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  1. Article ; Online: The NOD audit: Insights into the current state of management for neovascular age-related macular degeneration.

    Teo, Kelvin Yi Chong

    Eye (London, England)

    2023  Volume 37, Issue 17, Page(s) 3521–3522

    MeSH term(s) Humans ; Macular Degeneration/therapy ; Choroidal Neovascularization/drug therapy ; Wet Macular Degeneration/diagnosis ; Wet Macular Degeneration/drug therapy ; Angiogenesis Inhibitors/therapeutic use ; Tomography, Optical Coherence
    Chemical Substances Angiogenesis Inhibitors
    Language English
    Publishing date 2023-05-04
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-023-02546-4
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  2. Article ; Online: Real-world evidence for neovascular age-related macular degeneration: a practical approach.

    Teo, Kelvin Yi Chong

    Eye (London, England)

    2022  Volume 37, Issue 1, Page(s) 1–3

    MeSH term(s) Humans ; Angiogenesis Inhibitors/therapeutic use ; Vascular Endothelial Growth Factor A/therapeutic use ; Macular Degeneration/drug therapy ; Wet Macular Degeneration/diagnosis ; Wet Macular Degeneration/drug therapy ; Intravitreal Injections ; Ranibizumab/therapeutic use
    Chemical Substances Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A ; Ranibizumab (ZL1R02VT79)
    Language English
    Publishing date 2022-07-08
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-022-02151-x
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  3. Book ; Online ; E-Book: Swept-source optical coherence tomography

    Teo, Kelvin Yi Chong / Wong, Chee Wai / Tsai, Andrew S. H. / Ting, Daniel S. W.

    a color atlas

    2015  

    Author's details edited by Kelvin Yi Chong Teo, Wong Chee Wai, Andrew Shih Hsiang Tsai, Daniel Shu Wei Ting
    Keywords Retinal Diseases / diagnosis ; Tomography, Optical Coherence / methods
    Language English
    Size 1 Online-Ressource (xii, 56 Seiten), Illustrationen
    Publisher World Scientific Publishing
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Note Includes index
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019234184
    ISBN 978-981-4704-22-9 ; 9789814704212 ; 981-4704-22-9 ; 9814704210
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article: Clinical utility of ultra-widefield fluorescein angiography and optical coherence tomography angiography for retinal vein occlusions.

    Tan, Tien-En / Ibrahim, Farah / Chandrasekaran, Priya R / Teo, Kelvin Yi Chong

    Frontiers in medicine

    2023  Volume 10, Page(s) 1110166

    Abstract: Retinal vein occlusions (RVOs) are the second most common retinal vascular disease after diabetic retinopathy, and are a significant cause of visual impairment, especially in the elderly population. RVOs result in visual loss due to macular ischemia, ... ...

    Abstract Retinal vein occlusions (RVOs) are the second most common retinal vascular disease after diabetic retinopathy, and are a significant cause of visual impairment, especially in the elderly population. RVOs result in visual loss due to macular ischemia, cystoid macular edema (CME), and complications related to neovascularization. Vascular assessment in RVOs traditionally relies on standard fluorescein angiography (FA) for assessment of macular and retinal ischemia, which aids in prognostication and guides intervention. Standard FA has significant limitations-it is time-consuming, requires invasive dye administration, allows for limited assessment of the peripheral retina, and is usually evaluated semi-qualitatively, by ophthalmologists with tertiary expertise. More recently, the introduction of ultra-widefield FA (UWF FA) and optical coherence tomography angiography (OCTA) into clinical practice has changed the tools available for vascular evaluation in RVOs. UWF FA allows for evaluation of peripheral retinal perfusion, and OCTA is non-invasive, rapidly-acquired, and provides more information on capillary perfusion. Both modalities can be used to provide more quantitative parameters related to retinal perfusion. In this article, we review the clinical utility and impact of UWF FA and OCTA in the evaluation and management of patients with RVOs.
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1110166
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  5. Article ; Online: Reply to Comment on: "Outer Retinal Layer Thickening Predicts the Onset of Exudative Neovascular Age-Related Macular Degeneration".

    Invernizzi, Alessandro / Staurenghi, Giovanni / Cheung, Chui Ming Gemmy / Teo, Kelvin Yi Chong

    American journal of ophthalmology

    2021  Volume 235, Page(s) 330–331

    MeSH term(s) Choroidal Neovascularization ; Fluorescein Angiography ; Humans ; Macular Degeneration
    Language English
    Publishing date 2021-10-14
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2021.09.038
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  6. Article ; Online: Clinical utility of ultra-widefield fluorescein angiography and optical coherence tomography angiography for retinal vein occlusions

    Tien-En Tan / Farah Ibrahim / Priya R. Chandrasekaran / Kelvin Yi Chong Teo

    Frontiers in Medicine, Vol

    2023  Volume 10

    Abstract: Retinal vein occlusions (RVOs) are the second most common retinal vascular disease after diabetic retinopathy, and are a significant cause of visual impairment, especially in the elderly population. RVOs result in visual loss due to macular ischemia, ... ...

    Abstract Retinal vein occlusions (RVOs) are the second most common retinal vascular disease after diabetic retinopathy, and are a significant cause of visual impairment, especially in the elderly population. RVOs result in visual loss due to macular ischemia, cystoid macular edema (CME), and complications related to neovascularization. Vascular assessment in RVOs traditionally relies on standard fluorescein angiography (FA) for assessment of macular and retinal ischemia, which aids in prognostication and guides intervention. Standard FA has significant limitations—it is time-consuming, requires invasive dye administration, allows for limited assessment of the peripheral retina, and is usually evaluated semi-qualitatively, by ophthalmologists with tertiary expertise. More recently, the introduction of ultra-widefield FA (UWF FA) and optical coherence tomography angiography (OCTA) into clinical practice has changed the tools available for vascular evaluation in RVOs. UWF FA allows for evaluation of peripheral retinal perfusion, and OCTA is non-invasive, rapidly-acquired, and provides more information on capillary perfusion. Both modalities can be used to provide more quantitative parameters related to retinal perfusion. In this article, we review the clinical utility and impact of UWF FA and OCTA in the evaluation and management of patients with RVOs.
    Keywords branch retinal vein occlusion (BRVO) ; central retinal vein occlusion (CRVO) ; ultra-widefield (UWF) ; optical coherence tomography angiography (OCTA) ; fluorescein angiography (FA) ; retinal imaging ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: FIVE-YEAR INCIDENCE OF FELLOW EYE NEOVASCULAR INVOLVEMENT IN AGE-RELATED MACULAR DEGENERATION AND POLYPOIDAL CHOROIDAL VASCULOPATHY IN AN ASIAN POPULATION.

    Teo, Kelvin Yi Chong / Vyas, Chinmayi / Sun, Christopher / Cheong, Kai Xiong / Chakravarthy, Usha

    Retina (Philadelphia, Pa.)

    2023  Volume 43, Issue 2, Page(s) 294–302

    Abstract: Purpose: To assess 5-year cumulative incidence and risk factors of fellow eye involvement in Asian neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy.: Methods: In a prospective cohort study of Asian nAMD and ... ...

    Abstract Purpose: To assess 5-year cumulative incidence and risk factors of fellow eye involvement in Asian neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy.
    Methods: In a prospective cohort study of Asian nAMD and polypoidal choroidal vasculopathy, the fellow eyes were evaluated for exudation. The 5-year incidence of exudation was compared between nAMD and polypoidal choroidal vasculopathy.
    Results: A total of 488 patients were studied. The 5-year incidence of exudation in fellow eyes was 16.2% (95% confidence interval: 12.0-20.2). Polypoidal choroidal vasculopathy compared with nAMD in the first eye was associated with lower fellow eye progression (9.8% [95% confidence interval: 5.1-14.3]) vs. 22.9% [95% confidence interval: 15.8-29.3], P < 0.01). Drusen (hazards ratio 2.11 [95% confidence interval: 1.10-4.06]), shallow irregular retinal pigment epithelium elevation (2.86 [1.58-5.18]), and pigment epithelial detachment (3.01 [1.27-7.17]) were associated with greater progression. A combination of soft drusens and subretinal drusenoid deposits, and specific pigment epithelial detachment subtypes (multilobular, and sharp peaked) were associated with progression. Pigment epithelial detachment, shallow irregular retinal pigment epithelium elevation, and new subretinal hyperreflective material occurred at 10.4 ± 4.2 months, 11.1 ± 6.0 months, and 6.9 ± 4.3 months, respectively, before exudation.
    Conclusion: The 5-year incidence of fellow eye involvement in Asian nAMD is lower than among Caucasians because of a higher polypoidal choroidal vasculopathy prevalence. Drusens, shallow irregular retinal pigment epithelium elevation, and pigment epithelial detachment are risk factors for fellow eye progression.
    MeSH term(s) Humans ; Incidence ; Polypoidal Choroidal Vasculopathy ; Prospective Studies ; Choroid/blood supply ; Fluorescein Angiography ; Macular Degeneration/complications ; Retinal Detachment/complications ; Tomography, Optical Coherence ; Wet Macular Degeneration/complications ; Wet Macular Degeneration/diagnosis ; Wet Macular Degeneration/epidemiology ; Retrospective Studies ; Choroidal Neovascularization/diagnosis ; Choroidal Neovascularization/epidemiology ; Choroidal Neovascularization/complications
    Language English
    Publishing date 2023-01-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603192-4
    ISSN 1539-2864 ; 0275-004X
    ISSN (online) 1539-2864
    ISSN 0275-004X
    DOI 10.1097/IAE.0000000000003666
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  8. Article ; Online: Review of Fibrosis in Neovascular Age-Related Macular Degeneration.

    Cheong, Kai Xiong / Cheung, Chui Ming Gemmy / Teo, Kelvin Yi Chong

    American journal of ophthalmology

    2022  Volume 246, Page(s) 192–222

    Abstract: Purpose: To report the diagnosis and definitions, epidemiology, risk factors, and visual outcomes of fibrosis in neovascular age-related macular degeneration (nAMD).: Design: Systematic review and meta-analysis.: Methods: The review was performed ... ...

    Abstract Purpose: To report the diagnosis and definitions, epidemiology, risk factors, and visual outcomes of fibrosis in neovascular age-related macular degeneration (nAMD).
    Design: Systematic review and meta-analysis.
    Methods: The review was performed using the Cochrane Handbook and the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Observational studies and randomized controlled trials were included.
    Results: Identification of fibrosis is challenging. Optical coherence tomography angiography and polarization-sensitive optical coherence tomography represent novel options in multimodal imaging. The prevalence of fibrosis at baseline, 12, 24, and 60 months was 13%, 32%, 36%, and 56%, respectively. Approximately 60% of the fibrosis burden in nAMD at 5 years was present in the first year of treatment. Fibrosis development was highest in the first 12 months and slowed down over time. The risk factors of fibrosis included classic choroidal neovascularization (CNV), intra-retinal fluid, hemorrhage, hyperreflective material, CNV lesion size, and retinal thickness. Sub-retinal fluid and pigment epithelial detachment may be protective. Treatment-associated factors included disease activity and time to diagnosis. At baseline, the best corrected visual acuity in eyes with fibrosis was poorer than in eyes without fibrosis (-18.50 letters); this difference became larger at 12 months despite treatment (-26.86 letters).
    Conclusions: There is a need to identify effective treatment strategies for fibrosis and to closely monitor at-risk patients. More studies involving multimodal imaging are required to clarify the definitions and grading criteria for fibrosis.
    MeSH term(s) Humans ; Angiogenesis Inhibitors/therapeutic use ; Retina/pathology ; Choroidal Neovascularization/diagnosis ; Choroidal Neovascularization/etiology ; Choroidal Neovascularization/drug therapy ; Fibrosis ; Tomography, Optical Coherence ; Macular Degeneration/complications ; Macular Degeneration/diagnosis ; Macular Degeneration/epidemiology ; Fluorescein Angiography ; Intravitreal Injections ; Wet Macular Degeneration/diagnosis ; Wet Macular Degeneration/drug therapy ; Wet Macular Degeneration/epidemiology
    Chemical Substances Angiogenesis Inhibitors
    Language English
    Publishing date 2022-09-24
    Publishing country United States
    Document type Systematic Review ; Meta-Analysis ; Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 80030-2
    ISSN 1879-1891 ; 0002-9394
    ISSN (online) 1879-1891
    ISSN 0002-9394
    DOI 10.1016/j.ajo.2022.09.008
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  9. Article ; Online: Reply.

    Teo, Kelvin Yi Chong / Sadda, Srinivas R / Cheung, Chui Ming Gemmy / Chakravarthy, Usha / Gupta, Vishali / Lee, Won Ki / Lai, Timothy Y Y

    Ophthalmology. Retina

    2021  Volume 5, Issue 9, Page(s) e41–e42

    Language English
    Publishing date 2021-07-30
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2468-6530
    ISSN (online) 2468-6530
    DOI 10.1016/j.oret.2021.05.014
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  10. Article ; Online: Keeping our eyecare providers and patients safe during the COVID-19 pandemic.

    Teo, Kelvin Yi Chong / Chan, R V Paul / Cheung, Chui Ming Gemmy

    Eye (London, England)

    2020  Volume 34, Issue 7, Page(s) 1161–1162

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Ophthalmology ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country England
    Document type Editorial ; Comment
    ZDB-ID 91001-6
    ISSN 1476-5454 ; 0950-222X
    ISSN (online) 1476-5454
    ISSN 0950-222X
    DOI 10.1038/s41433-020-0960-7
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