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Article ; Online: Outcomes of COVID‑19 in solid organ transplant recipients: the need for treatment strategies and preventive measures.

Yi, Stephanie G

2021 Volume 131, Issue 11

MeSH term(s)	COVID-19 ; Humans ; Organ Transplantation ; SARS-CoV-2 ; Transplant Recipients
Language	English
Publishing date	2021-11-30
Publishing country	Poland
Document type	Editorial ; Comment
ZDB-ID	123500-x
ISSN	1897-9483 ; 0032-3772
ISSN (online)	1897-9483
ISSN	0032-3772
DOI	10.20452/pamw.16141
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Article ; Online: Patient Selection and Ethical Considerations-Justifying Combined Lung and Liver Transplantation.

Yi, Stephanie G

Transplantation

2019 Volume 103, Issue 8, Page(s) 1536–1537

MeSH term(s)	Humans ; Liver ; Liver Transplantation ; Living Donors ; Patient Selection ; Transplant Recipients
Language	English
Publishing date	2019-07-26
Publishing country	United States
Document type	Editorial ; Comment
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000002528
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: B-cell response in solid organ transplantation.

Yi, Stephanie G / Gaber, Ahmed Osama / Chen, Wenhao

Frontiers in immunology

2022 Volume 13, Page(s) 895157

Abstract: The transcriptional regulation of B-cell response to antigen stimulation is complex and involves an intricate network of dynamic signals from cytokines and transcription factors propagated from T-cell interaction. Long-term alloimmunity, in the setting ... ...

Abstract	The transcriptional regulation of B-cell response to antigen stimulation is complex and involves an intricate network of dynamic signals from cytokines and transcription factors propagated from T-cell interaction. Long-term alloimmunity, in the setting of organ transplantation, is dependent on this B-cell response, which does not appear to be halted by current immunosuppressive regimens which are targeted at T cells. There is emerging evidence that shows that B cells have a diverse response to solid organ transplantation that extends beyond plasma cell antibody production. In this review, we discuss the mechanistic pathways of B-cell activation and differentiation as they relate to the transcriptional regulation of germinal center B cells, plasma cells, and memory B cells in the setting of solid organ transplantation.
MeSH term(s)	B-Lymphocytes ; Germinal Center ; Graft Rejection ; Histocompatibility ; Organ Transplantation
Language	English
Publishing date	2022-08-09
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.895157
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Article ; Online: CD4

Zou, Dawei / Yin, Zheng / Yi, Stephanie G / Wang, Guohua / Guo, Yang / Xiao, Xiang / Li, Shuang / Zhang, Xiaolong / Gonzalez, Nancy M / Minze, Laurie J / Wang, Lin / Wong, Stephen T C / Osama Gaber, A / Ghobrial, Rafik M / Li, Xian C / Chen, Wenhao

Nature immunology

2024 Volume 25, Issue 1, Page(s) 66–76

Abstract: ... ...

Abstract	CD4
MeSH term(s)	Gene Expression Regulation ; Cell Differentiation ; T-Lymphocytes, Regulatory
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-023-01682-z
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Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Deceased donor vein extension grafts for right living donor kidney transplantation.

Meinders, Andrea M / Knight, Richard / Eagar, Todd N / Hobeika, Mark / Podder, Hemangshu / Gaber, A Osama / Yi, Stephanie G

Clinical transplantation

2023 Volume 37, Issue 8, Page(s) e14963

Abstract: Introduction: In an effort to maximize living donor kidney utilization, we describe the use of deceased donor vein extension grafts for right-sided living donor kidneys and report our single-center experience using this technique.: Methods: A ... ...

Abstract	Introduction: In an effort to maximize living donor kidney utilization, we describe the use of deceased donor vein extension grafts for right-sided living donor kidneys and report our single-center experience using this technique. Methods: A retrospective review of kidney transplant recipients (KTR) who received a right living donor kidney with deceased donor vein extension graft. Recipient demographics, postoperative graft function, and surgical complications were reviewed. Living donor nephrectomies were performed laparoscopically. Vein grafts were obtained from recent deceased donor procurements. End-to-end anastomosis of the graft to the renal vein was performed prior to implantation. Results: Thirty-eight KTR received a right kidney transplant with deceased donor extension grafts. The median recipient age and BMI were 53.0 years and 29.3 kg/m Conclusion: Utilization of deceased donor extension grafts for short right renal veins is a simple technique that expands the donor pool for living donor renal transplantation. Our experience resulted in no technical complications and excellent early graft function.
MeSH term(s)	Male ; Humans ; Female ; Kidney Transplantation/methods ; Living Donors ; Graft Survival ; Kidney ; Renal Veins/surgery ; Retrospective Studies ; Treatment Outcome
Language	English
Publishing date	2023-03-20
Publishing country	Denmark
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	639001-8
ISSN	1399-0012 ; 0902-0063
ISSN (online)	1399-0012
ISSN	0902-0063
DOI	10.1111/ctr.14963
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Article ; Online: A diversity of novel type-2 innate lymphoid cell subpopulations revealed during tumour expansion

Clara Wenjing Xia / Iryna Saranchova / Pablo L. Finkel / Stephanie Besoiu / Lonna Munro / Cheryl G. Pfeifer / Anne Haegert / Yen-Yi Lin / Stéphane Le Bihan / Colin Collins / Wilfred A. Jefferies

Communications Biology, Vol 7, Iss 1, Pp 1-

2024 Volume 15

Abstract: Abstract Type 2 innate lymphoid cells (ILC2s) perform vital functions in orchestrating humoral immune responses, facilitating tissue remodelling, and ensuring tissue homeostasis. Additionally, in a role that has garnered considerably less attention, ... ...

Abstract	Abstract Type 2 innate lymphoid cells (ILC2s) perform vital functions in orchestrating humoral immune responses, facilitating tissue remodelling, and ensuring tissue homeostasis. Additionally, in a role that has garnered considerably less attention, ILC2s can also enhance Th1-related cytolytic T lymphocyte immune responses against tumours. Studies have thus far generally failed to address the mystery of how one ILC2 cell-type can participate in a multiplicity of functions. Here we utilized single cell RNA sequencing analysis to create the first comprehensive atlas of naïve and tumour-associated lung ILC2s and discover multiple unique subtypes of ILC2s equipped with developmental gene programs that become skewed during tumour expansion favouring inflammation, antigen processing, immunological memory and Th1-related anti-tumour CTL responses. The discovery of these new subtypes of ILC2s challenges current paradigms of ILC2 biology and provides an explanation for their diversity of function.
Keywords	Biology (General) ; QH301-705.5
Subject code	616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A diversity of novel type-2 innate lymphoid cell subpopulations revealed during tumour expansion.

Xia, Clara Wenjing / Saranchova, Iryna / Finkel, Pablo L / Besoiu, Stephanie / Munro, Lonna / Pfeifer, Cheryl G / Haegert, Anne / Lin, Yen-Yi / Le Bihan, Stéphane / Collins, Colin / Jefferies, Wilfred A

Communications biology

2024 Volume 7, Issue 1, Page(s) 12

Abstract: Type 2 innate lymphoid cells (ILC2s) perform vital functions in orchestrating humoral immune responses, facilitating tissue remodelling, and ensuring tissue homeostasis. Additionally, in a role that has garnered considerably less attention, ILC2s can ... ...

Abstract	Type 2 innate lymphoid cells (ILC2s) perform vital functions in orchestrating humoral immune responses, facilitating tissue remodelling, and ensuring tissue homeostasis. Additionally, in a role that has garnered considerably less attention, ILC2s can also enhance Th1-related cytolytic T lymphocyte immune responses against tumours. Studies have thus far generally failed to address the mystery of how one ILC2 cell-type can participate in a multiplicity of functions. Here we utilized single cell RNA sequencing analysis to create the first comprehensive atlas of naïve and tumour-associated lung ILC2s and discover multiple unique subtypes of ILC2s equipped with developmental gene programs that become skewed during tumour expansion favouring inflammation, antigen processing, immunological memory and Th1-related anti-tumour CTL responses. The discovery of these new subtypes of ILC2s challenges current paradigms of ILC2 biology and provides an explanation for their diversity of function.
MeSH term(s)	Humans ; Immunity, Innate ; Lymphocytes ; Lung/pathology ; Inflammation/pathology ; Neoplasms/genetics ; Neoplasms/pathology
Language	English
Publishing date	2024-01-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2399-3642
ISSN (online)	2399-3642
DOI	10.1038/s42003-023-05536-0
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Article ; Online: Fiber and whole grain intakes in relation to liver cancer risk: An analysis in 2 prospective cohorts and systematic review and meta-analysis of prospective studies.

Watling, Cody Z / Wojt, Aika / Florio, Andrea A / Butera, Gisela / Albanes, Demetrius / Weinstein, Stephanie J / Huang, Wen-Yi / Parisi, Dominick / Zhang, Xuehong / Graubard, Barry I / Petrick, Jessica L / McGlynn, Katherine A

Hepatology (Baltimore, Md.)

2024

Abstract: ... grain intake; combined HRs for liver cancer risk were 0.83 (0.76-0.91) per 10 g/day of fiber and 0.92 (0 ... 85-0.99) per 16 g/day (1 serving) of whole grains.: Conclusions: Dietary fiber and whole grains ...

Abstract	Background and aims: The association between fiber or whole grain intakes and the risk of liver cancer remains unclear. We assessed the associations between fiber or whole grain intakes and liver cancer risk among 2 prospective studies, and systematically reviewed and meta-analyzed these results with published prospective studies. Approach and results: A total of 111,396 participants from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) and 26,085 men from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study were included. Intakes of total fiber and whole grains were estimated from validated food frequency questionnaires. Study-specific HRs and 95% CI with liver cancer risk were estimated using multivariable-adjusted Cox regression. We systematically reviewed existing literature, and studies were combined in a dose-response meta-analysis. A total of 277 (median follow-up = 15.6 y) and 165 (median follow-up = 16.0 y) cases of liver cancer were observed in Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial and Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, respectively. Dietary fiber was inversely associated with liver cancer risk in Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (HR 10g/day : 0.69; 95% CI: 0.55-0.86). No significant associations were observed between whole grain intakes and liver cancer risk in either study. Our meta-analysis included 2383 incident liver cancer cases (7 prospective cohorts) for fiber intake and 1523 cases (5 prospective cohorts) for whole grain intake; combined HRs for liver cancer risk were 0.83 (0.76-0.91) per 10 g/day of fiber and 0.92 (0.85-0.99) per 16 g/day (1 serving) of whole grains. Conclusions: Dietary fiber and whole grains were inversely associated with liver cancer risk. Further research exploring potential mechanisms and different fiber types is needed.
Language	English
Publishing date	2024-03-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	604603-4
ISSN	1527-3350 ; 0270-9139
ISSN (online)	1527-3350
ISSN	0270-9139
DOI	10.1097/HEP.0000000000000819
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Article ; Online: Accuracy of surveillance serum squamous cell carcinoma antigen for cervical cancer recurrence after definitive chemoradiation.

Shi, Victoria / Grover, Surbhi / Huang, Yi / Thaker, Premal H / Kuroki, Lindsay M / Powell, Matthew A / Mutch, David G / Contreras, Jessika A / Schwarz, Julie K / Grigsby, Perry W / Markovina, Stephanie

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society

2024

Abstract: Objective: Recurrence remains a significant clinical problem for patients with cervical cancer, and early detection may improve outcomes. Serum squamous cell carcinoma antigen (SCCA) is a biomarker of prognosis and response to chemoradiotherapy. We ... ...

Abstract	Objective: Recurrence remains a significant clinical problem for patients with cervical cancer, and early detection may improve outcomes. Serum squamous cell carcinoma antigen (SCCA) is a biomarker of prognosis and response to chemoradiotherapy. We hypothesized that elevated serum SCCA during surveillance is sensitive and specific for recurrence. Methods: Pre-treatment and follow-up serum SCCA from patients treated with definitive-intent radiotherapy were measured via enzyme-linked immunosorbent assay in a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory and analyzed retrospectively. Follow-up SCCA was defined as the value closest to recurrence, or as last available for patients without recurrence. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of follow-up SCCA for recurrence was determined for the whole cohort (Cohort 1), for patients with elevated (Cohort 2), and normal pre-treatment SCCA (Cohort 3). Patterns of failure were also evaluated. Results: Of 227 patients in Cohort 1, 23% experienced recurrence, and 17% died of cervical cancer. Mean follow-up SCCA was 0.9 (±2.5) for patients with no recurrence and 6.0 (±18.7) for patients with recurrence (p=0.02). Sensitivity, specificity, PPV, and NPV of follow-up SCCA for recurrence in Cohort 1 were 38.5%, 97.1%, 80%, and 84.2%, and for patients in Cohort 2 were 54.5%, 95%, 78.3%, and 86.5%, respectively. Four of 86 patients in Cohort 3 had an elevated follow-up SCCA, two of these at the time of recurrence. Elevated pre-treatment SCCA and follow-up SCCA were associated with isolated pelvic recurrence. Conclusions: Surveillance serum SCCA has high specificity and NPV for recurrence, and may be of limited utility in patients with normal pre-treatment SCCA.
Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1070385-8
ISSN	1525-1438 ; 1048-891X
ISSN (online)	1525-1438
ISSN	1048-891X
DOI	10.1136/ijgc-2024-005303
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Article ; Online: Resolution and b value dependent structural connectome in ex vivo mouse brain.

Crater, Stephanie / Maharjan, Surendra / Qi, Yi / Zhao, Qi / Cofer, Gary / Cook, James C / Johnson, G Allan / Wang, Nian

NeuroImage

2022 Volume 255, Page(s) 119199

Abstract: Diffusion magnetic resonance imaging has been widely used in both clinical and preclinical studies to characterize tissue microstructure and structural connectivity. The diffusion MRI protocol for the Human Connectome Project (HCP) has been developed and ...

Abstract	Diffusion magnetic resonance imaging has been widely used in both clinical and preclinical studies to characterize tissue microstructure and structural connectivity. The diffusion MRI protocol for the Human Connectome Project (HCP) has been developed and optimized to obtain high-quality, high-resolution diffusion MRI (dMRI) datasets. However, such efforts have not been fully explored in preclinical studies, especially for rodents. In this study, high quality dMRI datasets of mouse brains were acquired at 9.4T system from two vendors. In particular, we acquired a high-spatial resolution dMRI dataset (25 μm isotropic with 126 diffusion encoding directions), which we believe to be the highest spatial resolution yet obtained; and a high-angular resolution dMRI dataset (50 μm isotropic with 384 diffusion encoding directions), which we believe to be the highest angular resolution compared to the dMRI datasets at the microscopic resolution. We systematically investigated the effects of three important parameters that affect the final outcome of the connectome: b value (1000s/mm
MeSH term(s)	Animals ; Brain/diagnostic imaging ; Connectome/methods ; Diffusion Magnetic Resonance Imaging/methods ; Humans ; Image Processing, Computer-Assisted/methods ; Mice
Language	English
Publishing date	2022-04-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1147767-2
ISSN	1095-9572 ; 1053-8119
ISSN (online)	1095-9572
ISSN	1053-8119
DOI	10.1016/j.neuroimage.2022.119199
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