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  1. Book ; Online ; E-Book: Kawasaki disease

    Kuo, Ho-Chang

    2022  

    Abstract: Provides readers with up-to-date information on clinical research, diagnostic methods and treatment choice of Kawasaki disease. First chapters describe clinical symptoms, diagnosis, treatment, and complications of Kawasaki disease. Hot topics of ... ...

    Author's details Ho-Chang Kuo, editor
    Abstract Provides readers with up-to-date information on clinical research, diagnostic methods and treatment choice of Kawasaki disease. First chapters describe clinical symptoms, diagnosis, treatment, and complications of Kawasaki disease. Hot topics of precision medicine, big data analysis, genetics study, psychologic problems and allergic diseases after Kawasaki diseases are also discussed in details. Written by experts with wealthy experience in the field, this book will be an invaluable reference for pediatricians and clinicians working in the field of Kawasaki disease.
    Keywords Medicine ; Mucocutaneous lymph node syndrome ; Pediatrics ; Medical
    Subject code 618.9242
    Language English
    Size 1 online resource (196 pages)
    Publisher Springer Nature Singapore Pte Ltd
    Publishing place Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    ISBN 9789811929441 ; 9789811929434 ; 9811929440 ; 9811929432
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Diagnosis, Progress, and Treatment Update of Kawasaki Disease.

    Kuo, Ho-Chang

    International journal of molecular sciences

    2023  Volume 24, Issue 18

    Abstract: Kawasaki disease (KD) is an acute inflammatory disorder that primarily affects children and can lead to coronary artery lesions (CAL) if not diagnosed and treated promptly. The original clinical criteria for diagnosing KD were reported by Dr. Tomisaku ... ...

    Abstract Kawasaki disease (KD) is an acute inflammatory disorder that primarily affects children and can lead to coronary artery lesions (CAL) if not diagnosed and treated promptly. The original clinical criteria for diagnosing KD were reported by Dr. Tomisaku Kawasaki in 1967 and have been used for decades. However, research since then has highlighted the limitations of relying solely on these criteria, as they might lead to underdiagnosis or delayed diagnosis, potentially increasing the risk of coronary artery complications. This review appears to discuss several important aspects related to KD diagnosis and management. The current diagnostic methods for KD might need updates, especially considering cases that do not fit the typical clinical criteria. Recognizing diagnostic pitfalls and distinguishing KD from other conditions that might have similar clinical presentations is essential. The differences and similarities between KD and Multisystem Inflammatory Syndrome in Children (MIS-C), another inflammatory condition that has been associated with COVID-19, were also reviewed. The review explores the potential role of eosinophil count, new biomarkers, microRNA panels, and scoring systems in aiding the diagnosis of KD. Overall, the review article provides a comprehensive overview of the evolving landscape of KD diagnosis and management, incorporating new diagnostic methods, biomarkers, and treatment approaches to improve patient outcomes and reduce the risk of complications.
    MeSH term(s) Child ; Humans ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Mucocutaneous Lymph Node Syndrome/therapy ; COVID-19/diagnosis ; MicroRNAs ; Coronary Vessels ; COVID-19 Testing
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-09-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241813948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial: Genetic and Immunologic Response in Kawasaki Disease.

    Kuo, Ho-Chang

    Frontiers in pediatrics

    2022  Volume 10, Page(s) 876979

    Language English
    Publishing date 2022-04-12
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2711999-3
    ISSN 2296-2360
    ISSN 2296-2360
    DOI 10.3389/fped.2022.876979
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Diagnosis, Progress, and Treatment Update of Kawasaki Disease

    Ho-Chang Kuo

    International Journal of Molecular Sciences, Vol 24, Iss 13948, p

    2023  Volume 13948

    Abstract: Kawasaki disease (KD) is an acute inflammatory disorder that primarily affects children and can lead to coronary artery lesions (CAL) if not diagnosed and treated promptly. The original clinical criteria for diagnosing KD were reported by Dr. Tomisaku ... ...

    Abstract Kawasaki disease (KD) is an acute inflammatory disorder that primarily affects children and can lead to coronary artery lesions (CAL) if not diagnosed and treated promptly. The original clinical criteria for diagnosing KD were reported by Dr. Tomisaku Kawasaki in 1967 and have been used for decades. However, research since then has highlighted the limitations of relying solely on these criteria, as they might lead to underdiagnosis or delayed diagnosis, potentially increasing the risk of coronary artery complications. This review appears to discuss several important aspects related to KD diagnosis and management. The current diagnostic methods for KD might need updates, especially considering cases that do not fit the typical clinical criteria. Recognizing diagnostic pitfalls and distinguishing KD from other conditions that might have similar clinical presentations is essential. The differences and similarities between KD and Multisystem Inflammatory Syndrome in Children (MIS-C), another inflammatory condition that has been associated with COVID-19, were also reviewed. The review explores the potential role of eosinophil count, new biomarkers, microRNA panels, and scoring systems in aiding the diagnosis of KD. Overall, the review article provides a comprehensive overview of the evolving landscape of KD diagnosis and management, incorporating new diagnostic methods, biomarkers, and treatment approaches to improve patient outcomes and reduce the risk of complications.
    Keywords Kawasaki disease ; diagnosis ; biomarkers ; treatment ; eosinophil ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Hydrogen Gas Inhalation Regressed Coronary Artery Aneurysm in Kawasaki Disease-Case Report and Article Review.

    Kuo, Ho-Chang

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 895627

    Abstract: Kawasaki disease (KD) is a systemic vasculitis that primarily affects children under the age of 5 years old and is among the most common acquired heart disease in developed countries, particularly in Asia. No effective treatment is currently available ... ...

    Abstract Kawasaki disease (KD) is a systemic vasculitis that primarily affects children under the age of 5 years old and is among the most common acquired heart disease in developed countries, particularly in Asia. No effective treatment is currently available for aneurysm formation in KD. In this report, we showed a KD patient with an aneurysm over the right coronary artery with a size of 6.08 mm in diameter and 35 mm in length, which completely regressed to within normal range after hydrogen inhalation within 4 months after disease onset. This 10-year-old KD patient was diagnosed on the 12th day of disease onset with incomplete presentation of KD symptoms. Intravenous immunoglobulin was prescribed after KD diagnosis was confirmed by the formation of a coronary artery aneurysm. Once discharged from the hospital, the family used hydrogen inhalation (77% hydrogen and 23% oxygen) at home with nasal cannula 1 h per day. The aneurysm was found to be completely regressed at the 4-month follow-up (day 138 of the illness). The follow-up laboratory data showed complete blood cell count, differential count, electrolytes, liver enzyme, and renal function to all be within normal range. This is the first study to report an aneurysm from KD with regression under supplementary therapy with hydrogen gas inhalation and no other complications. Therefore, hydrogen gas inhalation may be an alternative anti-free radical or anti-oxidant therapy for KD, but further study is still required.
    Language English
    Publishing date 2022-05-12
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.895627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Modification of Caffeic Acid with Pyrrolidine Enhances Antioxidant Ability by Activating AKT/HO-1 Pathway in Heart.

    Ku, Hui-Chun / Lee, Shih-Yi / Yang, Kai-Chien / Kuo, Yueh-Hsiung / Su, Ming-Jai

    PloS one

    2016  Volume 11, Issue 2, Page(s) e0148545

    Abstract: ... than CA. These responses were accompanied with a prominent elevation in AKT and HO-1 expression and ... the intracellular ROS level more than CA in cardiomyocytes exposed to H2O2. When inhibiting the AKT or HO-1 pathways ... with oxidative stress, suggesting AKT/HO-1 pathway activation by PLCA plays an important role. In addition, inhibition ...

    Abstract Overproduction of free radicals during ischemia/reperfusion (I/R) injury leads to an interest in using antioxidant therapy. Activating an endogenous antioxidant signaling pathway is more important due to the fact that the free radical scavenging behavior in vitro does not always correlate with a cytoprotection effect in vivo. Caffeic acid (CA), an antioxidant, is a major phenolic constituent in nature. Pyrrolidinyl caffeamide (PLCA), a derivative of CA, was compared with CA for their antioxidant and cytoprotective effects. Our results indicate that CA and PLCA exert the same ability to scavenge DPPH in vitro. In response to myocardial I/R stress, PLCA was shown to attenuate lipid peroxydation and troponin release more than CA. These responses were accompanied with a prominent elevation in AKT and HO-1 expression and a preservation of mnSOD expression and catalase activity. PLCA also improved cell viability and alleviated the intracellular ROS level more than CA in cardiomyocytes exposed to H2O2. When inhibiting the AKT or HO-1 pathways, PLCA lost its ability to recover mnSOD expression and catalase activity to counteract with oxidative stress, suggesting AKT/HO-1 pathway activation by PLCA plays an important role. In addition, inhibition of AKT signaling further abolished HO-1 activity, while inhibition of HO-1 signaling attenuated AKT expression, indicating cross-talk between the AKT and HO-1 pathways. These protective effects may contribute to the cardiac function improvement by PLCA. These findings provide new insight into therapeutic approaches using a modified natural compound against oxidative stress from myocardial injuries.
    MeSH term(s) Animals ; Antioxidants/chemistry ; Antioxidants/pharmacology ; Caffeic Acids/chemistry ; Caffeic Acids/pharmacology ; Cardiotonic Agents/chemistry ; Cardiotonic Agents/pharmacology ; Cell Line ; Cell Survival/drug effects ; Disease Models, Animal ; Heme Oxygenase-1/metabolism ; Hydrogen Peroxide/pharmacology ; Male ; Mice ; Myocardial Reperfusion Injury/drug therapy ; Myocardial Reperfusion Injury/metabolism ; Myocardial Reperfusion Injury/pathology ; Myocardial Reperfusion Injury/physiopathology ; Myocardium/metabolism ; Myocytes, Cardiac/drug effects ; Myocytes, Cardiac/metabolism ; Neutrophil Infiltration/drug effects ; Oxidative Stress/drug effects ; Proto-Oncogene Proteins c-akt/metabolism ; Pyrrolidines/chemistry ; Rats ; Reactive Oxygen Species/metabolism ; Signal Transduction/drug effects ; Ventricular Function/drug effects
    Chemical Substances Antioxidants ; Caffeic Acids ; Cardiotonic Agents ; Pyrrolidines ; Reactive Oxygen Species ; Hydrogen Peroxide (BBX060AN9V) ; Heme Oxygenase-1 (EC 1.14.14.18) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; pyrrolidine (LJU5627FYV) ; caffeic acid (U2S3A33KVM)
    Language English
    Publishing date 2016
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0148545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Kawasaki Disease, MIS-C and COVID-19.

    Huang, Ying-Hsien / Kuo, Ho-Chang

    Children (Basel, Switzerland)

    2023  Volume 10, Issue 10

    Abstract: Kawasaki disease (KD) is a form of systemic vasculitis characterized by inflammation of blood vessels throughout the body, and its exact cause remains unknown [ ... ]. ...

    Abstract Kawasaki disease (KD) is a form of systemic vasculitis characterized by inflammation of blood vessels throughout the body, and its exact cause remains unknown [...].
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2732685-8
    ISSN 2227-9067
    ISSN 2227-9067
    DOI 10.3390/children10101587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Kawasaki-like disease among Italian children in the COVID-19 era.

    Kuo, Ho-Chang

    The Journal of pediatrics

    2020  Volume 224, Page(s) 179–183

    MeSH term(s) Autism Spectrum Disorder ; Betacoronavirus ; COVID-19 ; Child ; Coronavirus Infections ; Humans ; Italy ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Television
    Keywords covid19
    Language English
    Publishing date 2020-08-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.07.022
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Um IV Zs.116: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Modification of Caffeic Acid with Pyrrolidine Enhances Antioxidant Ability by Activating AKT/HO-1 Pathway in Heart.

    Hui-Chun Ku / Shih-Yi Lee / Kai-Chien Yang / Yueh-Hsiung Kuo / Ming-Jai Su

    PLoS ONE, Vol 11, Iss 2, p e

    2016  Volume 0148545

    Abstract: ... than CA. These responses were accompanied with a prominent elevation in AKT and HO-1 expression and ... the intracellular ROS level more than CA in cardiomyocytes exposed to H2O2. When inhibiting the AKT or HO-1 pathways ... with oxidative stress, suggesting AKT/HO-1 pathway activation by PLCA plays an important role. In addition, inhibition ...

    Abstract Overproduction of free radicals during ischemia/reperfusion (I/R) injury leads to an interest in using antioxidant therapy. Activating an endogenous antioxidant signaling pathway is more important due to the fact that the free radical scavenging behavior in vitro does not always correlate with a cytoprotection effect in vivo. Caffeic acid (CA), an antioxidant, is a major phenolic constituent in nature. Pyrrolidinyl caffeamide (PLCA), a derivative of CA, was compared with CA for their antioxidant and cytoprotective effects. Our results indicate that CA and PLCA exert the same ability to scavenge DPPH in vitro. In response to myocardial I/R stress, PLCA was shown to attenuate lipid peroxydation and troponin release more than CA. These responses were accompanied with a prominent elevation in AKT and HO-1 expression and a preservation of mnSOD expression and catalase activity. PLCA also improved cell viability and alleviated the intracellular ROS level more than CA in cardiomyocytes exposed to H2O2. When inhibiting the AKT or HO-1 pathways, PLCA lost its ability to recover mnSOD expression and catalase activity to counteract with oxidative stress, suggesting AKT/HO-1 pathway activation by PLCA plays an important role. In addition, inhibition of AKT signaling further abolished HO-1 activity, while inhibition of HO-1 signaling attenuated AKT expression, indicating cross-talk between the AKT and HO-1 pathways. These protective effects may contribute to the cardiac function improvement by PLCA. These findings provide new insight into therapeutic approaches using a modified natural compound against oxidative stress from myocardial injuries.
    Keywords Medicine ; R ; Science ; Q
    Subject code 500
    Language English
    Publishing date 2016-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Distinctive 'T-shaped' facial rash in Kawasaki disease.

    Guo, Mindy Ming-Huey / Kuo, Ho-Chang

    QJM : monthly journal of the Association of Physicians

    2023  Volume 116, Issue 9, Page(s) 797

    MeSH term(s) Humans ; Infant ; Mucocutaneous Lymph Node Syndrome/complications ; Mucocutaneous Lymph Node Syndrome/diagnosis ; Exanthema/etiology ; Diagnosis, Differential
    Language English
    Publishing date 2023-06-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 1199985-8
    ISSN 1460-2393 ; 0033-5622 ; 1460-2725
    ISSN (online) 1460-2393
    ISSN 0033-5622 ; 1460-2725
    DOI 10.1093/qjmed/hcad066
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.131: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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