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  1. Book ; Conference proceedings: Contributions to the 2nd Symposium on Regulatory Autoantibodies Targeting G-Protein-Coupled Receptors

    Riemekasten, Gabriela / Kerstein, Anja

    (Advances in regulatory autoantibody research ; 2018)

    2018  

    Event/congress Symposium on Regulatory Autoantibodies Targeting G-Protein-Coupled Receptors (2., 2018, Lübeck)
    Author's details Gabriela Riemenkasten and Anja Kerstein (Editors)
    Series title Advances in regulatory autoantibody research ; 2018
    Collection
    Keywords Anti-GPCR drug discovery ; Development of small molecules and monoclonal antibodies ; Treatment of cancer, infection, metabolic disorders or inflammatory diseases ; Autoantikörper ; G-Protein gekoppelter Rezeptor
    Subject G-Protein gekoppelte Rezeptoren ; GPCR
    Subject code 616.07987
    Language English
    Size circa 120 Seiten, Illustrationen, Diagramme, 25 cm
    Publisher Infinite Science Publishing
    Publishing place Lübeck
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT020045986
    ISBN 978-3-945954-51-5 ; 3-945954-51-7
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 562 available for loan (reading room) Lesesaal EG

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  2. Book ; Conference proceedings: 1st Symposium on Functional Autoantibodies Targeting G-Protein-Coupled Receptors

    Riemekasten, Gabriela / Kerstein, Anja

    book of abstracts

    2016  

    Event/congress Symposium on Functional Autoantibodies Targeting G-Protein-Coupled Receptors (1., 2016, Lübeck)
    Author's details Gabriela Riemekasten and Anja Kerstein (editors) ; Department of Rheumatology, University of Lübeck
    Keywords G-protein-coupled receptors ; GPCR signaling ; anti-GPCR therapy ; functional autoantibodies ; immune dysregulation
    Subject code 615.77
    Language English
    Size 62 Seiten, 25 cm
    Publisher Infinite Science Publishing
    Publishing place Lübeck
    Publishing country Germany
    Document type Book ; Conference proceedings
    HBZ-ID HT020046005
    ISBN 978-3-945954-25-6 ; 3-945954-25-8
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2019 A 561 available for loan (reading room) Lesesaal EG

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  3. Article ; Online: When natural antibodies become pathogenic: autoantibodies targeted against G protein-coupled receptors in the pathogenesis of systemic sclerosis.

    Akbarzadeh, Reza / Müller, Antje / Humrich, Jens Y / Riemekasten, Gabriela

    Frontiers in immunology

    2023  Volume 14, Page(s) 1213804

    Abstract: ... present in the sera of patients suffering from SSc, functionally active Abs against G protein-coupled ...

    Abstract Systemic sclerosis (SSc) is a chronic, multisystem connective tissue, and autoimmune disease with the highest case-specific mortality and complications among rheumatic diseases. It is characterized by complex and variable features such as autoimmunity and inflammation, vasculopathy, and fibrosis, which pose challenges in understanding the pathogenesis of the disease. Among the large variety of autoantibodies (Abs) present in the sera of patients suffering from SSc, functionally active Abs against G protein-coupled receptors (GPCRs), the most abundant integral membrane proteins, have drawn much attention over the last decades. These Abs play an essential role in regulating the immune system, and their functions are dysregulated in diverse pathological conditions. Emerging evidence indicates that functional Abs targeting GPCRs, such as angiotensin II type 1 receptor (AT1R) and the endothelin-1 type A receptor (ETAR), are altered in SSc. These Abs are part of a network with several GPCR Abs, such as those directed to the chemokine receptors or coagulative thrombin receptors. In this review, we summarize the effects of Abs against GPCRs in SSc pathologies. Extending the knowledge on pathophysiological roles of Abs against GPCRs could provide insights into a better understanding of GPCR contribution to SSc pathogenesis and therefore help in developing potential therapeutic strategies that intervene with pathological functions of these receptors.
    MeSH term(s) Humans ; Autoantibodies ; Scleroderma, Systemic ; Autoimmunity ; Fibrosis ; Receptor, Endothelin A
    Chemical Substances Autoantibodies ; Receptor, Endothelin A
    Language English
    Publishing date 2023-06-08
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2023.1213804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Autoantibodies targeting G protein-coupled receptors: An evolving history in autoimmunity. Report of the 4th international symposium.

    Cabral-Marques, Otávio / Moll, Guido / Catar, Rusan / Preuß, Beate / Bankamp, Lukas / Pecher, Ann-Christin / Henes, Joerg / Klein, Reinhild / Kamalanathan, A S / Akbarzadeh, Reza / van Oostveen, Wieke / Hohberger, Bettina / Endres, Matthias / Koolmoes, Bryan / Levarht, Nivine / Postma, Rudmer / van Duinen, Vincent / van Zonneveld, Anton Jan / de Vries-Bouwstra, Jeska /
    Fehres, Cynthia / Tran, Florian / do Vale, Fernando Yuri Nery / da Silva Souza, Kamilla Batista / Filgueiras, Igor Salerno / Schimke, Lena F / Baiocchi, Gabriela Crispim / de Miranda, Gustavo Cabral / da Fonseca, Dennyson Leandro Mathias / Freire, Paula Paccielli / Hackel, Alexander M / Grasshoff, Hanna / Stähle, Anja / Müller, Antje / Dechend, Ralf / Yu, Xinhua / Petersen, Frank / Sotzny, Franziska / Sakmar, Thomas P / Ochs, Hans D / Schulze-Forster, Kai / Heidecke, Harald / Scheibenbogen, Carmen / Shoenfeld, Yehuda / Riemekasten, Gabriela

    Autoimmunity reviews

    2023  Volume 22, Issue 5, Page(s) 103310

    Abstract: G protein-coupled receptors (GPCR) are involved in various physiological and ... e.g., systemic sclerosis and systemic lupus erythematosus). Beyond their association with disease ...

    Abstract G protein-coupled receptors (GPCR) are involved in various physiological and pathophysiological processes. Functional autoantibodies targeting GPCRs have been associated with multiple disease manifestations in this context. Here we summarize and discuss the relevant findings and concepts presented in the biennial International Meeting on autoantibodies targeting GPCRs (the 4th Symposium), held in Lübeck, Germany, 15-16 September 2022. The symposium focused on the current knowledge of these autoantibodies' role in various diseases, such as cardiovascular, renal, infectious (COVID-19), and autoimmune diseases (e.g., systemic sclerosis and systemic lupus erythematosus). Beyond their association with disease phenotypes, intense research related to the mechanistic action of these autoantibodies on immune regulation and pathogenesis has been developed, underscoring the role of autoantibodies targeting GPCRs on disease outcomes and etiopathogenesis. The observation repeatedly highlighted that autoantibodies targeting GPCRs could also be present in healthy individuals, suggesting that anti-GPCR autoantibodies play a physiologic role in modeling the course of diseases. Since numerous therapies targeting GPCRs have been developed, including small molecules and monoclonal antibodies designed for treating cancer, infections, metabolic disorders, or inflammatory conditions, anti-GPCR autoantibodies themselves can serve as therapeutic targets to reduce patients' morbidity and mortality, representing a new area for the development of novel therapeutic interventions.
    MeSH term(s) Humans ; Autoantibodies ; Autoimmunity ; COVID-19 ; Autoimmune Diseases ; Receptors, G-Protein-Coupled/metabolism
    Chemical Substances Autoantibodies ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2023-03-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2144145-5
    ISSN 1873-0183 ; 1568-9972
    ISSN (online) 1873-0183
    ISSN 1568-9972
    DOI 10.1016/j.autrev.2023.103310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5913: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: What Makes Antibodies Against G Protein-Coupled Receptors so Special? A Novel Concept to Understand Chronic Diseases.

    Riemekasten, Gabriela / Petersen, Frank / Heidecke, Harald

    Frontiers in immunology

    2020  Volume 11, Page(s) 564526

    Abstract: Expressions of G protein-coupled receptors (GPCR) on immune and tissue resident cells are ...

    Abstract Expressions of G protein-coupled receptors (GPCR) on immune and tissue resident cells are the consequence of the cellular environment, which is highly variable. As discussed here, antibodies directed to GPCR (GPCR abs), their levels and correlations to other abs, serve as biomarkers for various diseases. They also could reflect the individual interplay between the environment and the immune system. Thus, GPCR abs could display pathogenic chronic conditions and could help to identify disease-related pathways. Moreover, by acting as ligands to their corresponding receptors, GPCR abs modulate autoimmune as well as non-autoimmune diseases. This article introduces GPCR abs as drivers for diseases by their capability to induce a specific signaling and by determining immune cell homeostasis. The identification of the individual GPCR ab function is challenging but might be pivotal in the comprehension of the aetiology of diseases. This, hopefully, will lead to the identification of novel therapeutic strategies. This article provides an overview about concepts and recent developments in research. Accordingly, GPCR abs could represent ideal candidates for precision medicine. Here, we introduce the term antibodiom to cover the network of abs with GPCR abs as prominent players.
    MeSH term(s) Animals ; Autoantibodies/immunology ; Autoimmune Diseases/immunology ; Biomarkers ; Chronic Disease ; Homeostasis/immunology ; Humans ; Immunity, Cellular ; Ligands ; Molecular Targeted Therapy/methods ; Receptors, G-Protein-Coupled/immunology ; Signal Transduction/immunology ; T-Lymphocytes/immunology
    Chemical Substances Autoantibodies ; Biomarkers ; Ligands ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2020-12-15
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.564526
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Functional autoantibodies targeting G protein-coupled receptors in rheumatic diseases.

    Cabral-Marques, Otavio / Riemekasten, Gabriela

    Nature reviews. Rheumatology

    2017  Volume 13, Issue 11, Page(s) 648–656

    Abstract: G protein-coupled receptors (GPCRs) comprise the largest and most diverse family ...

    Abstract G protein-coupled receptors (GPCRs) comprise the largest and most diverse family of integral membrane proteins that participate in different physiological processes such as the regulation of the nervous and immune systems. Besides the endogenous ligands of GPCRs, functional autoantibodies are also able to bind GPCRs to trigger or block intracellular signalling pathways, resulting in agonistic or antagonistic effects, respectively. In this Review, the effects of functional GPCR-targeting autoantibodies on the pathogenesis of autoimmune diseases, including rheumatic diseases, are discussed. Autoantibodies targeting β1 and β2 adrenergic receptors, which are expressed by cardiac and airway smooth muscle cells, respectively, have an important role in the development of asthma and cardiovascular diseases. In addition, high levels of autoantibodies against the muscarinic acetylcholine receptor M3 as well as those targeting endothelin receptor type A and type 1 angiotensin II receptor have several implications in the pathogenesis of rheumatic diseases such as Sjögren syndrome and systemic sclerosis. Expanding the knowledge of the pathophysiological roles of autoantibodies against GPCRs will shed light on the biology of these receptors and open avenues for new therapeutic approaches.
    MeSH term(s) Autoantibodies/blood ; Autoantibodies/immunology ; Autoimmune Diseases ; Humans ; Membrane Proteins/immunology ; Membrane Proteins/metabolism ; Receptors, G-Protein-Coupled/immunology ; Receptors, G-Protein-Coupled/metabolism ; Rheumatic Diseases/blood ; Rheumatic Diseases/immunology
    Chemical Substances Autoantibodies ; Membrane Proteins ; Receptors, G-Protein-Coupled
    Language English
    Publishing date 2017-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2491532-4
    ISSN 1759-4804 ; 1759-4790
    ISSN (online) 1759-4804
    ISSN 1759-4790
    DOI 10.1038/nrrheum.2017.134
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6338: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Immunoglobulin G of systemic sclerosis patients programs a pro-inflammatory and profibrotic phenotype in monocyte-like THP-1 cells.

    Murthy, Sripriya / Wannick, Melanie / Eleftheriadis, Georgios / Müller, Antje / Luo, Jiao / Busch, Hauke / Dalmann, Anja / Riemekasten, Gabriela / Sadik, Christian D

    Rheumatology (Oxford, England)

    2020  Volume 60, Issue 6, Page(s) 3012–3022

    Abstract: Objectives: Functional IgG autoantibodies against diverse G protein-coupled receptors, i.e ...

    Abstract Objectives: Functional IgG autoantibodies against diverse G protein-coupled receptors, i.e. antibodies with agonistic or antagonistic activity at these receptors, are abundant in human serum. Their levels are altered in patients with SSc, and autoantibodies against angiotensin II receptor 1 (ATR1) and endothelin receptor A (ETA) have been suggested to drive SSc by inducing the chemokines CXCL8 and CCL18 in the blood. The objective of our study is to profile the effect of IgG in SSc (SSc-IgG) on the production of soluble mediators in monocytic cells.
    Methods: Monocyte-like THP-1 cells were stimulated with SSc-IgG and their secretome was analysed. Furthermore, the significance of major pro-inflammatory pathways for the induction of CXCL8 and CCL18 in response to SSc-IgG was assessed by a pharmacological approach.
    Results: Stimulation with SSc-IgG significantly alters the secretome of THP-1 cells towards a general pro-inflammatory and profibrotic phenotype, which includes an increase of CCL18 and CXCL8. The consequent expression profiles vary depending on the individual donor of the SSc-IgG. CCL18 and CXCL8 expression is thus regulated differentially, with AP-1 driving the induction of both CCL18 and CXCL8 and the TAK/IKK-β/NF-κB pathway and ERK1/2 driving that of CXCL8.
    Conclusions: Our results suggest that SSc-IgG contributes to the generation of the pro-inflammatory/profibrotic tissue milieu characteristic of SSc by its induction of a respective phenotype in monocytes. Furthermore, our results highlight AP-1 as a critical regulator of gene transcription of CCL18 in monocytic cells and as a promising pharmacological therapeutic target for the treatment of SSc.
    MeSH term(s) Autoantibodies/immunology ; Chemokines, CC/immunology ; Fibrosis/immunology ; Humans ; Immunoglobulin G/immunology ; Inflammation/immunology ; Interleukin-8/immunology ; Phenotype ; Scleroderma, Systemic/immunology ; THP-1 Cells
    Chemical Substances Autoantibodies ; CCL18 protein, human ; CXCL8 protein, human ; Chemokines, CC ; Immunoglobulin G ; Interleukin-8
    Language English
    Publishing date 2020-11-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/keaa747
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 240: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 497: Show issues

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  8. Article: Autoantibodies to Vasoregulative G-Protein-Coupled Receptors Correlate with Symptom Severity, Autonomic Dysfunction and Disability in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome.

    Freitag, Helma / Szklarski, Marvin / Lorenz, Sebastian / Sotzny, Franziska / Bauer, Sandra / Philippe, Aurélie / Kedor, Claudia / Grabowski, Patricia / Lange, Tanja / Riemekasten, Gabriela / Heidecke, Harald / Scheibenbogen, Carmen

    Journal of clinical medicine

    2021  Volume 10, Issue 16

    Abstract: ... Conclusion: Correlations of specific AAB against G-protein-coupled receptors (GPCR) with symptoms provide ...

    Abstract Background: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is an acquired complex disease with patients suffering from the cardinal symptoms of fatigue, post-exertional malaise (PEM), cognitive impairment, pain and autonomous dysfunction. ME/CFS is triggered by an infection in the majority of patients. Initial evidence for a potential role of natural regulatory autoantibodies (AAB) to beta-adrenergic (AdR) and muscarinic acetylcholine receptors (M-AChR) in ME/CFS patients comes from a few studies.
    Methods: Here, we analyzed the correlations of symptom severity with levels of AAB to vasoregulative AdR, AChR and Endothelin-1 type A and B (ETA/B) and Angiotensin II type 1 (AT1) receptor in a Berlin cohort of ME/CFS patients (
    Results: We found levels of most AABs significantly correlated with key symptoms of fatigue and muscle pain in patients with infection-triggered onset. The severity of cognitive impairment correlated with AT1-R- and ETA-R-AAB and severity of gastrointestinal symptoms with alpha1/2-AdR-AAB. In contrast, the patients with non-infection-triggered ME/CFS showed fewer and other correlations.
    Conclusion: Correlations of specific AAB against G-protein-coupled receptors (GPCR) with symptoms provide evidence for a role of these AAB or respective receptor pathways in disease pathomechanism.
    Language English
    Publishing date 2021-08-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10163675
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online ; Thesis: Charakterisierung neuer Autoantikörper gegen G-Protein gekoppelte Rezeptoren, Wachstumsfaktoren und Wachstumsfaktor-Rezeptoren bei der Systemischen Sklerose

    Bittern, Hannah [Verfasser] / Riemekasten, Gabriela [Akademischer Betreuer] / Krengel, Sven [Akademischer Betreuer]

    2022  

    Author's details Hannah Bittern ; Akademische Betreuer: Gabriela Riemekasten, Sven Krengel
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Zentrale Hochschulbibliothek Lübeck
    Publishing place Lübeck
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Book ; Online ; Thesis: Netzwerksignaturen neuer Autoantikörper gegen G-Protein-gekoppelte Rezeptoren und verwandte Moleküle bei Erkrankungsmanifestationen der systemischen Sklerose

    Sterner, Kristina [Verfasser] / Riemekasten, Gabriela [Akademischer Betreuer] / Sailer, Verena-Wilbeth [Akademischer Betreuer]

    2022  

    Author's details Kristina Sterner ; Akademische Betreuer: Gabriela Riemekasten, Verena-Wilbeth Sailer
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Zentrale Hochschulbibliothek Lübeck
    Publishing place Lübeck
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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