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  1. Article ; Online: Capacity and Declination of Care in the Surgical Patient.

    Lightsey, Harry M / Maier, Stephen P / Nisavic, Mladen / Kenney, Kristen / Lovett, Lisa Ann / Lussier-Cushing, Mary / Abrams, Joshua / Fleming, Mark

    The Journal of bone and joint surgery. American volume

    2023  Volume 106, Issue 3, Page(s) 262–267

    MeSH term(s) Humans ; Patients ; Attitude of Health Personnel
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 220625-0
    ISSN 1535-1386 ; 0021-9355
    ISSN (online) 1535-1386
    ISSN 0021-9355
    DOI 10.2106/JBJS.22.01373
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    Zs.MO 464: Show issues

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  2. Article ; Online: Publisher Correction: Remotely sensing potential climate change tipping points across scales.

    Lenton, Timothy M / Abrams, Jesse F / Bartsch, Annett / Bathiany, Sebastian / Boulton, Chris A / Buxton, Joshua E / Conversi, Alessandra / Cunliffe, Andrew M / Hebden, Sophie / Lavergne, Thomas / Poulter, Benjamin / Shepherd, Andrew / Smith, Taylor / Swingedouw, Didier / Winkelmann, Ricarda / Boers, Niklas

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 1917

    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45881-0
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  3. Article ; Online: "Non-healing Wounds": Addressing Complex Physical and Emotional Trauma in a Case of Factitious Disorder.

    Peng, Cynthia S / Koire, Amanda M / Eisendrath, Stuart / Abrams, Joshua / Feldman, Marc D / Jimenez-Madiedo, Carolina

    Harvard review of psychiatry

    2022  Volume 30, Issue 3, Page(s) 207–213

    MeSH term(s) Factitious Disorders/diagnosis ; Factitious Disorders/psychology ; Factitious Disorders/therapy ; Humans
    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1174775-4
    ISSN 1465-7309 ; 1067-3229
    ISSN (online) 1465-7309
    ISSN 1067-3229
    DOI 10.1097/HRP.0000000000000335
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  4. Article ; Online: Remotely sensing potential climate change tipping points across scales.

    Lenton, Timothy M / Abrams, Jesse F / Bartsch, Annett / Bathiany, Sebastian / Boulton, Chris A / Buxton, Joshua E / Conversi, Alessandra / Cunliffe, Andrew M / Hebden, Sophie / Lavergne, Thomas / Poulter, Benjamin / Shepherd, Andrew / Smith, Taylor / Swingedouw, Didier / Winkelmann, Ricarda / Boers, Niklas

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 343

    Abstract: Potential climate tipping points pose a growing risk for societies, and policy is calling for improved anticipation of them. Satellite remote sensing can play a unique role in identifying and anticipating tipping phenomena across scales. Where satellite ... ...

    Abstract Potential climate tipping points pose a growing risk for societies, and policy is calling for improved anticipation of them. Satellite remote sensing can play a unique role in identifying and anticipating tipping phenomena across scales. Where satellite records are too short for temporal early warning of tipping points, complementary spatial indicators can leverage the exceptional spatial-temporal coverage of remotely sensed data to detect changing resilience of vulnerable systems. Combining Earth observation with Earth system models can improve process-based understanding of tipping points, their interactions, and potential tipping cascades. Such fine-resolution sensing can support climate tipping point risk management across scales.
    Language English
    Publishing date 2024-01-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-023-44609-w
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  5. Article ; Online: Remotely sensing potential climate change tipping points across scales

    Timothy M. Lenton / Jesse F. Abrams / Annett Bartsch / Sebastian Bathiany / Chris A. Boulton / Joshua E. Buxton / Alessandra Conversi / Andrew M. Cunliffe / Sophie Hebden / Thomas Lavergne / Benjamin Poulter / Andrew Shepherd / Taylor Smith / Didier Swingedouw / Ricarda Winkelmann / Niklas Boers

    Nature Communications, Vol 15, Iss 1, Pp 1-

    2024  Volume 15

    Abstract: Abstract Potential climate tipping points pose a growing risk for societies, and policy is calling for improved anticipation of them. Satellite remote sensing can play a unique role in identifying and anticipating tipping phenomena across scales. Where ... ...

    Abstract Abstract Potential climate tipping points pose a growing risk for societies, and policy is calling for improved anticipation of them. Satellite remote sensing can play a unique role in identifying and anticipating tipping phenomena across scales. Where satellite records are too short for temporal early warning of tipping points, complementary spatial indicators can leverage the exceptional spatial-temporal coverage of remotely sensed data to detect changing resilience of vulnerable systems. Combining Earth observation with Earth system models can improve process-based understanding of tipping points, their interactions, and potential tipping cascades. Such fine-resolution sensing can support climate tipping point risk management across scales.
    Keywords Science ; Q
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: The Role of a Hospital Ethics Consultation Service in Decision-Making for Unrepresented Patients.

    Courtwright, Andrew M / Abrams, Joshua / Robinson, Ellen M

    Journal of bioethical inquiry

    2017  Volume 14, Issue 2, Page(s) 241–250

    Abstract: Despite increased calls for hospital ethics committees to serve as default decision-makers about life-sustaining treatment (LST) for unrepresented patients who lack decision-making capacity or a surrogate decision-maker and whose wishes regarding medical ...

    Abstract Despite increased calls for hospital ethics committees to serve as default decision-makers about life-sustaining treatment (LST) for unrepresented patients who lack decision-making capacity or a surrogate decision-maker and whose wishes regarding medical care are not known, little is known about how committees currently function in these cases. This was a retrospective cohort study of all ethics committee consultations involving decision-making about LST for unrepresented patients at a large academic hospital from 2007 to 2013. There were 310 ethics committee consultations, twenty-five (8.1 per cent) of which involved unrepresented patients. In thirteen (52.0 per cent) cases, the ethics consultants evaluated a possible substitute decision-maker identified by social workers and/or case managers. In the remaining cases, the ethics consultants worked with the medical team to contact previous healthcare professionals to provide substituted judgement, found prior advance care planning documents, or identified the patient's best interest as the decision-making standard. In the majority of cases, the final decision was to limit or withdraw LST (72 per cent) or to change code status to Do Not Resuscitate/Do Not Intubate (12 per cent). Substitute decision-makers who had been evaluated through the ethics consultation process and who made the final decision alone were more likely to continue LST than cases in which physicians made the final decision (50 per cent vs 6.3 per cent, p = 0.04). In our centre, the primary role of ethics consultants in decision-making for unrepresented patients is to identify appropriate decision-making standards. In the absence of other data suggesting that ethics committees, as currently constituted, are ready to serve as substitute decision-makers for unrepresented patients, caution is necessary before designating these committees as default decision-makers.
    Language English
    Publishing date 2017-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2253038-1
    ISSN 1872-4353 ; 1176-7529
    ISSN (online) 1872-4353
    ISSN 1176-7529
    DOI 10.1007/s11673-017-9773-1
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  7. Article ; Online: Tissue-Like 3D Standard and Protocols for Microscope Quality Management.

    Abrams, Benjamin / Pengo, Thomas / Wee, Tse-Luen / Deagle, Rebecca C / Vuillemin, Nelly / Callahan, Linda M / Smith, Megan A / Kubow, Kristopher E / Girard, Anne-Marie / Rappoport, Joshua Z / Bayles, Carol J / Cameron, Lisa A / Cole, Richard / Brown, Claire M

    Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada

    2023  Volume 29, Issue 2, Page(s) 616–634

    Abstract: This article outlines a global study conducted by the Association of Biomedical Resource Facilities (ABRF) Light Microscopy Research Group (LMRG). The results present a novel 3D tissue-like biologically relevant standard sample that is affordable and ... ...

    Abstract This article outlines a global study conducted by the Association of Biomedical Resource Facilities (ABRF) Light Microscopy Research Group (LMRG). The results present a novel 3D tissue-like biologically relevant standard sample that is affordable and straightforward to prepare. Detailed sample preparation, instrument-specific image acquisition protocols and image analysis methods are presented and made available to the community. The standard consists of sub-resolution and large well characterized relative intensity fluorescence microspheres embedded in a 120 µm thick 3D gel with a refractive index of 1.365. The standard allows the evaluation of several properties as a function of depth. These include the following: 1) microscope resolution with automated analysis of the point-spread function (PSF), 2) automated signal-to-noise ratio analysis, 3) calibration and correction of fluorescence intensity loss, and 4) quantitative relative intensity. Results demonstrate expected refractive index mismatch dependent losses in intensity and resolution with depth, but the relative intensities of different objects at similar depths are maintained. This is a robust standard showing reproducible results across laboratories, microscope manufacturers and objective lens types (e.g., magnification, immersion medium). Thus, these tools will be valuable for the global community to benchmark fluorescence microscopes and will contribute to improved scientific rigor and reproducibility.
    MeSH term(s) Reproducibility of Results ; Microscopy, Fluorescence/methods ; Image Processing, Computer-Assisted
    Language English
    Publishing date 2023-09-26
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1385710-1
    ISSN 1435-8115 ; 1431-9276
    ISSN (online) 1435-8115
    ISSN 1431-9276
    DOI 10.1093/micmic/ozad014
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  8. Article ; Online: Beyond the Do-not-resuscitate Order: An Expanded Approach to Decision-making Regarding Cardiopulmonary Resuscitation in Older Surgical Patients.

    Allen, Matthew B / Bernacki, Rachelle E / Gewertz, Bruce L / Cooper, Zara / Abrams, Joshua L / Peetz, Allan B / Bader, Angela M / Sadovnikoff, Nicholas

    Anesthesiology

    2021  Volume 135, Issue 5, Page(s) 781–787

    Abstract: American Society of Anesthesiologists guidelines recommend that anesthesiologists revisit do-not-resuscitate orders preoperatively and revise them if necessary based on patient preferences. In patients without do-not-resuscitate orders or other ... ...

    Abstract American Society of Anesthesiologists guidelines recommend that anesthesiologists revisit do-not-resuscitate orders preoperatively and revise them if necessary based on patient preferences. In patients without do-not-resuscitate orders or other directives limiting treatment however, "full code" is the default option irrespective of clinical circumstances and patient preferences. It is time to revisit this approach based on (1) increasing understanding of the power of default options in healthcare settings, (2) changing demographics and growing evidence suggesting that an expanding subset of patients is vulnerable to poor outcomes after perioperative cardiopulmonary resuscitation (CPR), and (3) recommendations from multiple societies promoting risk assessment and goal-concordant care in older surgical patients. The authors reconsider current guidelines in the context of these developments and advocate for an expanded approach to decision-making regarding CPR, which involves identifying high-risk elderly patients and eliciting their preferences regarding CPR irrespective of existing or presumed code status.
    MeSH term(s) Aged ; Aged, 80 and over ; Anesthesiology ; Cardiopulmonary Resuscitation/methods ; Clinical Decision-Making/methods ; Humans ; Patient Participation ; Practice Guidelines as Topic ; Resuscitation Orders ; Societies, Medical ; Surgical Procedures, Operative
    Language English
    Publishing date 2021-09-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 269-0
    ISSN 1528-1175 ; 0003-3022
    ISSN (online) 1528-1175
    ISSN 0003-3022
    DOI 10.1097/ALN.0000000000003937
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    Uk I Zs.133: Show issues Location:
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    Zs.MO 199: Show issues

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  9. Article ; Online: Committed Global Warming Risks Triggering Multiple Climate Tipping Points

    Jesse F. Abrams / Chris Huntingford / Mark S. Williamson / David I. Armstrong McKay / Chris A. Boulton / Joshua E. Buxton / Boris Sakschewski / Sina Loriani / Caroline Zimm / Ricarda Winkelmann / Timothy M. Lenton

    Earth's Future, Vol 11, Iss 11, Pp n/a-n/a (2023)

    2023  

    Abstract: Abstract Many scenarios for limiting global warming to 1.5°C assume planetary‐scale carbon dioxide removal sufficient to exceed anthropogenic emissions, resulting in radiative forcing falling and temperatures stabilizing. However, such removal technology ...

    Abstract Abstract Many scenarios for limiting global warming to 1.5°C assume planetary‐scale carbon dioxide removal sufficient to exceed anthropogenic emissions, resulting in radiative forcing falling and temperatures stabilizing. However, such removal technology may prove unfeasible for technical, environmental, political, or economic reasons, resulting in continuing greenhouse gas emissions from hard‐to‐mitigate sectors. This may lead to constant concentration scenarios, where net anthropogenic emissions remain non‐zero but small, and are roughly balanced by natural carbon sinks. Such a situation would keep atmospheric radiative forcing roughly constant. Fixed radiative forcing creates an equilibrium “committed” warming, captured in the concept of “equilibrium climate sensitivity.” This scenario is rarely analyzed as a potential extension to transient climate scenarios. Here, we aim to understand the planetary response to such fixed concentration commitments, with an emphasis on assessing the resulting likelihood of exceeding temperature thresholds that trigger climate tipping points. We explore transients followed by respective equilibrium committed warming initiated under low to high emission scenarios. We find that the likelihood of crossing the 1.5°C threshold and the 2.0°C threshold is 83% and 55%, respectively, if today's radiative forcing is maintained until achieving equilibrium global warming. Under the scenario that best matches current national commitments (RCP4.5), we estimate that in the transient stage, two tipping points will be crossed. If radiative forcing is then held fixed after the year 2100, a further six tipping point thresholds are crossed. Achieving a trajectory similar to RCP2.6 requires reaching net‐zero emissions rapidly, which would greatly reduce the likelihood of tipping events.
    Keywords climate change ; tipping point ; greenhouse gas ; committed warming ; irreversibility ; Environmental sciences ; GE1-350 ; Ecology ; QH540-549.5
    Subject code 550
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher Wiley
    Document type Article ; Online
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  10. Article ; Online: The evolution of synaptic and cognitive capacity: Insights from the nervous system transcriptome of

    Orvis, Joshua / Albertin, Caroline B / Shrestha, Pragya / Chen, Shuangshuang / Zheng, Melanie / Rodriguez, Cheyenne J / Tallon, Luke J / Mahurkar, Anup / Zimin, Aleksey V / Kim, Michelle / Liu, Kelvin / Kandel, Eric R / Fraser, Claire M / Sossin, Wayne / Abrams, Thomas W

    Proceedings of the National Academy of Sciences of the United States of America

    2022  Volume 119, Issue 28, Page(s) e2122301119

    Abstract: The gastropod ... ...

    Abstract The gastropod mollusk
    MeSH term(s) Animals ; Aplysia/genetics ; Aplysia/metabolism ; Biological Evolution ; Cognition ; Neuronal Plasticity/genetics ; Neurons/metabolism ; Protein Isoforms/genetics ; Proteome ; Synapses/metabolism ; Transcriptome
    Chemical Substances Protein Isoforms ; Proteome
    Language English
    Publishing date 2022-07-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2122301119
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