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Article ; Online: Finding a reliable assay for soluble neprilysin.

Liew, Oi Wah / Prickett, Timothy C R / Revuelta-López, Elena / Ling, Samantha S M / Cserkóová, Adriana / Lupón, Josep / Ng, Jessica Y X / Chong, Jenny P C / Lilyanna, Shera / Chan, Siew-Pang / Lin, Qifeng / Lim, Teck K / Lin, Qingsong / Barallat, Jaume / Bayés-Genís, Antoni / Richards, A Mark

Clinical biochemistry

2022 Volume 104, Page(s) 51–58

Abstract: Background: Lack of validation and standardization of research-use-only (RUO) immunoassays brings with it inherent threats to authenticity and functional quality. Poor correlation between different commercial neprilysin RUO immunoassays is concerning ... ...

Abstract	Background: Lack of validation and standardization of research-use-only (RUO) immunoassays brings with it inherent threats to authenticity and functional quality. Poor correlation between different commercial neprilysin RUO immunoassays is concerning and discordant findings need to be resolved. We seek to identify and validate reliable neprilysin immunoassays to strengthen the scientific rigor and reproducibility of neprilysin-related investigation and of biomarker research in general. Methods: Soluble neprilysin (sNEP) concentrations were determined in cohorts (n = 532) from Spain (Cohort 1), New Zealand (NZ, Cohort 2) and Singapore (Cohort 3), using commercial kits from six vendors. Apparent sNEP concentrations were correlated between different assays and with plasma neprilysin activity. Assay reliability was further validated by performance verification, MS analysis and cross-reactivity tests. Results: sNEP in Cohorts 1 and 2 measured concurrently in Spain and NZ showed significant inter-laboratory correlation only for the Aviscera Bioscience sNEP ELISA SK00724-01. Neprilysin concentrations obtained with the R&D systems and SK00724-01 ELISAs correlated with each other but not with neprilysin activity. In Cohort 3, sNEP concentrations from the Perkin Elmer AlphaLISA and Biotechne ELLA assays agreed (r = 0.89) and both correlated with neprilysin activity (r = 0.87, 0.77 respectively). MS analysis detected authentic neprilysin in the AlphaLISA kit calibrator and in antibody pull-down material from human plasma. The AlphaLISA assay performed within acceptable limits (spike and recovery, dilutional linearity, inter- and intra-assay CV) and showed no cross-reactivity against neprilysin substrates and closely-related analogues. Conclusion: AlphaLISA and ELLA assays provide reliable measures of sNEP concentrations. Reliability of other commercial neprilysin assays remains in question.
MeSH term(s)	Biomarkers ; Enzyme-Linked Immunosorbent Assay ; Heart Failure ; Humans ; Neprilysin ; Reproducibility of Results ; Spain
Chemical Substances	Biomarkers ; Neprilysin (EC 3.4.24.11)
Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	390372-2
ISSN	1873-2933 ; 0009-9120
ISSN (online)	1873-2933
ISSN	0009-9120
DOI	10.1016/j.clinbiochem.2022.03.004
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Article ; Online: Kidney abnormalities in sickle cell disease.

López Revuelta, K / Ricard Andrés, M P

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia

2011 Volume 31, Issue 5, Page(s) 591–601

Abstract: Patients with sickle cell disease exhibits numerous kidney structural and functional abnormalities, changes that are seen along the entire length of the nephron. Changes are most marked in patients with homozygous sickle cell anemia, but are also seen in ...

Abstract	Patients with sickle cell disease exhibits numerous kidney structural and functional abnormalities, changes that are seen along the entire length of the nephron. Changes are most marked in patients with homozygous sickle cell anemia, but are also seen in those with compound heterozygous states and the sickle cell trait. The renal features of sickle cell disease include some of the most common reasons for referral to nephrologists, such as hematuria, proteinuria, tubular disturbances and chronic kidney disease. Therapy of these conditions requires specialized knowledge of their distinct pathogenic mechanisms. Spanish Haemathology and Hemotherapy Association has recently publicated their Clinical Practice Guidelines of SCD management. Renal chapter is reproduced in this article for Nefrología difussion.
MeSH term(s)	Anemia, Sickle Cell/complications ; Carcinoma, Medullary/etiology ; Carcinoma, Medullary/pathology ; Cross-Sectional Studies ; Female ; Humans ; Kidney/pathology ; Kidney Diseases/diagnosis ; Kidney Diseases/epidemiology ; Kidney Diseases/etiology ; Kidney Diseases/pathology ; Kidney Diseases/therapy ; Kidney Neoplasms/etiology ; Kidney Neoplasms/pathology ; Kidney Transplantation ; Male ; Practice Guidelines as Topic ; Pregnancy ; Pregnancy Complications/etiology ; Prospective Studies ; Renal Replacement Therapy ; Sickle Cell Trait/complications ; Urinary Tract Infections/complications
Language	Spanish
Publishing date	2011
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	632512-9
ISSN	1989-2284 ; 0211-6995
ISSN (online)	1989-2284
ISSN	0211-6995
DOI	10.3265/Nefrologia.pre2011.Feb.10737
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Article: Presente de la historia clínica electrónica en nefrología ambulatoria.

López-Revuelta, K / Fernández-Juárez, G / Barba Martín, R / Tomás Pin, A / González-González, L / Portolés Pérez, J M

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia

2006 Volume 26 Suppl 3, Page(s) 103–108

Title translation	Current status of the electronic clinical record in outpatient nephrology.
MeSH term(s)	Ambulatory Care/organization & administration ; Forms and Records Control ; Humans ; Information Management ; Information Services ; Interdisciplinary Communication ; Kidney Diseases/therapy ; Medical Records Systems, Computerized/statistics & numerical data ; Medical Records Systems, Computerized/trends ; Nephrology/organization & administration ; Patient Care Team ; Primary Health Care/organization & administration ; Software
Language	Spanish
Publishing date	2006
Publishing country	Spain
Document type	Journal Article ; Review
ZDB-ID	632512-9
ISSN	1989-2284 ; 0211-6995
ISSN (online)	1989-2284
ISSN	0211-6995
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Article: The coexistence of diabetic retinopathy and diabetic nephropathy is associated with worse kidney outcomes.

Bermejo, Sheila / González, Ester / López-Revuelta, Katia / Ibernon, Meritxell / López, Diana / Martín-Gómez, Adoración / Garcia-Osuna, Rosa / Linares, Tania / Díaz, Montserrat / Martín, Nàdia / Barros, Xoana / Marco, Helena / Navarro, Maruja Isabel / Esparza, Noemí / Elias, Sandra / Coloma, Ana / Robles, Nicolás Roberto / Agraz, Irene / Poch, Esteban /

Rodas, Lida / Lozano, Víctor / Fernández-Fernández, Beatriz / Hernández, Eduardo / Martínez, Maria Isabel / Stanescu, Ramona Ionela / Moirón, José Pelayo / García-Fernández, Núria / Goicoechea, Marian / Calero, Francesca / Bonet, Josep / Liaño, Fernando / Pascual, Julio / Bestard, Oriol / Praga, Manuel / Fulladosa, Xavier / Soler, María José

Clinical kidney journal

2023 Volume 16, Issue 10, Page(s) 1656–1663

Abstract: Background: Up to 50-60% of patients with diabetes have non-diabetic kidney disease (NDKD) on kidney biopsy. Diabetic retinopathy (DR) is a microvascular complication of diabetes frequently associated with diabetic nephropathy (DN). The objective of the ...

Abstract	Background: Up to 50-60% of patients with diabetes have non-diabetic kidney disease (NDKD) on kidney biopsy. Diabetic retinopathy (DR) is a microvascular complication of diabetes frequently associated with diabetic nephropathy (DN). The objective of the current study was to investigate the kidney outcomes and survival in patients with biopsy diagnoses of DN and NDKD according to the presence of DR. Methods: We conducted an observational, multicentre and retrospective study of the pathological findings of renal biopsies from 832 consecutive patients with diabetes from 2002 to 2014 from 18 nephrology departments. The association of DR with kidney replacement therapy (KRT) or survival was assessed by Kaplan-Meier and Cox regression analyses. Results: Of 832 patients with diabetes and renal biopsy, 768 had a retinal examination and 221/768 (22.6%) had DR. During a follow-up of 10 years, 288/760 (37.9%) patients with follow-up data needed KRT and 157/760 (20.7%) died. The incidence of KRT was higher among patients with DN (alone or with NDKD) and DR [103/175 (58.9%)] than among patients without DR [88/216 (40.7%), Conclusions: DR is associated with a higher risk of progression to kidney failure in patients with histological DN and in patients with NDKD.
Language	English
Publishing date	2023-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2655800-2
ISSN	2048-8513 ; 2048-8505
ISSN (online)	2048-8513
ISSN	2048-8505
DOI	10.1093/ckj/sfad142
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Article ; Online: Late thrombotic complications after SARS-CoV-2 infection in hemodialysis patients.

Shabaka, Amir / Gruss, Enrique / Landaluce-Triska, Eugenia / Gallego-Valcarce, Eduardo / Cases-Corona, Clara / Ocaña, Javier / Tato-Ribera, Ana / Lopez-Revuelta, Katia / Furaz-Czerpak, Karina R / Fernández-Juárez, Gema

Hemodialysis international. International Symposium on Home Hemodialysis

2021 Volume 25, Issue 4, Page(s) 507–514

Abstract: Introduction: There is an increased risk of thrombotic complications in patients with COVID-19. Hemodialysis patients are already at an increased risk for thromboembolic events such as stroke and pulmonary embolism. The aim of our study was to determine ...

Abstract	Introduction: There is an increased risk of thrombotic complications in patients with COVID-19. Hemodialysis patients are already at an increased risk for thromboembolic events such as stroke and pulmonary embolism. The aim of our study was to determine the incidence of late thrombotic complications (deep vein thrombosis, pulmonary embolism, stroke, new-onset vascular access thrombosis) in maintenance hemodialysis patients after recovery from COVID-19. Methods: We performed a retrospective cohort study of 200 prevalent hemodialysis patients in our center at the start of the pandemic. We excluded incident patients after the cohort entry date and those who required hemodialysis for acute kidney injury, and excluded patients with less than 1 month follow-up due to kidney transplantation or death from non-thrombotic causes. Findings: One-hundred and eighty five prevalent hemodialysis patients finally met the inclusion criteria; 37 patients (17.6%) had SARS-CoV-2 infection, out of which 10 (27%) died during the acute phase of disease without evidence of thrombotic events. There was an increased risk of thrombotic events in COVID-19 survivors compared to the non-infected cohort (18.5% vs. 1.9%, p = 0.002) after a median follow-up of 7 months. Multivariate regression analysis showed that COVID-19 infection increased risk for late thrombotic events adjusted for age, sex, hypertension, diabetes, antithrombotic treatment, and previous thrombotic events (Odds Ratio (OR) 26.4, 95% confidence interval 2.5-280.6, p = 0.01). Clinical and laboratory markers did not predict thrombotic events. Conclusions: There is an increased risk of late thrombotic complications in hemodialysis patients after infection with COVID-19. Further studies should evaluate the benefit of prolonged prophylactic anticoagulation in hemodialysis patients after recovery from COVID-19.
MeSH term(s)	Anticoagulants ; COVID-19 ; Humans ; Renal Dialysis/adverse effects ; Retrospective Studies ; SARS-CoV-2 ; Thrombosis/epidemiology ; Thrombosis/etiology
Chemical Substances	Anticoagulants
Language	English
Publishing date	2021-05-31
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2192458-2
ISSN	1542-4758 ; 1492-7535
ISSN (online)	1542-4758
ISSN	1492-7535
DOI	10.1111/hdi.12935
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Article: Aplicación de la gestión por procesos en nefrología. Gestión del proceso hemodiálisis.

López-Revuelta, K / Lorenzo, S / Gruss, E / Garrido, M V / Moreno Barbas, J A

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia

2002 Volume 22, Issue 4, Page(s) 329–339

Abstract: Total Quality Management techniques have recently been introduced into clinical practice. We describe the application of process management to hemodialysis therapy in a Spanish public hospital. The "ownership" of the hemodialysis process and its limits ... ...

Title translation	Application of process management in nephrology. Hemodialysis process management.
Abstract	Total Quality Management techniques have recently been introduced into clinical practice. We describe the application of process management to hemodialysis therapy in a Spanish public hospital. The "ownership" of the hemodialysis process and its limits have been defined. We present a flowchart with all the activities involved in the process and the task description. Monitoring indicators have been selected according to the recommendations of the US Committee on the National Report on Health Care Delivery. Data sources for indicators have also been described.
MeSH term(s)	Hemodialysis Units, Hospital/organization & administration ; Hemodialysis Units, Hospital/utilization ; Hospitals, Public/organization & administration ; Hospitals, Public/utilization ; Humans ; Kidney Failure, Chronic/therapy ; Practice Guidelines as Topic ; Process Assessment (Health Care) ; Quality Assurance, Health Care ; Renal Dialysis/standards ; Renal Dialysis/utilization ; Software Design ; Spain ; Total Quality Management
Language	Spanish
Publishing date	2002-10-06
Publishing country	Spain
Document type	Journal Article
ZDB-ID	632512-9
ISSN	1989-2284 ; 0211-6995
ISSN (online)	1989-2284
ISSN	0211-6995
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Article: Implantación de sistemas de gestión de calidad en las unidades de nefrología españolas.

Arenas, M D / Lorenzo, S / Alvarez-Ude, F / Angoso, M / López-Revuelta, K / Aranaz, J

Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia

2006 Volume 26, Issue 2, Page(s) 234–245

Abstract: Objective: The aim of this study was to evaluate and analyze the implementation of a Quality Management Systems (QMS) and the use of Clinical Performance measures by the Nephrology Services and Hemodialysis Units in Spain.: Method: The Quality ... ...

Title translation	Quality control systems implementation in the Spanish Dialysis Units.
Abstract	Objective: The aim of this study was to evaluate and analyze the implementation of a Quality Management Systems (QMS) and the use of Clinical Performance measures by the Nephrology Services and Hemodialysis Units in Spain. Method: The Quality Management Work Group of the Spanish Society of Nephrology (SEN) realized a survey that was directed to all the Spanish Nephrology Services and Hemodialysis Units. No exclusion criteria were defined for the study. The survey was based on a multichotomous self completing "Ad Hoc" questionnaire. Results: The survey was answered by 46.7% of the polled centers (44.5% were public hospitals and 55.5% private centers). Of those replying the survey 70 % had a QMS, with a higher implementation in the area of Hemodialysis (HD). The ISO 9001-2000 was the prefer QMS model chosen by 76.4% of the centers. 68.6% of the centers with a QMS were certified by an external Auditing Group. 91.7% of the Nephrology Services and Hemodialysis units were using some clinical practice guideline. A high percentage of the centers had medical protocols and nursing plans (> 90%). A significantly higher implementation of QMS was observed in Private Hospitals and Hemodialysis Units (88.8 %) when compared to public Hospitals (46.1%) (X2: 31.5; p < 0.001). The ISO 9000 Standard certification was selected by 78,3% of the private centers and by 21,7% of the public centers (X2: 37.3; p < 0.001). The certification or accreditation were done by an external auditing group in 68. 1% of the private centers compared to 31.9% for the public Hospitals (X2: 24.8; p < 0.001). Although the rate of answers prevents from extracting definitive conclusions, the result seems to indicate that in the Spanish Nephrology Community a clear trend exists towards the use QMS. This tendency suggests, that in the near future, there will be a progressive implementation and routine use of QMS in the Nephrology Community in Spain.
MeSH term(s)	Hemodialysis Units, Hospital/standards ; Quality Control ; Renal Dialysis/standards ; Spain ; Surveys and Questionnaires
Language	Spanish
Publishing date	2006
Publishing country	Spain
Document type	English Abstract ; Journal Article ; Multicenter Study
ZDB-ID	632512-9
ISSN	1989-2284 ; 0211-6995
ISSN (online)	1989-2284
ISSN	0211-6995
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Article ; Online: Phenomenology of summer ozone episodes over the Madrid Metropolitan Area, central Spain

X. Querol / A. Alastuey / G. Gangoiti / N. Perez / H. K. Lee / H. R. Eun / Y. Park / E. Mantilla / M. Escudero / G. Titos / L. Alonso / B. Temime-Roussel / N. Marchand / J. R. Moreta / M. A. Revuelta / P. Salvador / B. Artíñano / S. García dos Santos / M. Anguas /

A. Notario / A. Saiz-Lopez / R. M. Harrison / M. Millán / K.-H. Ahn

Atmospheric Chemistry and Physics, Vol 18, Pp 6511-

2018 Volume 6533

Abstract: Various studies have reported that the photochemical nucleation of new ultrafine particles (UFPs) in urban environments within high insolation regions occurs simultaneously with high ground ozone (O 3 ) levels. In this work, we evaluate the atmospheric ... ...

Abstract	Various studies have reported that the photochemical nucleation of new ultrafine particles (UFPs) in urban environments within high insolation regions occurs simultaneously with high ground ozone (O 3 ) levels. In this work, we evaluate the atmospheric dynamics leading to summer O 3 episodes in the Madrid air basin (central Iberia) by means of measuring a 3-D distribution of concentrations for both pollutants. To this end, we obtained vertical profiles (up to 1200 m above ground level) using tethered balloons and miniaturised instrumentation at a suburban site located to the SW of the Madrid Metropolitan Area (MMA), the Majadahonda site (MJDH), in July 2016. Simultaneously, measurements of an extensive number of air quality and meteorological parameters were carried out at three supersites across the MMA. Furthermore, data from O 3 soundings and daily radio soundings were also used to interpret atmospheric dynamics. The results demonstrate the concatenation of venting and accumulation episodes, with relative lows (venting) and peaks (accumulation) in O 3 surface levels. Regardless of the episode type, the fumigation of high-altitude O 3 (arising from a variety of origins) contributes the major proportion of surface O 3 concentrations. Accumulation episodes are characterised by a relatively thinner planetary boundary layer (< 1500 m at midday, lower in altitude than the orographic features), light synoptic winds, and the development of mountain breezes along the slopes of the Guadarrama Mountain Range (located W and NW of the MMA, with a maximum elevation of > 2400 m a.s.l.). This orographic–meteorological setting causes the vertical recirculation of air masses and enrichment of O 3 in the lower tropospheric layers. When the highly polluted urban plume from Madrid is affected by these dynamics, the highest O x (O 3 + NO 2 ) concentrations are recorded in the MMA. Vertical O 3 profiles during venting episodes, with strong synoptic winds and a deepening of the planetary boundary layer reaching > 2000 m ...
Keywords	Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	290
Language	English
Publishing date	2018-05-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
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Article ; Online: Effect of Immunosuppressive Treatments on Kidney Outcomes After Gross Hematuria-Related Acute Kidney Injury in Older Patients With IgA Nephropathy.

Sevillano, Angel M / Caravaca-Fontán, Fernando / Cordero Garcia-Galan, Lucia / Fernandez-Juarez, Gema / Lopez-Revuelta, Katia / Guzmán, Diomaris A / Martín-Reyes, Guillermo / Quintana, Luis F / Rodas, Lida M / Sanchez de la Nieta, Maria Dolores / Rabasco, Cristina / Espinosa, Mario / Diaz-Encarnación, Monserrat / San Miguel, Luz / Barrios, Clara / Rodriguez, Eva / Garcia, Patricia / Valera, Alfonso / Peña, Jessy-Korina /

Shabaka, Amir / Velo, Mercedes / Sierra, Milagros / Gonzalez, Fayna / Fernandez-Reyes, Maria José / Heras, Manuel / Delgado, Patricia / Gutierrez, Eduardo / Moreno, Juan Antonio / Praga, Manuel

Kidney international reports

2023 Volume 8, Issue 8, Page(s) 1596–1604

Abstract: Introduction: Macroscopic hematuria (MH) bouts, frequently accompanied by acute kidney injury (AKI-MH) are one of the most common presentations of IgA nephropathy (IgAN) in the elderly. Immunosuppressive therapies are used in clinical practice; however, ...

Abstract	Introduction: Macroscopic hematuria (MH) bouts, frequently accompanied by acute kidney injury (AKI-MH) are one of the most common presentations of IgA nephropathy (IgAN) in the elderly. Immunosuppressive therapies are used in clinical practice; however, no studies have analyzed their efficacy on kidney outcomes. Methods: This is a retrospective, multicenter study of a cohort of patients aged ≥50 years with biopsy-proven IgAN presenting with AKI-MH. Outcomes were complete, partial, or no recovery of kidney function at 1 year after AKI-MH, and kidney survival at 1, 2, and 5 years. Propensity score matching (PSM) analysis was applied to balance baseline differences between patients treated with immunosuppression and those not treated with immunosuppression. Results: The study group consisted of 91 patients with a mean age of 65 ± 15 years, with a mean follow-up of 59 ± 36 months. Intratubular red blood cell (RBC) casts and acute tubular necrosis were found in all kidney biopsies. The frequency of endocapillary hypercellularity and crescents were low. Immunosuppressive therapies (corticosteroids alone or combined with mycophenolate mofetil or cyclophosphamide) were prescribed in 52 (57%) patients, whereas 39 (43%) received conservative treatment. There were no significant differences in the proportion of patients with complete, partial, or no recovery of kidney function at 1 year between patients treated with immunosuppression and those not treated with immunosuppression (29% vs. 36%, 30.8% vs. 20.5% and 40.4 % vs. 43.6%, respectively). Kidney survival at 1, 3, and 5 years was similar among treated and untreated patients (85% vs. 81%, 77% vs. 76% and 72% vs. 66%, respectively). Despite the PSM analysis, no significant differences were observed in kidney survival between the two groups. Fourteen patients (27%) treated with immunosuppression had serious adverse events. Conclusions: Immunosuppressive treatments do not modify the unfavorable prognosis of patients with IgAN who are aged ≥50 years presenting with AKI-MH, and are frequently associated with severe complications.
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Journal Article
ISSN	2468-0249
ISSN (online)	2468-0249
DOI	10.1016/j.ekir.2023.05.027
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Article: Diabetic Nephropathy without Diabetes.

López-Revuelta, Katia / Abreu, Angel A Méndez / Gerrero-Márquez, Carmen / Stanescu, Ramona-Ionela / Marín, Maria Isabel Martínez / Fernández, Elia Pérez

Journal of clinical medicine

2015 Volume 4, Issue 7, Page(s) 1403–1427

Abstract: Diabetic nephropathy without diabetes (DNND), previously known as idiopathic nodular glomerulosclerosis, is an uncommon entity and thus rarely suspected; diagnosis is histological once diabetes is discarded. In this study we describe two new cases of ... ...

Abstract	Diabetic nephropathy without diabetes (DNND), previously known as idiopathic nodular glomerulosclerosis, is an uncommon entity and thus rarely suspected; diagnosis is histological once diabetes is discarded. In this study we describe two new cases of DNND and review the literature. We analyzed all the individualized data of previous publications except one series of attached data. DNND appears to be favored by recognized cardiovascular risk factors. However, in contrast with diabetes, apparently no factor alone has been demonstrated to be sufficient to develop DNND. Other factors not considered as genetic and environmental factors could play a role or interact. The most plausible hypothesis for the occurrence of DNND would be a special form of atherosclerotic or metabolic glomerulopathy than can occur with or without diabetes. The clinical spectrum of cardiovascular risk factors and histological findings support this theory, with hypertension as one of the characteristic clinical features.
Language	English
Publishing date	2015-07-09
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm4071403
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