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Article: Direct assignment of the absolute configuration of a distinct class of deoxyribonucleoside cyclic N-acylphosphoramidites at phosphorus by M-GOESY nuclear magnetic resonance spectroscopy.

Wilk, Andrzej / Grajkowski, Andrzej / Bull, Thomas E / Dixon, Ann M / Freedberg, Darón I / Beaucage, Serge L

Journal of the American Chemical Society

2002 Volume 124, Issue 7, Page(s) 1180–1181

Abstract: ... is easily accomplished with computer-assisted molecular modeling and M-GOESY NMR spectroscopy ... interaction between benzylic H-5 and sugar H-2' ', which can predictably be detected by M-GOESY NMR in SP-3 ... predictions, M-GOESY NMR spectra of SP-3 and RP-3 revealed NOE signals generated from nuclei near ...

Abstract	The determination of the absolute configuration of deoxyribonucleoside cyclic N-acylphosphoramidites at phosphorus toward the synthesis of P-stereodifined phosphorothioated oligodeoxyribonucleotides is easily accomplished with computer-assisted molecular modeling and M-GOESY NMR spectroscopy. Specifically, computer-modeling diasteromeric phosphoramidite 3 has identifed a proximal (2.55 A) through-space interaction between benzylic H-5 and sugar H-2' ', which can predictably be detected by M-GOESY NMR in SP-3 but not in RP-3 because of being too distant (5.85 A). Consistent with computer-assisted modeling predictions, M-GOESY NMR spectra of SP-3 and RP-3 revealed NOE signals generated from nuclei near the selectively excited H-2' ' that are common to both SP-3 and RP-3, namely those of H-2', H-4', H-3', and H-1'. In addition, a diagnostic NOE signal at 5.5 ppm (benzylic H-5) is, as predicted, only detected in SP-3 and thus provides an unequivocal assessment of the configuration of the diastereomer at phosphorus. M-GOESY NMR data also confirm that the condensation of deoxyribonucleoside cyclic N-acylphosphoramidites with base-activated nucleosidic or nucleotidic 5'-hydroxyls proceeds via a single nucleophilic event.
MeSH term(s)	Models, Chemical ; Nuclear Magnetic Resonance, Biomolecular/methods ; Nucleic Acid Conformation ; Oligodeoxyribonucleotides/chemistry ; Organophosphorus Compounds/chemistry ; Phosphorus/chemistry
Chemical Substances	Oligodeoxyribonucleotides ; Organophosphorus Compounds ; phosphoramidite ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2002-02-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/ja017190d
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Article ; Online: Trends in use of proton pump inhibitors among adults in the United States from 1999 to 2018.

Bergin, Emily / Zylberberg, Haley M / Lebwohl, Benjamin / Freedberg, Daniel E

Pharmacoepidemiology and drug safety

2023 Volume 32, Issue 12, Page(s) 1406–1410

Abstract: Purpose: Proton pump inhibitors (PPIs) are among the most commonly used drugs in the United States (U.S.). We aimed to determine the trends in use of PPIs among adults in the U.S. from 1999 through 2018, hypothesizing the trend would follow an inverted ... ...

Abstract	Purpose: Proton pump inhibitors (PPIs) are among the most commonly used drugs in the United States (U.S.). We aimed to determine the trends in use of PPIs among adults in the U.S. from 1999 through 2018, hypothesizing the trend would follow an inverted U-shaped curve, with a decline in recent years due to safety concerns. Methods: Temporal trends in use of prescription PPIs were assessed using the 1999-2018 National Health and Nutrition Examination Survey (NHANES), a nationally representative cross-sectional survey of non-institutionalized U.S. civilians. Use of PPIs was defined as any use during the month preceding the survey. Descriptive statistics were produced and trends in PPI use were examined, stratified by sex, age, race, body mass index (BMI), and poverty level. Results: Use of prescription PPIs increased from 4.1% of U.S. adults in 1999-2000 to 8.6% in 2017-2018 (p for trend <0.01). All of the increase was observed during the first half of the study period (4.6% increase from 1999 to 2008 vs. 0.5% decrease from 2009 to 2018) and almost all of it was among those aged 55 or more (8.6% increase among those aged ≥ 55 compared to 1.2% increase among those aged < 55, p for interaction based on age <0.01). Conclusions: Use of prescription PPIs increased from 1999 to 2008 and then plateaued through 2018. This rise was driven by increased usage among older NHANES respondents.
MeSH term(s)	Adult ; Humans ; United States/epidemiology ; Proton Pump Inhibitors/adverse effects ; Nutrition Surveys ; Cross-Sectional Studies ; Prescriptions
Chemical Substances	Proton Pump Inhibitors
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article
ZDB-ID	1099748-9
ISSN	1099-1557 ; 1053-8569
ISSN (online)	1099-1557
ISSN	1053-8569
DOI	10.1002/pds.5676
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Article: Obesity among those newly diagnosed with Crohn's disease and ulcerative colitis compared with the general population.

Sehgal, Priya / Shen, Bo / Li, Jianhua / Freedberg, Daniel E

Frontline gastroenterology

2022 Volume 14, Issue 4, Page(s) 319–325

Abstract: ... as age ≥65. Obesity was classified as BMI ≥30 kg/m: Results: Included were 1573 patients (56.0 ... 20 kg/m: Conclusion: Patients with IBD diagnosed at age <18 were less likely to be obese compared ...

Abstract	Objective: Obesity is a potentially modifiable risk factor for inflammatory bowel disease (IBD). We aimed to evaluate the body mass index (BMI) of those diagnosed with IBD early versus late in life in the context of age-adjusted background population. Design/method: Patients with a new diagnosis of IBD from 2000 to 2021 were included. Early-onset IBD was classified as age <18 and late-onset IBD classified as age ≥65. Obesity was classified as BMI ≥30 kg/m Results: Included were 1573 patients (56.0%) with Crohn's disease (CD) and 1234 (44.0%) with ulcerative colitis (UC). Overall, the median BMI at IBD diagnosis was 20 kg/m Conclusion: Patients with IBD diagnosed at age <18 were less likely to be obese compared with the age-adjusted background population whereas those diagnosed at age ≥65 were more likely to be obese. Future prospective studies should investigate obesity as a modifiable risk factor for late-life IBD.
Language	English
Publishing date	2022-12-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2521857-8
ISSN	2041-4137
ISSN	2041-4137
DOI	10.1136/flgastro-2022-102276
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Article ; Online: Variability in life expectancy among people with HIV in Brazil by gender and sexual orientation.

Luz, Paula M / Spaeth, Hailey / Scott, Justine A / Grinsztejn, Beatriz / Veloso, Valdilea G / Freedberg, Kenneth A / Losina, Elena

The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

2024 Volume 28, Issue 1, Page(s) 103722

Abstract: Introduction: In Brazil, though Antiretroviral Therapy (ART) is available to all, the benefits may not be experienced uniformly. We projected Life Expectancy (LE) for People Living with HIV (PLHIV) in care as currently observed and estimated the impact ... ...

Abstract	Introduction: In Brazil, though Antiretroviral Therapy (ART) is available to all, the benefits may not be experienced uniformly. We projected Life Expectancy (LE) for People Living with HIV (PLHIV) in care as currently observed and estimated the impact of guideline-concordant care. Methods: Using a microsimulation model, we projected LE for a cohort of PLHIV and for four population groups: cisgender Men who have Sex with Men (MSM), cisgender Men who have Sex with Women (MSW), Cisgender Women (CGW), and Transgender Women (TGW). Cohort data from Evandro Chagas National Institute of Infectious Diseases/Oswaldo Cruz Foundation (INI/Fiocruz) informed model parameters. We modeled five scenarios: 1) Current care: ART initiation, adherence, and retention in care as currently observed, 2) Guideline-concordant care: immediate ART initiation, full adherence to treatment, and consistent retention in care, 3) Immediate ART initiation with observed adherence to treatment and retention in care, 4) Full adherence to treatment with observed timing of ART initiation and retention in care, and 5) Consistent retention in care with observed timing of ART initiation and adherence. Results: With current care, LE from age 15 would be 45.9, 44.4, 54.2, and 42.3 years, for MSM, MSW, CGW, and TGW. With guideline-concordant care, LE would be 54.2, 54.4, 63.1, and 53.2 years, for MSM, MSW, CGW and TGW, with TGW experiencing the greatest potential increase in LE (10.9 years). When investigating the components of care separately, MSW and CGW would gain most LE with immediate ART initiation, whereas for MSM and TGW consistent retention in care would be most impactful. Conclusions: In settings like INI/Fiocruz, MSW and CGW would benefit most from interventions focused on earlier diagnosis and linkage to care, whereas TGW and MSM would benefit from interventions to sustain engagement in care. Assessment of the HIV care continuum for specific populations should inform care priorities.
MeSH term(s)	Humans ; Male ; Female ; Adolescent ; Homosexuality, Male ; Brazil/epidemiology ; Sexual and Gender Minorities ; Transgender Persons ; Sexual Behavior ; HIV Infections/epidemiology
Language	English
Publishing date	2024-02-15
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2041400-6
ISSN	1678-4391 ; 1413-8670
ISSN (online)	1678-4391
ISSN	1413-8670
DOI	10.1016/j.bjid.2024.103722
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Article ; Online: Dispersal reduces interspecific competitiveness by spreading locally harmful traits.

Freedberg, Steven / Urban, Caroline / Cunniff, Brianna M

Journal of evolutionary biology

2021 Volume 34, Issue 9, Page(s) 1477–1487

Abstract: Just as intraorganismal selection can produce "selfish" elements that lower individual fitness, selection at the organismal level can favour traits that reduce the fitness of conspecifics and potentially impact population survival. Because dispersal can ... ...

Abstract	Just as intraorganismal selection can produce "selfish" elements that lower individual fitness, selection at the organismal level can favour traits that reduce the fitness of conspecifics and potentially impact population survival. Because dispersal can affect how these traits are distributed within species, it may determine whether their negative consequences are restricted locally or spread throughout the species' range. We present an individual-based simulation model that explores the interaction between dispersal rate and traits that increase individual fecundity at the expense of conspecific fitness. We first modelled dispersal as a trait that varied within species and then fixed the within-species dispersal rates and modelled competition between species that differed only in dispersal rate. Reproductive isolation allowed species differences in dispersal rates to become associated with traits moulded by intraspecific competition, but this association did not occur when dispersal variation was distributed within species due to recombination between the dispersal and competition loci. Alleles that reduced the fitness of conspecifics were maintained at lower frequencies in low-dispersal species, resulting in a competitive advantage over high-dispersing species. Although high-dispersal species initially outcompeted low-dispersal species owing to enhanced colonization opportunities, low-dispersal species ultimately showed greater representation across a range of ecological and genetic scenarios. This process may shift the makeup of communities over time towards a greater representation of low-dispersal species.
MeSH term(s)	Computer Simulation ; Phenotype ; Species Specificity
Language	English
Publishing date	2021-08-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1465318-7
ISSN	1420-9101 ; 1010-061X
ISSN (online)	1420-9101
ISSN	1010-061X
DOI	10.1111/jeb.13912
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Article: Dispersal reduces interspecific competitiveness by spreading locally harmful traits

Freedberg, Steven / Urban, Caroline / Cunniff, Brianna M.

Journal of evolutionary biology. 2021 Sept., v. 34, no. 9

2021

Abstract: Just as intraorganismal selection can produce “selfish” elements that lower individual fitness, selection at the organismal level can favour traits that reduce the fitness of conspecifics and potentially impact population survival. Because dispersal can ... ...

Abstract	Just as intraorganismal selection can produce “selfish” elements that lower individual fitness, selection at the organismal level can favour traits that reduce the fitness of conspecifics and potentially impact population survival. Because dispersal can affect how these traits are distributed within species, it may determine whether their negative consequences are restricted locally or spread throughout the species' range. We present an individual‐based simulation model that explores the interaction between dispersal rate and traits that increase individual fecundity at the expense of conspecific fitness. We first modelled dispersal as a trait that varied within species and then fixed the within‐species dispersal rates and modelled competition between species that differed only in dispersal rate. Reproductive isolation allowed species differences in dispersal rates to become associated with traits moulded by intraspecific competition, but this association did not occur when dispersal variation was distributed within species due to recombination between the dispersal and competition loci. Alleles that reduced the fitness of conspecifics were maintained at lower frequencies in low‐dispersal species, resulting in a competitive advantage over high‐dispersing species. Although high‐dispersal species initially outcompeted low‐dispersal species owing to enhanced colonization opportunities, low‐dispersal species ultimately showed greater representation across a range of ecological and genetic scenarios. This process may shift the makeup of communities over time towards a greater representation of low‐dispersal species.
Keywords	conspecificity ; evolutionary biology ; fecundity ; intraspecific competition ; reproductive isolation ; simulation models
Language	English
Dates of publication	2021-09
Size	p. 1477-1487.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	1465318-7
ISSN	1420-9101 ; 1010-061X
ISSN (online)	1420-9101
ISSN	1010-061X
DOI	10.1111/jeb.13912
Database	NAL-Catalogue (AGRICOLA)

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Book: Current dermatologic diagnosis & treatment

Freedberg, Irwin M.

2001

Title variant	Dermatologic diagnosis & treatment
Author's details	ed. by Irwin M. Freedberg
Keywords	Skin Diseases / diagnosis ; Skin Diseases / therapy
Language	English
Size	XII, 245 S. : Ill.
Publisher	Lippincott Williams & Wilkins
Publishing place	Philadelphia u.a.
Publishing country	United States
Document type	Book
HBZ-ID	HT013104452
ISBN	0-7817-3531-9 ; 978-0-7817-3531-5
Database	Catalogue ZB MED Medicine, Health

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Article ; Online: Global Incidence of IgA Nephropathy by Race and Ethnicity: A Systematic Review.

Kiryluk, Krzysztof / Freedberg, Daniel E / Radhakrishnan, Jai / Segall, Leslie / Jacobson, Judith S / Mathur, Mohit / Mohan, Sumit / Neugut, Alfred I

Kidney360

2023 Volume 4, Issue 8, Page(s) 1112–1122

MeSH term(s)	Humans ; Glomerulonephritis, IGA/ethnology ; Incidence ; Racial Groups
Language	English
Publishing date	2023-05-25
Publishing country	United States
Document type	Systematic Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
ISSN	2641-7650
ISSN (online)	2641-7650
DOI	10.34067/KID.0000000000000165
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Article: Effective connectivity underlying neural and behavioral components of prism adaptation.

Schintu, Selene / Gotts, Stephen J / Freedberg, Michael / Shomstein, Sarah / Wassermann, Eric M

Frontiers in psychology

2022 Volume 13, Page(s) 915260

Abstract: Prism adaptation (PA) is a form of visuomotor training that produces both sensorimotor and cognitive aftereffects depending on the direction of the visual displacement. Recently, a neural framework explaining both types of PA-induced aftereffects has ... ...

Abstract	Prism adaptation (PA) is a form of visuomotor training that produces both sensorimotor and cognitive aftereffects depending on the direction of the visual displacement. Recently, a neural framework explaining both types of PA-induced aftereffects has been proposed, but direct evidence for it is lacking. We employed Structural Equation Modeling (SEM), a form of effective connectivity analysis, to establish directionality among connected nodes of the brain network thought to subserve PA. The findings reveal two distinct network branches: (1) a loop involving connections from the parietal cortices to the right parahippocampal gyrus, and (2) a branch linking the lateral premotor cortex to the parahippocampal gyrus
Language	English
Publishing date	2022-09-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.915260
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Article ; Online: Hiding in Plain Sight.

Choy, Alexa M / Ko, Huaibin Mabel / Kelly, Maureen R / Bowman, Chip A / Green, Daniel / Freedberg, Daniel E

Gastroenterology

2023 Volume 165, Issue 3, Page(s) e14–e16

Language	English
Publishing date	2023-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	80112-4
ISSN	1528-0012 ; 0016-5085
ISSN (online)	1528-0012
ISSN	0016-5085
DOI	10.1053/j.gastro.2023.02.038
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Zs.MO 572: Show issues

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