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  1. Article ; Online: What are the determinants of change in walking fitness in patients with a history of depression following cardiac rehabilitation?

    Sever, Serdar / Harrison, Alexander / Doherty, Patrick

    European journal of cardiovascular nursing

    2024  

    Abstract: ... 6m for each year increase in age at baseline (P < 0.001). Females and unemployed patients had less ... with lower improvement (24.2m, p < 0.001), while physically active patients had 14.6m higher change. Higher ...

    Abstract Aims: This study aims to investigate the demographic, clinical and service level factors determining change in walking fitness in cardiac rehabilitation (CR) patients with a history of depression following the CR programme.
    Methods and results: National Audit of Cardiac Rehabilitation (NACR) clinical data were used to identify 1476 patients with a history of depression who had their pre and post incremental shuttle walk test (ISWT) recorded between 1st Jan 2016 and 31st Jan 2020. A multiple linear regression was conducted to examine the determinants of change in walking fitness (m) following CR. Mean age was 61 (SD 10.45) and mean ISWT distance at baseline and outcome were 352.06m (SD 169.48) and 463.43m (SD 197.65), respectively. Multivariate analysis revealed that change in walking distance reduced by 1.6m for each year increase in age at baseline (P < 0.001). Females and unemployed patients had less improvement in walking fitness (23.1m and 21.5m, respectively). Having a body mass index >30 was associated with lower improvement (24.2m, p < 0.001), while physically active patients had 14.6m higher change. Higher baseline ISWT quintiles were associated with less improvement, and increased waiting time to start CR was associated with reduced change in walking fitness following CR.
    Conclusion: Older age, female gender, unemployment, higher baseline BMI, longer waiting time, and lower physical activity were associated with reduced walking fitness improvement in patients with a history of depression. Targeted intervention and prompt access to CR can optimize outcomes.
    Language English
    Publishing date 2024-04-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2151245-0
    ISSN 1873-1953 ; 1474-5151
    ISSN (online) 1873-1953
    ISSN 1474-5151
    DOI 10.1093/eurjcn/zvae047
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  2. Article ; Online: Factors associated with new-onset depressive symptoms in patients starting cardiac rehabilitation: Pre-COVID-19 and COVID-19 period comparison.

    Sever, Serdar / Harrison, Alexander / Doherty, Patrick

    Journal of psychosomatic research

    2023  Volume 170, Page(s) 111342

    Abstract: Objective: We aim to: 1) investigate whether starting cardiac rehabilitation (CR) during the COVID-19 period was influential on new-onset depressive symptoms, 2) examine the relationship between sociodemographic and medical factors with the new-onset of ...

    Abstract Objective: We aim to: 1) investigate whether starting cardiac rehabilitation (CR) during the COVID-19 period was influential on new-onset depressive symptoms, 2) examine the relationship between sociodemographic and medical factors with the new-onset of depressive symptoms before and during the COVID-19 period in UK patients commencing CR.
    Methods: The national audit of cardiac rehabilitation (NACR) data were used and the two years of data before COVID-19 and during COVID-19 were analysed (Feb,2018 - Nov,2021). Hospital Anxiety and Depression Scale measurement was used to assess depressive symptoms. Bivariate analysis and logistic regression were conducted to examine the influence of the COVID-19 period on new-onset depressive symptoms and the patient characteristics associated with it.
    Results: 71055 patients screened for new-onset depressive symptoms were included in the analysis. Based on multivariate analysis, patients commencing CR during COVID-19 were 8% more likely to have new onset depressive symptoms compared to patients commencing before COVID-19. Smoking (OR: 1.26, 95%CI: 1.11, 1.43), physical inactivity (OR: 1.86, 95%CI: 1.74, 1.98), high anxiety (OR: 1.45, 95%CI: 1.44, 1.46), being male (OR: 1.21, 95%CI: 1.12, 1.30), single (OR: 1.25, 95%CI: 1.16, 1.35), having comorbidities of arthritis, diabetes, chronic bronchitis, emphysema, claudication (OR range: 1.19 to 1.60), receiving CABG treatment (OR: 1.47, 95%CI: 1.25, 1.73), and having heart failure (OR: 1.33, 95%CI: 1.19, 1.48) were the factors associated with having new-onset depressive symptoms at the start of CR.
    Conclusion: Our findings have shown that starting CR during the COVID-19 period was associated with increased odds of having new-onset depressive symptoms.
    MeSH term(s) Humans ; Male ; Female ; Cardiac Rehabilitation ; Depression/epidemiology ; Depression/diagnosis ; COVID-19 ; Comorbidity ; Anxiety/epidemiology
    Language English
    Publishing date 2023-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 80166-5
    ISSN 1879-1360 ; 0022-3999
    ISSN (online) 1879-1360
    ISSN 0022-3999
    DOI 10.1016/j.jpsychores.2023.111342
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  3. Article ; Online: Comparison of Transfix Screw Technique and Endobutton Technique in Terms of Tunnel Widening and Clinical Results in Anterior Cruciate Ligament Reconstruction

    Sever Çağlar

    Bagcilar Medical Bulletin, Vol 5, Iss 4, Pp 152-

    2020  Volume 159

    Abstract: ... for radiological comparison. Harner’s quadrant location, Frontal femoral tunnel angles and Frontal tibial tunnel ... difference in tunnel enlargement between two techniques (p>0.05). In the transfix technique, the HSKSS scores ...

    Abstract Objective:The aim of the present study was to compare transfix screw technique and endobutton technique in terms of femoral and tibial tunnel enlargement and clinical outcomes in anterior cruciate ligament (ACL) surgery and to discuss non-anatomic transtibial system under current circumstances.Method:This retrospective study was conducted on 50 patients who had ACL reconstruction in SCI Göztepe Training and Research Hospital between September, 1999 and March, 2003. Among the patients enrolled, 17 patients had endobutton and 33 had transfix screw technique for ACL reconstruction. The mean age of the patients who underwent ACL reconstruction through endobutton technique was 27.2 years whereas the mean age of those who had transfix screw method was 29.9 years. Femoral and tibial tunnel enlargement rates were reviewed for radiological comparison. Harner’s quadrant location, Frontal femoral tunnel angles and Frontal tibial tunnel angles were similar in both groups, and they were found comparable radiologically. The differences between the early postoperative and late postoperative tunnel widths of both groups were compared. Clinical comparison was performed through the Hospital for Special Surgery Knee score (HSSKS).Results:Tunnel widening was detected in a significant part of the cases who had both endobutton and transfix screw methods; and the cases with a tunnel dilatation difference at and over 2 mm were accepted as tunnel enlargement and evaluated in consideration of standard deviation. Consequently, significant tunnel enlargement was detected in 47% of the cases in endobutton continuous loop (CL) reconstruction group and in 51.5% of the cases in transfix screw technique group. There was not any statistically significant difference in tunnel enlargement between two techniques (p>0.05). In the transfix technique, the HSKSS scores of the patients with femoral tunnel width difference over 2 mm were 90.2 whereas in cases without femoral tunnel width or minimal, this score was 91.1. In Endobutton technique, HSKSS ...
    Keywords anterior cruciate ligament ; endobutton technique ; transfix technique ; transtibial technique ; tunnel widening ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2020-12-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
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  4. Article ; Online: Correction: The importance of a valid assessment of salt intake in individuals and populations. A scientific statement of the British and Irish Hypertension Society.

    Cappuccio, Francesco P / Sever, Peter S

    Journal of human hypertension

    2020  Volume 34, Issue 4, Page(s) 338

    Abstract: An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

    Abstract An amendment to this paper has been published and can be accessed via a link at the top of the paper.
    Language English
    Publishing date 2020-02-26
    Publishing country England
    Document type Published Erratum
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-020-0317-5
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  5. Article ; Online: Duodenocolic fistula healing by pentadecapeptide BPC 157 in rats. A cytoprotection viewpoint.

    Vukusic, D / Zenko Sever, A / Sever, M / Drmic, D / Milavic, M / Sikiric, S / Rasic, D / Krezic, I / Gojkovic, S / Prtoric, A / Bubalo, P / Coric, L / Dobric, I / Boban Blagaic, A / Rasic, Z / Skrtic, A / Seiwerth, S / Sikiric, P

    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society

    2024  Volume 75, Issue 1

    Abstract: Using duodenocolic fistula in rats, this study attempts to highlight the particular cytoprotection aspects of the healing of fistulas and therapy potential of the stable gastric pentadecapeptide BPC 157, a cytoprotection mediator (i.e. upgrading minor ... ...

    Abstract Using duodenocolic fistula in rats, this study attempts to highlight the particular cytoprotection aspects of the healing of fistulas and therapy potential of the stable gastric pentadecapeptide BPC 157, a cytoprotection mediator (i.e. upgrading minor vessels to induce healing at both fistula's sides). Upon duodenocolic fistula creation (two 'perforated' lesions put together) (assessed at 3, 6, 9, 12, and 15 min), BPC 157, given locally at the fistula, or intragastrically (10 μg/kg, 10 ng/kg), rapidly induces vessel 'recruitment', 'running' toward the defect, simultaneously at duodenum and colon, providing numerous collaterals and branching. The mRNA expression studies done at that time provided strongly elevated (nitric oxide synthase 2) and decreased (cyclooxygenase-2, vascular endothelial growth factor A, nitric oxide synthase (NOS)-1, NOS-3, nuclear factor-kappa-B-activating protein) gene expression. As therapy, rats with duodenocolic fistulas, received BPC 157 10 μg/kg, 10 ng/kg, per-orally, in drinking water till sacrifice, or alternatively, intraperitoneally, first application at 30 min after surgery, last at 24 h before sacrifice, at day 1, 3, 7, 14, 21, and 28. Controls exhibited both defects persisting, continuous fistula leakage, diarrhea, continuous weight loss, advanced adhesion formation and intestinal obstruction. Contrary, all BPC 157-treated rats have closed both defects, duodenal and colonic, no fistula leakage (finally, maximal instilled volume corresponds to healthy rats), no cachexia, the same weight as before surgery, no diarrhea, markedly less adhesion formation and intestinal passage obstruction. Thus, BPC 157 regimens resolve the duodenal/colon lesions and duodenocolic fistulas in rats, and rapid vessels recovery appears as the essential point in the implementation of the cytoprotection concept in the fistula therapy.
    MeSH term(s) Rats ; Animals ; Rats, Wistar ; Vascular Endothelial Growth Factor A ; Cytoprotection ; Fistula ; Peptide Fragments/pharmacology ; Peptide Fragments/therapeutic use ; Nitric Oxide Synthase ; Anti-Ulcer Agents/pharmacology ; Proteins
    Chemical Substances BPC 157 (8ED8NXK95P) ; Vascular Endothelial Growth Factor A ; Peptide Fragments ; Nitric Oxide Synthase (EC 1.14.13.39) ; Anti-Ulcer Agents ; Proteins
    Language English
    Publishing date 2024-04-03
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 1125221-2
    ISSN 1899-1505 ; 0867-5910 ; 0044-6033
    ISSN (online) 1899-1505
    ISSN 0867-5910 ; 0044-6033
    DOI 10.26402/jpp.2024.1.09
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    Zs.B 1358: Show issues Location:
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  6. Book ; Conference proceedings: Angiotensin II receptor antagonists

    Sever, Peter S.

    from science to clinical practice ; proceedings of a symposium to the 17th scientific meeting of the International Society of Hypertension, Amsterdam, June 7 - 11, 1998

    (Journal of human hypertension ; 13, Suppl. 1)

    1999  

    Institution International Society of Hypertension
    Author's details guest ed. Peter S. Sever
    Series title Journal of human hypertension ; 13, Suppl. 1
    Collection
    Keywords Angiotensin-II-Blocker
    Subject Angiotensin-II-Rezeptorantagonist ; AT2-Antagonist
    Language English
    Size S83 S. : Ill., graph. Darst.
    Publisher Stockton
    Publishing place Basingstoke
    Publishing country Great Britain
    Document type Book ; Conference proceedings
    HBZ-ID HT009980849
    Database Catalogue ZB MED Medicine, Health

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    Zs A 2380 -13,Suppl.1- not available for loan Zeitschriften-Lesesaal

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  7. Book ; Conference proceedings: Unexplored territories with calcium channel blockers - potential for the future

    Sever, Peter S.

    official satellite symposium for the XVIIIth congress of the European Society of Cardiology, the National Exhibition Centre, Birmingham, United Kingdom

    (Journal of cardiovascular pharmacology ; 33, Suppl. 2)

    1999  

    Institution European Society of Cardiology
    Author's details guest eds. Peter S. Sever
    Series title Journal of cardiovascular pharmacology ; 33, Suppl. 2
    Collection
    Language English
    Size VI, S22 S. : graph. Darst.
    Publisher Lippincott-Raven
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT010082970
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: Collective Domain Motion Facilitates Water Transport in SGLT1

    Marko Sever / Franci Merzel

    International Journal of Molecular Sciences, Vol 24, Iss 10528, p

    2023  Volume 10528

    Abstract: ... s of sample representative conformational states of SGLT1 and its complexes, with the natural ...

    Abstract The human sodium–glucose cotransporter protein (SGLT1) is an important representative of the sodium solute symporters belonging to the secondary active transporters that are critical to the homeostasis of sugar, sodium, and water in the cell. The underlying transport mechanism of SGLT1 is based on switching between inward- and outward-facing conformations, known as the alternating access model, which is crucial for substrate transport, and has also been postulated for water permeation. However, the nature of water transport remains unclear and is disputed along the passive and active transport, with the latter postulating the presence of the pumping effect. To better examine the water transport in SGLT1, we performed a series of equilibrium all-atom molecular dynamics simulations, totaling over 6 <semantics> μ </semantics> s of sample representative conformational states of SGLT1 and its complexes, with the natural substrates, ions, and inhibitors. In addition to elucidating the basic physical factors influencing water permeation, such as channel openings and energetics, we focus on dynamic flexibility and its relationship with domain motion. Our results clearly demonstrate a dependence of instantaneous water flux on the channel opening and local water diffusion in the channel, strongly supporting the existence of a passive water transport in SGLT1. In addition, a strong correlation found between the local water diffusion and protein domain motion, resembling the “rocking-bundle” motion, reveals its facilitating role in the water transport.
    Keywords molecular dynamics simulations ; SGLT1 protein ; transmembrane water transport ; diffusion ; intrinsic domain motion ; principal component analysis ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 612
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  9. Book ; Conference proceedings: Combination therapy - the comprehensive management of vulnerable hypertensive patients

    Sever, Peter S.

    proceedings of satellite symposium of the 8th European Meeting on Hypertension, June 13, 1997; Milan, Italy

    (Journal of cardiovascular pharmacology ; 31, Suppl. 2)

    1998  

    Event/congress European Meeting on Hypertension (8, 1997, Mailand)
    Author's details guest ed. P. Sever
    Series title Journal of cardiovascular pharmacology ; 31, Suppl. 2
    Collection
    Language English
    Size S44 S. : Ill., graph. Darst.
    Publisher Lippincott-Raven
    Publishing place Philadelphia u.a.
    Publishing country United States
    Document type Book ; Conference proceedings
    HBZ-ID HT008490842
    Database Catalogue ZB MED Medicine, Health

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  10. Article ; Online: Reply to Chiolero: Salt intake monitoring at a population level.

    Cappuccio, Francesco P / Sever, Peter S

    Journal of human hypertension

    2019  Volume 34, Issue 9, Page(s) 666–667

    MeSH term(s) Feeding Behavior ; Humans ; Hypertension/drug therapy ; Sodium ; Sodium Chloride, Dietary/adverse effects
    Chemical Substances Sodium Chloride, Dietary ; Sodium (9NEZ333N27)
    Language English
    Publishing date 2019-10-22
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 639472-3
    ISSN 1476-5527 ; 0950-9240
    ISSN (online) 1476-5527
    ISSN 0950-9240
    DOI 10.1038/s41371-019-0271-2
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