LIVIVO - Search results -

Search results

Result 1 - 10 of total 2761

Search options

Article ; Online: T cell help shapes B cell tolerance.

Akama-Garren, Elliot H / Yin, Xihui / Prestwood, Tyler R / Ma, Minghe / Utz, Paul J / Carroll, Michael C

Science immunology

2024 Volume 9, Issue 92, Page(s) eadj7029

Abstract: ... Follicular T cell specificity influences the breadth of epitope spreading by regulating wild-type B cell ... T cell help is a crucial component of the normal humoral immune response, yet whether it promotes ... or restrains autoreactive B cell responses remains unclear. Here, we observe that autoreactive ...

Abstract	T cell help is a crucial component of the normal humoral immune response, yet whether it promotes or restrains autoreactive B cell responses remains unclear. Here, we observe that autoreactive germinal centers require T cell help for their formation and persistence. Using retrogenic chimeras transduced with candidate TCRs, we demonstrate that a follicular T cell repertoire restricted to a single autoreactive TCR, but not a foreign antigen-specific TCR, is sufficient to initiate autoreactive germinal centers. Follicular T cell specificity influences the breadth of epitope spreading by regulating wild-type B cell entry into autoreactive germinal centers. These results demonstrate that TCR-dependent T cell help can promote loss of B cell tolerance and that epitope spreading is determined by TCR specificity.
MeSH term(s)	T-Lymphocytes ; B-Lymphocytes ; Receptors, Antigen, T-Cell ; Antigens ; Epitopes
Chemical Substances	Receptors, Antigen, T-Cell ; Antigens ; Epitopes
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ISSN	2470-9468
ISSN (online)	2470-9468
DOI	10.1126/sciimmunol.adj7029
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia.

Duault, Caroline / Kumar, Anil / Taghi Khani, Adeleh / Lee, Sung June / Yang, Lu / Huang, Min / Hurtz, Christian / Manning, Bryan / Ghoda, Lucy / McDonald, Tinisha / Lacayo, Norman J / Sakamoto, Kathleen M / Carroll, Martin / Tasian, Sarah K / Marcucci, Guido / Yu, Jianhua / Caligiuri, Michael A / Maecker, Holden T / Swaminathan, Srividya

Blood

2021 Volume 138, Issue 16, Page(s) 1465–1480

Abstract: B- and T-cell acute lymphoblastic leukemia (B/T-ALL) may be refractory or recur after therapy ... We delineated the phenotypic and functional defects in NK cells from high-risk patients with B/T-ALL using mass ... counterparts, NK cells from patients with B/T-ALL are less cytotoxic but exhibit an activated signature that is ...

Abstract	B- and T-cell acute lymphoblastic leukemia (B/T-ALL) may be refractory or recur after therapy by suppressing host anticancer immune surveillance mediated specifically by natural killer (NK) cells. We delineated the phenotypic and functional defects in NK cells from high-risk patients with B/T-ALL using mass cytometry, flow cytometry, and in silico cytometry, with the goal of further elucidating the role of NK cells in sustaining acute lymphoblastic leukemia (ALL) regression. We found that, compared with their normal counterparts, NK cells from patients with B/T-ALL are less cytotoxic but exhibit an activated signature that is characterized by high CD56, high CD69, production of activated NK cell-origin cytokines, and calcium (Ca2+) signaling. We demonstrated that defective maturation of NK cells into cytotoxic effectors prevents NK cells from ALL from lysing NK cell-sensitive targets as efficiently as do normal NK cells. Additionally, we showed that NK cells in ALL are exhausted, which is likely caused by their chronic activation. We found that increased frequencies of activated cytokine-producing NK cells are associated with increased disease severity and independently predict poor clinical outcome in patients with ALL. Our studies highlight the benefits of developing NK cell profiling as a diagnostic tool to predict clinical outcome in patients with ALL and underscore the clinical potential of allogeneic NK cell infusions to prevent ALL recurrence.
MeSH term(s)	Antigens, CD/immunology ; Antigens, Differentiation, T-Lymphocyte/immunology ; CD56 Antigen/immunology ; Cells, Cultured ; Cytokines/immunology ; Cytotoxicity, Immunologic ; Humans ; Killer Cells, Natural/immunology ; Lectins, C-Type/immunology ; Lymphocyte Activation ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor Cell Lymphoblastic Leukemia-Lymphoma/immunology ; Prognosis
Chemical Substances	Antigens, CD ; Antigens, Differentiation, T-Lymphocyte ; CD56 Antigen ; CD69 antigen ; Cytokines ; Lectins, C-Type
Language	English
Publishing date	2021-06-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood.2020009871
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uh III Zs.140: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 364: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease.

Akama-Garren, Elliot H / van den Broek, Theo / Simoni, Lea / Castrillon, Carlos / van der Poel, Cees E / Carroll, Michael C

Nature communications

2021 Volume 12, Issue 1, Page(s) 6687

Abstract: ... Follicular T cells are central regulators of germinal centers, although their contribution to autoantibody ... mediated disease remains unclear. Here we perform single cell RNA and T cell receptor (TCR) sequencing ... of follicular T cells in a mouse model of autoantibody-mediated disease, allowing for analyses of paired ...

Abstract	Pathogenic autoantibodies contribute to tissue damage and clinical decline in autoimmune disease. Follicular T cells are central regulators of germinal centers, although their contribution to autoantibody-mediated disease remains unclear. Here we perform single cell RNA and T cell receptor (TCR) sequencing of follicular T cells in a mouse model of autoantibody-mediated disease, allowing for analyses of paired transcriptomes and unbiased TCRαβ repertoires at single cell resolution. A minority of clonotypes are preferentially shared amongst autoimmune follicular T cells and clonotypic expansion is associated with differential gene signatures in autoimmune disease. Antigen prediction using algorithmic and machine learning approaches indicates convergence towards shared specificities between non-autoimmune and autoimmune follicular T cells. However, differential autoimmune transcriptional signatures are preserved even amongst follicular T cells with shared predicted specificities. These results demonstrate that follicular T cells are phenotypically distinct in B cell-driven autoimmune disease, providing potential therapeutic targets to modulate autoantibody development.
MeSH term(s)	Animals ; Autoimmune Diseases/genetics ; Autoimmune Diseases/immunology ; Autoimmune Diseases/metabolism ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cells, Cultured ; Clone Cells/immunology ; Clone Cells/metabolism ; Gene Expression Profiling/methods ; Germinal Center/cytology ; Germinal Center/immunology ; Germinal Center/metabolism ; Mice, Inbred C57BL ; Microscopy, Confocal ; RNA-Seq/methods ; Receptors, Antigen, T-Cell/genetics ; Receptors, Antigen, T-Cell/immunology ; Receptors, Antigen, T-Cell/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Single-Cell Analysis/methods ; T-Lymphocytes, Helper-Inducer/immunology ; T-Lymphocytes, Helper-Inducer/metabolism ; Mice
Chemical Substances	Receptors, Antigen, T-Cell
Language	English
Publishing date	2021-11-18
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-021-27035-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Follicular T cells are clonally and transcriptionally distinct in B cell-driven mouse autoimmune disease

Elliot H. Akama-Garren / Theo van den Broek / Lea Simoni / Carlos Castrillon / Cees E. van der Poel / Michael C. Carroll

Nature Communications, Vol 12, Iss 1, Pp 1-

2021 Volume 19

Abstract: Follicular T cells regulate germinal centre reactions, but their phenotypes in autoimmune disease ... T cells differ by TCR clonotype and transcriptional profile from non-autoimmune follicular T cells. ...

Abstract	Follicular T cells regulate germinal centre reactions, but their phenotypes in autoimmune disease are unclear. Using a mouse model of autoantibody disease, the authors show that autoimmune follicular T cells differ by TCR clonotype and transcriptional profile from non-autoimmune follicular T cells.
Keywords	Science ; Q
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: B cells regulate CD4+ T cell responses to papain following B cell receptor-independent papain uptake.

Dwyer, Daniel F / Woodruff, Matthew C / Carroll, Michael C / Austen, K Frank / Gurish, Michael F

Journal of immunology (Baltimore, Md. : 1950)

2014 Volume 193, Issue 2, Page(s) 529–539

Abstract: ... expression by T cells in the popliteal lymph nodes of mice following footpad immunization. In this study ... we identify a novel, non-BCR-mediated capacity for B cells to rapidly bind and internalize papain. B ... cells subsequently regulate the adaptive immune response by enhancing ICOS expression on CD4(+) T cells and ...

Abstract	Papain, a cysteine protease allergen with inherent adjuvant activity, induces potent IL-4 expression by T cells in the popliteal lymph nodes of mice following footpad immunization. In this study, we identify a novel, non-BCR-mediated capacity for B cells to rapidly bind and internalize papain. B cells subsequently regulate the adaptive immune response by enhancing ICOS expression on CD4(+) T cells and amplifying Th2 and follicular helper T cell induction. Ab blockade of ICOS ligand, expressed by popliteal lymph node B cells, but not dendritic cells, at the peak of the response inhibits IL-4 responses in wild-type mice but not B cell-deficient mice. Thus, B cells play a critical role in amplifying adjuvant-dependent Th2 polarization following noncanonical acquisition and internalization of the cysteine protease papain.
MeSH term(s)	Animals ; B-Lymphocytes/immunology ; B-Lymphocytes/metabolism ; CD4-Positive T-Lymphocytes/immunology ; CD4-Positive T-Lymphocytes/metabolism ; Cells, Cultured ; Flow Cytometry ; Immunization/methods ; Inducible T-Cell Co-Stimulator Protein/immunology ; Inducible T-Cell Co-Stimulator Protein/metabolism ; Interleukin-4/immunology ; Interleukin-4/metabolism ; Lymph Nodes/cytology ; Lymph Nodes/immunology ; Lymph Nodes/metabolism ; Mice ; Mice, 129 Strain ; Mice, Inbred C57BL ; Mice, Knockout ; Mice, Transgenic ; Microscopy, Confocal ; Microscopy, Fluorescence, Multiphoton ; Papain/administration & dosage ; Papain/immunology ; Papain/metabolism ; Protein Binding/immunology ; Receptors, Antigen, B-Cell/immunology ; Receptors, Antigen, B-Cell/metabolism ; Th2 Cells/immunology ; Th2 Cells/metabolism
Chemical Substances	Icos protein, mouse ; Inducible T-Cell Co-Stimulator Protein ; Receptors, Antigen, B-Cell ; Interleukin-4 (207137-56-2) ; Papain (EC 3.4.22.2)
Language	English
Publishing date	2014-06-13
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
DOI	10.4049/jimmunol.1303247
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Regulation of the B cell response to T-dependent antigens by classical pathway complement.

Fischer, M B / Ma, M / Goerg, S / Zhou, X / Xia, J / Finco, O / Han, S / Kelsoe, G / Howard, R G / Rothstein, T L / Kremmer, E / Rosen, F S / Carroll, M C

Journal of immunology (Baltimore, Md. : 1950)

1996 Volume 157, Issue 2, Page(s) 549–556

Abstract: ... defect in their Ab response to a T-dependent Ag (bacteriophage (phi X174). Characterization ... in isotype switching despite normal B cell signaling in vitro. The nature of the defect was found to lie at the B cell ... level, as the T cells were primed in C3- and C4-deficient mice as well as those in wild-type mice ...

Abstract	Mice deficient in complement components C3 (C3 -/-) and C4 (C4 -/-) were found to have a profound defect in their Ab response to a T-dependent Ag (bacteriophage (phi X174). Characterization of the deficient mice demonstrated a diminished level of peanut agglutinin+ germinal centers and a failure in isotype switching despite normal B cell signaling in vitro. The nature of the defect was found to lie at the B cell level, as the T cells were primed in C3- and C4-deficient mice as well as those in wild-type mice. These results, and the finding that the defect could be partly reversed by a 10-fold increase in Ag dose, support the hypothesis that covalent attachment of complement ligands, i.e., C3b and C3d to the Ag-Ab complex, increases its immunogenicity.
MeSH term(s)	Animals ; Antibodies, Viral/biosynthesis ; Antigens, Viral/pharmacology ; B-Lymphocytes/drug effects ; B-Lymphocytes/immunology ; Bacteriophage phi X 174/immunology ; Complement C3/deficiency ; Complement C4/deficiency ; Complement Pathway, Classical ; Complement System Proteins/pharmacology ; Female ; Germinal Center/immunology ; Lymphocyte Activation/genetics ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Spleen/cytology ; Spleen/immunology ; T-Lymphocytes/immunology
Chemical Substances	Antibodies, Viral ; Antigens, Viral ; Complement C3 ; Complement C4 ; Complement System Proteins (9007-36-7)
Language	English
Publishing date	1996-07-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	3056-9
ISSN	1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
ISSN (online)	1550-6606
ISSN	0022-1767 ; 1048-3233 ; 1047-7381
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ud II Zs.37: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MG 28: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Disruption of the Cr2 locus results in a reduction in B-1a cells and in an impaired B cell response to T-dependent antigen.

Ahearn, J M / Fischer, M B / Croix, D / Goerg, S / Ma, M / Xia, J / Zhou, X / Howard, R G / Rothstein, T L / Carroll, M C

Immunity

1996 Volume 4, Issue 3, Page(s) 251–262

Abstract: ... mCR2 (CD21), expressed primarily on B cells and follicular dendritic cells in mice. To dissect the role ... in both receptors. The deficient mice (Cr2-/-) were found to have a reduction in the CD5+ population of peritoneal B ... had a severe defect in their humoral response to T-dependent antigens that was characterized ...

Abstract	Covalent attachment of activated products of the third component of complement to antigen enhances its immunogenicity, but the mechanism is not clear. This effect is mediated by specific receptors, mCR1 (CD35) and mCR2 (CD21), expressed primarily on B cells and follicular dendritic cells in mice. To dissect the role of mCR1 and mCR2 in the humoral response, we have disrupted the Cr2 locus to generate mice deficient in both receptors. The deficient mice (Cr2-/-) were found to have a reduction in the CD5+ population of peritoneal B-1 cells, although their serum IgM levels were within the range of normal mice. Moreover, Cr2-/- mice had a severe defect in their humoral response to T-dependent antigens that was characterized by a reduction in serum antibody titers and in the number and size of germinal centers within splenic follicles. Reconstitution of the deficient mice with bone marrow from MHC-matched Cr2+/+ donors corrected the defect, demonstrating that the defect was due to B cells themselves. These results indicate an obligatory role of B cell complement receptors in responses of the B cells to protein antigens.
MeSH term(s)	Animals ; Antibodies, Viral/biosynthesis ; Antibodies, Viral/genetics ; Antigens, Viral/immunology ; B-Lymphocyte Subsets/immunology ; B-Lymphocyte Subsets/metabolism ; B-Lymphocyte Subsets/pathology ; Bacteriophage phi X 174/immunology ; Bone Marrow Transplantation ; CD40 Antigens/immunology ; CD5 Antigens ; Immunoglobulin G/biosynthesis ; Immunoglobulin G/genetics ; Immunologic Deficiency Syndromes/genetics ; Immunologic Deficiency Syndromes/pathology ; Immunologic Deficiency Syndromes/therapy ; Lymphocyte Count ; Mice ; Mice, Mutant Strains ; Receptors, Antigen, B-Cell/immunology ; Receptors, Complement 3d/genetics ; Receptors, Complement 3d/immunology ; Signal Transduction/immunology ; T-Lymphocytes/immunology
Chemical Substances	Antibodies, Viral ; Antigens, Viral ; CD40 Antigens ; CD5 Antigens ; Immunoglobulin G ; Receptors, Antigen, B-Cell ; Receptors, Complement 3d
Language	English
Publishing date	1996-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/s1074-7613(00)80433-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: T cell-independent somatic hypermutation in murine B cells with an immature phenotype.

Mao, Changchuin / Jiang, Liying / Melo-Jorge, Milena / Puthenveetil, Maya / Zhang, Xiuli / Carroll, Michael C / Imanishi-Kari, Thereza

Immunity

2004 Volume 20, Issue 2, Page(s) 133–144

Abstract: ... also plays a role in the generation of the murine immunoglobulin repertoire during B cell development ... which, by surface markers, RAG expression, and rapid turnover, had the phenotype of immature B cells. In addition ... in known hotspots. Mutation frequency was not diminished in the absence of T cells. Our results support ...

Abstract	Somatic hypermutation contributes to the generation of antibody diversity and is strongly associated with the maturation of antigen-specific immune responses. We asked whether somatic hypermutation also plays a role in the generation of the murine immunoglobulin repertoire during B cell development. To facilitate identification of somatic mutations, we examined mouse systems in which only antibodies expressing lambda1, lambda2, and lambdax light chains can be generated. Somatic mutations were found in cells, which, by surface markers, RAG expression, and rapid turnover, had the phenotype of immature B cells. In addition, expression of AID was detected in these cells. The mutations were limited to V regions and were localized in known hotspots. Mutation frequency was not diminished in the absence of T cells. Our results support the idea that somatic hypermutation can occur in murine immature B cells and may represent a mechanism for enlarging the V gene repertoire.
MeSH term(s)	Animals ; B-Lymphocytes/cytology ; B-Lymphocytes/physiology ; Bone Marrow Cells/immunology ; Cell Differentiation ; Cells, Cultured ; Cytidine Deaminase/biosynthesis ; DNA-Binding Proteins/biosynthesis ; Flow Cytometry ; Homeodomain Proteins/biosynthesis ; Immunoglobulin Variable Region/genetics ; Phenotype ; Point Mutation ; Reverse Transcriptase Polymerase Chain Reaction ; Somatic Hypermutation, Immunoglobulin/immunology ; T-Lymphocytes/immunology
Chemical Substances	DNA-Binding Proteins ; Homeodomain Proteins ; Immunoglobulin Variable Region ; V(D)J recombination activating protein 2 ; RAG-1 protein (128559-51-3) ; AICDA (activation-induced cytidine deaminase) (EC 3.5.4.-) ; Cytidine Deaminase (EC 3.5.4.5)
Language	English
Publishing date	2004-02-04
Publishing country	United States
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	1217235-2
ISSN	1097-4180 ; 1074-7613
ISSN (online)	1097-4180
ISSN	1074-7613
DOI	10.1016/s1074-7613(04)00019-6
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4227: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 69: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Pediatric acute lymphoblastic leukemia with a t(8;14)(q11.2;q32): B-cell disease with a high proportion of Down syndrome: a Children's Oncology Group study.

Messinger, Yoav H / Higgins, Rodney R / Devidas, Meenakshi / Hunger, Stephen P / Carroll, Andrew J / Heerema, Nyla A

Cancer genetics

2012 Volume 205, Issue 9, Page(s) 453–458

Abstract: The rare translocation t(8;14)(q11.2;q32) has been described in patients with B-cell ... 2;q32) have the B-cell phenotype and a high percentage have DS. Children with DS and the t(8;14)(q11 ... acute lymphoblastic leukemia (ALL), particularly patients with Down syndrome (DS). We describe patients with the t(8;14)(q11.2 ...

Abstract	The rare translocation t(8;14)(q11.2;q32) has been described in patients with B-cell acute lymphoblastic leukemia (ALL), particularly patients with Down syndrome (DS). We describe patients with the t(8;14)(q11.2;q32) who were identified by the Children's Oncology Group (COG) ALL cytogenetics database, expanding our previous report of 10 patients with this translocation. Twenty-two such patients were treated with COG protocols. All patients had B-cell ALL, and seven (31.8%) had DS. None of the children with DS had an event; thus, these patients had a superior estimated 5-year event-free survival (EFS) compared to non-DS patients (100% vs. 50.1 ± 17.7%; P = 0.04). Only one patient (4.5%) had a concomitant Philadelphia chromosome t(9;22)(q34;q11.2). The cytogenetics data of two additional patients, who were not eligible for COG protocols, are also included in this report. In conclusion, ALL patients with the recurring translocation t(8;14)(q11.2;q32) have the B-cell phenotype and a high percentage have DS. Children with DS and the t(8;14)(q11.2;q34) have improved EFS using standard COG therapy compared to non-DS patients. We did not find an increased number of patients with a concomitant Philadelphia chromosome in this population.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Chromosomes, Human, Pair 14 ; Chromosomes, Human, Pair 8 ; Cytogenetic Analysis ; Disease-Free Survival ; Down Syndrome/complications ; Down Syndrome/drug therapy ; Down Syndrome/genetics ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/complications ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Translocation, Genetic ; Treatment Outcome
Language	English
Publishing date	2012-09-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2599227-2
ISSN	2210-7762
ISSN	2210-7762
DOI	10.1016/j.cancergen.2012.07.016
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1521: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Significance of commonly used prognostic factors differs for children with T cell acute lymphocytic leukemia (ALL), as compared to those with B-precursor ALL. A Pediatric Oncology Group (POG) study.

Pullen, J / Shuster, J J / Link, M / Borowitz, M / Amylon, M / Carroll, A J / Land, V / Look, A T / McIntyre, B / Camitta, B

Leukemia

1999 Volume 13, Issue 11, Page(s) 1696–1707

Abstract: T cell acute lymphocytic leukemia (T-ALL) and B-precursor ALL differ significantly in the clinical ... We assessed for pediatric patients with T-ALL the relative importance of prognostic factors previously ... demonstrated to predict outcome in B-precursor ALL. Presenting clinical and laboratory features were correlated ...

Abstract	T cell acute lymphocytic leukemia (T-ALL) and B-precursor ALL differ significantly in the clinical characteristics of the patients at presentation and in laboratory-defined characteristics of the leukemic cells. We assessed for pediatric patients with T-ALL the relative importance of prognostic factors previously demonstrated to predict outcome in B-precursor ALL. Presenting clinical and laboratory features were correlated with outcome for 441 children 12 months to 21 years of age with previously untreated T-ALL, registered on the Pediatric Oncology Group (POG) T3 protocol between 1986 and 1992. These T-ALL prognostic factor analyses were then compared to similar analyses for 1993 patients with B-precursor ALL enrolled during the same time period on the POG ALinC 14 protocol. Quantitative interaction between phenotype and each prognostic factor was studied to determine the relative importance of the prognostic factor for each of the two major immunophenotypes. We also analyzed the importance of maturational stage as a T-ALL prognostic factor, using a modified Ludwig definition of maturational stage. We conclude that several of the clinical and laboratory prognostic factors, which are used reliably for B-precursor ALL, are much less predictive in T-ALL (ie age, WBC, consensus risk group, hyperdiploidy, presence of trans- locations and CALLA expression). There was no significant difference between the phenotypes in the prognostic importance of race or gender. Our data demonstrate a significant difference in outcome among the three maturational stages of T-cell ALL, with the intermediate group faring best. Using traditional risk group criteria to stratify patients with T-ALL for therapy may not be appropriate.
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Antigens, CD/analysis ; Burkitt Lymphoma/diagnosis ; Burkitt Lymphoma/metabolism ; Burkitt Lymphoma/pathology ; Burkitt Lymphoma/therapy ; CD24 Antigen ; Central Nervous System/pathology ; Child ; Child, Preschool ; Continental Population Groups ; Humans ; Immunophenotyping ; Infant ; Leukocyte Count ; Membrane Glycoproteins ; Ploidies ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/classification ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/diagnosis ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/pathology ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/therapy ; Prognosis ; Risk Factors ; Sex Factors ; Survival Rate ; T-Lymphocytes/metabolism ; T-Lymphocytes/pathology ; Translocation, Genetic/genetics ; Treatment Outcome
Chemical Substances	Antigens, CD ; CD24 Antigen ; CD24 protein, human ; Membrane Glycoproteins
Language	English
Publishing date	1999-11
Publishing country	England
Document type	Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	807030-1
ISSN	1476-5551 ; 0887-6924
ISSN (online)	1476-5551
ISSN	0887-6924
DOI	10.1038/sj.leu.2401555
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2295: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito