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Article ; Online: The H

Mons, Cécile / Botzanowski, Thomas / Nikolaev, Anton / Hellwig, Petra / Cianférani, Sarah / Lescop, Ewen / Bouton, Cécile / Golinelli-Cohen, Marie-Pierre

Biochemistry

2018 Volume 57, Issue 38, Page(s) 5616–5628

Abstract: Human mitoNEET (mNT) is the first identified Fe-S protein of the mammalian outer mitochondrial membrane. Recently, we demonstrated the involvement of mNT in a specific cytosolic pathway dedicated to the reactivation of oxidatively damaged cytosolic ... ...

Abstract	Human mitoNEET (mNT) is the first identified Fe-S protein of the mammalian outer mitochondrial membrane. Recently, we demonstrated the involvement of mNT in a specific cytosolic pathway dedicated to the reactivation of oxidatively damaged cytosolic aconitase by cluster transfer. In vitro studies using apo-ferredoxin (FDX) reveal that mNT uses an Fe-based redox switch mechanism to regulate the transfer of its cluster. Using the "gold standard" cluster recipient protein, FDX, we show that this transfer is direct and that only one of the two mNT clusters is transferred when the second one is decomposed. Combining complementary biophysical and biochemical approaches, we show that pH affects both the sensitivity of the cluster to O
MeSH term(s)	Ferredoxins/chemistry ; Ferredoxins/metabolism ; Humans ; Hydrogen Peroxide/metabolism ; Hydrogen-Ion Concentration ; Iron/metabolism ; Iron-Sulfur Proteins/chemistry ; Iron-Sulfur Proteins/metabolism ; Mitochondrial Proteins/chemistry ; Mitochondrial Proteins/metabolism ; Oxidation-Reduction ; Protein Multimerization ; Sulfur/metabolism
Chemical Substances	CISD1 protein, human ; Ferredoxins ; Iron-Sulfur Proteins ; Mitochondrial Proteins ; apoferredoxin ; Sulfur (70FD1KFU70) ; Hydrogen Peroxide (BBX060AN9V) ; Iron (E1UOL152H7)
Language	English
Publishing date	2018-09-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1108-3
ISSN	1520-4995 ; 0006-2960
ISSN (online)	1520-4995
ISSN	0006-2960
DOI	10.1021/acs.biochem.8b00777
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Article ; Online: Imaging-guided prognostic score-based approach to assess the benefits of combotherapy versus monotherapy with immune checkpoint inhibitors in metastatic MSI-H colorectal cancer patients.

European journal of cancer (Oxford, England : 1990)

2024 Volume 202, Page(s) 114020

Abstract: ... with microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) by analyzing quantitative imaging data and ... tumor volume, lesion count, the presence of peritoneal carcinomatosis, and age can guide MSI-H mCRC treatment ...

Abstract	Background: This retrospective study determined survival responses to immune checkpoint inhibitors (ICIs), comparing mono- (mono) and combo-immunotherapy (combo) in patients with microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC) by analyzing quantitative imaging data and clinical factors. Methods: One hundred fifty patients were included from two centers and divided into training (n = 105) and validation (n = 45) cohorts. Radiologists manually annotated chest-abdomen-pelvis computed tomography and calculated tumor burden. Progression-free survival (PFS) was assessed, and variables were selected through Recursive Feature Elimination. Cutoff values were determined using maximally selected rank statistics to binarize features, forming a risk score with hazard ratio-derived weights. Results: In total, 2258 lesions were annotated with excellent reproducibility. Key variables in the training cohort included: total tumor volume (cutoff: 73 cm Conclusions: A score based on total tumor volume, lesion count, the presence of peritoneal carcinomatosis, and age can guide MSI-H mCRC treatment decisions, allowing oncologists to identify suitable candidates for mono and combo ICI therapies.
MeSH term(s)	Humans ; Immune Checkpoint Inhibitors/therapeutic use ; Prognosis ; Colorectal Neoplasms/diagnostic imaging ; Colorectal Neoplasms/drug therapy ; Peritoneal Neoplasms/drug therapy ; Retrospective Studies ; Reproducibility of Results ; Colonic Neoplasms/drug therapy ; Microsatellite Instability ; DNA Mismatch Repair
Chemical Substances	Immune Checkpoint Inhibitors
Language	English
Publishing date	2024-03-16
Publishing country	England
Document type	Journal Article
ZDB-ID	82061-1
ISSN	1879-0852 ; 0277-5379 ; 0959-8049 ; 0964-1947
ISSN (online)	1879-0852
ISSN	0277-5379 ; 0959-8049 ; 0964-1947
DOI	10.1016/j.ejca.2024.114020
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Zs.A 456: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 583: Show issues

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Article ; Online: Should a minimum Daptomycin AUC24h of 666 mg/L/h be the target in Staphylococcus aureus infections?

Tannous, Elias / Lipman-Arens, Shelly / Cohen, Regev

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

2024

Language	English
Publishing date	2024-03-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	1099781-7
ISSN	1537-6591 ; 1058-4838
ISSN (online)	1537-6591
ISSN	1058-4838
DOI	10.1093/cid/ciae086
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Zs.A 1505: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 480: Show issues

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Article ; Online: The scientific career and life of Edmond H. Fischer-A personal tribute.

Cohen, Philip

IUBMB life

2022 Volume 75, Issue 4, Page(s) 284–288

Language	English
Publishing date	2022-12-08
Publishing country	England
Document type	Journal Article
ZDB-ID	1492141-8
ISSN	1521-6551 ; 1521-6543
ISSN (online)	1521-6551
ISSN	1521-6543
DOI	10.1002/iub.2695
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Zs.A 1611: Show issues

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Article ; Online: Correspondence to European Heart Journal-Quality of Care and Clinical Outcomes in response to letter by Dalal H. et al.

Thomas, Merrill / Jones, Philip G / Cohen, David J / Arnold, Suzanne V / Magnuson, Elizabeth A / Thourani, Vinod H / Fonarow, Gregg C / Sandhu, Alexander T / Spertus, John A

European heart journal. Quality of care & clinical outcomes

2021 Volume 7, Issue 4, Page(s) e8

MeSH term(s)	Humans ; Quality of Health Care
Language	English
Publishing date	2021-04-29
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	2823451-0
ISSN	2058-1742 ; 2058-5225
ISSN (online)	2058-1742
ISSN	2058-5225
DOI	10.1093/ehjqcco/qcab034
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Article ; Online: Retraction: A Metal-Organic Framework with Exceptional Activity for C-H Bond Amination.

Wang, Le / Agnew, Douglas W / Yu, Xiao / Figueroa, Joshua S / Cohen, Seth M

Angewandte Chemie (International ed. in English)

2022 Volume 61, Issue 30, Page(s) e202208564

Language	English
Publishing date	2022-07-15
Publishing country	Germany
Document type	Retraction of Publication
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202208564
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Article ; Online: Prognostic utility of rhythmic components in 24-h ambulatory blood pressure monitoring for the risk stratification of chronic kidney disease patients with cardiovascular co-morbidity.

El Jamal, Nadim / Brooks, Thomas G / Cohen, Jordana / Townsend, Raymond R / Sosa, Giselle Rodriguez de / Shah, Vallabh / Nelson, Robert G / Drawz, Paul E / Rao, Panduranga / Bhat, Zeenat / Chang, Alexander / Yang, Wei / FitzGerald, Garret A / Skarke, Carsten

Journal of human hypertension

2024

Abstract: ... determination of rhythmic components in 24-h profiles of ambulatory blood pressure monitoring (ABPM ...

Abstract	Chronic kidney disease (CKD) represents a significant global burden. Hypertension is a modifiable risk factor for rapid progression of CKD. We extend the risk stratification by introducing the non-parametric determination of rhythmic components in 24-h profiles of ambulatory blood pressure monitoring (ABPM) in the Chronic Renal Insufficiency Cohort (CRIC) and the African American Study for Kidney Disease and Hypertension (AASK) cohort using Cox proportional hazards models. We find that rhythmic profiling of BP through JTK_CYCLE analysis identifies subgroups of CRIC participants that were more likely to die due to cardiovascular causes. While our fully adjusted model shows a trend towards a significant association between absent cyclic components and cardiovascular death in the full CRIC cohort (HR: 1.71,95% CI: 0.99-2.97, p = 0.056), CRIC participants with a history of cardiovascular disease (CVD) and absent cyclic components in their BP profile had at any time a 3.4-times higher risk of cardiovascular death than CVD patients with cyclic components present in their BP profile (HR: 3.37, 95% CI: 1.45-7.87, p = 0.005). This increased risk was not explained by the dipping or non-dipping pattern in ABPM. Due to the large differences in patient characteristics, the results do not replicate in the AASK cohort. This study suggests rhythmic blood pressure components as a potential novel biomarker to unmask excess risk among CKD patients with prior cardiovascular disease.
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	639472-3
ISSN	1476-5527 ; 0950-9240
ISSN (online)	1476-5527
ISSN	0950-9240
DOI	10.1038/s41371-023-00884-0
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Zs.A 2380: Show issues

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Article ; Online: Cytoreductive surgery with hyperthermic intraperitoneal chemotherapy: Effects of postoperative fluids beyond the first 24 h.

Berger, Yael / Sullivan, Brianne J / Bekhor, Eliahu Y / Carpiniello, Matthew / Leigh, Natasha L / Pletcher, Eric R / Solomon, Daniel / Sarpel, Umut / Hiotis, Spiros P / Labow, Daniel M / Cohen, Noah A / Golas, Benjamin J

Journal of surgical oncology

2023 Volume 128, Issue 7, Page(s) 1133–1140

Abstract: ... volumes and types administered intraoperatively and during the first 72 h postoperatively. Optimal IVF ...

Abstract	Background and objectives: There are no guidelines for intravenous fluid (IVF) administration after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). This study assessed rates of post-CRS/HIPEC morbidity according to perioperative IVF administration. Methods: All patients undergoing CRS/HIPEC March 2007 to June 2018 were reviewed, recording clinicopathologic, operative, and postoperative variables. Patients were divided by peritoneal cancer index (PCI), comparing IVF volumes and types administered intraoperatively and during the first 72 h postoperatively. Optimal IVF rate cutoffs calculated using area under the receiver operating characteristic curves and Youden's index determined associations with complications. Results: Overall, 185 patients underwent CRS/HIPEC, and 81 (51%) had low PCI (<10) and 77 (49%) had high PCI (≥10). In low-PCI patients, high IVF rates on postoperative days (POD) #0-2 were associated with higher overall complications: POD#0 (46% vs. 89%, p = 0.001), POD#1 (40% vs. 86%, p < 0.05), and POD#2 (42% vs. 72%, p < 0.05). High IVF rates were associated with respiratory distress (7% vs. 26%, p = 0.02) on POD#0, ileus (14% vs. 47%, p = 0.007) and intensive care unit stay (11% vs. 33%, p = 0.022) on POD#1, and ICU stay (8% vs. 33%, p = 0.003) on POD#2. Conclusions: For low PCI patients undergoing CRS/HIPEC, higher IVF rates were associated with postoperative complications. Post-CRS/HIPEC, IVF rates should be limited to prevent morbidity.
Language	English
Publishing date	2023-07-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	82063-5
ISSN	1096-9098 ; 0022-4790
ISSN (online)	1096-9098
ISSN	0022-4790
DOI	10.1002/jso.27407
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Zs.A 706: Show issues

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Article ; Online: Probing Few-Body Nuclear Dynamics via ^{3}H and ^{3}He (e,e^{'}p)pn Cross-Section Measurements.

Cruz-Torres, R / Nguyen, D / Hauenstein, F / Schmidt, A / Li, S / Abrams, D / Albataineh, H / Alsalmi, S / Androic, D / Aniol, K / Armstrong, W / Arrington, J / Atac, H / Averett, T / Ayerbe Gayoso, C / Bai, X / Bane, J / Barcus, S / Beck, A /

Bellini, V / Benmokhtar, F / Bhatt, H / Bhetuwal, D / Biswas, D / Blyth, D / Boeglin, W / Bulumulla, D / Camsonne, A / Castellanos, J / Chen, J-P / Cohen, E O / Covrig, S / Craycraft, K / Dongwi, B / Duer, M / Duran, B / Dutta, D / Fuchey, E / Gal, C / Gautam, T N / Gilad, S / Gnanvo, K / Gogami, T / Golak, J / Gomez, J / Gu, C / Habarakada, A / Hague, T / Hansen, O / Hattawy, M / Hen, O / Higinbotham, D W / Hughes, E / Hyde, C / Ibrahim, H / Jian, S / Joosten, S / Kamada, H / Karki, A / Karki, B / Katramatou, A T / Keppel, C / Khachatryan, M / Khachatryan, V / Khanal, A / King, D / King, P / Korover, I / Kutz, T / Lashley-Colthirst, N / Laskaris, G / Li, W / Liu, H / Liyanage, N / Markowitz, P / McClellan, R E / Meekins, D / Mey-Tal Beck, S / Meziani, Z-E / Michaels, R / Mihovilovič, M / Nelyubin, V / Nuruzzaman, N / Nycz, M / Obrecht, R / Olson, M / Ou, L / Owen, V / Pandey, B / Pandey, V / Papadopoulou, A / Park, S / Patsyuk, M / Paul, S / Petratos, G G / Piasetzky, E / Pomatsalyuk, R / Premathilake, S / Puckett, A J R / Punjabi, V / Ransome, R / Rashad, M N H / Reimer, P E / Riordan, S / Roche, J / Sargsian, M / Santiesteban, N / Sawatzky, B / Segarra, E P / Schmookler, B / Shahinyan, A / Širca, S / Skibiński, R / Sparveris, N / Su, T / Suleiman, R / Szumila-Vance, H / Tadepalli, A S / Tang, L / Tireman, W / Topolnicki, K / Tortorici, F / Urciuoli, G / Weinstein, L B / Witała, H / Wojtsekhowski, B / Wood, S / Ye, Z H / Ye, Z Y / Zhang, J

Physical review letters

2020 Volume 124, Issue 21, Page(s) 212501

Abstract: ... in helium-3 (^{3}He) and tritium (^{3}H) at large momentum transfer [⟨Q^{2}⟩≈1.9 (GeV/c)^{2}] and x_{B}>1 ... for the full p_{miss} range for ^{3}H and for 100≤p_{miss}≤350 MeV/c for ^{3}He. Including the effects ... contributions from charge-exchange (SCX) rescattering. The isoscalar sum of ^{3}He plus ^{3}H, which is largely ...

Abstract	We report the first measurement of the (e,e^{'}p) three-body breakup reaction cross sections in helium-3 (^{3}He) and tritium (^{3}H) at large momentum transfer [⟨Q^{2}⟩≈1.9 (GeV/c)^{2}] and x_{B}>1 kinematics, where the cross section should be sensitive to quasielastic (QE) scattering from single nucleons. The data cover missing momenta 40≤p_{miss}≤500 MeV/c that, in the QE limit with no rescattering, equals the initial momentum of the probed nucleon. The measured cross sections are compared with state-of-the-art ab initio calculations. Overall good agreement, within ±20%, is observed between data and calculations for the full p_{miss} range for ^{3}H and for 100≤p_{miss}≤350 MeV/c for ^{3}He. Including the effects of rescattering of the outgoing nucleon improves agreement with the data at p_{miss}>250 MeV/c and suggests contributions from charge-exchange (SCX) rescattering. The isoscalar sum of ^{3}He plus ^{3}H, which is largely insensitive to SCX, is described by calculations to within the accuracy of the data over the entire p_{miss} range. This validates current models of the ground state of the three-nucleon system up to very high initial nucleon momenta of 500 MeV/c.
Language	English
Publishing date	2020-06-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.124.212501
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Article ; Online: C-H-E-A-T: Wordle Cheating Is Related to Religiosity and Cultural Tightness.

Wormley, Alexandra S / Cohen, Adam B

Perspectives on psychological science : a journal of the Association for Psychological Science

2022 Volume 18, Issue 3, Page(s) 702–709

Abstract: Wordle is a daily, online brainteaser. The widespread popularity of the game in the early months of 2022 has also led to widespread cheating. Here, we use data from Google Trends and Twitter to explore correlates of cheating on Wordle. We find that ... ...

Abstract	Wordle is a daily, online brainteaser. The widespread popularity of the game in the early months of 2022 has also led to widespread cheating. Here, we use data from Google Trends and Twitter to explore correlates of cheating on Wordle. We find that cheating behavior is negatively related to religiosity and cultural tightness. Although this is a benign example of cheating behavior, we discuss how popular trends can be used as case studies of group-level behavior.
MeSH term(s)	Humans ; Deception ; Games, Experimental ; Internet
Language	English
Publishing date	2022-10-27
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2224911-4
ISSN	1745-6924 ; 1745-6916
ISSN (online)	1745-6924
ISSN	1745-6916
DOI	10.1177/17456916221113759
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