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Article ; Online: The pathophysiology of the cell cycle in cancer and treatment strategies using various cell cycle checkpoint inhibitors.

Almalki, Sami G

2023 Volume 251, Page(s) 154854

Abstract: The cell cycle is the series of events that occur in a cell leading to its division and duplication. It can be divided into two main stages: interphase and mitosis. Interphase is the longest stage of the cell cycle and can be further divided into three ... ...

Abstract	The cell cycle is the series of events that occur in a cell leading to its division and duplication. It can be divided into two main stages: interphase and mitosis. Interphase is the longest stage of the cell cycle and can be further divided into three phases: G1, S, and G2. During G1, the cell grows and prepares for DNA synthesis. In the S phase, DNA synthesis occurs, leading to the replication of the genetic material. In G2, the cell continues to grow and prepares for mitosis. After mitosis, the cell enters the final stage of the cell cycle, called cytokinesis, during which the cytoplasm is divided, resulting in two separate daughter cells. The cell cycle then begins again with interphase. Cell cycle dysregulation is a hallmark of cancer, and it can have several consequences that contribute to the development and progression of cancer. Cyclin inhibitors and checkpoint activators have shown promise in the treatment of cancer, particularly in combination with other therapies.
MeSH term(s)	Humans ; Cell Cycle ; Mitosis ; DNA Replication ; Cell Cycle Checkpoints ; DNA ; Neoplasms/drug therapy
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2023-10-04
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	391889-0
ISSN	1618-0631 ; 0344-0338
ISSN (online)	1618-0631
ISSN	0344-0338
DOI	10.1016/j.prp.2023.154854
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Ud III Zs.20: Show issues

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Article ; Online: Adipose-derived mesenchymal stem cells and wound healing: Potential clinical applications in wound repair.

Almalki, Sami G

Saudi medical journal

2022 Volume 43, Issue 10, Page(s) 1075–1086

Abstract: Delayed and chronic wounds result from the dysregulation of molecular and cellular events associated with wound healing, including migration, inflammation, angiogenesis, extracellular matrix (ECM) remodeling, and re-epithelialization. Adipose tissue is ... ...

Abstract	Delayed and chronic wounds result from the dysregulation of molecular and cellular events associated with wound healing, including migration, inflammation, angiogenesis, extracellular matrix (ECM) remodeling, and re-epithelialization. Adipose tissue is an abundant, easily accessible, and rich source of mesenchymal stem cells (MSCs) with high therapeutic potential. In addition to their capability to differentiate into various lineages with specialized functions, adipose-derived MSCs (AMSCs) can mediate to the wound repair process through the secretion of different growth factors and mediators rather than making structural contribution alone. Adipose-derived MSCs mediate the formation of blood vessels, recruit progenitor cells, stimulate cell differentiation and ECM formation, and promote wound healing by releasing immune mediators and exosomes. Herein, we discuss and review the therapeutic potential of AMSCs for wound repair via acceleration of wound closure, re-epithelialization, enhancement of angiogenesis and immunomodulation of prolonged inflammatory responses, as well as the current challenges in clinical implementation.
MeSH term(s)	Humans ; Mesenchymal Stem Cells/metabolism ; Wound Healing/physiology ; Cell Differentiation ; Stem Cells ; Extracellular Matrix
Language	English
Publishing date	2022-10-05
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	392302-2
ISSN	1658-3175 ; 0379-5284
ISSN (online)	1658-3175
ISSN	0379-5284
DOI	10.15537/smj.2022.43.10.20220522
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Zs.B 2330: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 6: Show issues

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Article ; Online: Mesenchymal stem cells and their extracellular vesicles as emerging therapeutic tools in the treatment of ischemic stroke.

Pratiwi, Dewi Indah Noviana / Alhajlah, Sharif / Alawadi, Ahmed / Hjazi, Ahmed / Alawsi, Taif / Almalki, Sami G / Alsalamy, Ali / Kumar, Abhinav

Tissue & cell

2024 Volume 87, Page(s) 102320

Abstract: Ischemic stroke (IS) is a neurological condition characterized by severe long-term consequences and an unfavorable prognosis for numerous patients. Despite advancements in stroke treatment, existing therapeutic approaches possess certain limitations. ... ...

Abstract	Ischemic stroke (IS) is a neurological condition characterized by severe long-term consequences and an unfavorable prognosis for numerous patients. Despite advancements in stroke treatment, existing therapeutic approaches possess certain limitations. However, accumulating evidence suggests that mesenchymal stem/stromal cells (MSCs) hold promise as a potential therapy for various neurological disorders, including IS, owing to their advantageous properties, such as immunomodulation and tissue regeneration. Additionally, MSCs primarily exert their therapeutic effects through the release of extracellular vesicles (EVs), highlighting the significance of their paracrine activities. These EVs are small double-layered phospholipid membrane vesicles, carrying a diverse cargo of proteins, lipids, and miRNAs that enable effective cell-to-cell communication. Notably, EVs have emerged as attractive substitutes for stem cell therapy due to their reduced immunogenicity, lower tumorigenic potential, and ease of administration and handling. Hence, this review summarizes the current preclinical and clinical studies performed to investigate the safety and therapeutic potential of MSCs and their EVs derived from different sources, including bone marrow, adipose tissue, umbilical cord blood, and Wharton's jelly in IS.
MeSH term(s)	Humans ; Ischemic Stroke/metabolism ; Extracellular Vesicles/metabolism ; MicroRNAs/metabolism ; Wharton Jelly ; Mesenchymal Stem Cells/metabolism
Chemical Substances	MicroRNAs
Language	English
Publishing date	2024-02-02
Publishing country	Scotland
Document type	Journal Article ; Review
ZDB-ID	204424-9
ISSN	1532-3072 ; 0040-8166
ISSN (online)	1532-3072
ISSN	0040-8166
DOI	10.1016/j.tice.2024.102320
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Zs.A 1016: Show issues

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Article ; Online: Inhibitory Potential of the

Mir, Shabir Ahmad / Madkhali, Yahya / Firoz, Ahmad / Al Othaim, Ayoub / Alturaiki, Wael / Almalki, Sami G / Algarni, Abdulrahman / Alsagaby, Suliman A

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 8

Abstract: Chronic lymphocytic leukemia (CLL) is an incurable neoplasm of B-lymphocytes, which accounts for about one-third of all leukemias. ...

Abstract	Chronic lymphocytic leukemia (CLL) is an incurable neoplasm of B-lymphocytes, which accounts for about one-third of all leukemias.
MeSH term(s)	Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/drug therapy ; Leukemia, Lymphocytic, Chronic, B-Cell/metabolism ; Agammaglobulinaemia Tyrosine Kinase/metabolism ; Molecular Docking Simulation ; Ocimum sanctum/metabolism ; Protein Kinase Inhibitors/chemistry ; Rosmarinic Acid
Chemical Substances	Agammaglobulinaemia Tyrosine Kinase (EC 2.7.10.2) ; Protein Kinase Inhibitors
Language	English
Publishing date	2023-04-07
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28083287
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Zs.MO 81: Show issues

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Article ; Online: Antioxidant, LC-MS Analysis, and Cholinesterase Inhibitory Potentials of

Almalki, Sami G / Alqurashi, Yaser E / Alturaiki, Wael / Almawash, Saud / Khan, Amir / Ahmad, Parvej / Iqbal, Danish

Biomolecules

2023 Volume 13, Issue 10

Abstract: We evaluated the therapeutic potentials of Khudari fruit pulp, a functional food and cultivar ... ...

Abstract	We evaluated the therapeutic potentials of Khudari fruit pulp, a functional food and cultivar of
MeSH term(s)	Cholinesterases ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Acetylcholinesterase/metabolism ; Plant Extracts/pharmacology ; Plant Extracts/chemistry ; Phoeniceae/chemistry ; Phoeniceae/metabolism ; Chromatography, Liquid ; Molecular Docking Simulation ; Ligands ; Tandem Mass Spectrometry ; Phytochemicals
Chemical Substances	Cholinesterases (EC 3.1.1.8) ; Antioxidants ; Acetylcholinesterase (EC 3.1.1.7) ; Plant Extracts ; Ligands ; Phytochemicals
Language	English
Publishing date	2023-09-30
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2701262-1
ISSN	2218-273X ; 2218-273X
ISSN (online)	2218-273X
ISSN	2218-273X
DOI	10.3390/biom13101474
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Article: Comparative evaluation of natural neuroprotectives and their combinations on chronic immobilization stress-induced depression in experimental mice.

Ibrahim, Ibrahim M / Alsieni, Mohammed / Almalki, Sami G / Alqurashi, Yaser E / Kumar, Vinay

3 Biotech

2022 Volume 13, Issue 1, Page(s) 22

Abstract: The present study evaluates the potential of neuroprotective phytochemicals-rutin (R), resveratrol (Res), 17β-estradiol (17β-E2), and their different combinations against chronic immobilization stress (CIS)-induced depression-like behaviour in male ... ...

Abstract	The present study evaluates the potential of neuroprotective phytochemicals-rutin (R), resveratrol (Res), 17β-estradiol (17β-E2), and their different combinations against chronic immobilization stress (CIS)-induced depression-like behaviour in male albino mice. Here, the mice were exposed to stress via immobilization of their four limbs under a restrainer for 6 h daily until 7 days of the induction after 30 min of respective drug treatment in different mice groups. The result found the protective effect of these phytoconstituents and their combinations against CIS-induced depression due to their ability to suppress oxidative stress, restore mitochondria, HPA-axis modulation, neurotransmitter level, stress hormones, and inflammatory markers. Also, the combination drug regimens of these phytoconstituents showed synergistic results in managing the physiological and biochemical features of depression. Thus, these neuroprotective could be utilized well in combination to manage depression-like symptoms during episodic stress. Furthermore, such results could be well justified when administered in polyherbal formulation with these neuroprotective as major components. In addition, an advanced study can be designed at the molecular and epigenetics level using a formulation based on these neuroprotective.
Language	English
Publishing date	2022-12-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2600522-0
ISSN	2190-5738 ; 2190-572X
ISSN (online)	2190-5738
ISSN	2190-572X
DOI	10.1007/s13205-022-03438-2
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Article ; Online: Effect of sesame (Sesamum indicum L.) consumption on glycemic control in patients with type 2 diabetes: A systematic review and meta-analysis of randomized controlled trials.

Ramírez-Coronel, Andrés Alexis / Ali Alhilali, Khetam Abdalsada / Basheer Ahmed, Yasmin / Almalki, Sami G / Karimian, Jahangir

Phytotherapy research : PTR

2023 Volume 37, Issue 9, Page(s) 3809–3819

Abstract: Conflicting evidence exists on the effect of sesame consumption on glucose metabolism in patients with type 2 diabetes (T2D). Therefore, this meta-analysis focuses on the relationship between sesame (Sesamum indicum L.) intervention and glycemic control ... ...

Abstract	Conflicting evidence exists on the effect of sesame consumption on glucose metabolism in patients with type 2 diabetes (T2D). Therefore, this meta-analysis focuses on the relationship between sesame (Sesamum indicum L.) intervention and glycemic control in patients with T2D. Published literature was retrieved and screened from PubMed, Scopus, ISI Web of Science, and the Cochrane Library up to December 2022. Outcome measures included fasting blood sugar (FBS) concentrations, fasting insulin levels, and hemoglobin A1c (HbA1c) percentage. Pooled effect sizes were reported as weighted mean differences (WMDs) and 95% confidence intervals (CIs). Eight clinical trials (395 participants) were eligible for meta-analyses. Overall, sesame consumption significantly reduced serum FBS (WMD: -28.61 mg/dL, 95% CI: -36.07 to -21.16, p˂0.001; I
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/drug therapy ; Glycated Hemoglobin ; Sesamum/metabolism ; Blood Glucose ; Glycemic Control ; Prospective Studies ; Randomized Controlled Trials as Topic ; Insulins/therapeutic use ; Insulin ; Insulin Resistance
Chemical Substances	Glycated Hemoglobin ; Blood Glucose ; Insulins ; Insulin
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	639136-9
ISSN	1099-1573 ; 0951-418X
ISSN (online)	1099-1573
ISSN	0951-418X
DOI	10.1002/ptr.7918
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Zs.B 3092: Show issues

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Article ; Online: Therapeutic gene delivery by mesenchymal stem cell for brain ischemia damage: Focus on molecular mechanisms in ischemic stroke.

Saleh, Raed Obaid / Majeed, Ali A / Margiana, Ria / Alkadir, Ola Kamal A / Almalki, Sami G / Ghildiyal, Pallavi / Samusenkov, Vadim / Jabber, Noura Kareem / Mustafa, Yasser Fakri / Elawady, Ahmed

Cell biochemistry and function

2024 Volume 42, Issue 2, Page(s) e3957

Abstract: Cerebral ischemic damage is prevalent and the second highest cause of death globally across patient populations; it is as a substantial reason of morbidity and mortality. Mesenchymal stromal cells (MSCs) have garnered significant interest as a potential ... ...

Abstract	Cerebral ischemic damage is prevalent and the second highest cause of death globally across patient populations; it is as a substantial reason of morbidity and mortality. Mesenchymal stromal cells (MSCs) have garnered significant interest as a potential treatment for cerebral ischemic damage, as shown in ischemic stroke, because of their potent intrinsic features, which include self-regeneration, immunomodulation, and multi-potency. Additionally, MSCs are easily obtained, isolated, and cultured. Despite this, there are a number of obstacles that hinder the effectiveness of MSC-based treatment, such as adverse microenvironmental conditions both in vivo and in vitro. To overcome these obstacles, the naïve MSC has undergone a number of modification processes to enhance its innate therapeutic qualities. Genetic modification and preconditioning modification (with medications, growth factors, and other substances) are the two main categories into which these modification techniques can be separated. This field has advanced significantly and is still attracting attention and innovation. We examine these cutting-edge methods for preserving and even improving the natural biological functions and therapeutic potential of MSCs in relation to adhesion, migration, homing to the target site, survival, and delayed premature senescence. We address the use of genetically altered MSC in stroke-induced damage. Future strategies for improving the therapeutic result and addressing the difficulties associated with MSC modification are also discussed.
MeSH term(s)	Humans ; Ischemic Stroke/metabolism ; Brain Ischemia/therapy ; Brain Ischemia/metabolism ; Stroke/therapy ; Stroke/metabolism ; Ischemic Preconditioning/methods ; Mesenchymal Stem Cells/metabolism ; Mesenchymal Stem Cell Transplantation
Language	English
Publishing date	2024-03-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	283643-9
ISSN	1099-0844 ; 0263-6484
ISSN (online)	1099-0844
ISSN	0263-6484
DOI	10.1002/cbf.3957
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Article ; Online: A new vision of the efficacy of both CAR-NK and CAR-T cells in treating cancers and autoimmune diseases.

Hassan, Salim Hussein / Alshahrani, Mohammad Y / Saleh, Raed Obaid / Mohammed, Bahira Abdulrazzaq / Kumar, Abhinav / Almalki, Sami G / Alkhafaji, Adnan Taan / Ghildiyal, Pallavi / Al-Tameemi, Ahmed Read / Elawady, Ahmed

Medical oncology (Northwood, London, England)

2024 Volume 41, Issue 6, Page(s) 127

Abstract: Chimeric Antigen Receptor (CAR) based therapies are becoming increasingly important in treating patients. CAR-T cells have been shown to be highly effective in the treatment of hematological malignancies. However, harmful therapeutic barriers have been ... ...

Abstract	Chimeric Antigen Receptor (CAR) based therapies are becoming increasingly important in treating patients. CAR-T cells have been shown to be highly effective in the treatment of hematological malignancies. However, harmful therapeutic barriers have been identified, such as the potential for graft-versus-host disease (GVHD), neurotoxicity, and cytokine release syndrome (CRS). As a result, CAR NK-cell therapy is expected to be a new therapeutic option. NK cells act as cytotoxic lymphocytes, supporting the innate immune response against autoimmune diseases and cancer cells by precisely detecting and eliminating malignant cells. Genetic modification of these cells provides a dual approach to the treatment of AD and cancer. It can be used through both CAR-independent and CAR-dependent mechanisms. The use of CAR-based cell therapies has been successful in treating cancer patients, leading to further investigation of this innovative treatment for alternative diseases, including AD. The complementary roles of CAR T and CAR NK cells have stimulated exploration in this area. Our study examines the latest research on the therapeutic effectiveness of these cells in treating both cancer and ADs.
MeSH term(s)	Humans ; Killer Cells, Natural/immunology ; Killer Cells, Natural/transplantation ; Receptors, Chimeric Antigen/immunology ; Neoplasms/therapy ; Neoplasms/immunology ; Autoimmune Diseases/therapy ; Autoimmune Diseases/immunology ; Immunotherapy, Adoptive/methods ; Animals
Chemical Substances	Receptors, Chimeric Antigen
Language	English
Publishing date	2024-04-24
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1201189-7
ISSN	1559-131X ; 0736-0118 ; 1357-0560
ISSN (online)	1559-131X
ISSN	0736-0118 ; 1357-0560
DOI	10.1007/s12032-024-02362-0
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Article: Common variants in toll-like receptor family genes and risk of gastric cancer: a systematic review and meta-analysis.

Al Othaim, Ayoub / Al-Hawary, Sulieman Ibraheem Shelash / Alsaab, Hashem O / Almalki, Sami G / Najm, Mazin A A / Hjazi, Ahmed / Alsalamy, Ali / Firras Almulla, Abbas / Alizadeh, Hamzeh

Frontiers in genetics

2023 Volume 14, Page(s) 1280051

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2023-11-28
Publishing country	Switzerland
Document type	Systematic Review
ZDB-ID	2606823-0
ISSN	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2023.1280051
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