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Article ; Online: Corrigendum to "Modelling the potential effectiveness of hepatitis C screening and treatment strategies during pregnancy in Egypt and Ukraine" [J Hepatol (2023) 937-946].

Hachicha-Maalej, Nadia / Collins, Intira Jeannie / Ades, Anthony E / Scott, Karen / Judd, Ali / Mostafa, Aya / Chappell, Elizabeth / Hamdy-El-Sayed, Manal / Gibb, Diana / Pett, Sarah / Mariné-Barjoan, Eugènia / Volokha, Alla / Yazdanpanah, Yazdan / Deuffic-Burban, Sylvie

Journal of hepatology

2024 Volume 80, Issue 2, Page(s) 379

Language	English
Publishing date	2024-01-05
Publishing country	Netherlands
Document type	Published Erratum
ZDB-ID	605953-3
ISSN	1600-0641 ; 0168-8278
ISSN (online)	1600-0641
ISSN	0168-8278
DOI	10.1016/j.jhep.2023.12.013
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Zs.A 2027: Show issues

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Article ; Online: p53 stabilization: the importance of nuclear import.

Marine, J-C

Cell death and differentiation

2010 Volume 17, Issue 2, Page(s) 191–192

MeSH term(s)	Active Transport, Cell Nucleus/physiology ; Animals ; Cell Nucleus/metabolism ; Humans ; Stress, Physiological/physiology ; Tumor Suppressor Protein p53/metabolism ; Ubiquitination/physiology
Chemical Substances	Tumor Suppressor Protein p53
Language	English
Publishing date	2010-02
Publishing country	England
Document type	Editorial
ZDB-ID	1225672-9
ISSN	1476-5403 ; 1350-9047
ISSN (online)	1476-5403
ISSN	1350-9047
DOI	10.1038/cdd.2009.183
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Zs.A 4230: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 80: Show issues

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Article ; Online: Cotton plants as ideal models for teaching and research on inducible direct plant defenses

Marine Mamin / Armelle Vallat / Ted C. J. Turlings

Frontiers in Ecology and Evolution, Vol

2023 Volume 11

Abstract: Cotton (Gossypium hirsutum) stores defensive compounds in glands covering its leaves and other tissues. The density and the chemical filling of these glands increase systematically in developing leaves in response to herbivory on older leaves. Cotton ... ...

Abstract	Cotton (Gossypium hirsutum) stores defensive compounds in glands covering its leaves and other tissues. The density and the chemical filling of these glands increase systematically in developing leaves in response to herbivory on older leaves. Cotton seedlings are known to respond more strongly to actual caterpillar herbivory than to mere physical damage. It is not clear whether this amplified response is linked to insect-derived elicitors or difference in damage properties. To investigate this, we assessed the effect of repeated artificial damage without and with application of regurgitant from Spodoptera exigua caterpillars. Repeated mechanical damage led to a systemic increase of gland density, gland size, and content of defensive terpenes, with no detectable additional elicitation upon regurgitant treatment. Dual choice feeding assays further showed that defense induction triggered by just physical damage made newly developing leaves far less palatable to S. exigua larvae as compared to leaves from undamaged seedlings, whereas they did not distinguish between leaves from damaged plants treated with or without regurgitant. Our study confirms that the systemic induction of cotton glands is an unspecific response to physical damage, although cotton is known to respond to caterpillar-associated elicitors for other defensive traits. Cotton glands induction can be readily visualized under modest magnification, making the experiments described in this study highly suited to teach chemical ecology and aspects of plant defense theory in practical classes.
Keywords	cotton ; gossypol glands ; terpenoid aldehydes ; volatile terpenes ; constitutive and induced plant defense ; mechanical damage ; Evolution ; QH359-425 ; Ecology ; QH540-549.5
Subject code	580
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Unraveling the brain mechanisms of source monitoring with non-invasive brain stimulation: A systematic review.

Perret, Mélanie / Neige, Cécilia / Brunelin, Jerome / Mondino, Marine

International journal of clinical and health psychology : IJCHP

2024 Volume 24, Issue 2, Page(s) 100449

Abstract: Background/objective: Source monitoring refers to the ability to determine the source of memories and encompasses three subprocesses: internal source monitoring, reality monitoring, and external source monitoring. Neuroimaging studies provide valuable ... ...

Abstract	Background/objective: Source monitoring refers to the ability to determine the source of memories and encompasses three subprocesses: internal source monitoring, reality monitoring, and external source monitoring. Neuroimaging studies provide valuable insights about neural correlates of source monitoring, but the causal relationship between brain and behavior is lacking. This study aimed to identify brain circuits involved in source monitoring by synthesizing the effects of brain stimulation on source monitoring as a function of the targeted brain regions or circuits. Method: We conducted a systematic review of interventional studies that have examined the effects of brain stimulation on source monitoring across six databases. The principal outcome was the difference of source monitoring performance between active and control stimulation conditions. Results: 23 studies (920 healthy participants and 54 patients with schizophrenia) were included. Our findings revealed the involvement of i) the lateral prefrontal and temporoparietal cortices in Conclusions: These findings deepen our understanding of the brain mechanisms of source monitoring and highlight specific stimulation targets to alleviate source monitoring deficits.
Language	English
Publishing date	2024-02-17
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2208162-8
ISSN	2174-0852 ; 1697-2600
ISSN (online)	2174-0852
ISSN	1697-2600
DOI	10.1016/j.ijchp.2024.100449
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Article ; Online: Impact of social and demographic factors on the spread of the SARS-CoV-2 epidemic in the town of Nice.

Mariné Barjoan, Eugènia / Chaarana, Amel / Festraëts, Julie / Géloen, Carole / Prouvost-Keller, Bernard / Legueult, Kevin / Pradier, Christian

BMC public health

2023 Volume 23, Issue 1, Page(s) 1098

Abstract: Introduction: Socio-demographic factors are known to influence epidemic dynamics. The town of Nice, France, displays major socio-economic inequalities, according to the National Institute of Statistics and Economic Studies (INSEE), 10% of the population ...

Abstract	Introduction: Socio-demographic factors are known to influence epidemic dynamics. The town of Nice, France, displays major socio-economic inequalities, according to the National Institute of Statistics and Economic Studies (INSEE), 10% of the population is considered to live below the poverty threshold, i.e. 60% of the median standard of living. Objective: To identify socio-economic factors related to the incidence of SARS-CoV-2 in Nice, France. Methods: The study included residents of Nice with a first positive SARS-CoV-2 test (January 4-February 14, 2021). Laboratory data were provided by the National information system for Coronavirus Disease (COVID-19) screening (SIDEP) and socio-economic data were obtained from INSEE. Each case's address was allocated to a census block to which we assigned a social deprivation index (French Deprivation index, FDep) divided into 5 categories. For each category, we computed the incidence rate per age and per week and its mean weekly variation. A standardized incidence ratio (SIR) was calculated to investigate a potential excess of cases in the most deprived population category (FDep5), compared to the other categories. Pearson's correlation coefficient was computed and a Generalized Linear Model (GLM) applied to analyse the number of cases and socio-economic variables per census blocks. Results: We included 10,078 cases. The highest incidence rate was observed in the most socially deprived category (4001/100,000 inhabitants vs 2782/100,000 inhabitants for the other categories of FDep). The number of observed cases in the most social deprivated category (FDep5: N = 2019) was significantly higher than in the others (N = 1384); SIR = 1.46 [95% CI:1.40-1.52; p < 0.001]. Socio-economic variables related to poor housing, harsh working conditions and low income were correlated with the new cases of SARS-CoV-2. Conclusion: Social deprivation was correlated with a higher incidence of SARS-CoV-2 during the 2021 epidemic in Nice. Local surveillance of epidemics provides complementary data to national and regional surveillance. Mapping socio-economic vulnerability indicators at the census block level and correlating these with incidence could prove highly useful to guide political decisions in public health.
MeSH term(s)	Humans ; SARS-CoV-2 ; COVID-19/epidemiology ; Epidemics ; Housing ; Poverty
Language	English
Publishing date	2023-06-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2041338-5
ISSN	1471-2458 ; 1471-2458
ISSN (online)	1471-2458
ISSN	1471-2458
DOI	10.1186/s12889-023-15917-z
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Article ; Online: Unexpected behavioural adaptation of yellow fever mosquitoes in response to high temperatures.

Hug, David O H / Kropf, Alida / Amann, Marine O / Koella, Jacob C / Verhulst, Niels O

Scientific reports

2024 Volume 14, Issue 1, Page(s) 3659

Abstract: ... Aedes aegypti at two temperatures (24 °C, 30 °C) for 20 generations and used these cohorts to explicitly ... in a thermal gradient of 20-35 °C. We found that warm-evolved mosquitoes spent 31.5% less time at high ...

Abstract	Temperature is a major ecological driver of mosquito-borne diseases as it influences the life-history of both the mosquito and the pathogen harboured within it. Understanding the mosquitoes' thermal biology is essential to inform risk prediction models of such diseases. Mosquitoes can respond to temperatures by microhabitat selection through thermal preference. However, it has not yet been considered that mosquitoes are likely to adapt to changing temperatures, for example during climate change, and alter their preference over evolutionary time. We investigated this by rearing six cohorts of the yellow fever mosquito Aedes aegypti at two temperatures (24 °C, 30 °C) for 20 generations and used these cohorts to explicitly separate the effects of long-term evolution and within-generation acclimation on their thermal preferences in a thermal gradient of 20-35 °C. We found that warm-evolved mosquitoes spent 31.5% less time at high temperatures, which affects their efficiency as a vector. This study reveals the complex interplay of experimental evolution, rearing temperatures, and thermal preference in Ae. aegypti mosquitoes. It highlights the significance of incorporating mosquito microhabitat selection in disease transmission models, especially in the context of climate change.
MeSH term(s)	Animals ; Yellow Fever ; Temperature ; Mosquito Vectors ; Aedes/physiology ; Climate Change
Language	English
Publishing date	2024-02-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-54374-5
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Article ; Online: Identification of the novel HLA-DQB1*03:512 allele by next-generation sequencing.

Bouthemy, Charlène / Cargou, Marine / Milhes, Jean / Congy-Jolivet, Nicolas

HLA

2024 Volume 103, Issue 2, Page(s) e15374

Abstract: HLA-DQB1*03:512 differs from DQB1*03:02:01 by one nucleotide substitution in codon 89 in exon 2. ...

Abstract	HLA-DQB103:512 differs from DQB103:02:01 by one nucleotide substitution in codon 89 in exon 2.
MeSH term(s)	Humans ; Alleles ; HLA-DQ beta-Chains/genetics ; Codon ; High-Throughput Nucleotide Sequencing
Chemical Substances	HLA-DQB1 antigen ; HLA-DQ beta-Chains ; Codon
Language	English
Publishing date	2024-02-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2845111-9
ISSN	2059-2310 ; 2059-2302
ISSN (online)	2059-2310
ISSN	2059-2302
DOI	10.1111/tan.15374
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Zs.A 661: Show issues

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Article ; Online: C and N stable isotopes enlighten the trophic behaviour of the dugong (Dugong dugon).

Thibault, Martin / Letourneur, Yves / Cleguer, Christophe / Bonneville, Claire / Briand, Marine J / Derville, Solène / Bustamante, Paco / Garrigue, Claire

Scientific reports

2024 Volume 14, Issue 1, Page(s) 896

Abstract: ... Our stable isotope mixing models used C and N isotope values of 10 taxa bbelonging to five divisions ... The dugong (Dugong dugon), a large marine mammal herbivore of the Indo-Pacific, is vulnerable ... The species forages on seagrass habitats (marine phanerogams) and plays a key role in the functioning and ...

Abstract	The dugong (Dugong dugon), a large marine mammal herbivore of the Indo-Pacific, is vulnerable to extinction at a global scale due to a combination of human-related threats including habitat degradation. The species forages on seagrass habitats (marine phanerogams) and plays a key role in the functioning and sensitivity of these declining coastal ecosystems. The trophic behaviour and plasticity of dugong populations in response to extrinsic and intrinsic factors are therefore crucial features to both dugong and seagrass conservation. Yet, this knowledge remains limited to few visual observations and analyses of mouth, stomach or faecal contents of stranded individuals. We take advantage of a long-term monitoring of stranded individuals from the endangered New Caledonian population to depict features of dugongs' trophic ecology from Carbon and Nitrogen stable isotopes. A total of 59 dugong skin samples were used to portrait the stable isotope niche of dugongs according to their sex and maturity. In light of previous work conducted in New Caledonia, a subset of these samples was used to model the trophic mix of dugong males and females. Our stable isotope mixing models used C and N isotope values of 10 taxa bbelonging to five divisions of metazoans, plants, and chromists. Our results represent the first estimate of the species dietary niche in the isotopic space. They suggest that the diet of dugong calves overlaps more with that of adult females (δ
MeSH term(s)	Humans ; Adult ; Female ; Male ; Animals ; Cattle ; Dugong ; Ecosystem ; Lactation ; Health Behavior ; Nitrogen Isotopes ; Caniformia ; Cetacea
Chemical Substances	Nitrogen Isotopes
Language	English
Publishing date	2024-01-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50578-3
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Article ; Online: Predictive abilities comparison from multiple dynamic prediction models.

Moreau, Clémence / Riou, Jérémie / Roux, Marine

Statistical methods in medical research

2023 Volume 32, Issue 9, Page(s) 1811–1822

Abstract: With the development of personalized medicine, the study of individual prognosis appears to be a major contemporary scientific issue. Dynamic models are particularly well adapted to such studies by allowing some potential changes in the follow-up to be ... ...

Abstract	With the development of personalized medicine, the study of individual prognosis appears to be a major contemporary scientific issue. Dynamic models are particularly well adapted to such studies by allowing some potential changes in the follow-up to be taken into account. In particular, this leads to more accurate predictions by updating the available information throughout the patient monitoring. Some mathematical tools have been developed to quantify and compare the effectiveness of dynamic predictions using dynamic versions of the area under the receiver operating characteristic curve and the Brier score in the competing risks setting. Nevertheless, only two predictive abilities can be compared. This may be too restrictive in a clinical context where more and more information can be collected during patient follow-up thanks to recent technological advances. Here we propose a new procedure that allows multiple comparisons of the predictive abilities of different biomarkers, based on the dynamic area under the receiver operating characteristic curve or Brier score. Performances of our testing procedure were assessed by simulations. Moreover, a motivating application in hepatology will be presented. Finally, this work compares more than two dynamic predictive abilities of biomarkers and is available via R functions on GitHub.
MeSH term(s)	Humans ; Biomarkers ; Prognosis ; ROC Curve
Chemical Substances	Biomarkers
Language	English
Publishing date	2023-07-25
Publishing country	England
Document type	Comparative Study ; Journal Article ; Review
ZDB-ID	1136948-6
ISSN	1477-0334 ; 0962-2802
ISSN (online)	1477-0334
ISSN	0962-2802
DOI	10.1177/09622802231188521
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Article ; Online: Corrigendum to 'p53 Reactivation by PRIMA-1Met (APR-246) sensitises V600E/KBRAF melanoma to vemurafenib'[Eur J of Cancer 55 (2016) 98-110].

Krayem, Mohammad / Journe, Fabrice / Wiedig, Murielle / Morandini, Renato / Najem, Ahmad / Salès, François / van Kempen, Leon C / Sibille, Catherine / Awada, Ahmad / Marine, Jean-Christophe / Ghanem, Ghanem

European journal of cancer (Oxford, England : 1990)

2022 Volume 175, Page(s) 336–338

Language	English
Publishing date	2022-09-24
Publishing country	England
Document type	Published Erratum
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2022.09.002
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 583: Show issues

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