-ray absorptiometry. Subjects were divided into two groups according to habitual sodium intake (low-Na and high-Na group) assessed by questionnaire. Results: No difference was found between groups of low and high Na intake in BMD and BMC, or in biochemical markers of bone metabolism. Since the groups differed in Ca intake, energy and vitamin D, adjustments were made for those cofounders. Regression analysis showed that only the dietary intake of vitamin D was associated with dual femur BMD and BMC, and no correlation was found between bone remodelling indicators and Na intake after adjustment for vitamin D intake. Conclusion: The present results could not confirm that habitual sodium intake above recommended levels affects bone remodelling processes or decreases bone mineral density in young healthy people if combined with adequate calcium intake.
Keywords	sodium intake ; habitual diet ; bone density ; bone mineral content ; bone remodeling ; Medicine ; R
Subject code	616
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Slovenian Medical Association
Document type	Article ; Online
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Article ; Online: Successful treatment with Cinryze® replacement therapy of a pregnant patient with hereditary angioedema: a case report.

Kardum, Željka / Prus, Višnja / Milas Ahić, Jasminka / Kardum, Darjan

Journal of medical case reports

2021 Volume 15, Issue 1, Page(s) 20

Abstract: Background: Hereditary angioedema (HAE) is a rare disease characterized with recurrent swelling of subcutaneous or mucosal tissue that resolves in approximately 3 days. It can be presented with peripheral edema, abdominal and life-threatening laryngeal ... ...

Abstract	Background: Hereditary angioedema (HAE) is a rare disease characterized with recurrent swelling of subcutaneous or mucosal tissue that resolves in approximately 3 days. It can be presented with peripheral edema, abdominal and life-threatening laryngeal angioedema. A variety of triggers are known to cause episodes of angioedema including estrogen exposure. There are different reports regarding the effect of pregnancy on HAE attacks, and in some patients, the pregnancy is a recognized triggering factor. Case presentation: We present a female Caucasian patient with pre-existing HAE and disease exacerbations during pregnancy, requiring prophylactic use of plasma-derived C1 inhibitor concentrate. She was treated with Cinryze® replacement therapy throughout the pregnancy 1000 IU i.v. 48 times. She gave birth to a healthy male infant, via C-section. After the delivery, the patient was symptom-free for 6 months and required no treatment for HAE. Conclusions: In the case presented, the angioedema attacks worsened as the pregnancy progressed. The treatment with Cinryze® replacement therapy was effective and safe during pregnancy, with no adverse effects on the infant.
MeSH term(s)	Angioedema ; Angioedemas, Hereditary/drug therapy ; Complement C1 Inhibitor Protein/therapeutic use ; Edema ; Female ; Humans ; Male ; Pregnancy
Chemical Substances	Complement C1 Inhibitor Protein ; SERPING1 protein, human
Language	English
Publishing date	2021-01-24
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	2269805-X
ISSN	1752-1947 ; 1752-1947
ISSN (online)	1752-1947
ISSN	1752-1947
DOI	10.1186/s13256-020-02622-3
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Article ; Online: Effects of 8-week increment aerobic exercise program on bone metabolism and body composition in young non-athletes.

Davidović Cvetko, Erna / Nešić, Nebojša / Matić, Anita / Milas Ahić, Jasminka / Drenjančević, Ines

European journal of applied physiology

2022 Volume 122, Issue 4, Page(s) 1019–1034

Abstract: Purpose: The effects of aerobic exercise on bone metabolism are still unclear. Thus, the main goal of this study was to explore if there was an effect of the short-term aerobic exercise program on the bone remodeling process and if there were sex ... ...

Abstract	Purpose: The effects of aerobic exercise on bone metabolism are still unclear. Thus, the main goal of this study was to explore if there was an effect of the short-term aerobic exercise program on the bone remodeling process and if there were sex differences in the effect of the training program on bone metabolism. Methods: Twenty-one participants (men and women) aged 20-23 performed an 8-week aerobic exercise program three times per week in 1-h sessions with increases in the exercise load every 2 weeks. Bone density, bone mineral content and concentration of markers of bone metabolism: osteocalcin, C-terminal procollagen type I peptide, pyridinoline, parathyroid hormone, osteoprotegerin, and the receptor activator of nuclear kappa B ligand by ELISA were measured at the start and at the end of the study, while changes in body composition were assessed by a bioelectric impedance analysis method 6 times during the study. Results: The aerobic exercise program increased the concentration of osteocalcin (11.34 vs 14.24 ng/ml), pyridinoline (67.51 vs 73.99 nmol/l), and the receptor activator of nuclear kappa B ligand (95.122 vs 158.15 pg/ml). A statistically significant increase in bone density at neck mean (1.122 vs 1.176 g/cm Conclusion: 8 weeks of the aerobic exercise program with increment in intensity increased some of bone remodeling biomarkers and showed different effects for men and women.
MeSH term(s)	Adult ; Biomarkers/metabolism ; Body Composition ; Bone Density ; Collagen Type I/metabolism ; Collagen Type I/pharmacology ; Exercise ; Female ; Humans ; Male ; Osteocalcin ; Young Adult
Chemical Substances	Biomarkers ; Collagen Type I ; Osteocalcin (104982-03-8)
Language	English
Publishing date	2022-02-10
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124793-1
ISSN	1439-6327 ; 1432-1025 ; 0301-5548 ; 1439-6319
ISSN (online)	1439-6327 ; 1432-1025
ISSN	0301-5548 ; 1439-6319
DOI	10.1007/s00421-022-04900-y
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Article ; Online: Successful treatment with Cinryze® replacement therapy of a pregnant patient with hereditary angioedema

Željka Kardum / Višnja Prus / Jasminka Milas Ahić / Darjan Kardum

Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-

a case report

2021 Volume 4

Abstract: Abstract Background Hereditary angioedema (HAE) is a rare disease characterized with recurrent swelling of subcutaneous or mucosal tissue that resolves in approximately 3 days. It can be presented with peripheral edema, abdominal and life-threatening ... ...

Abstract	Abstract Background Hereditary angioedema (HAE) is a rare disease characterized with recurrent swelling of subcutaneous or mucosal tissue that resolves in approximately 3 days. It can be presented with peripheral edema, abdominal and life-threatening laryngeal angioedema. A variety of triggers are known to cause episodes of angioedema including estrogen exposure. There are different reports regarding the effect of pregnancy on HAE attacks, and in some patients, the pregnancy is a recognized triggering factor. Case presentation We present a female Caucasian patient with pre-existing HAE and disease exacerbations during pregnancy, requiring prophylactic use of plasma-derived C1 inhibitor concentrate. She was treated with Cinryze® replacement therapy throughout the pregnancy 1000 IU i.v. 48 times. She gave birth to a healthy male infant, via C-section. After the delivery, the patient was symptom-free for 6 months and required no treatment for HAE. Conclusions In the case presented, the angioedema attacks worsened as the pregnancy progressed. The treatment with Cinryze® replacement therapy was effective and safe during pregnancy, with no adverse effects on the infant.
Keywords	Hereditary angioedema ; Pregnancy ; C1 replacement therapy ; Cinryze® ; Case report ; Medicine ; R
Subject code	610
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article: Patofiziologija osteoporoze.

Milas-Ahić, Jasminka / Prus, Visnja / Kardum, Zeljka / Kovačević, Ivana

Reumatizam

2014 Volume 61, Issue 2, Page(s) 65–69

Abstract: The balance of degradation and bone formation is important for the normal process of remodeling and maintenance of bone mass. Genetic, hormonal, immunological and other factors affect bone remodeling throughout life. Disorder of bone turnover plays key ... ...

Title translation	Pathophysiology of osteoporosis.
Abstract	The balance of degradation and bone formation is important for the normal process of remodeling and maintenance of bone mass. Genetic, hormonal, immunological and other factors affect bone remodeling throughout life. Disorder of bone turnover plays key role in the pathophysiology of osteoporosis and presents a complex process which involves bone cells, cytokines and their receptors. Nowadays, important role of RANK/RANKL/OPG system in the pathophysiology of osteoporosis is well known, but it is still important to investigate the intracellular signaling pathways in the development of osteoporosis and other metabolic bone diseases.
Language	Croatian
Publishing date	2014
Publishing country	Croatia
Document type	English Abstract ; Journal Article
ZDB-ID	604372-0
ISSN	0374-1338
ISSN	0374-1338
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Zs.B 675: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 490: Show issues

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Article: Patofiziologija uricnog artritisa.

Milas-Ahić, Jasminka / Prus, Visnja / Visević, Roberta

Reumatizam

2012 Volume 59, Issue 2, Page(s) 89–92

Abstract: Hyperuricemia is rather often metabolic disorder in general population. It is multifactorial disorder influenced by purine rich diet, alcohol consumption, diuretics use and renal deterioration. In the presence of local urate superasturation and lower ... ...

Title translation	Pathophysiology of gout.
Abstract	Hyperuricemia is rather often metabolic disorder in general population. It is multifactorial disorder influenced by purine rich diet, alcohol consumption, diuretics use and renal deterioration. In the presence of local urate superasturation and lower solubility, monosodium crystals are deposited in joints, kidneys and soft tissue leading to clinical manifestations, such as gout, tophaceus deposits, nephrolithiasis and uric nephropathy. Major advances in understanding the pathogenesis of hyperuricemia and gout have been made recently, including genetic studies of urate transporters in kidneys as well as innate immune inflammatory responses and cytokine production which will be discussed thoroughly in this paper.
MeSH term(s)	Arthritis, Gouty/physiopathology ; Gout/physiopathology ; Humans
Language	Croatian
Publishing date	2012
Publishing country	Croatia
Document type	English Abstract ; Journal Article
ZDB-ID	604372-0
ISSN	0374-1338
ISSN	0374-1338
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Zs.B 675: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 490: Show issues

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Article: Patofiziologija osteoporoze.

Milas-Ahić, Jasminka / Prus, Visnja / Kardum, Zeljka / Kovačević, Ivana

Reumatizam

2014 Volume 61, Issue 2, Page(s) 65–69

Title translation	Pathophysiology of osteoporosis.
Abstract	The balance of degradation and bone formation is important for the normal process of remodeling and maintenance of bone mass. Genetic, hormonal, immunological and other factors affect bone remodeling throughout life. Disorder of bone turnover plays key role in the pathophysiology of osteoporosis and presents a complex process which involves bone cells, cytokines and their receptors. Nowadays, important role of RANK/RANKL/OPG system in the pathophysiology of osteoporosis is well known, but it is still important to investigate the intracellular signaling pathways in the development of osteoporosis and other metabolic bone diseases.
MeSH term(s)	Bone Density ; Bone Remodeling/physiology ; Humans ; Osteoporosis/physiopathology ; RANK Ligand/physiology ; Receptor Activator of Nuclear Factor-kappa B/physiology
Chemical Substances	RANK Ligand ; Receptor Activator of Nuclear Factor-kappa B ; TNFRSF11A protein, human
Language	Croatian
Publishing date	2014
Publishing country	Croatia
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	604372-0
ISSN	0374-1338
ISSN	0374-1338
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.B 675: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Serum Osteoprotegerin in Patients with Calcified Aortic Valve Stenosis in Relation to Heart Failure.

Makarović, Sandra / Makarović, Zorin / Bilić-Ćurčić, Ines / Milas-Ahić, Jasminka / Mihaljević, Ivan / Franceschi, Maja / Jukić, Tomislav

Acta clinica Croatica

2018 Volume 56, Issue 4, Page(s) 733–741

Abstract: The aim of the study was to assess the role of serum osteoprotegerin (OPG) as a biomarker in patients with aortic valve stenosis (AS) in relation to heart failure and symptomatic status. This was a case control study, which included 51 patients with AS ... ...

Abstract	The aim of the study was to assess the role of serum osteoprotegerin (OPG) as a biomarker in patients with aortic valve stenosis (AS) in relation to heart failure and symptomatic status. This was a case control study, which included 51 patients with AS and 39 control subjects. At the time of study enrolment, detailed medical history was obtained and all subjects underwent physical examination, chest x-ray and echocardiography. OPG levels were measured in all subjects, and serum N-terminal of the pro b-type natriuretic peptide (NT pro BNP) levels were determined in patients with AS. Serum OPG levels were elevated in patients with AS compared to control subjects (p=0.001). Patients with heart failure due to AS had elevated serum OPG levels in comparison to patients without heart failure (p=0.001). A significant correlation between OPG and symptomatic status was observed in all patients with AS (p<0.001), however, it was not the case in patients without heart failure (p=0.425). There was a positive correlation between OPG and NT pro BNP concentrations with objective signs of heart failure on chest x-ray (p<0.001). Negative correlation of OPG concentrations with aortic valve area was present (p<0.040), as well as with left ventricular ejection fraction (p<0.001). Serum OPG could be a valuable biomarker in the evaluation of severity of calcified AS and serve as an additional indicator besides clinical presentation and echocardiography in the assessment of surgical treatment or aortic valve replacement.
MeSH term(s)	Aortic Valve ; Aortic Valve Stenosis/blood ; Biomarkers ; Case-Control Studies ; Heart Failure/blood ; Humans ; Osteoprotegerin/blood
Chemical Substances	Biomarkers ; Osteoprotegerin
Language	English
Publishing date	2018-03-28
Publishing country	Croatia
Document type	Journal Article
ZDB-ID	1478635-7
ISSN	0353-9466
ISSN	0353-9466
DOI	10.20471/acc.2017.56.04.22
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Zs.A 5057: Show issues

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Article ; Online: Optic neuritis as a presenting feature of Behçet's disease: case-based review.

Kardum, Željka / Milas Ahić, Jasminka / Lukinac, Ana Marija / Ivelj, Ružica / Prus, Višnja

Rheumatology international

2020 Volume 41, Issue 1, Page(s) 189–195

Abstract: Behçet's disease (BD) is vasculitis affecting vessels of variable sizes characterized with recurrent oral and/or genital aphthous ulcers accompanied by cutaneous, ocular, articular, gastrointestinal, and/or central nervous system inflammatory lesions. ... ...

Abstract	Behçet's disease (BD) is vasculitis affecting vessels of variable sizes characterized with recurrent oral and/or genital aphthous ulcers accompanied by cutaneous, ocular, articular, gastrointestinal, and/or central nervous system inflammatory lesions. The disease is characterized by recurrent attacks and remissions of different durations, which is one of the reasons why the diagnosis is, in most cases, made several years after the onset of first symptoms. We present a 24-year old male, with South Eastern European heritage, with relapsing bilateral optic neuritis as a first symptom of the disease, followed by aseptic meningitis 2 years, and vascular manifestation 3 years after onset, which finally led to the diagnosis of Behçet's disease. Vascular symptoms were thromboembolism of the right leg and aneurism of the right popliteal artery that due to the size required surgical treatment. The patient was treated with glucocorticoids, azathioprine and anti-tumor necrosis factor-alpha therapy, that proved to be the best treatment options for all manifestations of the disease. Based on our literature review, optic neuritis is a known and rare clinical feature of BD. To our knowledge, there are only several literature reports in which optic neuritis is the initial symptom of BD. Our case report and literature review emphasize the importance of recognizing optic neuritis without inflammatory eye disease as a possible presenting symptom of BD and accentuate detailed medical history review at each patient's visit.
MeSH term(s)	Aneurysm/diagnostic imaging ; Aneurysm/etiology ; Aneurysm/pathology ; Aneurysm/surgery ; Behcet Syndrome/diagnosis ; Disease Progression ; Humans ; Lower Extremity/diagnostic imaging ; Male ; Optic Neuritis/etiology ; Ultrasonography, Doppler, Color ; Young Adult
Language	English
Publishing date	2020-08-29
Publishing country	Germany
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	8286-7
ISSN	1437-160X ; 0172-8172
ISSN (online)	1437-160X
ISSN	0172-8172
DOI	10.1007/s00296-020-04690-6
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