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Article ; Online: Predominant factors influencing reactive oxygen species in cancer stem cells.

Soundararajan, Loshini / Warrier, Sudha / Dharmarajan, Arun / Bhaskaran, Natarajan

2023 Volume 125, Issue 1, Page(s) 3–21

Abstract: Reactive oxygen species (ROS) and its related signaling pathways and regulating molecules play a major role in the growth and development of cancer stem cells. The concept of ROS and cancer stem cells (CSCs) has been gaining much attention since the past ...

Abstract	Reactive oxygen species (ROS) and its related signaling pathways and regulating molecules play a major role in the growth and development of cancer stem cells. The concept of ROS and cancer stem cells (CSCs) has been gaining much attention since the past decade and the evidence show that these CSCs possess robust self-renewal and tumorigenic potential and are resistant to conventional chemo- and radiotherapy and believed to be responsible for tumor progression, metastasis, and recurrence. It seems reasonable to say that cancer can be cured only if the CSCs are eradicated. ROS are Janus-faced molecules that can regulate cellular physiology as well as induce cytotoxicity, depending on the magnitude, duration, and site of generation. Unlike normal cancer cells, CSCs expel ROS efficiently by upregulating ROS scavengers. This unique redox regulation in CSCs protects them from ROS-mediated cell death and nullifies the effect of radiation, leading to chemoresistance and radioresistance. However, how these CSCs control ROS production by scavenging free radicals and how they maintain low levels of ROS is a challenging to understand and these attributes make CSCs as prime therapeutic targets. Here, we summarize the mechanisms of redox regulation in CSCs, with a focus on therapy resistance, its various pathways and microRNAs regulation, and the potential therapeutic implications of manipulating the ROS levels to eradicate CSCs. A better understanding of these molecules, their interactions in the CSCs may help us to adopt proper control and treatment measures.
MeSH term(s)	Humans ; Reactive Oxygen Species/metabolism ; Neoplasms/metabolism ; MicroRNAs/metabolism ; Oxidation-Reduction ; Neoplastic Stem Cells/metabolism
Chemical Substances	Reactive Oxygen Species ; MicroRNAs
Language	English
Publishing date	2023-11-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	392402-6
ISSN	1097-4644 ; 0730-2312
ISSN (online)	1097-4644
ISSN	0730-2312
DOI	10.1002/jcb.30506
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Thromboprophylaxis in Proximal Femur Fracture

Nayantara Srikanth / Naveen Sathiyaseelan / Jagadeesh Bhaskaran / S Natarajan

Journal of Clinical and Diagnostic Research, Vol 17, Iss 09, Pp 09-

A Pilot Survey among Practicing Orthopaedic Surgeons in India

2023 Volume 13

Abstract: Introduction: Venous Thromboembolism (VTE) and Pulmonary Embolism (PE) are more common following orthopaedic surgeries around the hip than other surgeries. However, there is still a dilemma among orthopaedic surgeons regarding whether routine ... ...

Abstract	Introduction: Venous Thromboembolism (VTE) and Pulmonary Embolism (PE) are more common following orthopaedic surgeries around the hip than other surgeries. However, there is still a dilemma among orthopaedic surgeons regarding whether routine thromboprophylaxis is justified in patients. Aim: To describe current practices among orthopaedic surgeons regarding routine thromboprophylaxis among patients with proximal femur fractures. Materials and Methods: A cross-sectional exploratory study was conducted at Department of Orthopaedics, Saveetha Medical College, Chennai, Tamil Nadu, India between March 2022 and May 2022 among orthopaedic surgeons. A Google survey form, containing 10 prevalidated multiple-choice questions, was shared on social media and medical groups. Descriptive analysis was undertaken, and statistical analysis was done with International Business Machines (IBM) Statistical Package for Social Sciences (SPSS) software version 28.0. Results: Among the 141 respondents, 72% were from private sector institutions/hospitals. Over 90.78% of the respondents indicated that there was a role for anticoagulation therapy in proximal femur fractures, and 92% used low molecular weight heparin. The responses varied slightly depending on whether anticoagulant treatment was used preoperatively (51%) or postoperatively (48%), and if there was a waiting time of less than 24 hours to 3-5 days before surgery. Most orthopaedic surgeons opted for anticoagulation therapy in the presence of a previous history of Deep Vein Thrombosis (DVT)/PE (79%), age greater than 70 years (61%), and use of hormone replacement therapy (64%), or if the surgery lasted more than two hours (61%). Conclusion: The present study concludes that 9.2% of orthopaedic surgeons do not use anticoagulation therapy and nearly half (48%) do not administer anticoagulation therapy preoperatively. As the proportion of elderly patients increases, consensus building will enable the formulation of practice guidelines based on evidence generated through such surveys.
Keywords	deep vein ; embolism ; heparin ; pulmonary ; thrombosis ; venous thromboembolism ; Medicine ; R
Language	English
Publishing date	2023-09-01T00:00:00Z
Publisher	JCDR Research and Publications Private Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Effect of a Submucosal Injection of Platelet-Rich Plasma on the Rate of Orthodontic Tooth Movement - A Split-Mouth, Single-Blind Randomized Controlled Trial.

Desai, Asavari / Nambiar, Supriya / Unnikrishnan, Bhaskaran / Rai, Sharada / Nayak, Sangeeta / Natarajan, Srikant

Contemporary clinical dentistry

2022 Volume 14, Issue 1, Page(s) 39–44

Abstract: Objective: To investigate the effect of submucosal injection of platelet-rich plasma (PRP) on the rate of mini-implant-supported retraction, using a split-mouth randomized clinical design.: Materials and methods: Twenty subjects of either gender ... ...

Abstract	Objective: To investigate the effect of submucosal injection of platelet-rich plasma (PRP) on the rate of mini-implant-supported retraction, using a split-mouth randomized clinical design. Materials and methods: Twenty subjects of either gender between 16 and 25 years of age with bimaxillary dentoalveolar protrusion and crowding of <4 mm scheduled to undergo fixed mechanotherapy with the extraction of 1 Results: Mean overall retraction was faster on the intervention side as compared to the control side by 1.5 times and was statistically significant with a Conclusions: Submucosal injection of PRP significantly accelerates orthodontic tooth movement and can therefore be used as an effective, safe, and minimally invasive method to expedite orthodontic treatment.
Language	English
Publishing date	2022-11-11
Publishing country	India
Document type	Journal Article
ZDB-ID	2582352-8
ISSN	0976-2361 ; 0976-237X
ISSN (online)	0976-2361
ISSN	0976-237X
DOI	10.4103/ccd.ccd_419_21
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Article ; Online: Adaptive sports for promoting physical activity in community-dwelling adults with stroke: A feasibility study.

Nayak, Pradeepa / Mahmood, Amreen / Kumaran D, Senthil / Natarajan, Manikandan / Unnikrishnan, Bhaskaran / Solomon, John M

Journal of bodywork and movement therapies

2021 Volume 28, Page(s) 341–347

Abstract: Background: Despite proven health benefits of regular participation in physical activities (PA), adults with stroke fail to achieve recommended levels of PA. Sports being an enjoyable activity is more likely to encourage participation. Therefore, the ... ...

Abstract	Background: Despite proven health benefits of regular participation in physical activities (PA), adults with stroke fail to achieve recommended levels of PA. Sports being an enjoyable activity is more likely to encourage participation. Therefore, the objectives of the present study are i) to develop and test the feasibility of adaptive sports for promoting PA and Quality of Life (QoL) in community-dwelling adults with stroke, and ii) to explore the participants perception and experiences of playing adaptive sports. Methods: Two focus groups were conducted among the eight experts and a person with stroke to develop adaptive sports. To test the feasibility of these adaptive sports, in a multi methods study eighteen community dwelling adults with stroke were recruited. Participants played adaptive sports twice a week for two months in a community center. Participants pre and post intervention PA levels and QoL were measured. Participants were also interviewed at the end of the program to explore their experiences of participation in adaptive sports. Results: At the end of the program retention rate of the participants was 83.33% and there was a significant improvement in PA levels, while the improvement in QoL was not statistically significant. Participants expressed positive experience with the program. There were no adverse events during or after the participation. Health benefits, fitness, and fun were reported as facilitators, while lack of access to the sporting facility and lack of caregiver support were reported as barriers to participation. Conclusion: Adaptive sports appear to be safe, feasible, and well accepted by the adults with stroke.
MeSH term(s)	Adult ; Exercise ; Feasibility Studies ; Humans ; Independent Living ; Quality of Life ; Sports for Persons with Disabilities ; Stroke
Language	English
Publishing date	2021-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2029441-4
ISSN	1532-9283 ; 1360-8592
ISSN (online)	1532-9283
ISSN	1360-8592
DOI	10.1016/j.jbmt.2021.07.004
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Article: The Role of Dectin-1 Signaling in Altering Tumor Immune Microenvironment in the Context of Aging.

Bhaskaran, Natarajan / Jayaraman, Sangeetha / Quigley, Cheriese / Mamileti, Prerna / Ghannoum, Mahmoud / Weinberg, Aaron / Thuener, Jason / Pan, Quintin / Pandiyan, Pushpa

Frontiers in oncology

2021 Volume 11, Page(s) 669066

Abstract: An increased accumulation of immune-dysfunction-associated ... ...

Abstract	An increased accumulation of immune-dysfunction-associated CD4
Language	English
Publishing date	2021-04-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2021.669066
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Article ; Online: Reciprocal Cooperation of Type A Procyanidin and Nitrofurantoin Against Multi-Drug Resistant (MDR) UPEC: A pH-Dependent Study.

Vasudevan, Sahana / Thamil Selvan, Gopalakrishnan / Bhaskaran, Sunil / Hari, Natarajan / Solomon, Adline Princy

Frontiers in cellular and infection microbiology

2020 Volume 10, Page(s) 421

Abstract: ... ...

Abstract	Uropathogenic
MeSH term(s)	Biflavonoids ; Biofilms ; Catechin ; Escherichia coli Infections ; Humans ; Hydrogen-Ion Concentration ; Nitrofurantoin/pharmacology ; Pharmaceutical Preparations ; Proanthocyanidins ; Urinary Tract Infections/drug therapy ; Uropathogenic Escherichia coli
Chemical Substances	Biflavonoids ; Pharmaceutical Preparations ; Proanthocyanidins ; procyanidin (4852-22-6) ; Catechin (8R1V1STN48) ; Nitrofurantoin (927AH8112L)
Language	English
Publishing date	2020-08-11
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2020.00421
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Beta-defensin index: A functional biomarker for oral cancer detection.

Cell reports. Medicine

2024 Volume 5, Issue 3, Page(s) 101447

Abstract: There is an unmet clinical need for a non-invasive and cost-effective test for oral squamous cell carcinoma (OSCC) that informs clinicians when a biopsy is warranted. Human beta-defensin 3 (hBD-3), an epithelial cell-derived anti-microbial peptide, is ... ...

Abstract	There is an unmet clinical need for a non-invasive and cost-effective test for oral squamous cell carcinoma (OSCC) that informs clinicians when a biopsy is warranted. Human beta-defensin 3 (hBD-3), an epithelial cell-derived anti-microbial peptide, is pro-tumorigenic and overexpressed in early-stage OSCC compared to hBD-2. We validate this expression dichotomy in carcinoma in situ and OSCC lesions using immunofluorescence microscopy and flow cytometry. The proportion of hBD-3/hBD-2 levels in non-invasively collected lesional cells compared to contralateral normal cells, obtained by ELISA, generates the beta-defensin index (BDI). Proof-of-principle and blinded discovery studies demonstrate that BDI discriminates OSCC from benign lesions. A multi-center validation study shows sensitivity and specificity values of 98.2% (95% confidence interval [CI] 90.3-99.9) and 82.6% (95% CI 68.6-92.2), respectively. A proof-of-principle study shows that BDI is adaptable to a point-of-care assay using microfluidics. We propose that BDI may fulfill a major unmet need in low-socioeconomic countries where pathology services are lacking.
MeSH term(s)	Humans ; Mouth Neoplasms/diagnosis ; Mouth Neoplasms/pathology ; beta-Defensins/analysis ; beta-Defensins/metabolism ; Carcinoma, Squamous Cell/diagnosis ; Carcinoma, Squamous Cell/pathology ; Biomarkers ; Squamous Cell Carcinoma of Head and Neck ; Head and Neck Neoplasms
Chemical Substances	beta-Defensins ; Biomarkers
Language	English
Publishing date	2024-03-04
Publishing country	United States
Document type	Journal Article
ISSN	2666-3791
ISSN (online)	2666-3791
DOI	10.1016/j.xcrm.2024.101447
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Microbiome Dependent Regulation of T

Pandiyan, Pushpa / Bhaskaran, Natarajan / Zou, Mangge / Schneider, Elizabeth / Jayaraman, Sangeetha / Huehn, Jochen

Frontiers in immunology

2019 Volume 10, Page(s) 426

Abstract: Mammals co-exist with resident microbial ecosystem that is composed of an incredible number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident microbes and mucosal surfaces, both parties are in continuous and complex ... ...

Abstract	Mammals co-exist with resident microbial ecosystem that is composed of an incredible number and diversity of bacteria, viruses and fungi. Owing to direct contact between resident microbes and mucosal surfaces, both parties are in continuous and complex interactions resulting in important functional consequences. These interactions govern immune homeostasis, host response to infection, vaccination and cancer, as well as predisposition to metabolic, inflammatory and neurological disorders. Here, we discuss recent studies on direct and indirect effects of resident microbiota on regulatory T cells (T
MeSH term(s)	Animals ; Gastrointestinal Microbiome/immunology ; Humans ; Immunity, Mucosal ; Intestinal Mucosa/immunology ; Intestinal Mucosa/microbiology ; T-Lymphocytes, Regulatory/immunology ; Th17 Cells/immunology
Language	English
Publishing date	2019-03-08
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2019.00426
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: IL-1β-MyD88-mTOR Axis Promotes Immune-Protective IL-17A

Bhaskaran, Natarajan / Faddoul, Fady / Paes da Silva, Andre / Jayaraman, Sangeetha / Schneider, Elizabeth / Mamileti, Prerna / Weinberg, Aaron / Pandiyan, Pushpa

Frontiers in immunology

2020 Volume 11, Page(s) 595936

Abstract: ... ...

Abstract	CD4
MeSH term(s)	Age Factors ; Aging/physiology ; Animals ; Biomarkers ; Cytokines/metabolism ; Disease Susceptibility ; Immunohistochemistry ; Immunophenotyping ; Interleukin-1beta/metabolism ; Mice ; Mucous Membrane/immunology ; Mucous Membrane/metabolism ; Mucous Membrane/microbiology ; Myeloid Differentiation Factor 88/genetics ; Myeloid Differentiation Factor 88/metabolism ; Signal Transduction ; Stomatitis/etiology ; Stomatitis/metabolism ; Stomatitis/pathology ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism ; TOR Serine-Threonine Kinases/metabolism
Chemical Substances	Biomarkers ; Cytokines ; Interleukin-1beta ; Myeloid Differentiation Factor 88 ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2020-11-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2020.595936
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Article: Patients who develop post-operative atrial fibrillation have reduced survival after off-pump coronary artery bypass grafting.

Ghurram, Akhil / Krishna, Neethu / Bhaskaran, Renjitha / Kumaraswamy, Natarajan / Jayant, Aveek / Varma, Praveen Kerala

Indian journal of thoracic and cardiovascular surgery

2019 Volume 36, Issue 1, Page(s) 6–13

Abstract: Objective: Post-operative atrial fibrillation (POAF) increases hospital stay, resource utilization, morbidity, and mortality. However, there is paucity of data about its effect in Indian patients undergoing off-pump coronary artery bypass grafting (CABG) ...

Abstract	Objective: Post-operative atrial fibrillation (POAF) increases hospital stay, resource utilization, morbidity, and mortality. However, there is paucity of data about its effect in Indian patients undergoing off-pump coronary artery bypass grafting (CABG). Methods: Seven hundred forty-eight patients underwent off-pump CABG from January 2015 to December 2016 (24 months). One hundred twenty-seven patients (16.7%) developed POAF. In an effort to mitigate the effects of wider risk factors on perioperative outcomes, a separate sub-analysis of patients based on risks quantified by EuroSCORE II (<> 3) was also performed. Results: Age > 60 years and development of sepsis were the independent predictors for the development of POAF. Thirty-day/mortality rate was higher in the POAF group (7.1% vs. 1.4%; Conclusion: The incidence of POAF was lower than reported in the wider global literature. Increasing age and development of post-operative sepsis were strong independent predictors of POAF. POAF increases the morbidity; length of hospital stay and these patients show decreased survival after off-pump CABG.
Keywords	covid19
Language	English
Publishing date	2019-07-19
Publishing country	India
Document type	Journal Article
ZDB-ID	2164386-6
ISSN	0973-7723 ; 0970-9134
ISSN (online)	0973-7723
ISSN	0970-9134
DOI	10.1007/s12055-019-00844-9
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