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  1. Article ; Online: Does ChatGPT Help Us Understand the Medical Literature?

    Lemley, Kevin V

    Journal of the American Society of Nephrology : JASN

    2023  Volume 35, Issue 2, Page(s) 232–233

    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3344: Show issues Location:
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  2. Article ; Online: APRIL - Springtime for New IgA Nephropathy Therapy?

    Lemley, Kevin V / Glassock, Richard J

    The New England journal of medicine

    2024  Volume 390, Issue 1, Page(s) 80–81

    MeSH term(s) Humans ; Glomerulonephritis, IGA/drug therapy ; Immunoglobulin A ; Clinical Trials as Topic
    Chemical Substances Immunoglobulin A
    Language English
    Publishing date 2024-01-03
    Publishing country United States
    Document type Editorial
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe2312300
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Kidney Fibrosis Assessment by CT Using Machine Learning.

    Lemley, Kevin V

    Kidney360

    2022  Volume 3, Issue 1, Page(s) 1–2

    MeSH term(s) Fibrosis ; Humans ; Kidney/diagnostic imaging ; Kidney Diseases ; Machine Learning ; Tomography, X-Ray Computed
    Language English
    Publishing date 2022-01-27
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0007262021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An Introduction to Stereology with Applications to the Glomerulus.

    Lemley, Kevin V

    Glomerular diseases

    2021  Volume 1, Issue 4, Page(s) 294–301

    Abstract: Background: Stereology is the science of inferring quantitative features of 3-dimensional structures from lower dimensional samples of those structures (probes). It is a statistical discipline and therefore may seem intimidating to many potential users. ...

    Abstract Background: Stereology is the science of inferring quantitative features of 3-dimensional structures from lower dimensional samples of those structures (probes). It is a statistical discipline and therefore may seem intimidating to many potential users. Without a proper understanding of its principles, though, errors may be made in the quantitative reporting of structural research results.
    Summary: This review article attempts to explain and justify the basic principles of stereology as applied to the glomerulus in a simple and accessible way. A few common errors in application are described. The strengths and weaknesses of "biased" (model-based) stereology are described as well as the basics of design-based ("unbiased") stereology.
    Key messages: Stereology is a useful body of theory and practices when quantitation of structural histological features of the glomerulus is desired.
    Language English
    Publishing date 2021-09-21
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 2673-3633
    ISSN (online) 2673-3633
    DOI 10.1159/000519719
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Machine Learning Comes to Nephrology.

    Lemley, Kevin V

    Journal of the American Society of Nephrology : JASN

    2019  Volume 30, Issue 10, Page(s) 1780–1781

    MeSH term(s) Algorithms ; Diabetic Nephropathies ; Humans ; Machine Learning ; Nephrology
    Language English
    Publishing date 2019-09-05
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.2019070664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3344: Show issues Location:
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  6. Article ; Online: Mechanical challenges to the glomerulus and podocyte loss: evolution of a paradigm.

    Lemley, Kevin V

    Pflugers Archiv : European journal of physiology

    2017  Volume 469, Issue 7-8, Page(s) 959–963

    Abstract: In this article, I shall outline some of the most important aspects of the evidentiary basis of the so-called Kriz model for the development of glomerular sclerosis, a model that we continue to modify to this day. In my mind, the most important findings ... ...

    Abstract In this article, I shall outline some of the most important aspects of the evidentiary basis of the so-called Kriz model for the development of glomerular sclerosis, a model that we continue to modify to this day. In my mind, the most important findings include the fact that podocytes are generally post-mitotic cells, so that loss of a significant number for any cause leads to podocyte insufficiency. Another pivotal finding is that in many experimental models and in human disease, podocytes detach from the GBM as living cells. These facts, together with biomechanical deduction, have led to the ongoing evolution of the original Heidelberg model.
    Language English
    Publishing date 2017-08
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 6380-0
    ISSN 1432-2013 ; 0031-6768
    ISSN (online) 1432-2013
    ISSN 0031-6768
    DOI 10.1007/s00424-017-2012-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Loss of Glomerular Permselectivity in Type 2 Diabetes Associates With Progression to Kidney Failure.

    Saulnier, Pierre J / Looker, Helen C / Layton, Anita / Lemley, Kevin V / Nelson, Robert G / Bjornstad, Petter

    Diabetes

    2023  Volume 72, Issue 11, Page(s) 1682–1691

    MeSH term(s) Humans ; Adult ; Middle Aged ; Diabetes Mellitus, Type 2/complications ; Glycated Hemoglobin ; Kidney Glomerulus ; Kidney Diseases ; Albuminuria ; Glomerular Filtration Rate ; Renal Insufficiency/etiology
    Chemical Substances Glycated Hemoglobin
    Language English
    Publishing date 2023-08-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80085-5
    ISSN 1939-327X ; 0012-1797
    ISSN (online) 1939-327X
    ISSN 0012-1797
    DOI 10.2337/db23-0310
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Glomerular pathology and the progression of chronic kidney disease.

    Lemley, Kevin V

    American journal of physiology. Renal physiology

    2016  Volume 310, Issue 11, Page(s) F1385–8

    Abstract: Structural studies of the glomerulus, largely undertaken in animal models, have informed our understanding of the progression of chronic kidney disease (CKD) for decades. A fundamental tenet of that understanding is that a loss of podocytes underlies ... ...

    Abstract Structural studies of the glomerulus, largely undertaken in animal models, have informed our understanding of the progression of chronic kidney disease (CKD) for decades. A fundamental tenet of that understanding is that a loss of podocytes underlies progression in many or most cases of progressive CKD. Recent attempts have been made to reconcile earlier findings from glomerular physiology (the primacy of glomerular capillary hypertension in causation of secondary glomerular sclerosis) with structural findings and have suggested a more detailed model of the mechanisms underlying podocyte detachment as viable cells. A new appreciation of the main locus of mechanical challenges to the podocyte (in the filtration slit) may both explain the renoprotective action of some current therapies and help to suggest novel therapeutic strategies.
    MeSH term(s) Animals ; Disease Models, Animal ; Disease Progression ; Humans ; Kidney Glomerulus/pathology ; Podocytes/pathology ; Renal Insufficiency, Chronic/pathology
    Language English
    Publishing date 2016-06-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00099.2016
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  9. Article ; Online: An unusual case of hypercalcemia in a patient with renal insufficiency.

    Lemley, Kevin V

    Pediatric nephrology (Berlin, Germany)

    2013  Volume 29, Issue 9, Page(s) 1529–1533

    MeSH term(s) Antibodies, Antineutrophil Cytoplasmic/immunology ; Autoimmune Diseases/complications ; Female ; Glomerulonephritis/complications ; Glomerulonephritis/immunology ; Humans ; Hypercalcemia/etiology ; Renal Insufficiency, Chronic/complications ; Thyroid Diseases/complications ; Thyrotoxicosis/complications ; Young Adult
    Chemical Substances Antibodies, Antineutrophil Cytoplasmic
    Language English
    Publishing date 2013-09-14
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 631932-4
    ISSN 1432-198X ; 0931-041X
    ISSN (online) 1432-198X
    ISSN 0931-041X
    DOI 10.1007/s00467-013-2611-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2196: Show issues Location:
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  10. Article ; Online: LMX1B mutations with nails and kneecaps: a new paradigm?

    Lemley, Kevin V

    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

    2013  Volume 29, Issue 1, Page(s) 9–12

    MeSH term(s) Humans ; LIM-Homeodomain Proteins/genetics ; Mutation ; Nail-Patella Syndrome/genetics ; Nails ; Transcription Factors/genetics
    Chemical Substances LIM homeobox transcription factor 1 beta ; LIM-Homeodomain Proteins ; Transcription Factors
    Language English
    Publishing date 2013-10-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 90594-x
    ISSN 1460-2385 ; 0931-0509
    ISSN (online) 1460-2385
    ISSN 0931-0509
    DOI 10.1093/ndt/gft418
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