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Article ; Online: [No title information]

van den Berg, Irma

Nursing

2020 Volume 26, Issue 6, Page(s) 24–25

Title translation	Kan inhalatieanesthesie midazolam vervangen bij ARDS-patiënten op de ic?
Keywords	covid19
Language	Dutch
Publishing date	2020-06-03
Publishing country	Netherlands
Document type	Journal Article
ISSN	2468-1431
ISSN (online)	2468-1431
DOI	10.1007/s41193-020-0086-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: INTERVIEW: "SCHWESTERN ENTLASTEN ÄRZTE". Telegesundheitsschwestern machen auf Rügen und in Lübbenau Hausbesuche - für Neeltje van den Berg ein Projekt, das bei Ärzten und Patienten ankommt

van den Berg, Neeltje / Töpfer, Änne

Gesundheit und Gesellschaft

2006 Volume 9, Issue 11, Page(s) 19

Language	German
Document type	Article
ZDB-ID	1435511-5
ISSN	1436-1728
Database	Current Contents Medicine

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Article ; Online: The Usefulness of Electronic Health Records From Preventive Youth Healthcare in the Recognition of Child Mental Health Problems.

Koning, Nynke R / Büchner, Frederike L / van den Berg, Anouk W / Choi, S Y Angelique / Leeuwenburgh, Nathalie A / Paijmans, Irma J M / van Dijk-van Dijk, D J Annemarie / Numans, Mattijs E / Crone, Mathilde R

Frontiers in public health

2021 Volume 9, Page(s) 658240

Abstract: Background and Objectives: ...

Abstract	Background and Objectives:
MeSH term(s)	Adolescent ; Child ; Cohort Studies ; Delivery of Health Care ; Electronic Health Records ; Humans ; Mental Health ; Netherlands/epidemiology
Language	English
Publishing date	2021-05-31
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2021.658240
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Article ; Online: Differential binding of human and murine IgGs to catalytic and cell wall binding domains of Staphylococcus aureus peptidoglycan hydrolases.

Wang, Min / van den Berg, Sanne / Mora Hernández, Yaremit / Visser, Aafke Hinke / Vera Murguia, Elias / Koedijk, Dennis G A M / Bellink, Channah / Bruggen, Hilde / Bakker-Woudenberg, Irma A J M / van Dijl, Jan Maarten / Buist, Girbe

Scientific reports

2021 Volume 11, Issue 1, Page(s) 13865

Abstract: Staphylococcus aureus is an opportunistic pathogen causing high morbidity and mortality. Since multi-drug resistant S. aureus lineages are nowadays omnipresent, alternative tools for preventive or therapeutic interventions, like immunotherapy, are ... ...

Abstract	Staphylococcus aureus is an opportunistic pathogen causing high morbidity and mortality. Since multi-drug resistant S. aureus lineages are nowadays omnipresent, alternative tools for preventive or therapeutic interventions, like immunotherapy, are urgently needed. However, there are currently no vaccines against S. aureus. Surface-exposed and secreted proteins are regarded as potential targets for immunization against S. aureus infections. Yet, many potential staphylococcal antigens of this category do not elicit protective immune responses. To obtain a better understanding of this problem, we compared the binding of serum IgGs from healthy human volunteers, highly S. aureus-colonized patients with the genetic blistering disease epidermolysis bullosa (EB), or immunized mice to the purified S. aureus peptidoglycan hydrolases Sle1, Aly and LytM and their different domains. The results show that the most abundant serum IgGs from humans and immunized mice target the cell wall-binding domain of Sle1, and the catalytic domains of Aly and LytM. Interestingly, in a murine infection model, these particular IgGs were not protective against S. aureus bacteremia. In contrast, relatively less abundant IgGs against the catalytic domain of Sle1 and the N-terminal domains of Aly and LytM were almost exclusively detected in sera from EB patients and healthy volunteers. These latter IgGs may contribute to the protection against staphylococcal infections, as previous studies suggest that serum IgGs protect EB patients against severe S. aureus infection. Together, these observations focus attention on the use of particular protein domains for vaccination to direct potentially protective immune responses towards the most promising epitopes within staphylococcal antigens.
MeSH term(s)	Animals ; Antibodies, Bacterial/immunology ; Antigens, Bacterial/immunology ; Catalytic Domain/genetics ; Catalytic Domain/immunology ; Cell Wall/genetics ; Cell Wall/immunology ; Epitopes/genetics ; Epitopes/immunology ; Humans ; Immunoglobulin G/genetics ; Immunoglobulin G/immunology ; Methicillin-Resistant Staphylococcus aureus/genetics ; Methicillin-Resistant Staphylococcus aureus/immunology ; Methicillin-Resistant Staphylococcus aureus/pathogenicity ; Mice ; N-Acetylmuramoyl-L-alanine Amidase/chemistry ; N-Acetylmuramoyl-L-alanine Amidase/immunology ; Peptidoglycan/genetics ; Peptidoglycan/immunology ; Staphylococcal Infections/genetics ; Staphylococcal Infections/immunology ; Staphylococcal Infections/prevention & control
Chemical Substances	Antibodies, Bacterial ; Antigens, Bacterial ; Epitopes ; Immunoglobulin G ; Peptidoglycan ; N-Acetylmuramoyl-L-alanine Amidase (EC 3.5.1.28)
Language	English
Publishing date	2021-07-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-93359-6
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Article ; Online: The Usefulness of Electronic Health Records From Preventive Youth Healthcare in the Recognition of Child Mental Health Problems

Nynke R. Koning / Frederike L. Büchner / Anouk W. van den Berg / S. Y. Angelique Choi / Nathalie A. Leeuwenburgh / Irma J. M. Paijmans / D. J. Annemarie van Dijk-van Dijk / Mattijs E. Numans / Mathilde R. Crone

Frontiers in Public Health, Vol

2021 Volume 9

Abstract: Background and Objectives: Early identification of child mental health problems (MHPs) is important to provide adequate, timely treatment. Dutch preventive youth healthcare monitors all aspects of a child's healthy development. We explored the usefulness ...

Abstract	Background and Objectives: Early identification of child mental health problems (MHPs) is important to provide adequate, timely treatment. Dutch preventive youth healthcare monitors all aspects of a child's healthy development. We explored the usefulness of their electronic health records (EHRs) in scientific research and aimed to develop prediction models for child MHPs.Methods: Population-based cohort study with anonymously extracted electronic healthcare data from preventive youth healthcare centers in the Leiden area, the Netherlands, from the period 2005–2015. Data was analyzed with respect to its continuity, percentage of cases and completeness. Logistic regression analyses were conducted to develop prediction models for the risk of a first recorded concern for MHPs in the next scheduled visit at age 3/4, 5/6, 10/11, and 13/14 years.Results: We included 26,492 children. The continuity of the data was low and the number of concerns for MHPs varied greatly. A large number of determinants had missing data for over 80% of the children. The discriminatory performance of the prediction models were poor.Conclusions: This is the first study exploring the usefulness of EHRs from Dutch preventive youth healthcare in research, especially in predicting child MHPs. We found the usefulness of the data to be limited and the performance of the developed prediction models was poor. When data quality can be improved, e.g., by facilitating accurate recording, or by data enrichment from other available sources, the analysis of EHRs might be helpful for better identification of child MHPs.
Keywords	mental health ; pediatrics ; public health ; primary care ; early identification ; Public aspects of medicine ; RA1-1270
Subject code	360
Language	English
Publishing date	2021-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Exploring metal availability in the natural niche of

van Beek, Lucille F / Surmann, Kristin / van den Berg van Saparoea, H Bart / Houben, Diane / Jong, Wouter S P / Hentschker, Christian / Ederveen, Thomas H A / Mitsi, Elena / Ferreira, Daniela M / van Opzeeland, Fred / van der Gaast-de Jongh, Christa E / Joosten, Irma / Völker, Uwe / Schmidt, Frank / Luirink, Joen / Diavatopoulos, Dimitri A / de Jonge, Marien I

Virulence

2020 Volume 11, Issue 1, Page(s) 1310–1328

Abstract: Nasopharyngeal colonization ... ...

Abstract	Nasopharyngeal colonization by
MeSH term(s)	Adult ; Animals ; Antibodies, Bacterial/blood ; Antibodies, Bacterial/immunology ; Antigens, Bacterial/immunology ; Antigens, Bacterial/isolation & purification ; Culture Media/chemistry ; Disease Models, Animal ; Female ; Humans ; Male ; Membrane Proteins/immunology ; Membrane Proteins/isolation & purification ; Metals/analysis ; Metals/pharmacology ; Mice ; Mice, Inbred C57BL ; Middle Aged ; Nasal Lavage Fluid/chemistry ; Nasopharynx/microbiology ; Pneumococcal Infections/immunology ; Pneumococcal Infections/prevention & control ; Pneumococcal Vaccines/administration & dosage ; Pneumococcal Vaccines/immunology ; Streptococcus pneumoniae/drug effects ; Young Adult
Chemical Substances	Antibodies, Bacterial ; Antigens, Bacterial ; Culture Media ; Membrane Proteins ; Metals ; Pneumococcal Vaccines
Language	English
Publishing date	2020-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2657572-3
ISSN	2150-5608 ; 2150-5594
ISSN (online)	2150-5608
ISSN	2150-5594
DOI	10.1080/21505594.2020.1825908
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Article ; Online: Differential binding of human and murine IgGs to catalytic and cell wall binding domains of Staphylococcus aureus peptidoglycan hydrolases

Min Wang / Sanne van den Berg / Yaremit Mora Hernández / Aafke Hinke Visser / Elias Vera Murguia / Dennis G.A.M. Koedijk / Channah Bellink / Hilde Bruggen / Irma A. J. M. Bakker-Woudenberg / Jan Maarten van Dijl / Girbe Buist

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 16

Abstract: Abstract Staphylococcus aureus is an opportunistic pathogen causing high morbidity and mortality. Since multi-drug resistant S. aureus lineages are nowadays omnipresent, alternative tools for preventive or therapeutic interventions, like immunotherapy, ... ...

Abstract	Abstract Staphylococcus aureus is an opportunistic pathogen causing high morbidity and mortality. Since multi-drug resistant S. aureus lineages are nowadays omnipresent, alternative tools for preventive or therapeutic interventions, like immunotherapy, are urgently needed. However, there are currently no vaccines against S. aureus. Surface-exposed and secreted proteins are regarded as potential targets for immunization against S. aureus infections. Yet, many potential staphylococcal antigens of this category do not elicit protective immune responses. To obtain a better understanding of this problem, we compared the binding of serum IgGs from healthy human volunteers, highly S. aureus-colonized patients with the genetic blistering disease epidermolysis bullosa (EB), or immunized mice to the purified S. aureus peptidoglycan hydrolases Sle1, Aly and LytM and their different domains. The results show that the most abundant serum IgGs from humans and immunized mice target the cell wall-binding domain of Sle1, and the catalytic domains of Aly and LytM. Interestingly, in a murine infection model, these particular IgGs were not protective against S. aureus bacteremia. In contrast, relatively less abundant IgGs against the catalytic domain of Sle1 and the N-terminal domains of Aly and LytM were almost exclusively detected in sera from EB patients and healthy volunteers. These latter IgGs may contribute to the protection against staphylococcal infections, as previous studies suggest that serum IgGs protect EB patients against severe S. aureus infection. Together, these observations focus attention on the use of particular protein domains for vaccination to direct potentially protective immune responses towards the most promising epitopes within staphylococcal antigens.
Keywords	Medicine ; R ; Science ; Q
Subject code	572
Language	English
Publishing date	2021-07-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Helminth antigens counteract a rapid high-fat diet-induced decrease in adipose tissue eosinophils.

van den Berg, Susan M / van Dam, Andrea D / Kusters, Pascal J H / Beckers, Linda / den Toom, Myrthe / van der Velden, Saskia / Van den Bossche, Jan / van Die, Irma / Boon, Mariëtte R / Rensen, Patrick C N / Lutgens, Esther / de Winther, Menno P J

Journal of molecular endocrinology

2017 Volume 59, Issue 3, Page(s) 245–255

Abstract: Brown adipose tissue (BAT) activation and white adipose tissue (WAT) beiging can increase energy expenditure and have the potential to reduce obesity and associated diseases. The immune system is a potential target in mediating brown and beige adipocyte ... ...

Abstract	Brown adipose tissue (BAT) activation and white adipose tissue (WAT) beiging can increase energy expenditure and have the potential to reduce obesity and associated diseases. The immune system is a potential target in mediating brown and beige adipocyte activation. Type 2 and anti-inflammatory immune cells contribute to metabolic homeostasis within lean WAT, with a prominent role for eosinophils and interleukin (IL)-4-induced anti-inflammatory macrophages. We determined eosinophil numbers in epididymal WAT (EpAT), subcutaneous WAT (ScAT) and BAT after 1 day, 3 days or 1 week of high-fat diet (HFD) feeding in C57Bl/6 mice. One day of HFD resulted in a rapid drop in eosinophil numbers in EpAT and BAT, and after 3 days, in ScAT. In an attempt to restore this HFD-induced drop in adipose tissue eosinophils, we treated 1-week HFD-fed mice with helminth antigens from
MeSH term(s)	Adipocytes/metabolism ; Adipose Tissue/immunology ; Adipose Tissue/metabolism ; Adipose Tissue/pathology ; Adipose Tissue, Brown/immunology ; Adipose Tissue, Brown/metabolism ; Adipose Tissue, Brown/pathology ; Animals ; Antigens, Helminth/immunology ; Biomarkers ; Chemokine CCL11/biosynthesis ; Diet, High-Fat ; Eosinophils/immunology ; Eosinophils/metabolism ; Immunity ; Interleukin-4/metabolism ; Leukocyte Count ; Male ; Mice ; Uncoupling Protein 1/genetics ; Uncoupling Protein 1/metabolism
Chemical Substances	Antigens, Helminth ; Biomarkers ; Chemokine CCL11 ; Uncoupling Protein 1 ; Interleukin-4 (207137-56-2)
Language	English
Publishing date	2017-07-10
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645012-x
ISSN	1479-6813 ; 0952-5041
ISSN (online)	1479-6813
ISSN	0952-5041
DOI	10.1530/JME-17-0112
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Article ; Online: Mild Staphylococcus aureus Skin Infection Improves the Course of Subsequent Endogenous S. aureus Bacteremia in Mice.

van den Berg, Sanne / de Vogel, Corné P / van Belkum, Alex / Bakker-Woudenberg, Irma A J M

PloS one

2015 Volume 10, Issue 6, Page(s) e0129150

Abstract: Staphylococcus aureus carriers with S. aureus bacteremia may have a reduced mortality risk compared to non-carriers. A role for the immune system is suggested. Here, we study in mice the effect of mild S. aureus skin infection prior to endogenous or ... ...

Abstract	Staphylococcus aureus carriers with S. aureus bacteremia may have a reduced mortality risk compared to non-carriers. A role for the immune system is suggested. Here, we study in mice the effect of mild S. aureus skin infection prior to endogenous or exogenous S. aureus bacteremia, and evaluate protection in relation to anti-staphylococcal antibody levels. Skin infections once or twice by a clinical S. aureus isolate (isolate P) or S. aureus strain 8325-4 were induced in mice free of S. aureus and anti-staphylococcal antibodies. Five weeks later, immunoglobulin G (IgG) levels in blood against 25 S. aureus antigens were determined, and LD50 or LD100 bacteremia caused by S. aureus isolate P was induced. S. aureus skin infections led to elevated levels of anti-staphylococcal IgG in blood. One skin infection improved the course of subsequent severe endogenous bacteremia only. A second skin infection further improved animal survival rate, which was associated with increased pre-bacteremia IgG levels against Efb, IsaA, LukD, LukE, Nuc, PrsA and WTA. In conclusion, S. aureus isolate P skin infection in mice reduces the severity of subsequent endogenous S. aureus bacteremia only. Although cellular immune effects cannot be rules out, anti-staphylococcal IgG against specified antigens may contribute to this effect.
MeSH term(s)	Animals ; Antibodies, Bacterial/blood ; Antigens, Bacterial/immunology ; Bacteremia/immunology ; Bacteremia/prevention & control ; Disease Models, Animal ; Female ; Immunoglobulin G/blood ; Mice ; Skin Diseases, Infectious/immunology ; Skin Diseases, Infectious/microbiology ; Staphylococcal Infections/immunology ; Staphylococcal Infections/prevention & control ; Staphylococcus aureus/immunology ; Survival Analysis
Chemical Substances	Antibodies, Bacterial ; Antigens, Bacterial ; Immunoglobulin G
Language	English
Publishing date	2015
Publishing country	United States
Document type	Journal Article
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0129150
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Mild Staphylococcus aureus Skin Infection Improves the Course of Subsequent Endogenous S. aureus Bacteremia in Mice.

Sanne van den Berg / Corné P de Vogel / Alex van Belkum / Irma A J M Bakker-Woudenberg

PLoS ONE, Vol 10, Iss 6, p e

2015 Volume 0129150

Abstract	Staphylococcus aureus carriers with S. aureus bacteremia may have a reduced mortality risk compared to non-carriers. A role for the immune system is suggested. Here, we study in mice the effect of mild S. aureus skin infection prior to endogenous or exogenous S. aureus bacteremia, and evaluate protection in relation to anti-staphylococcal antibody levels. Skin infections once or twice by a clinical S. aureus isolate (isolate P) or S. aureus strain 8325-4 were induced in mice free of S. aureus and anti-staphylococcal antibodies. Five weeks later, immunoglobulin G (IgG) levels in blood against 25 S. aureus antigens were determined, and LD50 or LD100 bacteremia caused by S. aureus isolate P was induced. S. aureus skin infections led to elevated levels of anti-staphylococcal IgG in blood. One skin infection improved the course of subsequent severe endogenous bacteremia only. A second skin infection further improved animal survival rate, which was associated with increased pre-bacteremia IgG levels against Efb, IsaA, LukD, LukE, Nuc, PrsA and WTA. In conclusion, S. aureus isolate P skin infection in mice reduces the severity of subsequent endogenous S. aureus bacteremia only. Although cellular immune effects cannot be rules out, anti-staphylococcal IgG against specified antigens may contribute to this effect.
Keywords	Medicine ; R ; Science ; Q
Language	English
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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