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  1. Article ; Online: Anti-Interleukin-23 Autoantibodies and Severe Infections.

    Netea, Mihai G / van de Veerdonk, Frank L

    The New England journal of medicine

    2024  Volume 390, Issue 12, Page(s) 1143–1146

    MeSH term(s) Humans ; Autoantibodies/immunology ; Interferon-gamma ; Interleukin-23/antagonists & inhibitors ; Interleukin-23/immunology ; Interleukin-6 ; Infections/immunology ; Patient Acuity
    Chemical Substances Autoantibodies ; Interferon-gamma (82115-62-6) ; Interleukin-23 ; Interleukin-6
    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2400475
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  2. Article ; Online: Managing secondary fungal infections in severe COVID-19: how to move forward?

    Verweij, Paul E / van de Veerdonk, Frank L

    The Lancet. Respiratory medicine

    2021  Volume 10, Issue 2, Page(s) 127–128

    MeSH term(s) COVID-19 ; Coinfection ; Humans ; Mycoses ; SARS-CoV-2
    Language English
    Publishing date 2021-11-26
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00500-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
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  3. Article ; Online: Anticytokine Autoantibodies in Infectious Diseases: A Practical Overview.

    Arts, Rob J W / Janssen, Nico A F / van de Veerdonk, Frank L

    International journal of molecular sciences

    2023  Volume 25, Issue 1

    Abstract: Anticytokine autoantibodies (ACAAs) are a fascinating group of antibodies that have gained more and more attention in the field of autoimmunity and secondary immunodeficiencies over the years. Some of these antibodies are characterized by their ability ... ...

    Abstract Anticytokine autoantibodies (ACAAs) are a fascinating group of antibodies that have gained more and more attention in the field of autoimmunity and secondary immunodeficiencies over the years. Some of these antibodies are characterized by their ability to target and neutralize specific cytokines. ACAAs can play a role in the susceptibility to several infectious diseases, and their infectious manifestations depending on which specific immunological pathway is affected. In this review, we will give an outline per infection in which ACAAs might play a role and whether additional immunomodulatory treatment next to antimicrobial treatment can be considered. Finally, we describe the areas for future research on ACAAs.
    MeSH term(s) Humans ; Autoantibodies ; Autoimmunity ; Cytokines ; Immunomodulation ; Communicable Diseases
    Chemical Substances Autoantibodies ; Cytokines
    Language English
    Publishing date 2023-12-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25010515
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Rare variants increase the risk of severe COVID-19.

    van de Veerdonk, Frank L / Netea, Mihai G

    eLife

    2021  Volume 10

    Abstract: Evidence is mounting that rare loss-of-function variants in ... ...

    Abstract Evidence is mounting that rare loss-of-function variants in the
    MeSH term(s) COVID-19 ; Case-Control Studies ; Humans ; Male ; SARS-CoV-2 ; Toll-Like Receptor 7
    Chemical Substances Toll-Like Receptor 7
    Language English
    Publishing date 2021-03-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.67860
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  5. Article ; Online: Opposing Effects of Interleukin-36γ and Interleukin-38 on Trained Immunity.

    Teufel, Lisa U / Netea, Mihai G / van de Veerdonk, Frank L / Dinarello, Charles A / Joosten, Leo A B / Arts, Rob J W

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Trained immunity is the process of long-term functional reprogramming ( ... ...

    Abstract Trained immunity is the process of long-term functional reprogramming (a
    MeSH term(s) Humans ; Animals ; Mice ; Immunity, Innate ; Trained Immunity ; Interleukins/pharmacology ; Interleukins/metabolism ; Macrophages/metabolism ; Cytokines/metabolism
    Chemical Substances Interleukins ; Cytokines ; IL-38 protein, human
    Language English
    Publishing date 2023-01-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032311
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  6. Article ; Online: Stimulating severe COVID-19: the potential role of GM-CSF antagonism.

    Leavis, Helen L / van de Veerdonk, Frank L / Murthy, Srinivas

    The Lancet. Respiratory medicine

    2021  Volume 10, Issue 3, Page(s) 223–224

    MeSH term(s) COVID-19 ; Granulocyte-Macrophage Colony-Stimulating Factor/therapeutic use ; Humans ; SARS-CoV-2
    Chemical Substances Granulocyte-Macrophage Colony-Stimulating Factor (83869-56-1)
    Language English
    Publishing date 2021-12-01
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00539-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7041: Show issues Location:
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  7. Article ; Online: Invasive

    van de Veerdonk, Frank L / Wauters, Joost / Verweij, Paul E

    American journal of respiratory and critical care medicine

    2020  Volume 202, Issue 5, Page(s) 646–648

    MeSH term(s) Aspergillosis/complications ; Aspergillus ; Critical Illness ; Humans ; Influenza, Human/complications ; Tracheitis/complications
    Keywords covid19
    Language English
    Publishing date 2020-06-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.202005-1883ED
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh II Zs.80: Show issues Location:
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  8. Article ; Online: Editorial overview: Emerging topics in host-fungus interactions.

    Carvalho, Agostinho / van de Veerdonk, Frank L

    Current opinion in microbiology

    2019  Volume 58, Page(s) iii–v

    MeSH term(s) Animals ; Fungi/genetics ; Fungi/physiology ; Host-Pathogen Interactions ; Humans ; Mycoses/microbiology ; Mycoses/physiopathology
    Language English
    Publishing date 2019-04-20
    Publishing country England
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1418474-6
    ISSN 1879-0364 ; 1369-5274
    ISSN (online) 1879-0364
    ISSN 1369-5274
    DOI 10.1016/j.mib.2020.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5514: Show issues Location:
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  9. Article ; Online: Rare variants increase the risk of severe COVID-19

    Frank L van de Veerdonk / Mihai G Netea

    eLife, Vol

    2021  Volume 10

    Abstract: Evidence is mounting that rare loss-of-function variants in the TLR7 gene predispose men with no medical history to severe forms of COVID-19. ...

    Abstract Evidence is mounting that rare loss-of-function variants in the TLR7 gene predispose men with no medical history to severe forms of COVID-19.
    Keywords TLR7 ; COVID-19 ; LASSO logistic regression analysis ; Medicine ; R ; Science ; Q ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher eLife Sciences Publications Ltd
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Blocking IL-1 to prevent respiratory failure in COVID-19.

    van de Veerdonk, Frank L / Netea, Mihai G

    Critical care (London, England)

    2020  Volume 24, Issue 1, Page(s) 445

    Abstract: COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation ... ...

    Abstract COVID-19 is an emerging disease that can manifest itself as asymptomatic or mild respiratory tract infection in the majority of individuals, but in some, it can progress into severe pneumonia and acute respiratory distress syndrome (ARDS). Inflammation is known to play a crucial role in the pathogenesis of severe infections and ARDS and evidence is emerging that the IL-1/IL-6 pathway is highly upregulated in patients with severe disease. These findings open new avenues for host-directed therapies in patients with symptomatic SARS-CoV-2 infection and might in addition to antiviral treatment be enough to curb the currently unacceptably high morbidity and mortality associated with COVID-19.
    MeSH term(s) COVID-19 ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Humans ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Interleukin-1/antagonists & inhibitors ; Pandemics ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Respiratory Insufficiency/prevention & control ; Respiratory Insufficiency/virology
    Chemical Substances Interleukin 1 Receptor Antagonist Protein ; Interleukin-1
    Keywords covid19
    Language English
    Publishing date 2020-07-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-020-03166-0
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    Zs.A 5517: Show issues Location:
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