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  1. Article ; Online: The impact of Lewis acid variation on reactions with di-

    Bedi, Vaibhav / Mandal, Dipendu / Hussain, Zahid / Chen, Shi-Ming / Wu, Yile / Qu, Zheng-Wang / Grimme, Stefan / Stephan, Douglas W

    Dalton transactions (Cambridge, England : 2003)

    2024  Volume 53, Issue 2, Page(s) 439–443

    Abstract: Reactions of ( ...

    Abstract Reactions of (
    Language English
    Publishing date 2024-01-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt03506a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Di[12]aneN

    Liu, Ming-Xuan / Liu, Xu-Ying / Liu, Jin-Yu / Tang, Jin-Tao / Shi, Ke / Mao, Jie / Lu, Zhong-Lin / Qiao, Hai-Jun / He, Lan

    ACS applied bio materials

    2021  Volume 4, Issue 9, Page(s) 7111–7122

    Abstract: Although a plethora of gene carriers have been developed for potential gene therapy, imageable stimuli-responsive gene vectors with fast access to the nucleus, high biocompatibility, and transfection efficiency are still scarce. Herein, we report the ... ...

    Abstract Although a plethora of gene carriers have been developed for potential gene therapy, imageable stimuli-responsive gene vectors with fast access to the nucleus, high biocompatibility, and transfection efficiency are still scarce. Herein, we report the design and synthesis of four dendrite-shaped cationic liposomes,
    MeSH term(s) Animals ; DNA/genetics ; Green Fluorescent Proteins/genetics ; Liposomes ; Luminescence ; Molecular Docking Simulation ; Transfection ; Zebrafish/genetics
    Chemical Substances Liposomes ; Green Fluorescent Proteins (147336-22-9) ; DNA (9007-49-2)
    Language English
    Publishing date 2021-08-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.1c00723
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: In Vivo Detection of Cyclic-di-AMP in

    Mukkayyan, Nagaraja / Poon, Raymond / Sander, Philipp N / Lai, Li-Yin / Zubair-Nizami, Zahra / Hammond, Ming C / Chatterjee, Som S

    ACS omega

    2022  Volume 7, Issue 36, Page(s) 32749–32753

    Abstract: Cyclic-di-AMP (CDA) is a signaling molecule that controls various cellular functions including ...

    Abstract Cyclic-di-AMP (CDA) is a signaling molecule that controls various cellular functions including antibiotic tolerance and osmoregulation in
    Language English
    Publishing date 2022-08-26
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.2c04538
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  4. Article ; Online: Two new di-tert-butyl-type compounds from a saline-lake derived

    Yu, Ya-Lin / Chen, Shuang / Fang, Jie-Bin / Chen, Xiao-Ming / Tang, Xin-Yi / Wang, Jin-Hui

    Natural product research

    2023  , Page(s) 1–7

    Abstract: Two novel di-tert-butyl-type structures ( ...

    Abstract Two novel di-tert-butyl-type structures (
    Language English
    Publishing date 2023-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2023.2175356
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  5. Article ; Online: Di(2-ethylhexyl) phthalate mediates IL-33 production

    Tsai, Mei-Lan / Hsu, Shih-Hsien / Wang, Li-Ting / Liao, Wei-Ting / Lin, Yi-Ching / Kuo, Chang-Hung / Hsu, Ya-Ling / Feng, Ming-Chu / Kuo, Fu-Chen / Hung, Chih-Hsing

    Frontiers in immunology

    2023  Volume 14, Page(s) 1193647

    Abstract: Background: Few studies assess cord blood biomarkers to predict prenatal exposure to di(2 ...

    Abstract Background: Few studies assess cord blood biomarkers to predict prenatal exposure to di(2-ethylhexyl) phthalate (DEHP) on the development of allergic diseases later in childhood. IL-33 has been indicated to play an important role in allergic diseases. We evaluated the association of prenatal DEHP exposure and IL-33 in cord blood on the development of allergic diseases. We also investigated the mechanism of DEHP in human lung epithelial cells and asthma animal models.
    Methods: 66 pregnant women were recruited, and their children followed when they were aged 3 years. Maternal urinary DEHP metabolites were determined using liquid chromatography-electrospray-ionization-tandem mass spectrometry. The effect of DEHP on IL-33 production was investigated in human lung epithelial cells and club cell-specific aryl hydrocarbon receptor (AhR) deficiency mice. ELISA and RT-PCR, respectively, measured the IL-33 cytokine concentration and mRNA expression.
    Results: The concentrations of maternal urinary DEHP metabolites and serum IL-33 in cord blood with childhood allergy were significantly higher than those in the non-childhood allergy group. DEHP and MEHP could induce IL-33 production and reverse by AhR antagonist and flavonoids
    Conclusions: Cord blood IL-33 level was correlated to childhood allergy and associated with maternal DEHP exposure. IL-33 might be a potential target to assess the development of DEHP-related childhood allergic disease. Flavonoids might be the natural antidotes for DEHP.
    MeSH term(s) Animals ; Female ; Humans ; Mice ; Pregnancy ; Asthma/chemically induced ; Diethylhexyl Phthalate/toxicity ; Hypersensitivity ; Interleukin-33 ; Receptors, Aryl Hydrocarbon/genetics ; Child, Preschool ; Maternal Exposure
    Chemical Substances Diethylhexyl Phthalate (C42K0PH13C) ; Interleukin-33 ; phthalic acid (6O7F7IX66E) ; Receptors, Aryl Hydrocarbon
    Language English
    Publishing date 2023-07-21
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1193647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cholesterol twists the transmembrane Di-Gly region of amyloid-precursor protein.

    Wang, David Tzu-Wei / Tang, Tiffany Y C / Kuo, Chun-Ting / Yu, Yun-Ting / Chen, Eric H L / Lee, Ming-Tao / Tsai, Ruei-Fong / Chen, Hung-Ying / Chiang, Yun-Wei / Chen, Rita P Y

    PNAS nexus

    2023  Volume 2, Issue 5, Page(s) pgad162

    Abstract: Nearly 95% of Alzheimer's disease (AD) occurs sporadically without genetic linkage. Aging, hypertension, high cholesterol content, and diabetes are known nongenomic risk factors of AD. Aggregation of Aβ peptides is an initial event of AD pathogenesis. Aβ ...

    Abstract Nearly 95% of Alzheimer's disease (AD) occurs sporadically without genetic linkage. Aging, hypertension, high cholesterol content, and diabetes are known nongenomic risk factors of AD. Aggregation of Aβ peptides is an initial event of AD pathogenesis. Aβ peptides are catabolic products of a type I membrane protein called amyloid precursor protein (APP). Aβ40 is the major product, whereas the 2-residue-longer version, Aβ42, induces amyloid plaque formation in the AD brain. Since cholesterol content is one risk factor for sporadic AD, we aimed to explore whether cholesterol in the membrane affects the structure of the APP transmembrane region, thereby modulating the γ-secretase cutting behavior. Here, we synthesized several peptides containing the APP transmembrane region (sequence 693-726, corresponding to the Aβ
    Language English
    Publishing date 2023-05-17
    Publishing country England
    Document type Journal Article
    ISSN 2752-6542
    ISSN (online) 2752-6542
    DOI 10.1093/pnasnexus/pgad162
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  7. Article ; Online: Long-term di-(2-ethylhexyl) phthalate exposure reduces sorafenib treatment efficacy by enhancing mesenchymal transition in hepatocellular carcinoma.

    Shih, Ming-Syuan / Suk, Fat-Moon / Chiu, Wan-Chun / Lee, Chun-Ya / Hsu, Fang-Yu / Liao, Yi-Jen

    Ecotoxicology and environmental safety

    2024  Volume 273, Page(s) 116161

    Abstract: Di(2-ethylhexyl) phthalate (DEHP) is a worldwide common plasticizer. Nevertheless, DEHP is easily ...

    Abstract Di(2-ethylhexyl) phthalate (DEHP) is a worldwide common plasticizer. Nevertheless, DEHP is easily leached out to the environment due to the lack of covalent bonds with plastic. High dose of DEHP exposure is often observed in hemodialysis patients because of the continual usage of plastic medical devices. Although the liver is the major organ that catabolizes DEHP, the impact of long-term DEHP exposure on the sensitivity of liver cancer to chemotherapy remains unclear. In this study, we established long-term DEHP-exposed hepatocellular carcinoma (HCC) cells and two NOD/SCID mice models to investigate the effects and the underlying mechanisms of long-term DEHP exposure on chemosensitivity of HCC. The results showed long-term DEHP exposure potentially increased epithelial-mesenchymal transition (EMT) in HCC cells. Next generation sequencing showed that long-term DEHP exposure increased cell adhesion/migratory related genes expression and blunted sorafenib treatment induced genes alterations. Long-term exposure to DEHP reduced the sensitivity of HCC cells to sorafenib-induced anti-migratory effect by enhancing the EMT transcription factors (slug, twist, and ZEB1) and mesenchymal protein (vimentin) expression. In NOD/SCID mice model, we showed that long-term DEHP-exposed HCC cells exhibited higher growth rate. Regarding the anti-HCC effects of sorafenib, subcutaneous HuH7 tumor grew slowly in sorafenib-treated mice. Nonetheless, the anti-tumor growth effect of sorafenib was not observed in long-term DEHP-exposed mice. Higher mesenchymal markers and proliferating cell nuclear antigen (PCNA) expression were found in sorafenib-treated long-term DEHP-exposed mice. In conclusion, long-term DEHP exposure promoted migratory activity in HCC cells and decreased sorafenib sensitivity in tumor-bearing mice.
    MeSH term(s) Humans ; Mice ; Animals ; Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Sorafenib/pharmacology ; Sorafenib/therapeutic use ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Diethylhexyl Phthalate/toxicity ; Mice, SCID ; Mice, Inbred NOD ; Treatment Outcome ; Phthalic Acids
    Chemical Substances Sorafenib (9ZOQ3TZI87) ; phthalic acid (6O7F7IX66E) ; Diethylhexyl Phthalate (C42K0PH13C) ; Phthalic Acids
    Language English
    Publishing date 2024-03-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 436536-7
    ISSN 1090-2414 ; 0147-6513
    ISSN (online) 1090-2414
    ISSN 0147-6513
    DOI 10.1016/j.ecoenv.2024.116161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1418: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters.

    Hsu, Yuan-Ting / Wu, Chao-Chien / Wang, Chin-Chou / Sheu, Chau-Chyun / Yang, Yi-Hsin / Cheng, Ming-Yen / Lai, Ruay-Sheng / Leung, Sum-Yee / Lin, Chi-Cheng / Wei, Yu-Feng / Lai, Yung-Fa / Cheng, Meng-Hsuan / Chen, Huang-Chi / Yang, Chih-Jen / Wang, Chien-Jen / Liu, Huei-Ju / Chen, Hua-Ling / Hung, Chih-Hsing / Lee, Chon-Lin /
    Huang, Ming-Shyan / Huang, Shau-Ku

    Respiratory research

    2024  Volume 25, Issue 1, Page(s) 139

    Abstract: Background: DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are "non-atopic", lacking a clear etiology.: Methods: In a case-control study ...

    Abstract Background: DEHP, a common plasticizer known for its hormone-disrupting properties, has been associated with asthma. However, a significant proportion of adult asthma cases are "non-atopic", lacking a clear etiology.
    Methods: In a case-control study conducted between 2011 and 2015, 365 individuals with current asthma and 235 healthy controls from Kaohsiung City were enrolled. The control group comprised individuals without asthma, Type 2 Diabetes Mellitus (T2DM), hypertension, or other respiratory/allergic conditions. The study leveraged asthma clusters (Clusters A to F) established in a prior investigation. Analysis involved the examination of urinary DEHP metabolites (MEHP and MEHHP), along with the assessment of oxidative stress, sphingolipid metabolites, and inflammatory biomarkers. Statistical analyses encompassed Spearman's rank correlation coefficients, multiple logistic regression, and multinomial logistic regression.
    Results: Asthma clusters (E, D, C, F, A) exhibited significantly higher ORs of MEHHP exposures compared to the control group. When considering asthma-related comorbidities (T2DM, hypertension, or both), patients without comorbidities demonstrated significantly higher ORs of the sum of primary and secondary metabolites (MEHP + MEHHP) and MEHHP compared to those with asthma comorbidities. A consistent positive correlation between urinary HEL and DEHP metabolites was observed, but a consistent negative correlation between DEHP metabolites and selected cytokines was identified.
    Conclusion: The current study reveals a heightened risk of MEHHP and MEHP + MEHHP exposure in specific asthma subgroups, emphasizing its complex relationship with asthma. The observed negative correlation with cytokines suggests a new avenue for research, warranting robust evidence from epidemiological and animal studies.
    MeSH term(s) Adult ; Animals ; Humans ; Diethylhexyl Phthalate/toxicity ; Diethylhexyl Phthalate/urine ; Diethylhexyl Phthalate/analogs & derivatives ; Environmental Exposure ; Diabetes Mellitus, Type 2 ; Case-Control Studies ; Asthma/chemically induced ; Asthma/diagnosis ; Asthma/epidemiology ; Cytokines ; Hypertension ; Phthalic Acids
    Chemical Substances phthalic acid (6O7F7IX66E) ; mono-(2-ethylhexyl)phthalate (FU2EWB60RT) ; Diethylhexyl Phthalate (C42K0PH13C) ; Cytokines ; Phthalic Acids
    Language English
    Publishing date 2024-03-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041675-1
    ISSN 1465-993X ; 1465-993X
    ISSN (online) 1465-993X
    ISSN 1465-993X
    DOI 10.1186/s12931-024-02764-8
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  9. Article: [Formation history of Dao-di herbs in Dabie Mountains].

    Peng, Hua-Sheng / Chu, Shan-Shan / Cheng, Ming-En

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2021  Volume 46, Issue 2, Page(s) 253–259

    Abstract: ... resources including many Dao-di herbs, and has a profound culture of traditional Chinese medicine ... of medicinal materials recorded in history, and a textual research on the historical evolution of Dao-di herbs ... Dao-di herbs Dendrobium huoshanense, Artemisia argyi, and Poria cocos are well-known in China, and ...

    Abstract Dabie Mountains, a unique transition area of subtropical and warm temperate zone, span Anhui, Hubei and Henan pro-vinces with a humid and suitable climate. It is rich in traditional Chinese medicine resources including many Dao-di herbs, and has a profound culture of traditional Chinese medicine with many herbalists in the past. This paper combed the historical geography of Dabie Mountains and development vein of medicinal materials recorded in history, and a textual research on the historical evolution of Dao-di herbs and special herbs in Dabie Mountains was carried out. The administrative region of Dabie Mountains has been changing constantly in history, which includes 25 counties and districts of six cities in Anhui, Henan and Hubei provinces at present. Dabie Mountains abound in a variety of Chinese herbal medicines, which have been recorded in herbal works in the past dynasties and local chronicles in detail. The recorded Dao-di herbs Dendrobium huoshanense, Artemisia argyi, and Poria cocos are well-known in China, and the output of Gastrodia elata, Ganoderma lucidum, and P. cocos is in the forefront of the country. Additionally, there are still many local special herbs emerging in modern times. In a word, this paper reviewed development of historical geography and ancient records of medicinal materials in Dabie Mountains, and made a textual research on the Dao-di herbs and special herbs, will provide a reference for the mo-dern research and intellectual property protection of Dao-di herbs in Dabie Mountains.
    MeSH term(s) China ; Drugs, Chinese Herbal ; Gastrodia ; Medicine, Chinese Traditional ; Plants, Medicinal
    Chemical Substances Drugs, Chinese Herbal
    Language Chinese
    Publishing date 2021-02-28
    Publishing country China
    Document type Journal Article ; Review
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20201013.101
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3056: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Synthesis of novel 3/5(3,5)-(di)nitropaeonol hydrazone derivatives as nematicidal agents.

    Chen, Gen-Qiang / Zhu, Li-Na / Yang, Jin-Ming / Zhang, Song / Li, Yuan-Hao / Guo, Xiao-Long / Sun, Di / He, Jia-Xuan / Tian, Yue-E / Liu, Sheng-Ming / Jiang, Jia / Huang, Xiao-Bo / Che, Zhi-Ping

    Journal of Asian natural products research

    2021  Volume 24, Issue 1, Page(s) 66–75

    Abstract: Eighteen novel 3/5(3,5)-(di)nitropaeonol hydrazone derivatives were prepared, and their structures ...

    Abstract Eighteen novel 3/5(3,5)-(di)nitropaeonol hydrazone derivatives were prepared, and their structures well characterized by
    MeSH term(s) Animals ; Antinematodal Agents ; Hydrazones/pharmacology ; Molecular Structure ; Tylenchoidea
    Chemical Substances Antinematodal Agents ; Hydrazones
    Language English
    Publishing date 2021-02-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2021.1874941
    Database MEDical Literature Analysis and Retrieval System OnLINE

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