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  1. Article: Viruslike Particles Encapsidating Respiratory Syncytial Virus M and M2 Proteins Induce Robust T Cell Responses.

    Schwarz, Benjamin / Morabito, Kaitlyn M / Ruckwardt, Tracy J / Patterson, Dustin P / Avera, John / Miettinen, Heini M / Graham, Barney S / Douglas, Trevor

    ACS biomaterials science & engineering

    2016  Volume 2, Issue 12, Page(s) 2324–2332

    Abstract: ... responses, the matrix (M) and matrix 2 (M2) proteins, were successfully coencapsidated within the P22 VLP ... vaccination elicited tissue-resident T cell populations. Upon subsequent RSV challenge, P22-M/M2-treated mice ...

    Abstract Subunit vaccines provide a safe, focused alternative to conventional vaccines. However, these vaccines often require significant adjuvants and are particularly hard to target toward cytotoxic T lymphocyte (CTL) immunity. Viruslike particles (VLPs) provide biomaterial scaffolds with pathogen-like polyvalent structures making them useful platforms for biomimetic antigen delivery to the immune system. Encapsidation of antigens within VLPs has been shown to enhance antigen availability for CD8 T cell responses. Here, we examine the potential to generate complex responses to multiple subunit antigens localized within the same VLP particle. Two proteins of respiratory syncytial virus (RSV) with well-characterized CD8 T cell responses, the matrix (M) and matrix 2 (M2) proteins, were successfully coencapsidated within the P22 VLP. Upon intranasal administration in mice, the particles stimulated CD8 T cell memory responses against both antigens. In addition, vaccination elicited tissue-resident T cell populations. Upon subsequent RSV challenge, P22-M/M2-treated mice displayed significantly reduced lung viral titers. This demonstrates the utility of the P22 VLP in directing immune responses to multiple encapsidated viral antigens, demonstrating the potential of this technology to facilitate immunity to multiple targets simultaneously.
    Language English
    Publishing date 2016-11-03
    Publishing country United States
    Document type Journal Article
    ISSN 2373-9878
    ISSN 2373-9878
    DOI 10.1021/acsbiomaterials.6b00532
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Towards automated 10–30 m resolution land cover mapping in insular South-East Asia

    Miettinen, Jukka / Shi, Chenghua / Liew, Soo Chin

    Geocarto international. 2019 Mar. 21, v. 34, no. 4

    2019  

    Abstract: ... for regional level land cover mapping in insular South-East Asian conditions, using a combination of 10–30 m ... Overall, the study demonstrates the great potential of multi-source 10–30 m resolution high data volume ...

    Abstract In this study, we create and critically analyse an automated decision tree classification approach for regional level land cover mapping in insular South-East Asian conditions, using a combination of 10–30 m resolution optical and radar data. The resulting map contains 11 land cover classes and reveals a great deal of contextual information due to high spatial resolution. A limited accuracy assessment indicates 59–97% class wise accuracies. The unprecedented spatial detail of closed canopy oil palm mapping (with user’s accuracy of 90%) is seen as the most promising feature of the mapping approach. The incapability of separating primary forests from other tree cover, and the large variety of different landscapes (e.g. home gardens and tea plantations) classified as shrubland, are considered the main areas for future improvement. Overall, the study demonstrates the great potential of multi-source 10–30 m resolution high data volume land cover mapping approaches in insular South-East Asian conditions.
    Keywords Elaeis guineensis ; automation ; canopy ; decision support systems ; home gardens ; land cover ; landscapes ; plantations ; primary forests ; radar ; shrublands ; tea ; trees ; South East Asia
    Language English
    Dates of publication 2019-0321
    Size p. 443-457.
    Publishing place Taylor & Francis
    Document type Article
    ISSN 1752-0762
    DOI 10.1080/10106049.2017.1408700
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: 2015 Land cover map of Southeast Asia at 250 m spatial resolution

    Miettinen, Jukka / Chenghua Shi / Soo Chin Liew

    Remote sensing letters. 2016 July 2, v. 7, no. 7

    2016  

    Abstract: In this letter, we present the methodology and accuracy assessment results of a new 250 m spatial ...

    Abstract In this letter, we present the methodology and accuracy assessment results of a new 250 m spatial resolution land cover map of Southeast Asia (covering Brunei, Cambodia, Indonesia, Laos, Malaysia, Myanmar, Philippines, Singapore, Thailand, Timor-Leste and Vietnam). The map is based on semi-automated classification of Moderate Resolution Imaging Spectroradiometer data (acquired January to November 2015) supported by various auxiliary data sets. The classification scheme with 18 land cover classes reflects the characteristics of land cover in Southeast Asia and aims to provide useful input for various regional-level analyses requiring information on land cover distribution. The accuracy of the map is assessed separately for the seasonal (north of 9° N) and humid (south of 9° N) parts of the region, reaching 82% and 86% overall accuracies respectively. The map will be made available at: https://ormt-crisp.nus.edu.sg/ormt/Home/Disclaimer
    Keywords data collection ; land cover ; moderate resolution imaging spectroradiometer ; remote sensing ; Brunei ; Cambodia ; East Timor ; Indonesia ; Laos ; Malaysia ; Myanmar ; Philippines ; Singapore ; Thailand ; Vietnam
    Language English
    Dates of publication 2016-0702
    Size p. 701-710.
    Publishing place Taylor & Francis
    Document type Article
    ISSN 2150-7058
    DOI 10.1080/2150704X.2016.1182659
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: A Unified Cropland Layer at 250 m for Global Agriculture Monitoring

    Waldner, François / Fritz, Steffen / di Gregorio, A. / Plotnikov, Dmitry / Bartalev, Sergey / Kussul, Nataliia / Gong, P. / Thenkabail, Prasad / Hazeu, G.W. / Klein, I. / Löw, Fabian / Miettinen, Jukka / Dadhwal, V.K. / Lamarche, C. / Bontemps, S. / Defourny, Pierre

    Data

    2016  Volume 1, Issue 1

    Abstract: ... a Unified Cropland Layer that combines the fittest products into a 250 m global cropland map was assembled ...

    Abstract Accurate and timely information on the global cropland extent is critical for food security monitoring, water management and earth system modeling. Principally, it allows for analyzing satellite image time-series to assess the crop conditions and permits isolation of the agricultural component to focus on food security and impacts of various climatic scenarios. However, despite its critical importance, accurate information on the spatial extent, cropland mapping with remote sensing imagery remains a major challenge. Following an exhaustive identification and collection of existing land cover maps, a multi-criteria analysis was designed at the country level to evaluate the fitness of a cropland map with regards to four dimensions: its timeliness, its legend, its resolution adequacy and its confidence level. As a result, a Unified Cropland Layer that combines the fittest products into a 250 m global cropland map was assembled. With an evaluated accuracy ranging from 82% to 95%, the Unified Cropland Layer successfully improved the accuracy compared to single global products.
    Keywords Cropland ; KB SIGMA
    Subject code 333
    Language English
    Publishing country nl
    Document type Article ; Online
    ISSN 2306-5729
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Book: Tumors of the soft tissues

    Miettinen, Markku

    (AFIP atlas of tumor pathology : Ser. 4, 20 ; Ser. 4, 20)

    2014  

    Author's details by Markku Miettinen
    Series title AFIP atlas of tumor pathology : Ser. 4, 20 ; Ser. 4, 20
    AFIP atlas of tumor pathology
    AFIP atlas of tumor pathology ; Ser. 4, 20
    Collection AFIP atlas of tumor pathology
    AFIP atlas of tumor pathology ; Ser. 4, 20
    Language English
    Size XIII, 523 S. : zahlr. Ill.
    Publisher American Registry of Pathology
    Publishing place Silver Spring, Maryland
    Publishing country United States
    Document type Book
    HBZ-ID HT019144172
    ISBN 978-1-933477-31-2 ; 1-933477-31-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Se 1357 -4,20- verfügbar in Königswinter Königswinter

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  6. Article: Remote sensing of forest degradation in Southeast Asia—Aiming for a regional view through 5–30 m satellite data

    Miettinen, Jukka / Hans-Jürgen Stibig / Frédéric Achard

    Global Ecology and Conservation. 2014 Dec., v. 2

    2014  

    Abstract: ... forest degradation monitoring with satellite remote sensing data at high to medium spatial resolution (5–30 m ...

    Abstract In this review paper we present geographical, ecological and historical aspects of Southeast Asia from the perspective of forest degradation monitoring and critically discuss available approaches for large area forest degradation monitoring with satellite remote sensing data at high to medium spatial resolution (5–30 m). Several authors have achieved promising results in geographically limited areas within Southeast Asia using automated detection algorithms. However, the application of automated methods to large area assessments remains a major challenge. To-date, nearly all large area assessments of forest degradation in the region have included a strong visual interpretation component. We conclude that due to the variety of forest types and forest disturbance levels, as well as the variable image acquisition conditions in Southeast Asia, it is unlikely that forest degradation monitoring can be conducted throughout the region using a single automated approach with currently available remote sensing data. The provision of regionally consistent information on forest degradation from satellite remote sensing data remains therefore challenging. However, the expected increase in observation frequency in the near future (due to Landsat 8 and Sentinel-2 satellites) may lead to the desired improvement in data availability and enable consistent and robust regional forest degradation monitoring in Southeast Asia.
    Keywords Landsat ; algorithms ; ecology ; forest damage ; forest types ; monitoring ; remote sensing ; spatial data ; South East Asia
    Language English
    Dates of publication 2014-12
    Size p. 24-36.
    Publishing place Elsevier B.V.
    Document type Article
    ZDB-ID 2814786-8
    ISSN 2351-9894
    ISSN 2351-9894
    DOI 10.1016/j.gecco.2014.07.007
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Remote sensing of forest degradation in Southeast Asia—Aiming for a regional view through 5–30 m satellite data

    Jukka Miettinen / Hans-Jürgen Stibig / Frédéric Achard

    Global Ecology and Conservation, Vol 2, Iss , Pp 24-

    2014  Volume 36

    Abstract: ... forest degradation monitoring with satellite remote sensing data at high to medium spatial resolution (5–30 m ...

    Abstract In this review paper we present geographical, ecological and historical aspects of Southeast Asia from the perspective of forest degradation monitoring and critically discuss available approaches for large area forest degradation monitoring with satellite remote sensing data at high to medium spatial resolution (5–30 m). Several authors have achieved promising results in geographically limited areas within Southeast Asia using automated detection algorithms. However, the application of automated methods to large area assessments remains a major challenge. To-date, nearly all large area assessments of forest degradation in the region have included a strong visual interpretation component. We conclude that due to the variety of forest types and forest disturbance levels, as well as the variable image acquisition conditions in Southeast Asia, it is unlikely that forest degradation monitoring can be conducted throughout the region using a single automated approach with currently available remote sensing data. The provision of regionally consistent information on forest degradation from satellite remote sensing data remains therefore challenging. However, the expected increase in observation frequency in the near future (due to Landsat 8 and Sentinel-2 satellites) may lead to the desired improvement in data availability and enable consistent and robust regional forest degradation monitoring in Southeast Asia. Keywords: Tropical forest disturbance, Selective logging, Shifting cultivation, Satellite data, Indochina peninsula, Maritime continent
    Keywords Ecology ; QH540-549.5
    Language English
    Publishing date 2014-12-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Anionic nanocellulose as competing agent in microbial DNA extraction from mine process samples.

    Bomberg, Malin / Miettinen, Hanna

    Journal of microbiological methods

    2023  Volume 215, Page(s) 106850

    Abstract: Microorganisms in flotation and minerals processing may significantly affect the grade and yield of metal concentrates. However, studying the phenomena requires working techniques to detach microorganisms and their DNA from mineral particles to which ... ...

    Abstract Microorganisms in flotation and minerals processing may significantly affect the grade and yield of metal concentrates. However, studying the phenomena requires working techniques to detach microorganisms and their DNA from mineral particles to which they strongly adhere. We developed a new method utilizing the competitive properties of anionic nanocellulose to block sorption of DNA to and detach microbial cells from mineral particles from ore processing. In general, up to one ng DNA mL
    MeSH term(s) DNA, Bacterial/analysis ; Bacteria/genetics ; DNA ; Microbiota ; Minerals ; RNA, Ribosomal, 16S/genetics
    Chemical Substances DNA, Bacterial ; DNA (9007-49-2) ; Minerals ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2023-10-30
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 604916-3
    ISSN 1872-8359 ; 0167-7012
    ISSN (online) 1872-8359
    ISSN 0167-7012
    DOI 10.1016/j.mimet.2023.106850
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1849: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Corrigendum to "Anionic nanocellulose as competing agent in microbial DNA extraction from mine process samples" [Journal of Microbiological Methods volume 215 (2023) 106850].

    Bomberg, Malin / Miettinen, Hanna

    Journal of microbiological methods

    2023  Volume 215, Page(s) 106865

    Language English
    Publishing date 2023-11-30
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 604916-3
    ISSN 1872-8359 ; 0167-7012
    ISSN (online) 1872-8359
    ISSN 0167-7012
    DOI 10.1016/j.mimet.2023.106865
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1849: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Book: Neuroleptanalgesia in cataract surgery / 2 / by Pöntinen, P. J., Miettinen, P., and Reinikainen, M.

    Pöntinen, Pekka J. / Miettinen, Pentti / Reinikainen, Mikko

    1966  

    Collection Neuroleptanalgesia in cataract surgery
    Language English
    Size 36 S.
    Publisher Munksgaard
    Publishing place Copenhagen
    Publishing country Denmark
    Document type Book
    HBZ-ID HT004925765
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Ul I Zs 90 -Suppl.80,2- verfügbar in Königswinter Königswinter

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