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  1. Article ; Online: Percutaneous Modified Blalock-Taussig Shunt Closure in a Patient with Isolated Right Ventricular Hypoplasia.

    Krasic, Stasa / Dizdarevic, Ivan / Vranic, Lana / Nešić, Dejan / Vukomanovic, Vladislav

    Journal of cardiovascular development and disease

    2023  Volume 10, Issue 11

    Abstract: Clinical presentation, course, and treatment for patients with isolated right ventricular (RV) hypoplasia (IRVH) depends on the degree of hypoplasia that is present-this is a spectrum from spontaneous maturation to Fontan circulation over time. An 8- ... ...

    Abstract Clinical presentation, course, and treatment for patients with isolated right ventricular (RV) hypoplasia (IRVH) depends on the degree of hypoplasia that is present-this is a spectrum from spontaneous maturation to Fontan circulation over time. An 8-month-old infant presented with IRVH; in the patient, a modified Blalock-Taussig (MBTS) shunt was closed percutaneously after spontaneous RV function recovery. A female newborn was diagnosed with differential cyanosis at birth. The echocardiography showed a hypertrophic RV with a small cavity, a right-left shunt on the atrial septal defect, an almost closed ductus arteriosus (DA), and a small tricuspid valve ring (Z-score-2) with mild regurgitation (pressure gradient 30 mmHg). On the 4th day of life, the patient showed deepened cyanosis and hyperlactatemia was registered. The echocardiography examination revealed a closed DA. Right ventriculography performed on the 5th day of life evidenced the presence of a small hypertrabeculated RV. The pressure in the RV increased. A right-side MBTS was created on the 6th day of life. Further echocardiographic findings indicated a gradual development of the RV and a decrease in RV pressure. MBTS occlusion was performed when the patient was 8 months old. Vital parameters were monitored invasively and noninvasively after the balloon occlusion of MBTS. Percutaneous MBTS occlusion was successfully performed using an Amplatzer vascular plug 2 (AVP2). During the follow-up period, the patient was found to have maintained a normal percutaneous oxyhaemoglobin blood saturation.
    Language English
    Publishing date 2023-11-15
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2777082-5
    ISSN 2308-3425 ; 2308-3425
    ISSN (online) 2308-3425
    ISSN 2308-3425
    DOI 10.3390/jcdd10110460
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Intracardiac Thrombosis in the Three-Year-Old Boy with Normal Left Ventricle Systolic Function in MIS-C Associated with COVID-19.

    Krasic, Stasa / Popovic, Sasa / Kravljanac, Ruzica / Prijic, Sergej / Vukomanovic, Vladislav

    Mediterranean journal of hematology and infectious diseases

    2022  Volume 14, Issue 1, Page(s) e2022028

    Language English
    Publishing date 2022-03-01
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2674750-9
    ISSN 2035-3006
    ISSN 2035-3006
    DOI 10.4084/MJHID.2022.028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Mechanisms of redox balance and inflammatory response after the use of methylprednisolone in children with multisystem inflammatory syndrome associated with COVID-19.

    Krasic, Stasa / Vukomanovic, Vladislav / Ninic, Sanja / Pasic, Srdjan / Samardzija, Gordana / Mitrovic, Nemanja / Cehic, Maja / Nesic, Dejan / Bajcetic, Milica

    Frontiers in immunology

    2023  Volume 14, Page(s) 1249582

    Abstract: Background: Multisystem inflammatory syndrome in children (MIS-C) associated with being infected with coronavirus-19 (COVID-19) is a life-threatening condition resulting from cytokine storm, increased synthesis of reactive oxygen species (ROSs), and ... ...

    Abstract Background: Multisystem inflammatory syndrome in children (MIS-C) associated with being infected with coronavirus-19 (COVID-19) is a life-threatening condition resulting from cytokine storm, increased synthesis of reactive oxygen species (ROSs), and hyperinflammation occurring in genetically predisposed children following an infection with SARS-CoV-2.
    Aim: The primary aims of our study were to identify changes in the activity of antioxidant enzymes in erythrocytes and total oxidative status in plasma after being treated with methylprednisolone (MP).
    Methods: A prospective cohort study of 67 children (56.7% male) under 18 with MIS-C being treated with MP was conducted at the Mother and Child Health Institute from January 2021 to April 2022. The impact of the therapy was assessed on the basis of the clinical condition, haematological and biochemical blood parameters, and echocardiographic findings.
    Results: 59.7% of patients presented cardiovascular (CV) manifestations, while myocardial dysfunction was observed in half of all patients (50.7%). A severe clinical course was observed in 22/67 patients. Children with CV involvement had a significantly higher relative concentration of B lymphocytes and lower relative concentration of NK cells than patients without CV issues (p < 0.001 and p = 0.004, respectively). Patients with severe MIS-C had a lower relative count of NK cells than those with moderate MIS-C (p = 0.015). Patients with myocardial dysfunction had a higher total oxidative plasma status (TOPS) than children without (p = 0.05), which implicates pronounced oxidative stress in the former cohort. In patients with shock, lower erythrocytes superoxide dismutase (SOD) activity was observed on admission compared to patients without shock (p = 0.04). After MP was administered, TOPS was significantly reduced, while catalase (CAT) and SOD activity increased significantly. Treatment failure (TF) was observed in 6 patients, only females (p=0.005). These patients were younger (p=0.05) and had lower CAT activity on admission (p=0.04) than patients with favorable treatment responses. In the group of patients with TF, TOPS increased after treatment (before 176.2 ± 10.3 mV, after 199.0 ± 36.7 mV).
    Conclusion: MP leads to rapid modulation of TOPS and increases the activity of antioxidant enzymes in erythrocytes resulting in clinical and echocardiographic improvement. Based on the observed changes in the activity of the antioxidant enzymes, we can conclude that s hydrogen peroxide is the dominant ROS in patients with MIS-C. Patients with TF showed reduced CAT activity, whereas the treatment with MP led to pronounced oxidation. This implies that low CAT activity may be a contraindication for using MP.
    MeSH term(s) Male ; Female ; Humans ; Antioxidants ; Methylprednisolone/therapeutic use ; COVID-19/complications ; Prospective Studies ; SARS-CoV-2 ; Oxidation-Reduction ; Connective Tissue Diseases ; Superoxide Dismutase
    Chemical Substances Antioxidants ; Methylprednisolone (X4W7ZR7023) ; Superoxide Dismutase (EC 1.15.1.1)
    Language English
    Publishing date 2023-08-14
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1249582
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  4. Article ; Online: Double pseudoaneurysms of the aortic bulbus after aortic valve replacement surgery

    Stasa Krasic / Igor Zivkovic / Zorana Kovacevic / Vladislav Vukomanovic

    Polish Journal of Thoracic and Cardiovascular Surgery, Vol 16, Iss 3, Pp 141-

    2019  Volume 143

    Keywords Surgery ; RD1-811 ; Internal medicine ; RC31-1245
    Language English
    Publishing date 2019-10-01T00:00:00Z
    Publisher Termedia Publishing House
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: The features of neonatal seizures as predictors of drug-resistant epilepsy in children.

    Vučetić Tadić, Biljana / Kravljanac, Ružica / Sretenović, Vlada / Martić, Jelena / Vukomanović, Vladislav

    Epilepsy & behavior : E&B

    2020  Volume 106, Page(s) 107004

    Abstract: Purpose: The aim of this study was to evaluate the predictive value of the features of neonatal seizures for pharmacoresistant epilepsy in children.: Method: This is a retrospective study that involved all children diagnosed as having epilepsy who ... ...

    Abstract Purpose: The aim of this study was to evaluate the predictive value of the features of neonatal seizures for pharmacoresistant epilepsy in children.
    Method: This is a retrospective study that involved all children diagnosed as having epilepsy who had neonatal seizures and who were hospitalized at the Neurology Department of the Mother and Child Healthcare Institute in Belgrade from January the 1st 2017 until December 31st 2017. The following parameters and their impact on the outcome were investigated: perinatal data, the characteristics of epileptic seizures in the neonatal period, and the response to anticonvulsant treatment. The presence of pharmacoresistance was observed as an outcome parameter. Univariate and multivariate logistic regression analyses were used to define predictors of drug-resistant epilepsy.
    Results: The study involved 55 children, 35 (63.6%) male and 20 (36.4%) female. The average age of the children at the end of the observation period was 5.17 years (min: 0.25, max: 17.75, iqr (interquartile range): 6.92). Pharmacoresistant epilepsy was found in 36 (65.5%) children. The most common type of epilepsy was focal, which affected 30 patients (54.5%), than generalized, which affected 15 patients (27.3%), and combined generalized and focal, which affected 8 patients (14.5%). At the end of the observation period, 28 patients (50.9%) had no seizures, while 14 (25.5%) had daily seizures. It was found that the pharmacoresistant neonatal seizures and metabolic-genetic disorders were predictive factors of the occurrence of pharmacoresistant epilepsy.
    Conclusion: Patients prone to developing pharmacoresistant epilepsy might be identified as early as the neonatal and early infant period. High incidence of asphyxia cooccurring with established genetic-metabolic disease further emphasizes need for genetic testing in infants with neonatal seizures including in the presence of hypoxic-ischemic injury.
    MeSH term(s) Adolescent ; Child ; Child, Preschool ; Cohort Studies ; Drug Resistant Epilepsy/diagnosis ; Drug Resistant Epilepsy/etiology ; Drug Resistant Epilepsy/physiopathology ; Electroencephalography/trends ; Female ; Humans ; Infant ; Infant, Newborn ; Male ; Predictive Value of Tests ; Retrospective Studies ; Seizures/complications ; Seizures/diagnosis ; Seizures/physiopathology
    Language English
    Publishing date 2020-03-14
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2010587-3
    ISSN 1525-5069 ; 1525-5050
    ISSN (online) 1525-5069
    ISSN 1525-5050
    DOI 10.1016/j.yebeh.2020.107004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Double pseudoaneurysms of the aortic bulbus after aortic valve replacement surgery.

    Krasic, Stasa Dragan / Zivkovic, Igor Slavoljub / Kovacevic, Zorana / Vukomanovic, Vladislav

    Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery

    2019  Volume 16, Issue 3, Page(s) 141–143

    Language English
    Publishing date 2019-10-28
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 2237053-5
    ISSN 1897-4252 ; 1731-5530
    ISSN (online) 1897-4252
    ISSN 1731-5530
    DOI 10.5114/kitp.2019.88606
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  7. Article ; Online: Evaluation of carotid intima media thickness in children with idiopathic nephrotic syndrome.

    Paripović, Aleksandra / Stajić, Nataša / Putnik, Jovana / Gazikalović, Ana / Bogdanović, Radovan / Vladislav, Vukomanović

    Nephrologie & therapeutique

    2020  Volume 16, Issue 7, Page(s) 420–423

    Abstract: Aim: Aim of the study was to determine if carotid intima media thickness in children with idiopathic nephrotic syndrome is greater than in healthy subjects, and to assess whether carotid intima media thickness in children with nephrotic syndrome is ... ...

    Abstract Aim: Aim of the study was to determine if carotid intima media thickness in children with idiopathic nephrotic syndrome is greater than in healthy subjects, and to assess whether carotid intima media thickness in children with nephrotic syndrome is associated with clinical (including disease duration, cumulative dose of steroids, number of relapses) and biochemical parameters.
    Methods: A cross-sectional study included 40 patients with nephrotic syndrome (mean age 11.7±4.7 years). Steroid dependent nephrotic syndrome was established in 32 patients (80%), while 8 (20%) had steroid resistant nephrotic syndrome. Control group consisted of 20 age and gender matched healthy children. Blood pressure based on 24-h ambulatory blood pressure monitoring (ABPM), carotid intima media thickness, fasting glucose, insulin, HbA1c, lipid concentrations were measured in all children.
    Results: A significant difference was detected in carotid intima media thickness values (P=0.036). Children with nephrotic syndrome had significantly greater carotid intima media thickness compared with healthy children (0.42±0.06 and 0.38±0.03mm). Carotid intima-media thickness was positively associated with duration of nephrotic syndrome (r=0.45; P=0.004), body mass index (r=0.48; P=0.002), daytime systolic blood pressure (r=0.46; P=0.003) and night-time systolic blood pressure (r=0.52; P=0.001). Multiple linear regression showed that duration of nephrotic syndrome was the only independent predictor of carotid intima media thickness in children with nephrotic syndrome (R
    Conclusion: The findings of the present study suggest subclinical vascular damage in patients with nephrotic syndrome. Duration of nephrotic syndrome was the only independent predictor of carotid intima media thickness.
    MeSH term(s) Blood Pressure ; Body Mass Index ; Carotid Intima-Media Thickness ; Case-Control Studies ; Child ; Cross-Sectional Studies ; Female ; Humans ; Male ; Nephrotic Syndrome/complications ; Systole
    Language English
    Publishing date 2020-11-06
    Publishing country France
    Document type Journal Article
    ZDB-ID 2229575-6
    ISSN 1872-9177 ; 1769-7255
    ISSN (online) 1872-9177
    ISSN 1769-7255
    DOI 10.1016/j.nephro.2020.09.004
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  8. Article ; Online: A Novel Mutation of the Plakophilin-2 Gene in a Child with Early Onset Arrhythmogenic Right Ventricular Cardiomyopathy and Intractable Arrhythmia.

    Krasic, Stasa / Vukomanovic, Vladislav / Putnik, Svetozar / Kosutic, Jovan / Ninic, Sanja / Popovic, Sasa / Cerovic, Ivana / Prijic, Sergej

    Indian journal of pediatrics

    2021  Volume 88, Issue 5, Page(s) 504

    MeSH term(s) Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/genetics ; Arrhythmogenic Right Ventricular Dysplasia/diagnosis ; Arrhythmogenic Right Ventricular Dysplasia/genetics ; Child ; Humans ; Mutation ; Pedigree ; Plakophilins/genetics
    Chemical Substances PKP2 protein, human ; Plakophilins
    Language English
    Publishing date 2021-02-11
    Publishing country India
    Document type Case Reports ; Letter
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-021-03679-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Analysis of cardiac manifestation and treatment of multisystem inflammatory syndrome in children related to SARS-CoV-2.

    Krasic, Stasa / Ninic, Sanja / Prijic, Sergej / Popovic, Sasa / Pasic, Srdjan / Petrovic, Gordana / Zec, Boris / Ristic, Snezana / Nesic, Dejan / Nikolic, Luka / Vukomanovic, Vladislav

    Biomolecules and biomedicine

    2023  Volume 23, Issue 2, Page(s) 335–343

    Abstract: Cardiovascular manifestations are common (35-100%) in the multisystem inflammatory syndrome in children. Our study aimed to analyze treatment impact and cardiovascular involvement in patients with multisystem inflammatory syndrome in children. The ... ...

    Abstract Cardiovascular manifestations are common (35-100%) in the multisystem inflammatory syndrome in children. Our study aimed to analyze treatment impact and cardiovascular involvement in patients with multisystem inflammatory syndrome in children. The retrospective cohort included 81 patients treated between April 2020 and December 2021 (9.3±4.6 years). Elevated cardiac troponin I and pro-B-type natriuretic peptide were observed in 34.2% and 88.5% of patients, respectively. Myocardial dysfunction was observed in 50.6%. Children older than 10 years had a 4-fold increased risk of myocardial dysfunction (odds ratio [OR] 3.6, 95% confidence interval [CI] 1.4-8.9; p=0.006). A moderate negative correlation was proved between left ventricle ejection fraction and C-reactive protein (rr = - 0.48; p < 0.001). More than one-fifth of the patients presented with shock. Coronary artery dilatation was observed in 6.2% of patients. Mild pericardial effusion was detected in 27.1% of children. On standard electrocardiogram, 52.6% of children had negative T waves in the inferior and/or precordial leads; transient QTc prolongation was registered in 43% of patients. Treatment failure was observed in 19 patients. Patients initially treated with intravenous immunoglobulins had 10-fold higher chances for treatment failure than patients treated with corticosteroids (OR 10.6, 95% CI 3,18 - 35.35; p < 0.001). Cardiovascular manifestations were observed in more than half of the patients, with acute myocardial dysfunction being the most common, especially in children older than 10 years. We established a negative association between the degree of elevation of inflammatory markers and left ventricular ejection fraction. Patients treated with intravenous immunoglobulins who had cardiovascular manifestations had treatment failures more frequently than patients treated with corticosteroids.
    MeSH term(s) Child ; Humans ; COVID-19/complications ; Immunoglobulins, Intravenous/therapeutic use ; Retrospective Studies ; SARS-CoV-2 ; Stroke Volume ; Ventricular Function, Left ; Child, Preschool
    Chemical Substances Immunoglobulins, Intravenous
    Language English
    Publishing date 2023-03-16
    Publishing country Bosnia and Herzegovina
    Document type Journal Article
    ISSN 2831-090X
    ISSN (online) 2831-090X
    DOI 10.17305/bjbms.2022.7820
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Fulminant Myocarditis in Children Successfully Treated with High Dose of Methyl-Prednisolone.

    Bjelakovic, Bojko / Vukomanovic, Vladislav / Jovic, Marko

    Indian journal of pediatrics

    2016  Volume 83, Issue 3, Page(s) 268–269

    MeSH term(s) Acute Disease ; Child ; Echocardiography ; Glucocorticoids/administration & dosage ; Humans ; Methylprednisolone/administration & dosage ; Myocarditis/complications ; Myocarditis/drug therapy ; Shock, Cardiogenic/drug therapy ; Shock, Cardiogenic/etiology
    Chemical Substances Glucocorticoids ; Methylprednisolone (X4W7ZR7023)
    Language English
    Publishing date 2016-03
    Publishing country India
    Document type Case Reports ; Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 218231-2
    ISSN 0973-7693 ; 0019-5456
    ISSN (online) 0973-7693
    ISSN 0019-5456
    DOI 10.1007/s12098-015-1831-2
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