LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 11307

Search options

  1. Article ; Online: Pharmacokinetics of Hu-Pi-Cheng-Qi decoction administered via enema to rats with acute pancreatitis.

    Wu, Qiu-Ting / Chen, Huan / Xiang, Jin / Tang, Wen-Fu / Wan, Mei-Hua

    Chinese medical journal

    2020  Volume 133, Issue 12, Page(s) 1510–1512

    MeSH term(s) Acute Disease ; Animals ; Drugs, Chinese Herbal/therapeutic use ; Enema ; Pancreatitis/drug therapy ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2020-06-04
    Publishing country China
    Document type Letter
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000000853
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Ua VI Zs.425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  2. Article: Effect of Da-Cheng-Qi decoction for treatment of acute kidney injury in rats with severe acute pancreatitis.

    Yuan, Ling / Zhu, Lv / Zhang, Yumei / Chen, Huan / Kang, Hongxin / Li, Juan / Zhao, Xianlin / Wan, Meihua / Miao, Yifan / Tang, Wenfu

    Chinese medicine

    2018  Volume 13, Page(s) 38

    Abstract: Background: The traditional Chinese formula Da-Cheng-Qi-decoction (DCQD) has been used to treat ...

    Abstract Background: The traditional Chinese formula Da-Cheng-Qi-decoction (DCQD) has been used to treat acute pancreatitis for decades. DCQD could ameliorate the disease severity and the complications of organ injuries, including those of the liver and lungs. However, the pharmacological effects in the kidney, a target organ, are still unclear. This study aimed to investigate the herbal tissue pharmacology of DCQD for acute kidney injury (AKI) in rats with severe acute pancreatitis (SAP).
    Methods: Rats were randomly divided into the sham-operation group (SG), the model group (MG) and the low-, medium- and high-dose treatment groups (LDG, MDG, and HDG, respectively). Sodium taurocholate (3.5%) was retrogradely perfused into the biliopancreatic duct to establish the model of SAP in rats. Different doses of DCQD were administered to the treatment groups 2 h after the induction of SAP. The major components of DCQD in kidney tissues were detected by HPLC-MS/MS. Inflammatory mediators in the kidney tissues, as well as serum creatinine (Scr), blood urea nitrogen (BUN) and pathologic scores, were also evaluated.
    Results: Ten components of DCQD were detected in the kidneys of the treatment groups, and their concentrations increased dose-dependently. Compared with the SG, the levels of inflammatory mediators, Scr, BUN and pathological scores in the MG were obviously increased (
    Conclusions: DCQD ameliorated AKI in rats with SAP via regulating the inflammatory response, which might be closely related to the distribution of its components in the kidney.
    Language English
    Publishing date 2018-07-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2260322-0
    ISSN 1749-8546
    ISSN 1749-8546
    DOI 10.1186/s13020-018-0195-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article: Tissue Pharmacology of Da-Cheng-Qi Decoction in Experimental Acute Pancreatitis in Rats.

    Zhao, Xianlin / Zhang, Yumei / Li, Juan / Wan, Meihua / Zhu, Shifeng / Guo, Hui / Xiang, Jin / Thrower, Edwin C / Tang, Wenfu

    Evidence-based complementary and alternative medicine : eCAM

    2015  Volume 2015, Page(s) 283175

    Abstract: Objectives. The Chinese herbal medicine Da-Cheng-Qi Decoction (DCQD) can ameliorate the severity ...

    Abstract Objectives. The Chinese herbal medicine Da-Cheng-Qi Decoction (DCQD) can ameliorate the severity of acute pancreatitis (AP). However, the potential pharmacological mechanism remains unclear. This study explored the potential effective components and the pharmacokinetic characteristics of DCQD in target tissue in experimental acute pancreatitis in rats. Methods. Acute pancreatitis-like symptoms were first induced in rats and then they were given different doses of DCQD (6 g/kg, 12 g/kg, and 24 g/kg body weight) orally. Tissue drug concentration, tissue pathological score, and inflammatory mediators in pancreas, intestine, and lung tissues of rats were examined after 24 hours, respectively. Results. Major components of DCQD could be found in target tissues and their concentrations increased in conjunction with the intake dose of DCQD. The high-dose compounds showed maximal effect on altering levels of anti-inflammatory (interleukin-4 and interleukin-10) and proinflammatory markers (tumor necrosis factor α and interleukin-6) and ameliorating the pathological damage in target tissues (P < 0.05). Conclusions. DCQD could alleviate pancreatic, intestinal, and lung injury by altering levels of inflammatory cytokines in AP rats with tissue distribution of its components.
    Language English
    Publishing date 2015-06-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2015/283175
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  4. Article ; Online: Pharmacokinetics of Hu-Pi-Cheng-Qi decoction administered via enema to rats with acute pancreatitis

    Qiu-Ting Wu / Huan Chen / Jin Xiang / Wen-Fu Tang / Mei-Hua Wan / Ning-Ning Wang

    Chinese Medical Journal, Vol 133, Iss 12, Pp 1510-

    2020  Volume 1512

    Keywords Medicine ; R
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: [Analysis on Cheng Dan-an's educational thought in his book Chinese acupuncturology].

    Zhang, Chao-nan / Huang, Xue-kuan / Luo, Yan / Jiang, Juan / Wan, Lei / Wang, Ling

    Zhen ci yan jiu = Acupuncture research

    2014  Volume 39, Issue 5, Page(s) 410–412

    Abstract: Mr. CHENG Dan-an, a famous acupuncture master, is the beginner of "Chengjiang Acupuncturological ... and its educational thought and teaching features chiefly reflect in CHENG's works. In the present ... paper, the authors analyze the influence of contemporary historical factors and sum up Mr. CHENG's ...

    Abstract Mr. CHENG Dan-an, a famous acupuncture master, is the beginner of "Chengjiang Acupuncturological School" in China. This school of thought has a far-reaching impact on current acupunturological education,and its educational thought and teaching features chiefly reflect in CHENG's works. In the present paper, the authors analyze the influence of contemporary historical factors and sum up Mr. CHENG's educational thought on the basis of the written foundation, style and contents of his book Chinese Acupuncturology from four aspects (1) the role of education, (2) the process of education, (3) the teacher's and students' relationship in educational activities,and (4) the compilation of teaching materials about acupuncture and moxibustion.
    MeSH term(s) Acupuncture/education ; Acupuncture/history ; Acupuncture/methods ; Books/history ; China ; History, 19th Century ; History, 20th Century ; Humans
    Language Chinese
    Publishing date 2014-10
    Publishing country China
    Document type Biography ; English Abstract ; Historical Article ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1283179-7
    ISSN 1000-0607
    ISSN 1000-0607
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 4364: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  6. Article: Modified Da-Cheng-Qi Decoction reduces intra-abdominal hypertension in severe acute pancreatitis: a pilot study.

    Wan, Mei-Hua / Li, Juan / Huang, Wei / Mukherjee, Rajarshi / Gong, Han-Lin / Xia, Qing / Zhu, Lin / Cheng, Gui-Lan / Tang, Wen-Fu

    Chinese medical journal

    2012  Volume 125, Issue 11, Page(s) 1941–1944

    Abstract: ... indicate that a Da-Cheng-Qi Decoction (DCQD) is beneficial in the treatment of SAP. The purpose ...

    Abstract Background: Intra-abdominal hypertension (IAH) is a recognized prognostic marker for severity of severe acute pancreatitis (SAP) and has a strong impact on the clinical course of SAP. Previous studies indicate that a Da-Cheng-Qi Decoction (DCQD) is beneficial in the treatment of SAP. The purpose of this study was to evaluate the effect of modified DCQD on IAH in patients with SAP.
    Methods: Between January 2008 and December 2008, 42 patients from the West China Hospital were randomized into either the DCQD or control group (n = 21 in each group). Mortality, intra-abdominal pressure (IAP), Acute Physiology and Chronic Health Evaluation II (APACHE II) score, C-reactive protein (CRP), oxygenation index, Balthazar CT score, rate of renal failure, decompression rate, intensive care unit (ICU) transfer rate, and length of hospital stay (LOS) were compared between the two groups.
    Results: Compared to the control group, the modified DCQD treatment significantly decreased IAP (P < 0.05) and APACHE II (P < 0.05) scores on days 4 - 8, CRP on day 8 (P < 0.01), renal failure rate (P < 0.05), and LOS (P < 0.05). The oxygenation index was significantly improved in the DCQD group compared with the control group (P < 0.05). No significant differences in the Balthazar CT score, shock rate, ICU transfer rate, or mortality occurred between the two groups.
    Conclusions: The modified DCQD can effectively relieve IAH and decrease LOS for patients with SAP. Larger clinical trials are needed to confirm these findings.
    MeSH term(s) Adult ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Intra-Abdominal Hypertension/drug therapy ; Male ; Middle Aged ; Pancreatitis/drug therapy ; Treatment Outcome
    Chemical Substances Da-Cheng-Qi ; Drugs, Chinese Herbal
    Language English
    Publishing date 2012-06
    Publishing country China
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 127089-8
    ISSN 0366-6999 ; 1002-0187
    ISSN 0366-6999 ; 1002-0187
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Ua VI Zs.425: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Optimal timing for the oral administration of Da-Cheng-Qi decoction based on the pharmacokinetic and pharmacodynamic targeting of the pancreas in rats with acute pancreatitis.

    Zhang, Yu-Mei / Zhu, Lin / Zhao, Xian-Lin / Chen, Huan / Kang, Hong-Xin / Zhao, Jian-Lei / Wan, Mei-Hua / Li, Juan / Zhu, Lv / Tang, Wen-Fu

    World journal of gastroenterology

    2017  Volume 23, Issue 39, Page(s) 7098–7109

    Abstract: Aim: To identify the optimal oral dosing time of Da-Cheng-Qi decoction (DCQD) in rats with acute ...

    Abstract Aim: To identify the optimal oral dosing time of Da-Cheng-Qi decoction (DCQD) in rats with acute pancreatitis (AP) based on the pharmacokinetic and pharmacodynamic parameters.
    Methods: First, 24 male Sprague-Dawley rats were divided into a sham-operated group [NG(a)] and three model groups [4hG(a), 12hG(a) and 24hG(a)]. The NG(a) and model groups were administered DCQD (10 g/kg.BW) intragastrically at 4 h, 4 h, 12 h and 24 h, respectively, after AP models induced by 3% sodium taurocholate. Plasma samples were collected from the tails at 10 min, 20 min, 40 min, 1 h, 2 h, 4 h, 8 h, 12 h and 24 h after a single dosing with DCQD. Plasma and pancreatic tissue concentrations of the major components of DCQD were determined by high-performance liquid chromatography tandem mass spectroscopy. The pharmacokinetic parameters and serum amylase were detected and compared. Second, rats were divided into a sham-operated group [NG(b)] and three treatment groups [4hG(b), 12hG(b) and 24hG(b)] with three corresponding control groups [MG(b)s]. Blood and pancreatic tissues were collected 24 h after a single dosing with DCQD. Serum amylase, inflammatory cytokines and pathological scores of pancreatic tissues were detected and compared.
    Results: The concentrations of emodin, naringin, honokiol, naringenin, aloe-emodin, chrysophanol and rheochrysidin in the 12hG(a) group were higher than those in the 4hG(a) group in the pancreatic tissues (
    Conclusion: Late-time dosing may have higher concentrations of the most major components of DCQD, with better pharmacokinetics and pharmacodynamics of anti-inflammation than early-time dosing, which showed the late time to be the optimal dosing time of DCQD for AP.
    MeSH term(s) Acute Disease ; Administration, Oral ; Amylases/blood ; Animals ; Biomarkers/blood ; Disease Models, Animal ; Drug Administration Schedule ; Interleukin-10/blood ; Interleukin-6/blood ; Male ; Pancreas/drug effects ; Pancreas/metabolism ; Pancreas/pathology ; Pancreatitis/blood ; Pancreatitis/chemically induced ; Pancreatitis/drug therapy ; Pancreatitis/pathology ; Plant Extracts/administration & dosage ; Plant Extracts/pharmacokinetics ; Rats, Sprague-Dawley ; Taurocholic Acid
    Chemical Substances Biomarkers ; Interleukin-6 ; Plant Extracts ; dachengqi decoction ; Interleukin-10 (130068-27-8) ; Taurocholic Acid (5E090O0G3Z) ; Amylases (EC 3.2.1.-)
    Language English
    Publishing date 2017-10-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185929-2
    ISSN 2219-2840 ; 1007-9327
    ISSN (online) 2219-2840
    ISSN 1007-9327
    DOI 10.3748/wjg.v23.i39.7098
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6039: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: Effect of Da-Cheng-Qi decoction for treatment of acute kidney injury in rats with severe acute pancreatitis

    Ling Yuan / Lv Zhu / Yumei Zhang / Huan Chen / Hongxin Kang / Juan Li / Xianlin Zhao / Meihua Wan / Yifan Miao / Wenfu Tang

    Chinese Medicine, Vol 13, Iss 1, Pp 1-

    2018  Volume 8

    Abstract: Abstract Background The traditional Chinese formula Da-Cheng-Qi-decoction (DCQD) has been used ...

    Abstract Abstract Background The traditional Chinese formula Da-Cheng-Qi-decoction (DCQD) has been used to treat acute pancreatitis for decades. DCQD could ameliorate the disease severity and the complications of organ injuries, including those of the liver and lungs. However, the pharmacological effects in the kidney, a target organ, are still unclear. This study aimed to investigate the herbal tissue pharmacology of DCQD for acute kidney injury (AKI) in rats with severe acute pancreatitis (SAP). Methods Rats were randomly divided into the sham-operation group (SG), the model group (MG) and the low-, medium- and high-dose treatment groups (LDG, MDG, and HDG, respectively). Sodium taurocholate (3.5%) was retrogradely perfused into the biliopancreatic duct to establish the model of SAP in rats. Different doses of DCQD were administered to the treatment groups 2 h after the induction of SAP. The major components of DCQD in kidney tissues were detected by HPLC–MS/MS. Inflammatory mediators in the kidney tissues, as well as serum creatinine (Scr), blood urea nitrogen (BUN) and pathologic scores, were also evaluated. Results Ten components of DCQD were detected in the kidneys of the treatment groups, and their concentrations increased dose-dependently. Compared with the SG, the levels of inflammatory mediators, Scr, BUN and pathological scores in the MG were obviously increased (p < 0.05). The high dose of DCQD showed a maximal effect in downregulating the pro-inflammatory mediators interleukin-6 (IL)-6 and tumour necrosis factor-α (TNF-α), upregulating anti-inflammatory mediators IL-4 and IL-10 in the kidney and alleviating the pathological damages. DCQD decreased the pancreas and kidney pathological scores of rats with SAP, especially in the HDG (p < 0.05). Compared with the MG, the level of Scr in the HDG was significantly decreased (p < 0.05). Conclusions DCQD ameliorated AKI in rats with SAP via regulating the inflammatory response, which might be closely related to the distribution of its components in the ...
    Keywords Da-Cheng-Qi decoction ; Acute pancreatitis ; Acute kidney injury ; Tissue distribution ; Inflammatory response ; Other systems of medicine ; RZ201-999
    Subject code 616
    Language English
    Publishing date 2018-07-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  9. Article ; Online: Metabolomic profiles illuminate the efficacy of Chinese herbal Da-Cheng-Qi decoction on acute pancreatitis in rats.

    Li, Juan / Zhu, Shi-Feng / Zhao, Xian-Lin / Liu, Yi-Xia / Wan, Mei-Hua / Guo, Hui / Liu, Yi-Ling / Gong, Han-Lin / Chen, Guang-Yuan / Tang, Wen-Fu

    Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.

    2015  Volume 15, Issue 4, Page(s) 337–343

    Abstract: Background and objectives: Chinese herbal drug Da-Cheng-Qi decoction (DCQD) has been widely used ...

    Abstract Background and objectives: Chinese herbal drug Da-Cheng-Qi decoction (DCQD) has been widely used for decades to treat acute pancreatitis (AP). Previous trials are mostly designed to state the potential mechanisms of the therapeutic effects rather than to detect its whole effect on metabolism. This study aimed to investigate the efficacy of DCQD on metabolism in AP.
    Methods: Twenty-two male adult Sprague-Dawley rats were randomized into three groups. AP was induced by retrograde ductal infusion of 3.5% sodium taurocholate solution in DCQD and AP group, while 0.9% saline solution was used in sham operation (SO) group. Blood samples were obtained 12 h after drug administration and a 600 MHz superconducting Nuclear Magnetic Resonance (NMR) spectrometer was used to detected plasma metabolites. Principal Components Analysis (PCA) and Partial Least Squares-Discriminant Analysis after Orthogonal Signal Correction (OSC-PLS-DA) were applied to analyze the Longitudinal Eddy-delay (LED) and Carr-Purcell-Meiboom-Gill (CPMG) spectra.
    Results: Differences in concentrations of metabolites among the three groups were detected by OSC-PLS-DA of 1HNMR spectra (both LED and CPMG). Compared with SO group, DCQD group had higher levels of plasma glycerol, glutamic acid, low density lipoprotein (LDL), saturated fatty acid (FA) and lower levels of alanine and glutamine, while the metabolic changes were reversed in the AP group.
    Conclusions: Our results demonstrated that DCQD was capable of altering the changed concentrations of metabolites in rats with AP and 1HNMR-based metabolomic approach provided a new methodological cue for systematically investigating the efficacies and mechanisms of DCQD in treating AP.
    MeSH term(s) Alanine/blood ; Animals ; Biotransformation ; Cholesterol, LDL/blood ; Drugs, Chinese Herbal/pharmacokinetics ; Drugs, Chinese Herbal/therapeutic use ; Fatty Acids/blood ; Glutamic Acid/blood ; Glutamine/blood ; Glycerol/blood ; Magnetic Resonance Spectroscopy ; Male ; Metabolomics ; Pancreatitis/drug therapy ; Pancreatitis/metabolism ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Cholesterol, LDL ; Da-Cheng-Qi ; Drugs, Chinese Herbal ; Fatty Acids ; Glutamine (0RH81L854J) ; Glutamic Acid (3KX376GY7L) ; Alanine (OF5P57N2ZX) ; Glycerol (PDC6A3C0OX)
    Language English
    Publishing date 2015-07
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2056680-3
    ISSN 1424-3911 ; 1424-3903
    ISSN (online) 1424-3911
    ISSN 1424-3903
    DOI 10.1016/j.pan.2015.04.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 5553: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Tissue Pharmacology of Da-Cheng-Qi Decoction in Experimental Acute Pancreatitis in Rats

    Xianlin Zhao / Yumei Zhang / Juan Li / Meihua Wan / Shifeng Zhu / Hui Guo / Jin Xiang / Edwin C. Thrower / Wenfu Tang

    Evidence-Based Complementary and Alternative Medicine, Vol

    2015  Volume 2015

    Abstract: Objectives. The Chinese herbal medicine Da-Cheng-Qi Decoction (DCQD) can ameliorate the severity ...

    Abstract Objectives. The Chinese herbal medicine Da-Cheng-Qi Decoction (DCQD) can ameliorate the severity of acute pancreatitis (AP). However, the potential pharmacological mechanism remains unclear. This study explored the potential effective components and the pharmacokinetic characteristics of DCQD in target tissue in experimental acute pancreatitis in rats. Methods. Acute pancreatitis-like symptoms were first induced in rats and then they were given different doses of DCQD (6 g/kg, 12 g/kg, and 24 g/kg body weight) orally. Tissue drug concentration, tissue pathological score, and inflammatory mediators in pancreas, intestine, and lung tissues of rats were examined after 24 hours, respectively. Results. Major components of DCQD could be found in target tissues and their concentrations increased in conjunction with the intake dose of DCQD. The high-dose compounds showed maximal effect on altering levels of anti-inflammatory (interleukin-4 and interleukin-10) and proinflammatory markers (tumor necrosis factor α and interleukin-6) and ameliorating the pathological damage in target tissues P<0.05. Conclusions. DCQD could alleviate pancreatic, intestinal, and lung injury by altering levels of inflammatory cytokines in AP rats with tissue distribution of its components.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 610
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top