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  1. Article ; Online: Αnti-KLK5/KLK7 Antibody-based Strategies for the Treatment of Epidermal Diseases.

    Pampalakis, Georgios

    Current pharmaceutical design

    2023  Volume 29, Issue 29, Page(s) 2354–2357

    MeSH term(s) Humans ; Antibodies ; Kallikreins
    Chemical Substances Antibodies ; Kallikreins (EC 3.4.21.-) ; KLK5 protein, human (EC 3.4.21.-) ; KLK7 protein, human (EC 3.4.21.-)
    Language English
    Publishing date 2023-11-21
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/0113816128258924231011103813
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Underestimations in the In Silico-Predicted Toxicities of V-Agents.

    Pampalakis, Georgios

    Journal of xenobiotics

    2023  Volume 13, Issue 4, Page(s) 615–624

    Abstract: V-agents are exceedingly toxic nerve agents. Recently, it was highlighted that V-agents constitute a diverse subclass of compounds with most of them not extensively studied. Although chemical weapons have been banned under the Chemical Weapons Convention ...

    Abstract V-agents are exceedingly toxic nerve agents. Recently, it was highlighted that V-agents constitute a diverse subclass of compounds with most of them not extensively studied. Although chemical weapons have been banned under the Chemical Weapons Convention (CWC), there is an increased concern for chemical terrorism. Thus, it is important to understand their properties and toxicities, especially since some of these agents are not included in the CWC list. Nonetheless, to achieve this goal, the testing of a huge number of compounds is needed. Alternatively, in silico toxicology offers a great advantage for the rapid assessment of toxic compounds. Here, various in silico tools (TEST, VEGA, pkCSM ProTox-II) were used to estimate the acute oral toxicity (LD50) of different V-agents and compare them with experimental values. These programs underestimated the toxicity of V-agents, and certain V-agents were estimated to be relatively non-toxic. TEST was also used to estimate the physical properties and found to provide good approximations for densities, surface tensions and vapor pressures but not for viscosities. Thus, attention should be paid when interpreting and estimating the toxicities of V-agents in silico, and it is necessary to conduct future detailed experiments to understand their properties and develop effective countermeasures.
    Language English
    Publishing date 2023-10-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649720-7
    ISSN 2039-4713 ; 2039-4713
    ISSN (online) 2039-4713
    ISSN 2039-4713
    DOI 10.3390/jox13040039
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Growth of chemical gardens in gaseous acidic atmospheres.

    Angelis, Georgios / Sant, Georgios / Vizirianakis, Ioannis S / Pampalakis, Georgios

    Chemical communications (Cambridge, England)

    2023  Volume 59, Issue 11, Page(s) 1505–1508

    Abstract: The generation of chemobrionic architectures through slow injection of aqueous silicate solution in gaseous ... ...

    Abstract The generation of chemobrionic architectures through slow injection of aqueous silicate solution in gaseous TiCl
    Language English
    Publishing date 2023-02-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d2cc06843e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Corrigendum: The Generation of an Organic Inverted Chemical.

    Pampalakis, Georgios

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2019  Volume 25, Issue 54, Page(s) 12653

    Language English
    Publishing date 2019-09-13
    Publishing country Germany
    Document type Journal Article ; Published Erratum
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.201903968
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Chemical, Physical, and Toxicological Properties of V-Agents.

    Pampalakis, Georgios / Kostoudi, Stavroula

    International journal of molecular sciences

    2023  Volume 24, Issue 10

    Abstract: V-agents are exceedingly toxic organophosphate nerve agents. The most widely known V-agents are the phosphonylated thiocholines VX and VR. Nonetheless, other V-subclasses have been synthesized. Here, a holistic overview of V-agents is provided, where ... ...

    Abstract V-agents are exceedingly toxic organophosphate nerve agents. The most widely known V-agents are the phosphonylated thiocholines VX and VR. Nonetheless, other V-subclasses have been synthesized. Here, a holistic overview of V-agents is provided, where these compounds have been categorized based on their structures to facilitate their study. A total of seven subclasses of V-agents have been identified, including phospho(n/r)ylated selenocholines and non-sulfur-containing agents, such as VP and EA-1576 (EA: Edgewood Arsenal). Certain V-agents have been designed through the conversion of phosphorylated pesticides to their respective phosphonylated analogs, such as EA-1576 derived from mevinphos. Further, this review provides a description of their production, physical properties, toxicity, and stability during storage. Importantly, V-agents constitute a percutaneous hazard, while their high stability ensures the contamination of the exposed area for weeks. The danger of V-agents was highlighted in the 1968 VX accident in Utah. Until now, VX has been used in limited cases of terrorist attacks and assassinations, but there is an increased concern about potential terrorist production and use. For this reason, studying the chemistry of VX and other less-studied V-agents is important to understand their properties and develop potential countermeasures.
    MeSH term(s) Chemical Warfare Agents/chemistry ; Organothiophosphorus Compounds/chemistry ; Nerve Agents/toxicity ; Nerve Agents/chemistry ; Pesticides/toxicity
    Chemical Substances VX (9A4381183B) ; Chemical Warfare Agents ; Organothiophosphorus Compounds ; Nerve Agents ; Pesticides
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24108600
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Improvements, Variations and Biomedical Applications of the Michaelis-Arbuzov Reaction.

    Kostoudi, Stavroula / Pampalakis, Georgios

    International journal of molecular sciences

    2022  Volume 23, Issue 6

    Abstract: Compounds bearing the phosphorus-carbon (P-C) bond have important pharmacological, biochemical, and toxicological properties. Historically, the most notable reaction for the formation of the P-C bond is the Michaelis-Arbuzov reaction, first described in ... ...

    Abstract Compounds bearing the phosphorus-carbon (P-C) bond have important pharmacological, biochemical, and toxicological properties. Historically, the most notable reaction for the formation of the P-C bond is the Michaelis-Arbuzov reaction, first described in 1898. The classical Michaelis-Arbuzov reaction entails a reaction between an alkyl halide and a trialkyl phosphite to yield a dialkylalkylphosphonate. Nonetheless, deviations from the classical mechanisms and new modifications have appeared that allowed the expansion of the library of reactants and consequently the chemical space of the yielded products. These involve the use of Lewis acid catalysts, green methods, ultrasound, microwave, photochemically-assisted reactions, aryne-based reactions, etc. Here, a detailed presentation of the Michaelis-Arbuzov reaction and its developments and applications in the synthesis of biomedically important agents is provided. Certain examples of such applications include the development of alkylphosphonofluoridates as serine hydrolase inhibitors and activity-based probes, and the P-C containing antiviral and anticancer agents.
    MeSH term(s) Antiviral Agents ; Catalysis ; Lewis Acids ; Microwaves ; Phosphorus
    Chemical Substances Antiviral Agents ; Lewis Acids ; Phosphorus (27YLU75U4W)
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23063395
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Generation of an Organic Inverted Chemical Garden.

    Pampalakis, Georgios

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2016  Volume 22, Issue 20, Page(s) 6779–6782

    Abstract: A chemical garden based on iron salt that grows in organic solvents and ions is demonstrated for the first time. This prototype chemical garden develops in an inverted orientation, thus providing evidence that downward growth is feasible. ...

    Abstract A chemical garden based on iron salt that grows in organic solvents and ions is demonstrated for the first time. This prototype chemical garden develops in an inverted orientation, thus providing evidence that downward growth is feasible.
    Language English
    Publishing date 2016-04-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.201504773
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  8. Article ; Online: Novel specific activity-based probes validate KLK proteases as druggable targets.

    Sotiropoulou, Georgia / Zingkou, Eleni / Pampalakis, Georgios

    Cancer biology & therapy

    2022  Volume 23, Issue 1, Page(s) 401–403

    MeSH term(s) Endopeptidases ; Humans ; Peptide Hydrolases
    Chemical Substances Endopeptidases (EC 3.4.-) ; Peptide Hydrolases (EC 3.4.-)
    Language English
    Publishing date 2022-06-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2146305-0
    ISSN 1555-8576 ; 1538-4047
    ISSN (online) 1555-8576
    ISSN 1538-4047
    DOI 10.1080/15384047.2022.2074775
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5887: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: A chemogenomic approach is required for effective treatment of amyotrophic lateral sclerosis.

    Pampalakis, Georgios / Angelis, Georgios / Zingkou, Eleni / Vekrellis, Kostas / Sotiropoulou, Georgia

    Clinical and translational medicine

    2022  Volume 12, Issue 1, Page(s) e657

    Abstract: ALS is a fatal untreatable disease involving degeneration of motor neurons. Μultiple causative genes encoding proteins with versatile functions have been identified indicating that diverse biological pathways lead to ALS. Chemical entities still ... ...

    Abstract ALS is a fatal untreatable disease involving degeneration of motor neurons. Μultiple causative genes encoding proteins with versatile functions have been identified indicating that diverse biological pathways lead to ALS. Chemical entities still represent a promising choice to delay ALS progression, attenuate symptoms and/or increase life expectancy, but also gene-based and stem cell-based therapies are in the process of development, and some are tested in clinical trials. Various compounds proved effective in transgenic models overexpressing distinct ALS causative genes unfortunately though, they showed no efficacy in clinical trials. Notably, while animal models provide a uniform genetic background for preclinical testing, ALS patients are not stratified, and the distinct genetic forms of ALS are treated as one group, which could explain the observed discrepancies between treating genetically homogeneous mice and quite heterogeneous patient cohorts. We suggest that chemical entity-genotype correlation should be exploited to guide patient stratification for pharmacotherapy, that is administered drugs should be selected based on the ALS genetic background.
    MeSH term(s) Amino Acids, Diamino/adverse effects ; Amyotrophic Lateral Sclerosis/drug therapy ; Amyotrophic Lateral Sclerosis/genetics ; Amyotrophic Lateral Sclerosis/metabolism ; Animals ; Cyanobacteria Toxins/adverse effects ; Cycas/adverse effects ; Cycas/metabolism ; Disease Models, Animal ; Mice
    Chemical Substances Amino Acids, Diamino ; Cyanobacteria Toxins ; beta-N-methylamino-L-alanine (108SA6URTV)
    Language English
    Publishing date 2022-01-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.657
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Cocktails of KLK5 Protease Inhibitors and Anti-TNFα Therapeutics: an Effective Treatment for Netherton Syndrome.

    Zingkou, Eleni / Pampalakis, Georgios / Sotiropoulou, Georgia

    Journal of clinical immunology

    2022  Volume 42, Issue 3, Page(s) 597–605

    Abstract: Netherton syndrome (NS) is a rare, severe type of ichthyosis, often lethal in neonates, for which there is no therapy. ... ...

    Abstract Netherton syndrome (NS) is a rare, severe type of ichthyosis, often lethal in neonates, for which there is no therapy. Spink5
    MeSH term(s) Animals ; Inflammation ; Kallikreins/genetics ; Kallikreins/therapeutic use ; Mice ; Netherton Syndrome/drug therapy ; Netherton Syndrome/genetics ; Phenotype ; Protease Inhibitors/therapeutic use
    Chemical Substances Protease Inhibitors ; Kallikreins (EC 3.4.21.-) ; Klk5 protein, mouse (EC 3.4.21.-)
    Language English
    Publishing date 2022-01-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 779361-3
    ISSN 1573-2592 ; 0271-9142
    ISSN (online) 1573-2592
    ISSN 0271-9142
    DOI 10.1007/s10875-021-01195-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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