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  1. Article ; Online: Smartic: A smart tool for Big Data analytics and IoT.

    Sayeed, Shohel / Ahmad, Abu Fuad / Peng, Tan Choo

    F1000Research

    2024  Volume 11, Page(s) 17

    Abstract: The Internet of Things (IoT) is leading the physical and digital world of technology to converge. Real-time and massive scale connections produce a large amount of versatile data, where Big Data comes into the picture. Big Data refers to large, diverse ... ...

    Abstract The Internet of Things (IoT) is leading the physical and digital world of technology to converge. Real-time and massive scale connections produce a large amount of versatile data, where Big Data comes into the picture. Big Data refers to large, diverse sets of information with dimensions that go beyond the capabilities of widely used database management systems, or standard data processing software tools to manage within a given limit. Almost every big dataset is dirty and may contain missing data, mistyping, inaccuracies, and many more issues that impact Big Data analytics performances. One of the biggest challenges in Big Data analytics is to discover and repair dirty data; failure to do this can lead to inaccurate analytics results and unpredictable conclusions. Different imputation methods were employed in the experimentation with various missing value imputation techniques, and the performances of machine learning (ML) models were compared. A hybrid model that integrates ML and sample-based statistical techniques for missing value imputation is being proposed. Furthermore, the continuation involved the dataset with the best missing value imputation, chosen based on ML model performance for subsequent feature engineering and hyperparameter tuning. K-means clustering and principal component analysis were applied in our study. Accuracy, the evaluated outcome, improved dramatically and proved that the XGBoost model gives very high accuracy at around 0.125 root mean squared logarithmic error (RMSLE). To overcome overfitting, K-fold cross-validation was implemented.
    MeSH term(s) Data Science ; Internet of Things ; Machine Learning ; Software ; Longitudinal Studies
    Language English
    Publishing date 2024-02-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.73613.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Current situation and publication trends of skeletal muscle related research: A bibliometric analysis.

    Ahmad, Syed Sayeed / Choi, Inho

    Heliyon

    2024  Volume 10, Issue 3, Page(s) e24942

    Abstract: Skeletal muscle (SM) is a highly plastic and dynamic tissue of the body and is largely responsible for body maintenance. SM is primarily responsible for body balance, movement, postural support, thermogenesis, and blood glucose homeostasis. SM ... ...

    Abstract Skeletal muscle (SM) is a highly plastic and dynamic tissue of the body and is largely responsible for body maintenance. SM is primarily responsible for body balance, movement, postural support, thermogenesis, and blood glucose homeostasis. SM regeneration depends on the activation of muscle satellite (stem) cells (MSCs) under the regulation of several muscle regulatory factors that regulate myogenesis. Bibliometric analysis involves the quantitative and qualitative assessments of research and scientific progress that provides researchers access to recent publications, research directions, and thus generates ideas that can be implemented to guide future research. In this analysis, the Web of Science database was searched for articles using the search term "skeletal muscle AND myogenesis AND muscle satellite cell", and 1777 articles (original research/review articles) published from the year 1997 to June 2023 were retrieved. After applying several other exclusion and inclusion criteria, 129 articles were considered for analysis. Types of research, keywords, journals, authors, years, institutions, funding agencies, and average annual citations were analyzed. Muscle regeneration, satellite cell, and myogenesis were often used keywords and exhibited increasing trends in research articles over the decades. Some journals were found to strongly support research publications with high impact factors and citation scores. This study aimed to examine research ideas and growth in the skeletal muscle related field for atrophy and aging improvement.
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 2835763-2
    ISSN 2405-8440
    ISSN 2405-8440
    DOI 10.1016/j.heliyon.2024.e24942
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Analysis and Regulation of Traditional Indian Unani Medicines.

    Ahmad, Sayeed

    Journal of AOAC International

    2019  Volume 103, Issue 3, Page(s) 607–608

    MeSH term(s) Medicine, Ayurvedic ; Medicine, Traditional
    Language English
    Publishing date 2019-10-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1103149-9
    ISSN 1944-7922 ; 1060-3271
    ISSN (online) 1944-7922
    ISSN 1060-3271
    DOI 10.5740/jaoacint.19-0320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Potential profound fluctuation in tacrolimus concentration on consumption of pomegranate rind extract: A Pharmacokinetic Experiment.

    Karwasra, Ritu / Ahmad, Sayeed / Singh, Surender

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1140706

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1140706
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Amelioration of cyclophosphamide-induced DNA damage, oxidative stress, and hepato- and neurotoxicity by

    Yadav, Vaishali / Krishnan, Anuja / Zahiruddin, Sultan / Ahmad, Sayeed / Vohora, Divya

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1147823

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2023-03-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1147823
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Utilization of Quince

    Hanan, Entesar / Hasan, Nazeer / Zahiruddin, Sultan / Ahmad, Sayeed / Sharma, Vasudha / Ahmad, Farhan J

    ACS omega

    2023  Volume 8, Issue 43, Page(s) 40036–40050

    Abstract: Quince ( ...

    Abstract Quince (
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c00698
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Evaluations of FDA-approved drugs targeting 3CLP of SARS-CoV-2 employing a repurposing strategy.

    Ahmad, Syed Sayeed / Khalid, Mohammad

    Combinatorial chemistry & high throughput screening

    2022  

    Abstract: Background: The SARS-CoV-2 coronavirus (COVID-19) has raised innumerable global concerns, and few effective treatment strategy has yet been permitted by the FDA to lighten the disease burden. SARS-CoV-2 3C-like proteinase (3CLP) is a crucial protease ... ...

    Abstract Background: The SARS-CoV-2 coronavirus (COVID-19) has raised innumerable global concerns, and few effective treatment strategy has yet been permitted by the FDA to lighten the disease burden. SARS-CoV-2 3C-like proteinase (3CLP) is a crucial protease and plays a key role in the viral life cycle, as it controls replication, and thus, it is viewed as a target for drug design.
    Method: In this study, we performed structure-based virtual screening of FDA drugs approved during the period 2015-2019 (total 220 drugs) for interaction with the active site of 3CLP (PDB ID 6LU7) using AutoDock 4.2. We report the top ten drugs that outperform the reported drugs against 3CLP (Elbasvir and Nelfinavir), particularly Cefiderocol having the highest affinity among the compounds tested, with a binding energy of -9.97 kcal/mol. H-bond (LYS102:HZ2-ligand:O49), hydrophobic (ligand-VAL104), and electrostatic (LYS102:NZ-ligand:O50) interactions were observed in cefiderocol-3CLP complex. The docked complex was subjected to a 50 ns molecular dynamics study to check its stability, and stable RMSD and RMSF graphs were observed.
    Result: Accordingly, we suggest cefiderocol might be effective against SARS-CoV-2 and urge that experimental validation to be performed to determine the antiviral efficacy of cefiderocol against SARS-CoV-2.
    Discussion: Along with these, cefiderocol is effective for the treatment of respiratory tract pathogens and wide range of gram-negative bacteria for whom there are limited therapeutic alternatives.
    Conclusion: The aim of this article was to explore the FDA approved drugs as repurposing study against 3CLP for COVID-19 management.
    Language English
    Publishing date 2022-08-16
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2064785-2
    ISSN 1875-5402 ; 1386-2073
    ISSN (online) 1875-5402
    ISSN 1386-2073
    DOI 10.2174/1386207325666220816125639
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Therapeutic applications of biological macromolecules and scaffolds for skeletal muscle regeneration: A review.

    Ahmad, Syed Sayeed / Ahmad, Khurshid / Lim, Jeong Ho / Shaikh, Sibhghatulla / Lee, Eun Ju / Choi, Inho

    International journal of biological macromolecules

    2024  Volume 267, Issue Pt 2, Page(s) 131411

    Abstract: Skeletal muscle (SM) mass and strength maintenance are important requirements for human well-being. SM regeneration to repair minor injuries depends upon the myogenic activities of muscle satellite (stem) cells. However, losses of regenerative properties ...

    Abstract Skeletal muscle (SM) mass and strength maintenance are important requirements for human well-being. SM regeneration to repair minor injuries depends upon the myogenic activities of muscle satellite (stem) cells. However, losses of regenerative properties following volumetric muscle loss or severe trauma or due to congenital muscular abnormalities are not self-restorable, and thus, these conditions have major healthcare implications and pose clinical challenges. In this context, tissue engineering based on different types of biomaterials and scaffolds provides an encouraging means of structural and functional SM reconstruction. In particular, biomimetic (able to transmit biological signals) and several porous scaffolds are rapidly evolving. Several biological macromolecules/biomaterials (collagen, gelatin, alginate, chitosan, and fibrin etc.) are being widely used for SM regeneration. However, available alternatives for SM regeneration must be redesigned to make them more user-friendly and economically feasible with longer shelf lives. This review aimed to explore the biological aspects of SM regeneration and the roles played by several biological macromolecules and scaffolds in SM regeneration in cases of volumetric muscle loss.
    Language English
    Publishing date 2024-04-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131411
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Effect-Directed Assays and Biological Detection Approaches Coupled with Thin-Layer Chromatography as an Evolving Hyphenated Technique: A Comprehensive Review.

    Siddiquee, Zoya / Parveen, Rabea / Ahmad, Sayeed

    Combinatorial chemistry & high throughput screening

    2023  Volume 26, Issue 15, Page(s) 2679–2717

    Abstract: Background: Bioautography is a technique for the detection of biological activity that combines the elements of planar chromatography. Its hyphenated variants are widely used in the screening of natural products possessing biological activity. It can be ...

    Abstract Background: Bioautography is a technique for the detection of biological activity that combines the elements of planar chromatography. Its hyphenated variants are widely used in the screening of natural products possessing biological activity. It can be used in the activity-based screening of phytochemical ingredients by employing various enzyme processes and reactions and facilitates the rapid determination of bioactive compounds in pant samples.
    Objective: To give a comprehensive overview of effect-directed assays and biological detection approaches used in conjugation with thin layer chromatography technique. The present review article attempts to throw light on the various aspects of bioautography, including its types and applications, thereby giving its concise overview and its relevance in the field of natural product screening.
    Methods: Various search engines were used for the literature survey, including Google Scholar, Semantic Scholar, PubMed, ResearchGate and Scopus.
    Results: Bioautography has wide-ranging uses in the screening of compounds such as antioxidants, antifungals, antimicrobials, estrogenic, antitumors, and various enzyme inhibitors compounds like α and β-glucosidase inhibitors and α-amylase inhibitors.
    Conclusion: Bioautography serves to be an effective tool for the isolation of bioactive phytochemicals, thereby allowing us to scientifically validate the biological activities of various compounds, which can then be utilized for making potent medications for various diseases.
    MeSH term(s) Chromatography, Thin Layer/methods ; Anti-Infective Agents/pharmacology ; Enzyme Inhibitors ; Antioxidants/pharmacology ; Antioxidants/chemistry ; Plant Extracts/chemistry
    Chemical Substances Anti-Infective Agents ; Enzyme Inhibitors ; Antioxidants ; Plant Extracts
    Language English
    Publishing date 2023-04-10
    Publishing country United Arab Emirates
    Document type Review ; Journal Article
    ZDB-ID 2064785-2
    ISSN 1875-5402 ; 1386-2073
    ISSN (online) 1875-5402
    ISSN 1386-2073
    DOI 10.2174/1386207326666230406083555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: In-silico analysis reveals Quinic acid as a multitargeted inhibitor against Cervical Cancer.

    Ahmad, Shaban / Sayeed, Salwa / Bano, Nagmi / Sheikh, Kayenat / Raza, Khalid

    Journal of biomolecular structure & dynamics

    2022  Volume 41, Issue 19, Page(s) 9770–9786

    Abstract: The cervix is the lowermost part of the uterus that connects to the vagina, and cervical cancer is a malignant cervix tumour. One of this cancer's most important risk factors is HPV infection. In the approach to finding an effective treatment for this ... ...

    Abstract The cervix is the lowermost part of the uterus that connects to the vagina, and cervical cancer is a malignant cervix tumour. One of this cancer's most important risk factors is HPV infection. In the approach to finding an effective treatment for this disease, various works have been done around genomics and drug discovery. Finding the major altered genes was one of the most significant studies completed in the field of cervical cancer by TCGA (The Cancer Genome Atlas), and these genes are TGFBR2, MED1, ERBB3, CASP8, and HLA-A. The greatest genomic alterations were found in the PI3K/MAPK and TGF-Beta signalling pathways, suggesting that numerous therapeutic targets may come from these pathways in the future. We, therefore, conducted a combined enrichment analysis of genes gathered from various works of literature for this study. The final six key genes from the list were obtained after enrichment analysis using GO, KEGG, and Reactome methods. The six proteins against the identified genes were then subjected to a docking-based screening against a library of 6,87,843 prepared natural compounds from the ZINC15 database. The most stable compound was subsequently discovered through virtual screening to be the natural substance Quinic acid, which also had the highest binding affinity for all six proteins and a better docking score. To examine their stability, the study was extended to MM/GBSA and MD simulations on the six docked proteins, and comparative docking-based calculations led us to identify the Quinic Acid as a multitargeted compound. The overall deviation of the compound was less than 2 Å for all the complexes considered best for the biological molecules, and the simulation interaction analysis reveals a huge web of interaction during the simulation.Communicated by Ramaswamy H. Sarma.
    MeSH term(s) Female ; Humans ; Uterine Cervical Neoplasms/drug therapy ; Uterine Cervical Neoplasms/genetics ; Quinic Acid ; Computer Simulation ; Drug Discovery ; Genomics ; Molecular Docking Simulation ; Molecular Dynamics Simulation
    Chemical Substances Quinic Acid (058C04BGYI)
    Language English
    Publishing date 2022-11-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2022.2146202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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